{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:37:29Z","timestamp":1784180249051,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.fct.2013.11.011","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T16:20:09Z","timestamp":1385137209000},"page":"20-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Prevention of rat liver fibrosis and carcinogenesis by coffee and caffeine"],"prefix":"10.1016","volume":"64","author":[{"given":"Kelly S.","family":"Furtado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jossimara","family":"Polletini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos C.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.M.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Barbisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2013.11.011_b0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/emm.2001.31","article-title":"Chronic liver injury, TGF-beta, and cancer","volume":"33","author":"Bissell","year":"2001","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.fct.2013.11.011_b0015","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/mnfr.201100115","article-title":"Coffees rich in chlorogenic acid or N-methylpyridium induces chemopreventive phase II-enzymes via the Nrf2\/ARE pathway in vitro and in vivo","volume":"55","author":"Boettler","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2013.11.011_b0020","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/hep.21708","article-title":"Coffee drinking and hepatocellular carcinoma risk: a meta-analysis","volume":"46","author":"Bravi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2013.11.011_b0025","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1242\/jcs.031682","article-title":"Control of mitochondrial apoptosis by the Bcl-2 family","volume":"122","author":"Brunelle","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.fct.2013.11.011_b0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.fct.2013.11.011_b0035","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/10408390903586412","article-title":"Coffee and its consumption: benefits and risks","volume":"51","author":"Butt","year":"2011","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fct.2013.11.011_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2036.2007.03319.x","article-title":"Review article: possible beneficial effects of coffee on liver disease and function","volume":"26","author":"Cadden","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2013.11.011_b0045","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1007\/s10620-010-1143-3","article-title":"Protective role of coffee in non-alcoholic fatty liver disease (NAFLD)","volume":"55","author":"Catalano","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.fct.2013.11.011_b0050","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.fct.2007.09.099","article-title":"Induction of Nrf2-mediated cellular defences and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver","volume":"46","author":"Cavin","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2013.11.011_b0055","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S1047-2797(01)00223-X","article-title":"Collaborative SIDECIRGroup: Coffee, caffeine, and the risk of liver cirrhosis","volume":"11","author":"Corrao","year":"2001","journal-title":"Annu. Epidemiol."},{"key":"10.1016\/j.fct.2013.11.011_b0060","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jhep.2010.08.027","article-title":"Association of caffeine intake and histological features of chronic hepatitis C","volume":"54","author":"Costentin","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.fct.2013.11.011_b0065","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.1021\/jf201906p","article-title":"Effect of simultaneous consumption of milk and coffee on chlorogenic acids\u2019 bioavailability in humans","volume":"59","author":"Duarte","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2013.11.011_b0070","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/mnfr.200600034","article-title":"Chlorogenic acid is poorly absorbed, independently of the food matrix: A Caco-2 cells and rat chronic absorption study","volume":"50","author":"Dupas","year":"2006","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2013.11.011_b0075","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cld.2006.08.022","article-title":"Reversal of fibrosis: No longer a pipe dream?","volume":"10","author":"Fallowfield","year":"2006","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.fct.2013.11.011_b0080","first-page":"1779","article-title":"Preventive effect of caffeine and curcumin on hepatocarcinogenesis in diethylnitrosamine-induced rats","volume":"40","author":"Fujise","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.fct.2013.11.011_b0085","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1742-7843.2012.00903.x","article-title":"Coffee and caffeine protect against liver injury induced by thioacetamide in male Wistar rats","volume":"111","author":"Furtado","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.fct.2013.11.011_b0090","unstructured":"Goodman, D.G., Maronpot, R.R., Newberne, P.M., Popp, J.A., Squire, R.A. 1994. Proliferative and selected other lesions in the liver of rats. In: Guides for Toxicologic Pathology. STP\/ARP\/AFIP, 1994. Washington, DC."},{"key":"10.1016\/j.fct.2013.11.011_b0095","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1053\/j.gastro.2010.09.025","article-title":"In the search of the magic bullet","volume":"139","author":"Gressner","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2013.11.011_b0100","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.fct.2013.11.011_b0105","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0278-6915(95)80242-8","article-title":"Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats","volume":"33","author":"Hasegawa","year":"1995","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2013.11.011_b0110","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1111\/j.1750-3841.2010.01561.x","article-title":"Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters","volume":"75","author":"Heckman","year":"2010","journal-title":"J. Food Sci."},{"key":"10.1016\/j.fct.2013.11.011_b0115","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Ann. Rev. Pathol."