{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:51:37Z","timestamp":1759539097828,"version":"build-2065373602"},"reference-count":125,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.fct.2016.04.027","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T19:27:34Z","timestamp":1462476454000},"page":"S90-S100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["RIFM fragrance ingredient safety assessment, benzyl isobutyrate, CAS Registry Number 103-28-6"],"prefix":"10.1016","volume":"97","author":[{"given":"A.M.","family":"Api","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Belsito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Calow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Dagli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Dekant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Kromidas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3849-1100","authenticated-orcid":false,"given":"S.","family":"La Cava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F.","family":"Lalko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lapczynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.C.","family":"Liebler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.T.","family":"Politano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ritacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Salvito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.W.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.G.","family":"Sipes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.K.","family":"Wilcox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.fct.2016.04.027_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0300-483X(85)90121-0","article-title":"Benzyl acetate carcinogenicity, metabolism, and disposition in fischer 344 rats and B6C3F1 mice","volume":"37","author":"Abdo","year":"1985","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.fct.2016.04.027_bib2","first-page":"19","article-title":"Requirement for adequate glycine for the detoxification of benzyl acetate and maintenance of its detoxification pathways","volume":"15","author":"Abdo","year":"1995","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1177\/019262339802600314","article-title":"Glycine modulates the toxicity of benzyl acetate in F344 rats","volume":"26","author":"Abdo","year":"1998","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.fct.2016.04.027_bib4","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.fct.2014.11.014","article-title":"Criteria for the research Institute for fragrance materials, Inc. (RIFM) safety evaluation process for fragrance ingredients","volume":"82","author":"Api","year":"2015","journal-title":"Food Chem. Toxicol."},{"issue":"part 1","key":"10.1016\/j.fct.2016.04.027_bib5","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3891\/acta.chem.scand.16-0240","article-title":"On the specificity of arylesterases","volume":"16","author":"Augustinsson","year":"1962","journal-title":"Acta Chem. Scand."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.fct.2016.04.027_bib6","first-page":"S269","article-title":"A\u00a0toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients. Food and Chemical Toxicology","volume":"50","author":"Belsito","year":"2012"},{"year":"2013","series-title":"Report on the Testing of Benzyl Isobutyrate in the BlueScreen HC Assay (-\/+ S9 Metabolic Activation)","author":"Birrell","key":"10.1016\/j.fct.2016.04.027_bib7"},{"issue":"5","key":"10.1016\/j.fct.2016.04.027_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0278-6915(90)90111-Y","article-title":"In\u00a0vivo percutaneous absorption of fragrance ingredients in rhesus monkeys and humans","volume":"28","author":"Bronaugh","year":"1990","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/rtph.2002.1581","article-title":"Consumer exposure to fragrance ingredients: providing estimates for safety evaluation","volume":"36","author":"Cadby","year":"2002","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2016.04.027_bib10","first-page":"209","article-title":"Absorption and disposition of topically-applied methylene-carbon-14 benzyl acetate in the rat","volume":"1","author":"Caldwell","year":"1987","journal-title":"Pharmacol. Skin"},{"issue":"6","key":"10.1016\/j.fct.2016.04.027_bib11","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.fct.2009.02.024","article-title":"Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products","volume":"47","author":"Carthew","year":"2009","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2016.04.027_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-1110(88)90028-0","article-title":"The mutagenic activity of selected compounds at the TK locus: rodent vs. human cells","volume":"196","author":"Caspary","year":"1988","journal-title":"Mutat. Research-Reviews Genet. Toxicol."},{"key":"10.1016\/j.fct.2016.04.027_bib13","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1752-153X-4-S1-S4","article-title":"\u201cCAESAR models for developmental toxicity.