{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:14:10Z","timestamp":1792880050844,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004858","name":"Sichuan University of Science and Engineering","doi-asserted-by":"crossref","award":["2013RC14"],"award-info":[{"award-number":["2013RC14"]}],"id":[{"id":"10.13039\/501100004858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.fct.2013.11.017","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T01:47:03Z","timestamp":1385344023000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"special_numbering":"C","title":["Hepatoprotective properties of sesamin against CCl4 induced oxidative stress-mediated apoptosis in mice via JNK pathway"],"prefix":"10.1016","volume":"64","author":[{"given":"Jie-Qiong","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2013.11.017_b0005","doi-asserted-by":"crossref","first-page":"19704","DOI":"10.1074\/jbc.M707744200","article-title":"All JNKs can kill, but nuclear localization is critical for neuronal death","volume":"283","author":"Bj\u00f6rkblom","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2013.11.017_b0010","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bbadis.2013.01.014","article-title":"Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis","volume":"1832","author":"Borkham-Kamphorst","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fct.2013.11.017_b0015","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1089\/rej.2011.1242","article-title":"Quercetin and sesamin protect neuronal PC12 cells from high-glucose-induced oxidation, nitrosative stress, and apoptosis","volume":"15","author":"Bournival","year":"2012","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.fct.2013.11.017_b0020","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/bjp.2008.338","article-title":"The antioxidant activity of chondroitin-4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-kB and caspase activation","volume":"155","author":"Campo","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fct.2013.11.017_b0025","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ptr.2602","article-title":"Effect of schisandrin B and sesamin mixture on CCl4-induced hepatic oxidative stress in rats","volume":"23","author":"Chang","year":"2009","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fct.2013.11.017_b0030","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1038\/onc.2008.301","article-title":"JNK signaling in apoptosis","volume":"27","author":"Dhanasekaran","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.fct.2013.11.017_b0035","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1054\/drup.2001.0214","article-title":"Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy","volume":"4","author":"Fan","year":"2001","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.fct.2013.11.017_b0040","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1079\/BJN20041239","article-title":"Dietary sesame oils inhibits iron-induced oxidative stress in rats","volume":"92","author":"Hemalatha","year":"2004","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fct.2013.11.017_b0045","first-page":"1259","article-title":"Suppressive effect of sesamin against 7,12-dimethylbenz[a]-anthracene induced rat mammary carcinogenesis","volume":"12","author":"Hirose","year":"1992","journal-title":"Anticancer Res."},{"key":"10.1016\/j.fct.2013.11.017_b0050","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/1471-2164-9-288","article-title":"Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants","volume":"9","author":"Huang","year":"2008","journal-title":"BMC Genom."},{"key":"10.1016\/j.fct.2013.11.017_b0055","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tox.2011.01.017","article-title":"Ferulic acid protects against carbon tetrachloride-induced liver injury in mice","volume":"6","author":"Kim","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2013.11.017_b0060","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/10715760601118361","article-title":"Sallyl cysteine prevents CCl4-induced acute liver injury in rats","volume":"41","author":"Kodai","year":"2007","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.fct.2013.11.017_b0065","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2009.08.023","article-title":"Sesamin improves endothelial dysfunction in renovascular hypertensive rats fed with a high-fat, high-sucrose diet","volume":"620","author":"Kong","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2013.11.017_b0070","doi-asserted-by":"crossref","first-page":"11406","DOI":"10.1021\/jf902876p","article-title":"Sesamin mitigates inflammation and oxidative stress in endothelial cells exposed to oxidized low-density lipoprotein","volume":"57","author":"Lee","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2013.11.017_b0075","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10753-010-9226-z","article-title":"Sesamin inhibits macrophage-induced vascular endothelial growth factor and matrix metalloproteinase-9 expression and proangiogenic activity in breast cancer cells","volume":"34","author":"Lee","year":"2011","journal-title":"Inflammation"},{"key":"10.1016\/j.fct.2013.11.017_b0080","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3109\/10715762.2010.550917","article-title":"Apoptosis via the redox-sensitive ERK\/Nrf2 pathway in AML12 hepatocytes","volume":"45","author":"Leong","year":"2011","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.fct.2013.11.017_b0090","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1349-7006.2004.tb03323.x","article-title":"Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination","volume":"95","author":"Li","year":"2004","journal-title":"Cancer Sci."},{"key":"10.1016\/j.fct.2013.11.017_b0095","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.taap.2011.11.015","article-title":"Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K\/Akt\/eNOS pathway","volume":"258","author":"Liu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2013.11.017_b0085","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1021\/jf304562b","article-title":"Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway","volume":"61","author":"Liu","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2013.11.017_b0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.etap.2012.03.010","article-title":"Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice","volume":"34","author":"Lu","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2013.11.017_b0105","doi-asserted-by":"crossref","first-page":"e68710","DOI":"10.1371\/journal.pone.0068710","article-title":"Growth inhibition and apoptosis induction by (+)-cyanidan-3-ol in hepatocellular carcinoma","volume":"8","author":"Monga","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2013.11.017_b0110","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1021\/jf0258961","article-title":"Novel antioxidative metabolites in rat liver with ingested sesamin","volume":"51","author":"Nakai","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2013.11.017_b0115","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cbf.1575","article-title":"Protective effects of ascorbic acid on hepatotoxicity and oxidative stress caused by carbon tetrachloride in the liver of Wistar rats","volume":"27","author":"Ozturk","year":"2009","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.fct.2013.11.017_b0120","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00394-006-0617-8","article-title":"Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice","volume":"45","author":"Pe\u00f1alvo","year":"2006","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.fct.2013.11.017_b0125","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.taap.2009.11.005","article-title":"Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response","volume":"242","author":"Shim","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2013.11.017_b0130","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.neuro.2007.03.002","article-title":"Differential induction of oxidative impairments in brain regions of male mice following subchronic consumption of Khesari dhal (Lathyrus sativus) and detoxified Khesari dhal","volume":"28","author":"Shinomol","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.fct.2013.11.017_b0135","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00204-013-1034-4","article-title":"Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis","volume":"87","author":"Sinha","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2013.11.017_b0140","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.3390\/ijms12064053","article-title":"Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats","volume":"12","author":"Tien","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2013.11.017_b0145","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.fct.2013.11.017_b0150","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejphar.2012.01.029","article-title":"Sesamin exerts renoprotective effects by enhancing NO bioactivity in renovascular hypertensive rats fed with high-fat-sucrose diet","volume":"683","author":"Wu","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2013.11.017_b0155","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11095-008-9791-0","article-title":"Naringenin-loaded nanoparticles improve the physicochemical properties and the hepatoprotective effects of naringenin in orally-administered rats with CCl4-induced acute liver failure","volume":"26","author":"Yen","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.fct.2013.11.017_b0160","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.fct.2012.12.041","article-title":"Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice","volume":"55","author":"Zhang","year":"2013","journal-title":"Food Chem. Toxicol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869151300776X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869151300776X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:16:03Z","timestamp":1759526163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869151300776X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":32,"alternative-id":["S027869151300776X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2013.11.017","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotective properties of sesamin against CCl4 induced oxidative stress-mediated apoptosis in mice via JNK pathway","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2013.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}