{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:06:19Z","timestamp":1769738779556,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC 94-2320-B-241-005"],"award-info":[{"award-number":["NSC 94-2320-B-241-005"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003828","name":"Hungkuang University","doi-asserted-by":"crossref","award":["HK-97-B-03"],"award-info":[{"award-number":["HK-97-B-03"]}],"id":[{"id":"10.13039\/501100003828","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005007","name":"Asia University","doi-asserted-by":"crossref","award":["101-asia-50"],"award-info":[{"award-number":["101-asia-50"]}],"id":[{"id":"10.13039\/501100005007","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.fct.2014.04.009","type":"journal-article","created":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T12:31:43Z","timestamp":1397910703000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Polysaccharide extract of Cordyceps sobolifera attenuates renal injury in endotoxemic rats"],"prefix":"10.1016","volume":"69","author":[{"given":"Chun-Hung","family":"Chiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charng-Cherng","family":"Chyau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Chu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hsine","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Hung","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Chin","family":"Mong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2014.04.009_b0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.fct.2014.04.009_b0010","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Inves. Dermatol."},{"key":"10.1016\/j.fct.2014.04.009_b0015","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.fct.2014.04.009_b0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0300-483X(02)00381-5","article-title":"Fighting the stranger\u2013antioxidant protection against endotoxin toxicity","volume":"180","author":"Cadenas","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2014.04.009_b0025","doi-asserted-by":"crossref","unstructured":"Chyau, C.C., Chen, C.C., Chen J.C., Yang, T.C., Shu, K.H., Cheng, C.H., 2014. Mycelia glycoproteins from Cordyceps sobolifera ameliorate cyclosporine-induced renal tubule dysfunction in rats. J. Ethnopharmacol. http:\/\/dx.doi.org\/10.1016\/j.jep.2014.03.020.","DOI":"10.1016\/j.jep.2014.03.020"},{"key":"10.1016\/j.fct.2014.04.009_b9000","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jep.2010.08.052","article-title":"Anti-oxidation activity of the crude polysaccharides isolated from Polygonum Cillinerve (Nakai) Ohwi in immunosuppressed mice","volume":"132","author":"Cui","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0030","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/FJC.0b013e3181da774b","article-title":"The role of cytokines and inducible nitric oxide synthase in endotoxemia-induced endothelial dysfunction","volume":"55","author":"Draisma","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0035","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.bcp.2006.04.011","article-title":"NF-kB activation by reactive oxygen species: fifteen years later","volume":"72","author":"Gloire","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0040","article-title":"Multi-organ injuries caused by lipopolysaccharide-induced periodontal inflammation in rats: role of melatonin","author":"Gulle","year":"2013","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.fct.2014.04.009_b0045","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/01.shk.0000112346.38599.10","article-title":"Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice","volume":"21","author":"Han","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.fct.2014.04.009_b0050","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1615\/IntJMedMushr.v10.i3.30","article-title":"Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) link (Ascomycetes). A review","volume":"10","author":"Holliday","year":"2008","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.fct.2014.04.009_b0055","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/01.shk.0000194719.82845.39","article-title":"Attenuation of endotoxin-induced oxidative stress and multiple organ injury by 3,4-methylenedioxyphenol in rats","volume":"25","author":"Hsu","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.fct.2014.04.009_b0060","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.intimp.2010.09.011","article-title":"Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells","volume":"10","author":"Jeong","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0065","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1021\/jf0510034","article-title":"Antioxidant capability of polysaccharides fractionated from submerge-cultured Agaricus blazei Mycelia","volume":"53","author":"Ker","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2014.04.009_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0041-008X(03)00152-2","article-title":"Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kappaB activation","volume":"190","author":"Kim","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0075","first-page":"192","article-title":"Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells","volume":"545","author":"Kim","year":"2006","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.fct.2014.04.009_b0080","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0006-291X(76)90747-6","article-title":"Glutathione peroxidase activity in selenium-deficient rat liver","volume":"71","author":"Lawrence","year":"1976","journal-title":"Biochem. Biophy. Res. Commun."