\u201d","volume":"4(Suppl.\u00a01)","author":"Cassano","year":"2010","journal-title":"Chem. Central J."},{"issue":"12","key":"10.1016\/j.fct.2016.04.027_bib14","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/0278-6915(86)90057-8","article-title":"Studies on benzyl acetate II. Use of specific metabolic inhibitors to define the pathway leading to the formation of benzylmercapturic acid in the rat","volume":"24","author":"Chidgey","year":"1986","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.fct.2016.04.027_bib15","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0278-6915(86)90056-6","article-title":"Studies on benzyl acetate I. Effect of dose size and vehicle on the plasma pharmacokinetics and metabolism of [methylene-(14)C]benzyl acetate in the rat","volume":"24","author":"Chidgey","year":"1986","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.fct.2016.04.027_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0278-6915(87)90203-1","article-title":"Studies on benzyl acetate. III. The percutaneous absorption and disposition of [Methylene{14}C]benzyl acetate in the rat","volume":"25","author":"Chidgey","year":"1987","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.fct.2016.04.027_bib17","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1042\/bj1180765","article-title":"Formation of mercapturic acids in rats after the administration of aralkyl esters","volume":"118","author":"Clapp","year":"1970","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.fct.2016.04.027_bib18","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.fct.2010.02.016","article-title":"Assessment of genotoxic effects of benzyl derivatives by the comet assay","volume":"48","author":"Demir","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"Part D","key":"10.1016\/j.fct.2016.04.027_bib19","first-page":"379","article-title":"Evaluation of the bioluminescence assays as screens for genotoxic chemicals","volume":"340","author":"Elmore","year":"1990","journal-title":"Prog. clin. Biol. Res."},{"key":"10.1016\/j.fct.2016.04.027_bib20","unstructured":"Essential Estimation Programs Interface (EPI) SuiteTM (version 4.1) [Software]. (Copyright 2000-2011). US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation. Retrieved from http:\/\/www.epa.gov\/opptintr\/exposure\/pubs\/episuite.htm Research, 20(6), 482\u2013487."},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0300-483X(80)90055-4","article-title":"Screening of tobacco smoke constituents for mutagenicity using the Ames Test","volume":"18","author":"Florin","year":"1980","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.fct.2016.04.027_bib22","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/rtph.1999.1362","article-title":"Criteria for development of a database for safety evaluation of fragrance ingredients","volume":"31","author":"Ford","year":"2000","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib23","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/em.2850230310","article-title":"Chemical mutagenesis testing in Drosophila. X. Results of 70 coded chemicals tested for the National Toxicology Program","volume":"23","author":"Foureman","year":"1994","journal-title":"Environ. Mol. Mutagen."},{"issue":"10","key":"10.1016\/j.fct.2016.04.027_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/em.2850100502","article-title":"Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals","volume":"10","author":"Galloway","year":"1987","journal-title":"Environ. Mol. Mutagen."},{"issue":"11","key":"10.1016\/j.fct.2016.04.027_bib25","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0278-6915(94)90147-3","article-title":"Percutaneous absorption of benzyl acetate through rat skin in\u00a0vitro. 3. A comparison with human skin","volume":"32","author":"Garnett","year":"1994","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.04.027_bib26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0300-483X(77)90084-1","article-title":"Toxicological assessment of flavouring esters","volume":"8","author":"Grundschober","year":"1977","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.fct.2016.04.027_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jphotobiol.2009.04.005","article-title":"Can light absorption and photostability data be used to assess the photosafety risks in patients for a new drug molecule?","volume":"96","author":"Henry","year":"2009","journal-title":"J.\u00a0Photochem. Photobiol. B Biol."},{"issue":"1","key":"10.1016\/j.fct.2016.04.027_bib28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/mutage\/14.1.5","article-title":"Evaluation of the mouse lymphoma tk assay (microwell method) as an alternative to the in\u00a0vitro chromosomal aberration test","volume":"14","author":"Honma","year":"1999","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2016.04.027_bib29","series-title":"Presented at ISSX-88 Mtg., Kobe, Japan","article-title":"The percutaneous absorption of benzyl acetate through rat skin in\u00a0vitro","author":"Hotchkiss","year":"1988"},{"issue":"1","key":"10.1016\/j.fct.2016.04.027_bib30","first-page":"71","article-title":"Percutaneous absorption of topically applied benzyl acetate in-vitro effect of vehicle on skin penetration","volume":"8","author":"Hotchkiss","year":"1989","journal-title":"Hum. Toxicol."