{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:18:48Z","timestamp":1788844728126,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005407","name":"Food and Health Bureau of The Government of Hong Kong Special Administration Region","doi-asserted-by":"publisher","award":["HMRF10111971"],"award-info":[{"award-number":["HMRF10111971"]}],"id":[{"id":"10.13039\/501100005407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Municipal Science and Technology Program of Shenzhen (Basic Research Fund","award":["[2015]1342"],"award-info":[{"award-number":["[2015]1342"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.fct.2016.08.031","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T20:18:05Z","timestamp":1473452285000},"page":"150-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Pre-clinical toxicity of a combination of berberine and\u00a05-aminosalicylic acid in mice"],"prefix":"10.1016","volume":"97","author":[{"given":"Yan-hong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-bo","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-tao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-xiang","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2016.08.031_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-62703-131-8_4","article-title":"The OECD guidelines for the testing of chemicals and pesticides","volume":"947","author":"Buschmann","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.fct.2016.08.031_bib2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/01926230600867743","article-title":"Normal structure, function, and histology of the spleen","volume":"34","author":"Cesta","year":"2006","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.fct.2016.08.031_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-4615-0757-4_7","article-title":"Regulation of spleen white pulp structure and function by lymphotoxin","volume":"512","author":"Chaplin","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.fct.2016.08.031_bib4","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/ptr.5475","article-title":"A\u00a0randomized clinical trial of berberine hydrochloride in patients with diarrhea-predominant irritable bowel syndrome","volume":"29","author":"Chen","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fct.2016.08.031_bib5","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.2174\/138945011796818126","article-title":"Is 5-ASA still the treatment of choice for ulcerative colitis?","volume":"12","author":"Cottone","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.fct.2016.08.031_bib6","article-title":"Berberine sulfate, an ancient remedy for diarrhea, has profound effects on intestinal motility","volume":"94","author":"Eaker","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2016.08.031_bib7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.fct.2016.04.010","article-title":"Oral subchronic exposure to silver nanoparticles in rats","volume":"92","author":"Garcia","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.08.031_bib8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.fct.2011.12.002","article-title":"Behavioral effects of oral subacute exposure to BDE-209 in young adult mice: a preliminary study","volume":"50","author":"Heredia","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.08.031_bib9","first-page":"661","article-title":"Effect of chronic chromium toxicity on growth, organ-body weight ratio and tissue enzymic activity in broiler chickens","volume":"72","author":"Islam","year":"2002","journal-title":"Indian J. Anim. Sci."},{"key":"10.1016\/j.fct.2016.08.031_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2008.03.008","article-title":"Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats","volume":"201","author":"Jia","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fct.2016.08.031_bib11","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s11306-012-0407-7","article-title":"Metabolic profile associated with glucose and cholesterol lowering effects of berberine in Sprague-Dawley rats","volume":"8","author":"Jiang","year":"2012","journal-title":"Metabolomics"},{"key":"10.1016\/j.fct.2016.08.031_bib12","first-page":"1","article-title":"5-ASA dose-response: maximizing efficacy and adherence","volume":"6","author":"Katz","year":"2010","journal-title":"Gastroenterol. Hepatol. (N Y)"},{"key":"10.1016\/j.fct.2016.08.031_bib13","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.fct.2010.01.033","article-title":"Acute toxicity of berberine and its correlation with the blood concentration in mice","volume":"48","author":"Kheir","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.08.031_bib14","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1136\/bmj.291.6509.1601","article-title":"Clinical-trial of berberine in acute watery diarrhea","volume":"291","author":"Khinmaungu","year":"1985","journal-title":"Br. Med. J."},{"key":"10.1016\/j.fct.2016.08.031_bib15","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in\u00a0vivo experiments: the ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fct.2016.08.031_bib16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.molimm.2015.07.013","article-title":"Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1\/Th17 differentiation","volume":"67","author":"Li","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fct.2016.08.031_bib17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.phrs.2016.02.010","article-title":"Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL\/6 mice by suppressing Th17 responses","volume":"110","author":"Li","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.fct.2016.08.031_bib18","doi-asserted-by":"crossref","first-page":"e0144101","DOI":"10.1371\/journal.pone.0144101","article-title":"Addition of berberine to 5-Aminosalicylic acid for treatment of dextran sulfate sodium-induced chronic colitis in C57BL\/6 mice","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2016.08.031_bib19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jep.2010.01.047","article-title":"Identification of the toxic constituents in rhizoma Coptidis","volume":"128","author":"Ma","year":"2010","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.fct.2016.08.031_bib20","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/liv.12508","article-title":"Elevated alanine aminotransferase (ALT) in the deceased donor: impact on early post-transplant liver allograft function","volume":"35","author":"Mangus","year":"2015","journal-title":"Liver Int."