},{"key":"10.1016\/j.fct.2013.11.011_b0120","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0278-6915(00)00175-7","article-title":"Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene","volume":"39","author":"Hosaka","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2013.11.011_b0125","first-page":"1129","article-title":"Prevention of hepatocellular carcinoma: potential targets, experimental models, and clinical challenges","volume":"12","author":"Hoshida","year":"2012","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.fct.2013.11.011_b0130","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.fct.2007.09.094","article-title":"Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver","volume":"46","author":"Huber","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2013.11.011_b0135","article-title":"Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat","author":"Katayama","year":"2013","journal-title":"Clin Nutr"},{"key":"10.1016\/j.fct.2013.11.011_b0140","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1111\/j.1440-1746.2006.04658.x","article-title":"Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis","volume":"22","author":"Kisseleva","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.fct.2013.11.011_b0150","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1001\/archinte.166.11.1190","article-title":"Coffee, cirrhosis, and transaminase enzymes","volume":"166","author":"Klatsky","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.fct.2013.11.011_b0155","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ceb.2003.10.004","article-title":"Bcl-2-family proteins and the role of mitochondria in apoptosis","volume":"15","author":"Kuwana","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.fct.2013.11.011_b0160","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/j.fct.2007.05.010","article-title":"Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice","volume":"45","author":"Lee","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2013.11.011_b0165","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1093\/nar\/gkp056","article-title":"RDML consortium. RDML structured language and reporting guidelines for real-time quantitative PCR data","volume":"37","author":"Lefever","year":"2009","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.fct.2013.11.011_b0170","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1136\/jech.2009.104125","article-title":"Moderate coffee consumption reduces the risk of hepatocellular carcinoma in hepatitis B chronic carriers: a case control-study","volume":"65","author":"Leung","year":"2011","journal-title":"J. Epidemiol. Commun. Health"},{"key":"10.1016\/j.fct.2013.11.011_b0175","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.cld.2008.07.007","article-title":"The global impact of hepatic fibrosis and end-stage liver disease","volume":"12","author":"Lim","year":"2008","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.fct.2013.11.011_b0180","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))","volume":"25","author":"Livak","year":"2001","journal-title":"Method"},{"key":"10.1016\/j.fct.2013.11.011_b0185","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/hep.23279","article-title":"Increased caffeine consumption is associated with reduced hepatic fibrosis","volume":"51","author":"Modi","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2013.11.011_b0195","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s12072-010-9247-6","article-title":"Coffee prevents CCl(4)-induced liver cirrhosis in the rat","volume":"5","author":"Moreno","year":"2011","journal-title":"Hep. Intl."},{"key":"10.1016\/j.fct.2013.11.011_b0190","doi-asserted-by":"crossref","first-page":"H155","DOI":"10.1111\/j.1750-3841.2009.01192.x","article-title":"Effects of instant coffee consumption on oxidative DNA damage, DNA repair, and redox system in mouse liver","volume":"74","author":"Morii","year":"2009","journal-title":"J. Food Sci."},{"key":"10.1016\/j.fct.2013.11.011_b0200","first-page":"163","article-title":"Does instant coffee prevent acute liver injury induced by carbon tetrachoride (CCl4)?","volume":"35","author":"Ozercan","year":"2006","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.fct.2013.11.011_b0205","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0278-6915(03)00171-6","article-title":"Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat","volume":"41","author":"Pinheiro","year":"2003","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2013.11.011_b0210","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.clnu.2009.12.007","article-title":"Protective effect of a coffee preparation (Nescafe pure) against carbon tetrachloride-induced liver fibrosis in rats","volume":"29","author":"Shi","year":"2010","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.fct.2013.11.011_b0215","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/jsfa.3838","article-title":"Experimental evidence for the protective effects of coffee against liver fibrosis in SD rats","volume":"90","author":"Shin","year":"2010","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.fct.2013.11.011_b0005","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1139\/h2012-129","article-title":"Effects of swim training on liver carcinogenesis in male Wistar rats fed a low-fat or high-fat diet","volume":"37","author":"Aguiar e Silva","year":"2012","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.fct.2013.11.011_b0220","doi-asserted-by":"crossref","unstructured":"Silva, J.P., Ferreira, E.B., Barbisan, L.F., Brigagao, M.R., Paula, F.B., Moraes, G.O., Magalh\u00e3es, C.S., Azevedo, L. 2013. Organically produced coffee exerts protective effects against the micronuclei induction by mutagens in mouse gut and bone marrow. Food Research International. <http:\/\/dx.doi.org\/10.1016\/j.foodres.2013.07.006>.","DOI":"10.1016\/j.foodres.2013.07.006"},{"key":"10.1016\/j.fct.2013.11.011_b0225","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/01635580903407205","article-title":"Effect of coffee on chemical hepatocarcinogenesis in rats","volume":"62","author":"Silva-Oliveira","year":"2010","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.fct.2013.11.011_b0230","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.mehy.2008.06.026","article-title":"The multifaceted mechanisms for coffee\u2019s anti-tumorigenic effect on liver","volume":"71","author":"Tao","year":"2008","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.fct.2013.11.011_b0235","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1047-2797(02)00462-3","article-title":"Coffee intake and mortality from liver cirrhosis","volume":"13","author":"Tverdal","year":"2003","journal-title":"Annu. Epidemiol."},{"key":"10.1016\/j.fct.2013.11.011_b0240","doi-asserted-by":"crossref","first-page":"S369","DOI":"10.1111\/j.1440-1746.2004.03705.x","article-title":"Pathogenesis of cirrhosis","volume":"19","author":"Wanless","year":"2004","journal-title":"J. Gastroenterol. Hepatol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691513007564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691513007564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:15:49Z","timestamp":1759526149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691513007564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":47,"alternative-id":["S0278691513007564"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2013.11.011","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevention of rat liver fibrosis and carcinogenesis by coffee and caffeine","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2013.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}