},{"key":"10.1016\/j.fct.2016.04.027_bib31","first-page":"123","article-title":"An in\u00a0vitro skin diffusion technique for the prediction of in\u00a0vivo absorption; a case study with benzyl acetate. In prediction of percutan. Penetration-Methods","author":"Hotchkiss","year":"1990","journal-title":"Meas. Model."},{"issue":"6","key":"10.1016\/j.fct.2016.04.027_bib32","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0278-6915(90)90091-Z","article-title":"Percutaneous absorption of benzyl acetate through rat skin in\u00a0vitro. 1. Validation of an in\u00a0vitro model against in\u00a0vivo data","volume":"28","author":"Hotchkiss","year":"1990","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.fct.2016.04.027_bib33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0278-6915(92)90150-J","article-title":"Percutaneous absorption of benzyl acetate through rat skin in\u00a0vitro. 2. Effect of vehicle and occlusion","volume":"30","author":"Hotchkiss","year":"1992","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.04.027_bib34","first-page":"158","article-title":"In\u00a0vitro metabolism of benzyl acetate and benzoic acid in cultured human keratinocytes and full thickness human skin","volume":"2","author":"Hotchkiss","year":"1992"},{"key":"10.1016\/j.fct.2016.04.027_bib35","first-page":"173","article-title":"Percutaneous absorption of fragrance chemicals through human skin in\u00a0vitro","author":"Hotchkiss","year":"1992","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2016.04.027_bib36","series-title":"Proceedings of the British Pharmacological Society, Clinical Pharmacology Section, 8-10, April 1992","first-page":"148P","article-title":"Percutaneous absorption of topically applied chemicals through human skin in\u00a0vitro","author":"Hotchkiss","year":"1992"},{"key":"10.1016\/j.fct.2016.04.027_bib37","series-title":"Fragrances: Beneficial and Adverse Effects","first-page":"125","article-title":"Absorption of fragrance ingredients using in\u00a0vitro models with human skin","author":"Hotchkiss","year":"1998"},{"year":"2008","series-title":"Use Level Survey, September 2008","author":"IFRA (International Fragrance Association)","key":"10.1016\/j.fct.2016.04.027_bib38"},{"year":"2011","series-title":"Volume of Use Survey, February 2011","author":"IFRA (International Fragrance Association)","key":"10.1016\/j.fct.2016.04.027_bib39"},{"key":"10.1016\/j.fct.2016.04.027_bib40","first-page":"25","volume":"43","author":"Ishiguro","year":"1993"},{"issue":"S-1","key":"10.1016\/j.fct.2016.04.027_bib41","first-page":"291","article-title":"Exposure characterization from a fragranced plug-in air freshener","volume":"72","author":"Isola","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2016.04.027_bib42","series-title":"Exposure Characterization of Fragranced Air Fresheners","first-page":"132","author":"Isola","year":"2003"},{"issue":"S-1","key":"10.1016\/j.fct.2016.04.027_bib43","first-page":"107","article-title":"Exposure characterization from a surrogate fine fragrance","volume":"78","author":"Isola","year":"2004","journal-title":"Toxicology"},{"issue":"6","key":"10.1016\/j.fct.2016.04.027_bib44","first-page":"397","article-title":"Exposure characterizations of three fragranced products","volume":"23","author":"Isola","year":"2004","journal-title":"Int. J. Toxicol. Former. J. Am. Coll. Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib45","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1346-8138.1983.tb01132.x","article-title":"Penetration of fragrance compounds through human epidermis","volume":"10","author":"Jimbo","year":"1983","journal-title":"J.\u00a0Dermatol."},{"issue":"1","key":"10.1016\/j.fct.2016.04.027_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1383-5718(99)00141-2","article-title":"SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest)","volume":"445","author":"Kevekordes","year":"1999","journal-title":"Mutat. Research-Genetic Toxicol. Environ. Mutagen."},{"issue":"1A","key":"10.1016\/j.fct.2016.04.027_bib47","first-page":"461","article-title":"Micronucleus formation in human lymphocytes and in the metabolically competent human hepatoma cell line Hep G2: results with 15 naturally occurring substances","volume":"21","author":"Kevekordes","year":"2001","journal-title":"Anticancer Res."},{"key":"10.1016\/j.fct.2016.04.027_bib48","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000411610","article-title":"The Freund's complete adjuvant test and the open epicutaneous test","volume":"14","author":"Klecak","year":"1985","journal-title":"Curr. Problems Dermatol."