},{"key":"10.1016\/j.fct.2016.08.031_bib21","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1476-5381.2010.00873.x","article-title":"Guidelines for reporting experiments involving animals: the ARRIVE guidelines","volume":"160","author":"McGrath","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fct.2016.08.031_bib22","first-page":"97","article-title":"Comparative study of berberis vulgaris fruit extract and berberine chloride effects on acetic acid-induced colitis in rats","volume":"10","author":"Minaiyan","year":"2011","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.fct.2016.08.031_bib23","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2165\/00002018-200326140-00002","article-title":"Changes in toxicity and effectiveness with timing of drug administration: implications for drug safety","volume":"26","author":"Ohdo","year":"2003","journal-title":"Drug Saf."},{"key":"10.1016\/j.fct.2016.08.031_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112937","article-title":"Transportation of berberine into HepG2, HeLa and SY5Y Cells: a correlation to its anti-cancer effect","volume":"9","author":"Pang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2016.08.031_bib25","first-page":"185","article-title":"Kidney function tests in chronic renal disease. Serum urea nitrogen, creatinine, and creatine clearance","volume":"16","author":"Patton","year":"1968","journal-title":"Henry Ford Hosp. Med."},{"key":"10.1016\/j.fct.2016.08.031_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.atherosclerosis.2015.09.032","article-title":"Berberine, a plant alkaloid with lipid- and glucose-lowering properties: from in\u00a0vitro evidence to clinical studies","volume":"243","author":"Pirillo","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fct.2016.08.031_bib27","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/infdis\/155.5.979","article-title":"Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia-Coli and Vibrio-Cholerae","volume":"155","author":"Rabbani","year":"1987","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.fct.2016.08.031_bib28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1517\/13543776.2013.746314","article-title":"Berberine and its derivatives: a patent review (2009\u20132012)","volume":"23","author":"Singh","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.fct.2016.08.031_bib29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1080\/01926230600867750","article-title":"Histopathology of the spleen","volume":"34","author":"Suttie","year":"2006","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.fct.2016.08.031_bib30","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jep.2009.08.009","article-title":"Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations","volume":"126","author":"Tang","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2016.08.031_bib31","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bcp.2012.07.018","article-title":"Berberine: new perspectives for old remedies","volume":"84","author":"Tillhon","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2016.08.031_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016556","article-title":"Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis","volume":"6","author":"Xia","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2016.08.031_bib33","article-title":"Berberine promotes glucose consumption independently of AMP-activated protein kinase activation","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2016.08.031_bib34","doi-asserted-by":"crossref","first-page":"G504","DOI":"10.1152\/ajpgi.00312.2011","article-title":"Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice","volume":"302","author":"Yan","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.fct.2016.08.031_bib35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s12016-012-8328-9","article-title":"Considerations of traditional Chinese medicine as adjunct therapy in the management of ulcerative colitis","volume":"44","author":"Zhang","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.fct.2016.08.031_bib36","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejphar.2010.10.030","article-title":"Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid","volume":"651","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2016.08.031_bib37","first-page":"1","article-title":"Berberine moderates glucose and lipid metabolism through multipathway mechanism","author":"Zhang","year":"2011","journal-title":"Evid-Based Compl. Alt."},{"key":"10.1016\/j.fct.2016.08.031_bib38","doi-asserted-by":"crossref","first-page":"e94208","DOI":"10.1371\/journal.pone.0094208","article-title":"5-Aminosalicylates reduce the risk of colorectal neoplasia in patients with ulcerative colitis: an updated meta-analysis","volume":"9","author":"Zhao","year":"2014","journal-title":"PLoS One"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516302952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516302952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:30:01Z","timestamp":1759527001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691516302952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":38,"alternative-id":["S0278691516302952"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2016.08.031","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-clinical toxicity of a combination of berberine and\u00a05-aminosalicylic acid in mice","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2016.08.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}