{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:26:56Z","timestamp":1759530416212,"version":"build-2065373602"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.fct.2013.08.069","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T03:47:10Z","timestamp":1384573630000},"page":"S51-S55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"S1","title":["Fragrance material review on 2-cyclohexyl-1,6-heptadien-3-one"],"prefix":"10.1016","volume":"62","author":[{"given":"J.","family":"Scognamiglio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.S.","family":"Letizia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Api","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2013.08.069_b0005","doi-asserted-by":"crossref","unstructured":"Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and Dermatologic Assessment of Alkyl Cyclic Ketones When Used as Fragrance Ingredients. Submitted with this manuscript.","DOI":"10.1016\/j.fct.2013.09.033"},{"key":"10.1016\/j.fct.2013.08.069_b0010","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/rtph.2002.1581","article-title":"Consumer exposure to fragrance ingredients: providing estimates for safety evaluation","volume":"36","author":"Cadby","year":"2002","journal-title":"Regulatory Toxicology and Pharmacology"},{"key":"10.1016\/j.fct.2013.08.069_b0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/rtph.1999.1362","article-title":"Criteria for development of a database for safety evaluation of fragrance ingredients","volume":"31","author":"Ford","year":"2000","journal-title":"Regulatory Toxicology and Pharmacology"},{"key":"10.1016\/j.fct.2013.08.069_b0020","unstructured":"IFRA (International Fragrance Association), 2008. Volume of Use Survey, February 2008."},{"issue":"3","key":"10.1016\/j.fct.2013.08.069_b0025","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/1523-1747.ep12676801","article-title":"The identification of contact allergens by animal assay. The guinea pig maximization test","volume":"52","author":"Kligman","year":"1969","journal-title":"Journal of Investigative Dermatology"},{"key":"10.1016\/j.fct.2013.08.069_b0030","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2001a. 1,6-Heptadien-3-one, 2-cyclohexyl-(pharaone): Acute oral toxicity study in rats, Report number 59371, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2013.08.069_b0035","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2001b. 1,6-Heptadien-3-one, 2-cyclohexyl- (pharaone): Contact hypersensitivity in albino guinea pigs, maximization-test. 04 December, Report number 59410, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2013.08.069_b0040","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2001c. 1,6-Heptadien-3-one, 2-cyclohexyl-(pharaone): Primary skin irritation study in rabbits (4-hour semi-occlusive application), Report number 59379, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2013.08.069_b0045","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2001d. Salmonella typhimurium reverse mutation assay with 1,6-heptadien-3-one, 2-cyclohexyl-(pharaone) (Amendment Attached). 16 November. Report number 59404, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2013.08.069_b0055","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2002. 1,6-Heptadien-3-one, 2-cyclohexyl- (pharaone): Determination of photoallergenicity in albino guinea pigs (including information about allergenicity, photoirritation and irritation). 15 February. Report number 59408, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2013.08.069_b0060","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2003. Repeated insult patch test with 1,6-heptadien-3-one, 2-cyclohexyl- (pharaone). 24 January. Report number 59411, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2013.08.069_b0065","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2004a. 1,6-Heptadien-3-one, 2-cyclohexyl-(pharaone): Acute dermal toxicity study in rats. Report number 59370, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2013.08.069_b0070","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2004b. Five day dose range finding and 28-day oral toxicity (gavage) study and 5 day range-finding oral toxicity study in the Wistar rat with 1,6-heptadien-3-one, 2-cyclohexyl- (pharaone). 21 May, Report number 59412, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2013.08.069_b0075","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2004c. In vitro chromosome aberration test in Chinese hamster V79 cells with 1,6-heptadien-3-one, 2-cyclohexyl-(pharaone). Report number 59406, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2013.08.069_b0080","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2005. Micronucleus assay in bone marrow cells of the mouse with 1,6-heptadien-3-one, 2-cyclohexyl-(pharaone), 12 April, Report number 59407, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2013.08.069_b0085","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 2007. Escherichia coli reverse mutation assay with 1,6-heptadien-3-one, 2-cyclohexyl- (pharaone), 20 September, Report number 59405, RIFM, Woodcliff Lake, NJ, USA."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691513006157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691513006157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:15:29Z","timestamp":1759526129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691513006157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":16,"alternative-id":["S0278691513006157"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2013.08.069","relation":{},"ISSN":["0278-6915"],"issn-type":[{"type":"print","value":"0278-6915"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fragrance material review on 2-cyclohexyl-1,6-heptadien-3-one","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2013.08.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}