},{"key":"10.1016\/j.fct.2016.04.027_bib49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0300-483X(77)90008-7","article-title":"The hydrolysis of flavouring esters by artificial gastrointestinal juices and rat tissue preparations","volume":"8","author":"Longland","year":"1977","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2016.04.027_bib50","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1289\/ehp.8668197","article-title":"Effects of corn oil and benzyl acetate on number and size of azaserine-induced foci in the pancreas of LEW and F344 rats","volume":"68","author":"Longnecker","year":"1986","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.fct.2016.04.027_bib51","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0278-6915(90)90141-9","article-title":"Evaluation of promotion of pancreatic carcinogenesis in rats by benzyl acetate","volume":"28","author":"Longnecker","year":"1990","journal-title":"Food Chem. Toxicol."},{"issue":"3\u20134","key":"10.1016\/j.fct.2016.04.027_bib52","first-page":"243","article-title":"Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay 'unique positive' NTP carcinogens","volume":"369","author":"Matsuoka","year":"1996","journal-title":"Mutat. Research-Reviews Mutat. Res."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.fct.2016.04.027_bib53","doi-asserted-by":"crossref","first-page":"S363","DOI":"10.1016\/j.fct.2012.02.057","article-title":"Fragrance material review on benzyl acetate","volume":"50","author":"McGinty","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.fct.2016.04.027_bib54","doi-asserted-by":"crossref","first-page":"S420","DOI":"10.1016\/j.fct.2012.02.066","article-title":"Fragrance material review on benzyl isobutyrate","volume":"50","author":"McGinty","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.fct.2016.04.027_bib55","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/em.2860120111","article-title":"Responses of the L5178Y tk+\/tk- mouse lymphoma cell forward mutation assay: III. 72 Coded chemicals","volume":"12","author":"McGregor","year":"1988","journal-title":"Environ. Mol. Mutagen."},{"issue":"1","key":"10.1016\/j.fct.2016.04.027_bib56","first-page":"88","article-title":"Age related changes in disposition of benzyl acetate (BA): a model compound for glycine conjugation","volume":"9","author":"McMahon","year":"1989","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.fct.2016.04.027_bib57","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0090-9556(25)07662-7","article-title":"Age-related changes in the disposition of benzyl acetate: a model compound for glycine conjugation","volume":"17","author":"McMahon","year":"1989","journal-title":"Drug Metabol. Dispos."},{"key":"10.1016\/j.fct.2016.04.027_bib58","unstructured":"Meyer, F. (1965). Penetrating agents. Patent, British, 1,001,949, M49750IVa\/30h, 7\/20\/61."},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib59","first-page":"482","article-title":"Induction of unscheduled DNA synthesis (UDS) in hepatocytes following in\u00a0vitro and in\u00a0vivo treatment","volume":"5","author":"Mirsalis","year":"1983","journal-title":"Environ. Mutagen."},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib60","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/em.2850140305","article-title":"Measurement of unscheduled DNA synthesis and S-phase synthesis in rodent hepatocytes following in\u00a0vivo treatment: testing of 24 compounds","volume":"14","author":"Mirsalis","year":"1989","journal-title":"Environ. Mol. Mutagen."},{"issue":"Suppl.\u00a08","key":"10.1016\/j.fct.2016.04.027_bib61","first-page":"74","article-title":"Concordance of results between in-vitro mammalian cell mutagenesis and clastogenesis assays","volume":"9","author":"Mitchell","year":"1987","journal-title":"Environ. Mutagen."},{"issue":"1","key":"10.1016\/j.fct.2016.04.027_bib62","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0165-1218(95)90082-9","article-title":"The in\u00a0vivo-in\u00a0vitro replicative DNA synthesis (RDS) test with hepatocytes prepared from male B6C3F1 mice as an early prediction assay for putative nongenotoxic (Ames-negative) mouse hepatocarcinogens","volume":"343","author":"Miyagawa","year":"1995","journal-title":"Mutat. Research-Genetic Toxicol."},{"key":"10.1016\/j.fct.2016.04.027_bib63","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0047-6374(80)90060-3","article-title":"Identification of compounds in mouse urine vapor by gas chromatography and mass spectrometry","volume":"13","author":"Miyashita","year":"1980","journal-title":"Mech. Ageing Dev."},{"issue":"2","key":"10.1016\/j.fct.2016.04.027_bib64","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0272-0590(88)90159-5","article-title":"Evaluation of rodent sperm, vaginal cytology and reproductive organ weight data from national toxicology program 13 week studies","volume":"11","author":"Morrissey","year":"1988","journal-title":"Fundam. Appl. Toxicol."},{"issue":"7","key":"10.1016\/j.fct.2016.04.027_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/em.2860080802","article-title":"Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals","volume":"8","author":"Mortelmans","year":"1986","journal-title":"Environ. Mutagen."