},{"key":"10.1016\/j.fct.2014.04.009_b0085","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/01.fjc.0000157438.72483.ae","article-title":"Inducible nitric oxide synthase inhibition potentialtes multiple organ dysfunction indued by endotoxin in conscious rats","volume":"45","author":"Lee","year":"2005","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0090","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.phymed.2005.02.002","article-title":"Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia","volume":"13","author":"Li","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fct.2014.04.009_b0095","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.fct.2014.04.009_b0100","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/niox.2000.0319","article-title":"A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite","volume":"5","author":"Miranda","year":"2001","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.fct.2014.04.009_b0105","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1684\/ecn.2012.0300","article-title":"Inflammation augments the development of experimental glomerulonephritis by accelerating proteinuria and enhancing mortality","volume":"23","author":"Pfeifer","year":"2012","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.fct.2014.04.009_b0110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.intimp.2010.10.016","article-title":"Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress","volume":"11","author":"Qiao","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0115","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jep.2010.07.020","article-title":"Constituents isolated from Cordyceps militaris suppress enhanced inflammatory mediator\u2019s production and human cancer cell proliferation","volume":"131","author":"Rao","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/ki.2012.62","article-title":"Acute endotoxemia in mice induces downregulation ofmegalin and cubilin in the kidney","volume":"82","author":"Schreiber","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.fct.2014.04.009_b0125","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1525-139X.2011.01029.x","article-title":"Septic shock with multiorgan failure: from conventional apheresis to adsorption therapies","volume":"25","author":"Stegmayr","year":"2012","journal-title":"Semin. Dial."},{"key":"10.1016\/j.fct.2014.04.009_b0130","doi-asserted-by":"crossref","first-page":"e30134","DOI":"10.1371\/journal.pone.0030134","article-title":"Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat","volume":"7","author":"Takahashi","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.fct.2014.04.009_b0135","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2010.05.011","article-title":"Beneficial effects of magnolol in a rodent model of endotoxin shock","volume":"641","author":"Tsai","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0140","doi-asserted-by":"crossref","first-page":"e56526","DOI":"10.1371\/journal.pone.0056526","article-title":"Cobalt protoporphyrin accelerates TFEB activation and lysosome reformation during LPS-induced septic insults in the rat heart","volume":"8","author":"Unuma","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.fct.2014.04.009_b0145","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.fitote.2009.11.008","article-title":"Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis","volume":"81","author":"Wang","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fct.2014.04.009_b0150","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.carbpol.2012.03.029","article-title":"Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice","volume":"89","author":"Wang","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.fct.2014.04.009_b0155","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1097\/CCM.0b013e3181d8cc1d","article-title":"Long-term mortality and quality of life in sepsis: a systematic review","volume":"38","author":"Winters","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.fct.2014.04.009_b0160","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1142\/S0192415X11009007","article-title":"Cordyceps sobolifera extract ameliorates lipopolysaccharide-induced renal dysfunction in the rat","volume":"39","author":"Wu","year":"2011","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.fct.2014.04.009_b0165","article-title":"Polysaccharides from the medicinal mushroom Cordyceps taii show antioxidant and immunoenhancing activities in a d-galactose-induced aging mouse model","volume":"273435","author":"Xiao","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.fct.2014.04.009_b0170","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0006-2952(99)00324-X","article-title":"Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney","volume":"59","author":"Zhang","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0175","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1016\/j.intimp.2011.09.019","article-title":"Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co","volume":"11","author":"Zhang","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2014.04.009_b0180","first-page":"304","article-title":"Advances in research of polysaccharides in Cordyceps species","volume":"47","author":"Zhong","year":"2009","journal-title":"Food Technol. Biotechnol."},{"key":"10.1016\/j.fct.2014.04.009_b0185","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1211\/jpp.61.03.0002","article-title":"Cordyceps fungi: natural products, pharmacological functions and developmental products","volume":"60","author":"Zhou","year":"2009","journal-title":"J. Pharm. Pharmacol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691514001914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691514001914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:22:20Z","timestamp":1759526540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691514001914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":38,"alternative-id":["S0278691514001914"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2014.04.009","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polysaccharide extract of Cordyceps sobolifera attenuates renal injury in endotoxemic rats","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2014.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}