{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:28:28Z","timestamp":1765700908592,"version":"build-2065373602"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.fct.2013.04.019","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T02:36:29Z","timestamp":1366166189000},"page":"387-388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Hormetic effect of Rosa laevigata Michx in CCl4-induced hepatotoxicity and the presumptive role of PPARs"],"prefix":"10.1016","volume":"57","author":[{"given":"Salvatore","family":"Chirumbolo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.fct.2013.04.019_b0005","doi-asserted-by":"crossref","first-page":"534","DOI":"10.4161\/cib.21508","article-title":"Transient complex peroxisome interactions: a new facet of peroxisome dynamics in mammalian cells","volume":"5","author":"Bonekamp","year":"2012","journal-title":"Commun. Integrat. Biol."},{"issue":"8","key":"10.1016\/j.fct.2013.04.019_b0010","first-page":"1013","article-title":"Study on purification of total flavonoids from Rosa laevigata with macroporous resin column chromatography","volume":"30","author":"Chen","year":"2007","journal-title":"Zhong Yao Cai."},{"issue":"6","key":"10.1016\/j.fct.2013.04.019_b0015","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s10522-012-9402-7","article-title":"Possible role of NF-\u03baB in hormesis during ageing","volume":"13","author":"Chirumbolo","year":"2012","journal-title":"Biogerontology"},{"issue":"1","key":"10.1016\/j.fct.2013.04.019_b0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0960327112455674","article-title":"Therapeutic efficacy of silymarin from milk thistle in reducing manganese-induced hepatic damage and apoptosis in rats","volume":"32","author":"Chtourou","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"issue":"27","key":"10.1016\/j.fct.2013.04.019_b0025","first-page":"1421","article-title":"Antioxidants in liver protection","volume":"145","author":"Hagym\u00e1si","year":"2004","journal-title":"Orv. Hetil."},{"issue":"5","key":"10.1016\/j.fct.2013.04.019_b0030","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1271\/bbb.80897","article-title":"Protective effects of radix Rosa laevigata against Propionibacterium acnes and lipopolysaccharide-induced liver injury","volume":"73","author":"He","year":"2009","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"21","key":"10.1016\/j.fct.2013.04.019_b0035","doi-asserted-by":"crossref","first-page":"E1369","DOI":"10.1073\/pnas.1202464109","article-title":"Protection from liver fibrosis by a peroxisome proliferator-activated receptor \u03b4 agonist","volume":"109","author":"Iwaisako","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.fct.2013.04.019_b0040","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1016\/j.fct.2012.06.047","article-title":"Total flavonoids from Rosa laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells","volume":"50","author":"Jia","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.fct.2013.04.019_b0045","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.fct.2012.02.025","article-title":"Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-\u03baB bioluminescent imaging-guided transcriptomic analysis","volume":"50","author":"Li","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.fct.2013.04.019_b0050","first-page":"410","article-title":"A review of plants used in the treatment of liver disease: part 1","volume":"3","author":"Luper","year":"1998","journal-title":"Altern. Med. Rev."},{"issue":"1","key":"10.1016\/j.fct.2013.04.019_b0055","doi-asserted-by":"crossref","first-page":"C8","DOI":"10.1111\/j.1750-3841.2011.02499.x","article-title":"Phenolics composition and antioxidant activity of wine produced from spine grape (Vitis davidii Foex) and Cherokee rose (Rosa laevigata Michx.) fruits from South China","volume":"77","author":"Meng","year":"2012","journal-title":"J. Food Sci."},{"issue":"11","key":"10.1016\/j.fct.2013.04.019_b0060","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/nm.2048","article-title":"PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance","volume":"15","author":"Mukundan","year":"2009","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.fct.2013.04.019_b0065","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/13880209.2010.493179","article-title":"Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPAR\u03b3 and inhibiting TGF\u03b21","volume":"49","author":"Qiao","year":"2011","journal-title":"Pharm. Biol."},{"issue":"6","key":"10.1016\/j.fct.2013.04.019_b0070","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1021\/pr050229j","article-title":"Order from chaos: observing hormesis at the proteome level","volume":"4","author":"Randi\u0107","year":"2005","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.fct.2013.04.019_b0075","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3164\/jcbn.10-139","article-title":"Administration of PPAR\u03b2\/\u03b4 agonist reduces copper-induced liver damage in mice: possible implications in clinical practice","volume":"49","author":"Sanchez-Siles","year":"2011","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"1","key":"10.1016\/j.fct.2013.04.019_b0080","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/hep.21925","article-title":"Peroxisome proliferator-activated receptor-beta\/delta protects against chemically induced liver toxicity in mice","volume":"47","author":"Shan","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2013.04.019_b0085","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2164-11-16","article-title":"Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha)","volume":"11","author":"Vallanat","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.fct.2013.04.019_b0090","first-page":"545","article-title":"Antihepatotoxic flavonoids","volume":"213","author":"Wagner","year":"1986","journal-title":"Prog. Clin. Biol. Res."},{"issue":"10","key":"10.1016\/j.fct.2013.04.019_b0095","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00011-010-0199-z","article-title":"Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice","volume":"59","author":"Xu","year":"2010","journal-title":"Inflamm. Res."},{"issue":"2","key":"10.1016\/j.fct.2013.04.019_b0100","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.foodchem.2010.09.080","article-title":"Hepatoprotective activity of the total flavonoids from Rosa laevigata Michx fruit in mice treated by paracetamol","volume":"125","author":"Yue-tao","year":"2011","journal-title":"Food Chem."},{"issue":"2","key":"10.1016\/j.fct.2013.04.019_b0105","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.yrtph.2011.12.009","article-title":"Subchronic toxicity study of the total flavonoids from Rosa laevigata Michx fruit in rats","volume":"62","author":"Zhang","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2013.04.019_b0110","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.fct.2012.12.041","article-title":"Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice","volume":"55","author":"Zhang","year":"2013","journal-title":"Food Chem. Toxicol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691513002524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691513002524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:15:12Z","timestamp":1759526112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691513002524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":22,"alternative-id":["S0278691513002524"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2013.04.019","relation":{},"ISSN":["0278-6915"],"issn-type":[{"type":"print","value":"0278-6915"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hormetic effect of Rosa laevigata Michx in CCl4-induced hepatotoxicity and the presumptive role of PPARs","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2013.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}