{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:55:51Z","timestamp":1781592951025,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.fct.2013.06.045","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T20:01:26Z","timestamp":1372795286000},"page":"476-484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Immunostimulatory activity of polysaccharides from Cheonggukjang"],"prefix":"10.1016","volume":"59","author":[{"given":"Seung-Jun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Kun","family":"Rim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Yun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jin","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Sun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Won","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Kyoung","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Do","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Tae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2013.06.045_b0005","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0003-2697(73)90377-1","article-title":"New method for quantitative determination of uronic acid","volume":"54","author":"Blumenkarntz","year":"1973","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2013.06.045_b0010","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2013.06.045_b0015","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/S0022-3468(03)00582-7","article-title":"Wandering spleen and its complications in children: a case series and review of the literature","volume":"38","author":"Brown","year":"2003","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.fct.2013.06.045_b0020","first-page":"255","article-title":"Fibrinolytic and immunostimulating activities of Bacillus spp. strains isolated from Chungkuk-jang","volume":"37","author":"Chang","year":"2005","journal-title":"Korean J. Food Sci. Technol."},{"key":"10.1016\/j.fct.2013.06.045_b0025","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.foodchem.2008.09.056","article-title":"Biotransformation of phenolics (isoflavones, flavanols and phenolic acids) during the fermentation of Cheonggukjang by Bacillus pumilus HY1","volume":"114","author":"Cho","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2013.06.045_b0030","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.foodchem.2007.06.024","article-title":"Free-radical-scavenging and tyrosinase-inhibition activities of Cheonggukjang samples fermented for various times","volume":"106","author":"Choi","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2013.06.045_b0035","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0091-3057(97)00028-2","article-title":"Forced swim test-induced neurochemical endocrine, and immune changes in the rat","volume":"58","author":"Connor","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.fct.2013.06.045_b0040","first-page":"240","article-title":"Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise","volume":"40","author":"Coombes","year":"2000","journal-title":"J. Sports Med. Phys. Fit."},{"key":"10.1016\/j.fct.2013.06.045_b0050","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1074\/jbc.274.1.264","article-title":"P38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes","volume":"274","author":"Dean","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2013.06.045_b0045","first-page":"537","article-title":"Effect of exercise during pregnancy and dam age on maternal blood chemistry and fetal growth","volume":"25","author":"de-Mello","year":"1992","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.fct.2013.06.045_b0055","first-page":"A211","article-title":"Sports and type I diabetes: personal experience","volume":"23","author":"Dorchy","year":"2002","journal-title":"Rev. Med. Brux."},{"key":"10.1016\/j.fct.2013.06.045_b0060","first-page":"350","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"Dubois","year":"1956","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2013.06.045_b0065","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.4049\/jimmunol.149.6.2114","article-title":"Both tumor necrosis factor and nitric oxide participate in lysis of simian virus 40-transformed cells by activated macrophages","volume":"149","author":"Duerksen-Hughes","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.fct.2013.06.045_b0070","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1139\/Y10-048","article-title":"Ketoconazole antagonizes the immune and gonadotropic systems in the forced swimming test in male Wistar rats","volume":"88","author":"Frih","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.fct.2013.06.045_b0075","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","article-title":"NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses","volume":"16","author":"Ghosh","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fct.2013.06.045_b0080","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0022-3565(24)39105-0","article-title":"Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-kappaB\/Rel in lipopolysaccharide-stimulated macrophages","volume":"294","author":"Jeon","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.fct.2013.06.045_b0085","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.rmed.2004.10.007","article-title":"Effects of antioxidants and NO on TNF-alpha-induced adhesion molecule expression in human pulmonary microvascular endothelial cells","volume":"99","author":"Jiang","year":"2005","journal-title":"Respir. Med."},{"key":"10.1016\/j.fct.2013.06.045_b0090","first-page":"2317","article-title":"Suppression of the vitro humoral immune response of mouse splenocytes by benzo(a)pyrene metabolites and inhibition of benzo(a)pyrene-induced immunosuppression by alpha-naphthoflavone","volume":"47","author":"Kawabata","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2013.06.045_b0105","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00284-003-4193-3","article-title":"Identification and antimicrobial activity of phenylacetic acid produced by Bacillus licheniformis isolated from fermented soybean, Chungkook-Jang","volume":"48","author":"Kim","year":"2004","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.fct.2013.06.045_b0095","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1271\/bbb.100858","article-title":"Correlation between antioxidative activities and metabolite changes during Cheonggukjang fermentation","volume":"75","author":"Kim","year":"2011","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.fct.2013.06.045_b0100","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3109\/08923973.2011.576254","article-title":"Immune-enhancing effect of Danggwibohyeoltang, an extract from Astragali Radix and Angelicae gigantis Radix, in vitro and in