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.fct.2016.04.027_bib66","first-page":"168","article-title":"Metabolism of benzyl acetate in rat and human keratinocytes and rat hepatocytes: comparative studies with cells in suspension and in culture","author":"Nasseri-Sina","year":"1992","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2016.04.027_bib67","series-title":"Toxicology and Carcinogenesis Studies of Benzyl Acetate in F344 Rats and B6C3F1 Mice (Feed Studies). NTP-tr-431","first-page":"92","author":"National Toxicology Program","year":"1993"},{"key":"10.1016\/j.fct.2016.04.027_bib68","first-page":"177","volume":"9","author":"Oda","year":"1978"},{"year":"2012","series-title":"The OECD QSAR Toolbox, V. 3.1","author":"OECD","key":"10.1016\/j.fct.2016.04.027_bib69"},{"issue":"1","key":"10.1016\/j.fct.2016.04.027_bib70","first-page":"416","article-title":"Evaluation of nose-only inhalation exposure to aerosolized benzyl acetate in Sprague-Dawley rats","volume":"138","author":"Randazzo","year":"2014","journal-title":"Toxicology"},{"year":"1957","series-title":"Toxicological Screening of Ethyl Benzoate, Isobutyl Benzoate, Benzyl Acetate, Benzyl Butyrate, and Ethyl Methylphenylglycidate in Rats. Class V. Aromatic Esters","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib71"},{"year":"1961","series-title":"Sensitization and Irritation Studies","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib72"},{"year":"1971","series-title":"Appraisal of Sensitizing Powers by Maximization Testing in Humans","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib73"},{"year":"1975","series-title":"Repeated Insult Patch Test of Benzyl Acetate in Human Subjects. Unpublished Report from International Flavors and Fragrances","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib74"},{"year":"1975","series-title":"Repeated Insult Patch Test of Benzyl Acetate in Human Subjects","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib75"},{"year":"1975","series-title":"Repeated Insult Patch Test of Benzyl Acetate on Human Subjects","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib76"},{"year":"1975","series-title":"Repeated Insult Patch Test of Benzyl Acetate in Human Subjects","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib77"},{"year":"1975","series-title":"Repeated Insult Patch Test of Benzyl Acetate in Human Subjects","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib78"},{"year":"1977","series-title":"Doctoral Dissertation: the Comparative Respiratory Irritation Potential of Fourteen Fragrance Raw Materials","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib79"},{"year":"1985","series-title":"Open and Closed Epicutaneous and Maximization Tests of Fragrance Materials in Guinea Pigs","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib80"},{"year":"1985","series-title":"Closed Epicutaneous Test of Methyl-2-octynoate, Methyl-2-nonynoate, Benzyl Acetate, Trans,trans-2,4-hexadienal, 2-hexylidene Cyclopentanone, Hexen-2-al, Trans-2-hexenal Diethyl Acetal and Isoeugenol in Guinea Pigs","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib81"},{"year":"1985","series-title":"Guinea pig Maximization Test","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib82"},{"year":"1986","series-title":"Delayed Contact Hypersensitivity Study of Benzyl Acetate in Guinea Pigs","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib83"},{"year":"1986","series-title":"Toxicology and Carcinogenesis Studies of Benzyl Acetate in F344\/N Rats and B6CF1 Mice (Gavage Studies)","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib84"},{"year":"1987","series-title":"Report on Human Repeated Insult Patch Test","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib85"},{"year":"1988","series-title":"Repeated Insult Patch Test in Human Subjects","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib86"},{"year":"1988","series-title":"Repeated Insult Patch Test in Human Subjects","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib87"},{"year":"1988","series-title":"Repeated Insult Patch Test in Human Subjects","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib88"},{"year":"1988","series-title":"Repeated Insult Patch Test in Human Subjects","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib89"},{"year":"1989","series-title":"In\u00a0Vitro Dermal Absorption and Metabolism of Benzyl Acetate","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib90"},{"year":"1989","series-title":"Evidence for the Existence of a Cutaneous Reservoir for Benzyl Acetate","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib91"},{"year":"1997","series-title":"Benzyl Acetate - Acute Inhalation Toxicity in Rats 4-hour Exposure","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib92"},{"year":"1997","series-title":"Investigation of Oxidation Gases from Paraffin Aromatic Candles in Toxicological Relevance to Classes of Damaging Materials","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib93"},{"year":"2003","series-title":"Indoor Air Quality Evaluation of a Plug-in Air Freshener","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib94"},{"year":"2003","series-title":"Airborne Levels of Selected Fragrance Materials in a Simulated Bathroom","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib95"},{"key":"10.1016\/j.fct.2016.04.027_bib96","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.). reportAirborne Levels of Selected Fragrance Materials Following a Controlled Exposure to a Surrogate Fine Fragrance. RIFM report number 47425 (RIFM, Woodcliff Lake, NJ, USA.)