{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:15:33Z","timestamp":1780107333843,"version":"3.54.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.fct.2016.04.015","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T10:46:22Z","timestamp":1461840382000},"page":"245-255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["High calcium diet improves the liver oxidative stress and microsteatosis in adult obese rats that were overfed during lactation"],"prefix":"10.1016","volume":"92","author":[{"given":"E.P.S.","family":"Concei\u00e7\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.G.","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.N.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.X.","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2477-4364","authenticated-orcid":false,"given":"P.C.","family":"Lisboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2016.04.015_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in\u00a0vitro methods","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.fct.2016.04.015_bib2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.arplant.55.031903.141701","article-title":"Reactive oxygen species: metabolism, oxidative stress, and signal transduction","volume":"55","author":"Apel","year":"2004","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.fct.2016.04.015_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/9780470110539.ch5","article-title":"Assays for superoxide dismutase","volume":"32","author":"Bannister","year":"1987","journal-title":"Methods Biochem. Anal."},{"key":"10.1016\/j.fct.2016.04.015_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.14503\/THIJ-15-5096","article-title":"Overweight versus obese: different risk and different management","volume":"42","author":"Barnes","year":"2015","journal-title":"Tex. Heart Inst. J."},{"key":"10.1016\/j.fct.2016.04.015_bib5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.nutres.2014.11.006","article-title":"Early hepatic insult in the offspring of obese maternal mice","volume":"35","author":"Bringhenti","year":"2015","journal-title":"Nutr. Res."},{"key":"10.1016\/j.fct.2016.04.015_bib6","article-title":"Calcium supplementation modulates gut microbiota in a prebiotic manner in dietary obese mice","author":"Chaplin","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2016.04.015_bib7","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1113\/JP271189","article-title":"Early redox imbalance is associated with liver dysfunction at weaning in overfed rats","volume":"593","author":"Concei\u00e7\u00e3o","year":"2015","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.fct.2016.04.015_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fct.2015.01.025","article-title":"Maternal nicotine exposure leads to higher liver oxidative stress and steatosis in adult rat offspring","volume":"78","author":"Concei\u00e7\u00e3o","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.04.015_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jnutbio.2012.02.010","article-title":"Oxidative stress programming in a rat model of postnatal early overnutrition\u2013role of insulin resistance","volume":"1","author":"Concei\u00e7\u00e3o","year":"2013","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.fct.2016.04.015_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12380","article-title":"Effect of early overfeeding on palatable food preference and brain dopaminergic reward system at adulthood: role of calcium supplementation","author":"Concei\u00e7\u00e3o","year":"2016","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.1016\/j.fct.2016.04.015_bib11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/hmg\/5.2.283","article-title":"Elevation in the ratio of Cu\/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide","volume":"5","author":"de Haan","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.fct.2016.04.015_bib12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1017\/S0022029913000058","article-title":"Bile composition, plasma lipids and oxidative hepatic damage induced by calcium supplementation; effects of goat or cow milk consumption","volume":"80","author":"D\u00edaz-Castro","year":"2013","journal-title":"J.\u00a0Dairy Res."},{"key":"10.1016\/j.fct.2016.04.015_bib13","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.fct.2016.04.015_bib14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","article-title":"Assays of glutathione peroxidase","volume":"105","author":"Floh\u00e9","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.fct.2016.04.015_bib15","first-page":"1343","article-title":"A\u00a0simple method for the isolation and purification of total lipids from animal tissues","volume":"115","author":"Folch","year":"1957","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fct.2016.04.015_bib16","article-title":"Metabolic syndrome update","author":"Grundy","year":"2015","journal-title":"Trends Cardiovasc Med."},{"key":"10.1016\/j.fct.2016.04.015_bib17","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.25011\/cim.v36i1.19399","article-title":"Protein oxidation in metabolic syndrome","volume":"36","author":"Hopps","year":"2013","journal-title":"Clin. Investig. Med."},{"key":"10.1016\/j.fct.2016.04.015_bib18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1248\/bpb.b15-00503","article-title":"Cholesterol-lowering effect of calcium alginate in rats","volume":"39","author":"Idota","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.fct.2016.04.015_bib19","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/sj.ijo.0802785","article-title":"Effect of short- term high dietary calcium intake on 24-h energy expenditure, fat oxidation, and fecal fat excretion","volume":"29","author":"Jacobsen","year":"2005","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.fct.2016.04.015_bib20","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.fct.2016.04.015_bib21","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1002\/hep.25539","article-title":"Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease","volume":"55","author":"Lomonaco","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2016.04.015_bib22","article-title":"Approaches for the development of drugs for treatment of obesity and metabolic syndrome","author":"Maksimov","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.fct.2016.04.015_bib23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.5662\/wjm.v5.i4.216","article-title":"Biomarkers of oxidative stress in erythrocytes as a function of human age","volume":"26","author":"Maurya","year":"2015","journal-title":"World J. Methodol."