vivo","volume":"34","author":"Kim","year":"2012","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.fct.2013.06.045_b0110","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.foodchem.2008.05.005","article-title":"Effects of alginate microencapsulation on the fibrinolytic activity of fermented soybean paste Cheonggukjang extract","volume":"111","author":"Ko","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2013.06.045_b0115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1472-8206.2008.00638.x","article-title":"Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations","volume":"23","author":"Kumar","year":"2009","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.fct.2013.06.045_b0130","doi-asserted-by":"crossref","first-page":"6717","DOI":"10.1158\/0008-5472.CAN-06-4263","article-title":"Effect of dominant negative transforming growth factor-beta receptor type II on cytotoxic activity of RAW 264.7, a murine macrophage cell line","volume":"67","author":"Lee","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2013.06.045_b0120","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.intimp.2009.09.011","article-title":"Immunomodulating effects of Korean mistletoe lectin in vitro and in vivo","volume":"9","author":"Lee","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2013.06.045_b0125","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3746\/jkfn.2011.40.9.1227","article-title":"Immunostimulatory effects of traditional Doenjang","volume":"40","author":"Lee","year":"2011","journal-title":"J. Korean Soc. Food Sci. Nutr."},{"key":"10.1016\/j.fct.2013.06.045_b0135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/08923970600815139","article-title":"Aqueous extract of Rhodiola imbricata rhizome stimulates proinflammatory mediators via phosphorylated IkappaB and transcription factor nuclear factor-kappaB","volume":"28","author":"Mishra","year":"2006","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.fct.2013.06.045_b0140","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.fct.2013.06.045_b0145","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1128\/IAI.01412-06","volume":"75","author":"Olson","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fct.2013.06.045_b0150","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/333664a0","article-title":"Vascular endothelial cells synthesize nitric oxide from L-arginine","volume":"333","author":"Palmer","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.fct.2013.06.045_b0155","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.fct.2013.06.045_b0160","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-2776(07)96002-2","article-title":"Regulation of interferon-gamma during innate and adaptive immune responses","volume":"96","author":"Schoenborn","year":"2007","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.fct.2013.06.045_b0165","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1089\/jmf.2009.0081","article-title":"Identification of Bacillus cereus in a chungkukjang that showed high anticancer effects against AGS human gastric adenocarcinoma cells","volume":"12","author":"Seo","year":"2009","journal-title":"J. Med. Food"},{"key":"10.1016\/j.fct.2013.06.045_b0170","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1248\/bpb.27.1521","article-title":"Immune-enhancing effect of the Korean natural medicine WooKiEum","volume":"27","author":"Shin","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.fct.2013.06.045_b0175","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1111\/j.1476-5381.2011.01670.x","article-title":"Potent anti-inflammatory effect of a novel furan-2,5-dione derivative, BPD, mediated by dual suppression of COX-2 activity and LPS-induced inflammatory gene expression via NF-kappaB inactivation","volume":"165","author":"Shin","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fct.2013.06.045_b0180","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1126\/science.3131876","article-title":"Interleukin-2: inception, impact, and implications","volume":"240","author":"Smith","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.fct.2013.06.045_b0185","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijbiomac.2008.06.009","article-title":"Structural characterization of a water-soluble polysaccharide from the roots of Codonopsis pilosula and its immunity activity","volume":"43","author":"Sun","year":"2008","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fct.2013.06.045_b0190","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1104\/pp.49.6.926","article-title":"A gas chromatographic method for the determination of aldose and uronic acid constituents of plant cell wall polysaccharides","volume":"49","author":"Thomas","year":"1972","journal-title":"Plant Physiol."},{"key":"10.1016\/j.fct.2013.06.045_b0195","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1126\/science.1198687","article-title":"Innate or adaptive immunity? The example of natural killer cells","volume":"331","author":"Vivier","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.fct.2013.06.045_b0200","first-page":"E883","article-title":"Carbohydrate supplementation, glycogen depletion, and amino acid metabolism during exercise","volume":"260","author":"Wagenmakers","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.fct.2013.06.045_b0205","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.foodchem.2010.03.012","article-title":"Structural analysis of a rhamnoarabinogalactan from the stems of Dendrobium nobile Lindl","volume":"3","author":"Wang","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2013.06.045_b0210","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2222.2006.02401.x","volume":"36","author":"Xu","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.fct.2013.06.045_b0215","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0144-8617(00)00294-0","article-title":"Structural characterization of intestinal immune system modulating new arabino-3,6-galactan from rhizomes of Atractylodes lancea DC","volume":"46","author":"Yu","year":"2001","journal-title":"Carbohydr. Polym."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691513004249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691513004249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:17:42Z","timestamp":1759526262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691513004249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":43,"alternative-id":["S0278691513004249"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2013.06.045","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunostimulatory activity of polysaccharides from Cheonggukjang","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2013.06.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}