."},{"year":"2013","series-title":"A\u00a0Two-week Inhalation Toxicity Study of Aerosolized Benzyl Acetate in the Sprague Dawley Rat","author":"RIFM (Research Institute for Fragrance Materials, Inc.)","key":"10.1016\/j.fct.2016.04.027_bib97"},{"issue":"7","key":"10.1016\/j.fct.2016.04.027_bib98","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/tx700024w","article-title":"Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization","volume":"20","author":"Roberts","year":"2007","journal-title":"Chem. Res. Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib99","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0009-2797(86)80102-8","article-title":"Mutagenicity of benzylic acetates, sulfates and bromides of polycyclic aromatic hydrocarbons","volume":"58","author":"Rogan","year":"1986","journal-title":"Chem. Biol. Int. Rep."},{"issue":"2","key":"10.1016\/j.fct.2016.04.027_bib100","doi-asserted-by":"crossref","first-page":"S239","DOI":"10.1016\/S0091-6749(03)80842-4","article-title":"Characterization of potential human exposure to fragrances during residential consumer product use","volume":"111","author":"Rogers","year":"2003","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"issue":"20","key":"10.1016\/j.fct.2016.04.027_bib101","doi-asserted-by":"crossref","first-page":"7810","DOI":"10.1021\/es040534q","article-title":"Simulated inhalation levels of fragrance materials in a surrogate air freshener formulation","volume":"39","author":"Rogers","year":"2005","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.fct.2016.04.027_bib102","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1021\/ci100050t","article-title":"Extended-connectivity fingerprints","volume":"50","author":"Rogers","year":"2010","journal-title":"J.\u00a0Chem. Inf. Model."},{"issue":"4","key":"10.1016\/j.fct.2016.04.027_bib103","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0165-1218(91)90021-D","article-title":"Performance of 133 compounds in the lambda prophage induction endpoint of the Microscreen assay and a comparison with S. typhimurium mutagenicity and rodent carcinogenicity assays","volume":"260","author":"Rossman","year":"1991","journal-title":"Mutat. Research-Genetic Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib104","first-page":"419","article-title":"L5178Y Mouse lymphoma cell mutagenesis assay of coded chemicals incorporating analyses of the colony size distributions","volume":"5","author":"Rudd","year":"1983","journal-title":"Environ. Mutagen."},{"issue":"6","key":"10.1016\/j.fct.2016.04.027_bib105","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/etc.5620210627","article-title":"A\u00a0Framework for prioritizing fragrance materials for aquatic risk assessment","volume":"21","author":"Salvito","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"issue":"6","key":"10.1016\/j.fct.2016.04.027_bib126","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/10408440008951123","article-title":"The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and US NTP Carcinogenicity Database","volume":"30","author":"Sasaki","year":"2000","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.fct.2016.04.027_bib106","series-title":"Flavors Frag., a World Persp. Proc. 10th Internat. Cong. Es. Oils","first-page":"1045","article-title":"Biological and chemical studies on photochemical products obtained from eugenol, benzyl acetate and benzyl benzoate","author":"Schunk","year":"1986"},{"issue":"2\u20133","key":"10.1016\/j.fct.2016.04.027_bib107","first-page":"104","article-title":"An assessment of the performance of an automated scoring system (Cellomics) for the in\u00a0vitro micronucleus assay in CHPO-K1 cells","volume":"231","author":"Scott","year":"2007","journal-title":"Toxicology"},{"issue":"1\u20132","key":"10.1016\/j.fct.2016.04.027_bib108","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1383-5718(02)00034-7","article-title":"Comparative investigation of multiple organs of mice and rats in the comet assay","volume":"517","author":"Sekihashi","year":"2002","journal-title":"Mutat. Research-Genetic Toxicol. Environ. Mutagen."},{"issue":"2","key":"10.1016\/j.fct.2016.04.027_bib109","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/em.2850210210","article-title":"Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals","volume":"21","author":"Shelby","year":"1993","journal-title":"Environ. Mol. Mutagen."