},{"key":"10.1016\/j.fct.2016.04.015_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/hep.27395","article-title":"The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease","volume":"61","author":"Maximos","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2016.04.015_bib25","doi-asserted-by":"crossref","first-page":"9330","DOI":"10.3748\/wjg.v20.i28.9330","article-title":"Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations","volume":"28","author":"Mili\u0107","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2016.04.015_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1126\/science.1104680","article-title":"Biomedicine. Insulin resistance takes a trip through the ER","volume":"306","author":"Muoio","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.fct.2016.04.015_bib27","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.yjmcc.2012.02.006","article-title":"Activation of CaMKII as a key regulator of reactive oxygen species production in diabetic rat heart","volume":"52","author":"Nishio","year":"2012","journal-title":"J.\u00a0Mol. Cell Cardiol."},{"key":"10.1016\/j.fct.2016.04.015_bib28","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1017\/S0007114511003928","article-title":"Calcium supplementation prevents obesity, hyperleptinaemia and hyperglycaemia in adult rats programmed by early weaning","volume":"7","author":"Nobre","year":"2012","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fct.2016.04.015_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201500735","article-title":"Role of vitamin D in adipose tissue in obese rats programmed by early weaning and post diet calcium","author":"Nobre","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2016.04.015_bib30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1530\/JOE-11-0172","article-title":"Calcium supplementation reverts central adiposity, leptin, and insulin resistance in adult offspring programed by neonatal nicotine exposure","volume":"3","author":"Nobre","year":"2011","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.fct.2016.04.015_bib31","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.4254\/wjh.v7.i10.1325","article-title":"Oxidative stress: new insights on the association of non-alcoholic fatty liver disease and atherosclerosis","volume":"8","author":"Polimeni","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.fct.2016.04.015_bib32","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/mnfr.201400666","article-title":"Anti-obesogenic effects of calcium prevent changes in the GLP-1 profile in adult rats primed by early weaning","volume":"59","author":"Quitete","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2016.04.015_bib33","doi-asserted-by":"crossref","first-page":"838S","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 diets as improvements in the AIN-76A diet","volume":"127","author":"Reeves","year":"1997","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.fct.2016.04.015_bib34","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.3748\/wjg.v21.i11.3223","article-title":"Biomarkers in nonalcoholic fatty liver disease-the emperor has no clothes?","volume":"21","author":"Sanal","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2016.04.015_bib35","doi-asserted-by":"crossref","first-page":"10768","DOI":"10.1073\/pnas.0804672105","article-title":"An allosteric model of calmodulin explains differential activation of PP2B and CaMKII","volume":"5","author":"Stefan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fct.2016.04.015_bib36","doi-asserted-by":"crossref","first-page":"e52130","DOI":"10.1371\/journal.pone.0052130","article-title":"Effects of neonatal overfeeding on juvenile and adult feeding and energy expenditure in the rat","volume":"7","author":"Stefanidis","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2016.04.015_bib37","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/sj.ijo.0803294","article-title":"Dietary calcium regulates ROS production in aP2-agouti transgenic mice on high-fat\/high-sucrose diets","volume":"30","author":"Sun","year":"2006","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.fct.2016.04.015_bib38","first-page":"1084","article-title":"Direct determination of the thiobarbituric acid value in thricloracetic acid extracts of fish as a measure of oxidative rancidity","volume":"72","author":"Vynche","year":"1970","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"10.1016\/j.fct.2016.04.015_bib39","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1089\/ars.2012.4818","article-title":"Redox regulation of sodium and calcium handling","volume":"20","author":"Wagner","year":"2013","journal-title":"Antioxid. Redox. Signal"},{"key":"10.1016\/j.fct.2016.04.015_bib40","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1745-7254.2006.00390.x","article-title":"Cross-talk between calcium and reactive oxygen species signaling","volume":"27","author":"Yan","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"issue":"11","key":"10.1016\/j.fct.2016.04.015_bib41","doi-asserted-by":"crossref","first-page":"9127","DOI":"10.3390\/nu7115454","article-title":"Nutritional modulation of non-alcoholic fatty liver disease and insulin resistance","volume":"7","author":"Yki-J\u00e4rvinen","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2016.04.015_bib42","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1017\/S0007114515000914","article-title":"A\u00a0combination of probiotics and whey proteins enhances anti-obesity effects of calcium and dairy products during nutritional energy restriction in aP2-agouti transgenic mice","volume":"14","author":"Yoda","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fct.2016.04.015_bib43","first-page":"50","article-title":"Dietary calcium and dairy modulation of oxidative stress and mortality in ap2-agouti and wild-type mice","volume":"1","author":"Zemel","year":"2008","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2016.04.015_bib44","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1096\/fasebj.14.9.1132","article-title":"Regulation of adiposity by dietary calcium","volume":"14","author":"Zemel","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.fct.2016.04.015_bib45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3945\/ajcn.2009.28468","article-title":"Effects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjects","volume":"91","author":"Zemel","year":"2010","journal-title":"Am. J. Clin. Nutr."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516301211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516301211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:31:26Z","timestamp":1759527086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691516301211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":45,"alternative-id":["S0278691516301211"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2016.04.015","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High calcium diet improves the liver oxidative stress and microsteatosis in adult obese rats that were overfed during lactation","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2016.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}