},{"issue":"12","key":"10.1016\/j.fct.2016.04.027_bib110","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.fct.2014.09.015","article-title":"\u201cAn in silico skin absorption model for fragrance materials.\u201d","volume":"74","author":"Shen","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.04.027_bib111","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1749-6632.1992.tb16540.x","article-title":"Neural and pharmacological basis for nasal irritation","volume":"641","author":"Silver","year":"1992","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib112","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/taap.2000.9025","article-title":"Exposure characterizations of three fragranced products","volume":"197","author":"Smith","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2016.04.027_bib113","first-page":"163","article-title":"About the fission and oxidation of benzyl alcohol and benzyl esters in the human organism","volume":"155","author":"Snapper","year":"1925","journal-title":"Biochem. Z."},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib114","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/em.2860060308","article-title":"Measurement of DNA repair in primary cultures of rat pancreatic cells following in\u00a0vivo treatment","volume":"6","author":"Steinmetz","year":"1984","journal-title":"Environ. Mutagen."},{"key":"10.1016\/j.fct.2016.04.027_bib115","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.3554512","article-title":"Prediction of chemical carcinogenicity in rodents from in\u00a0vitro genetic toxicity assays","volume":"236","author":"Tennant","year":"1987","journal-title":"Science"},{"year":"2012","series-title":"Estimation Programs Interface Suite\u2122 for Microsoft\u00ae Windows, V. 4.11","author":"USEPA","key":"10.1016\/j.fct.2016.04.027_bib117"},{"issue":"9","key":"10.1016\/j.fct.2016.04.027_bib118","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3109\/02770903.2013.822079","article-title":"Fragrance materials in asthma: a pilot study using a surrogate aerosol product","volume":"50","author":"Vethanayagam","year":"2013","journal-title":"J.\u00a0Asthma"},{"issue":"3","key":"10.1016\/j.fct.2016.04.027_bib119","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/1098-2280(2000)36:3<163::AID-EM1>3.0.CO;2-P","article-title":"Micronucleated erythrocyte frequency in peripheral blood of B6C3F1 mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program","volume":"36","author":"Witt","year":"2000","journal-title":"Environ. Mol. Mutagen."},{"issue":"4","key":"10.1016\/j.fct.2016.04.027_bib120","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/em.20053","article-title":"Evaluation of the Salmonella umu test with 83 NTP chemicals","volume":"44","author":"Yasunaga","year":"2004","journal-title":"Environ. Mol. Mutagen."},{"issue":"3\u20134","key":"10.1016\/j.fct.2016.04.027_bib121","first-page":"267","article-title":"Mutagenic and antimutagenic activities of flavoring agents used in foodstuffs","volume":"34","author":"Yoo","year":"1985","journal-title":"J.\u00a0Osaka City Med. Cent."},{"issue":"3\u20134","key":"10.1016\/j.fct.2016.04.027_bib122","first-page":"267","article-title":"Mutagenic and antimutagenic activities of flavoring agents used in foodstuffs","volume":"34","author":"Yoo","year":"1986","journal-title":"J.\u00a0Osaka City Med. Cent."},{"issue":"1","key":"10.1016\/j.fct.2016.04.027_bib123","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1289\/ehp.9610440","article-title":"Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: nongenotoxic carcinogens and genotoxic noncarcinogens","volume":"104","author":"Yoshikawa","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2016.04.027_bib124","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0300-483X(89)90061-9","article-title":"What is the proper experimental unit for long-term rodent studies? an examination of the NTP benzyl acetate study","volume":"54","author":"Young","year":"1989","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.fct.2016.04.027_bib125","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0165-1218(89)90168-7","article-title":"Induction of chromosome loss by mixtures of organic solvents","volume":"224","author":"Zimmermann","year":"1989","journal-title":"Mutat. Research-Genetic Toxicol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516301430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516301430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:29:13Z","timestamp":1759526953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691516301430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":125,"alternative-id":["S0278691516301430"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2016.04.027","relation":{},"ISSN":["0278-6915"],"issn-type":[{"type":"print","value":"0278-6915"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RIFM fragrance ingredient safety assessment, benzyl isobutyrate, CAS Registry Number 103-28-6","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2016.04.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}