{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:58:53Z","timestamp":1769839133247,"version":"3.49.0"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.fct.2016.09.001","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T13:55:44Z","timestamp":1473429344000},"page":"S147-S156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"S","title":["RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7"],"prefix":"10.1016","volume":"97","author":[{"given":"A.M.","family":"Api","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Belsito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Calow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Dagli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Dekant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Kromidas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3849-1100","authenticated-orcid":false,"given":"S.","family":"La Cava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F.","family":"Lalko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lapczynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.C.","family":"Liebler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Penning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.T.","family":"Politano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ritacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Salvito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.W.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.G.","family":"Sipes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.K.","family":"Wilcox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2016.09.001_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/15287398509530719","article-title":"Mutagenicity evaluation of phthalic acid esters and metabolites in Salmonella typhimurium cultures","volume":"16","author":"Agarwal","year":"1985","journal-title":"J.\u00a0Toxicol. Environ. Health"},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/oxfordjournals.jbchem.a126202","article-title":"The fate of branched-chain fatty acids in animal body. III. Biological oxidation of branched-chain fatty acids in relationship to optical activity","volume":"37","author":"Akiya","year":"1950","journal-title":"J.\u00a0Biochem."},{"issue":"10","key":"10.1016\/j.fct.2016.09.001_bib3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3109\/00498257509056132","article-title":"The metabolism of 2-ethylhexanol in rats","volume":"5","author":"Albro","year":"1975","journal-title":"Xenobiotica"},{"key":"10.1016\/j.fct.2016.09.001_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1289\/ehp.824519","article-title":"Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP","volume":"45","author":"Albro","year":"1982","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2016.09.001_bib5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.fct.2014.11.014","article-title":"Criteria for the research institute for fragrance materials, inc. (RIFM) safety evaluation process for fragrance ingredients","volume":"82","author":"Api","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.09.001_bib6","volume":"I and vol. II","author":"Arctander","year":"1969"},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/oxfordjournals.jbchem.a126201","article-title":"The fate of branched chain fatty acids in animal body. II. Chemical changes of some synthetic branched-chain fatty acids in\u00a0vivo","volume":"37","author":"Asano","year":"1950","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.fct.2016.09.001_bib8","first-page":"329","article-title":"Chemical industry voluntary test program for phthalate esters: health effect studies","volume":"65","author":"Astill","year":"1986","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/faat.1996.0003","article-title":"Prechronic toxicity studies on 2-ethylhexanol in F334 rats and B6C3f1 mice","volume":"29","author":"Astill","year":"1996","journal-title":"Fundam. Appl. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/faat.1996.0073","article-title":"Oncogenicity testing of 2-ethylhexanol in Fischer 344 rats and B6C3F1 mice","volume":"31","author":"Astill","year":"1996","journal-title":"Fundam. Appl. Toxicol."},{"issue":"4","key":"10.1016\/j.fct.2016.09.001_bib11","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0006-2952(90)90150-J","article-title":"Interactions between plasticizers and fatty acid metabolism in the perfused rat liver and in\u00a0vivo","volume":"39","author":"Badr","year":"1990","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib12","first-page":"211","article-title":"The testing of di(2-ethylhexyl) phthalate (DEHP) mono (2-ethylhexyl) phthalate (MEHP), di(2-ethylhexyl) adipate (DEHA) and 2-ethylhexanol (2EH) in a battery of genotoxicity assays","volume":"5","author":"Barber","year":"1985","journal-title":"Toxicology"},{"issue":"4","key":"10.1016\/j.fct.2016.09.001_bib13","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0272-0590(92)90086-W","article-title":"A\u00a0comparative study of the rates of in\u00a0vitro percutaneous absorption of eight chemicals using rat & human skin","volume":"19","author":"Barber","year":"1992","journal-title":"Fundam. Appl. Toxicol."},{"issue":"11","key":"10.1016\/j.fct.2016.09.001_bib14","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0278-6915(95)00060-F","article-title":"Subchronic 90-day oral toxicology of di(2-ethylhexyl) terephthalate in the rat","volume":"33","author":"Barber","year":"1995","journal-title":"Food Chem. Toxicol."},{"issue":"Suppl.\u00a04","key":"10.1016\/j.fct.2016.09.001_bib15","first-page":"S1","article-title":"A\u00a0safety assessment of branched chain saturated alcohols when used as fragrance ingredients","volume":"48","author":"Belsito","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.fct.2016.09.001_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/taap.1994.1112","article-title":"Peroxisomal proliferators inhibit acyl CoA synthetase and stimulate protein kinase C in\u00a0vivo","volume":"126","author":"Bojes","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0300-483X(97)00171-6","article-title":"Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanolic acid, 2-ethylhexanol and valproic acid","volume":"126","author":"Bui","year":"1998","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/rtph.2002.1581","article-title":"Consumer exposure to fragrance ingredients: providing estimates for safety evaluation","volume":"36","author":"Cadby","year":"2002","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"4","key":"10.1016\/j.fct.2016.09.001_bib19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0022-5347(24)07537-2","article-title":"The in\u00a0vitro hydrolysis of di(2-ethylhexyl)-phthalate by rat tissues","volume":"2","author":"Carter","year":"1974","journal-title":"Drug Metab. Dispos."},{"issue":"6","key":"10.1016\/j.fct.2016.09.001_bib20","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.fct.2009.02.024","article-title":"Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products","volume":"47","author":"Carthew","year":"2009","journal-title":"Food Chem. Toxicol."},{"issue":"10","key":"10.1016\/j.fct.2016.09.001_bib22","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/0006-2952(92)90171-E","article-title":"Identification of the proximate peroxisome proliferator(s) derived from di (2-ethylhexyl) adipate and species differences in response","volume":"43","author":"Cornu","year":"1992","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib23","first-page":"179","article-title":"Pharmacokinetic studies with 2-ethylhexanol in the female Fischer 344 rat","volume":"13","author":"Deisinger","year":"1993","journal-title":"Toxicol."},{"issue":"5","key":"10.1016\/j.fct.2016.09.001_bib24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3109\/00498259409043246","article-title":"Metabolism of 2-ethylhexanol administered orally and dermally to the female Fischer 344 rat","volume":"24","author":"Deisinger","year":"1994","journal-title":"Xenobiotica"},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib25","first-page":"471","article-title":"Mutagenicity testing of urine from rat dosed with 2-ethylhexanol derived plasticizers","volume":"5","author":"DiVincenzo","year":"1983","journal-title":"Environ. Mutagen."},{"key":"10.1016\/j.fct.2016.09.001_bib26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0300-483X(85)90175-1","article-title":"Bacterial mutagenicity testing of urine from rats dosed with 2-ethylhexanol derived plasticizers","volume":"34","author":"DiVincenzo","year":"1985","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2016.09.001_bib27","unstructured":"ECHA REACH Dossier: 2-Butyloctan-1-ol: http:\/\/echa.europa.eu\/."},{"key":"10.1016\/j.fct.2016.09.001_bib28","unstructured":"ECHA REACH Dossier: 2-Propylheptan-1-ol: http:\/\/echa.europa.eu\/."},{"issue":"5","key":"10.1016\/j.fct.2016.09.001_bib29","first-page":"452","article-title":"Cutaneous developmental toxicity study of 2-ethylhexanol (2-EH) in Fischer 344 rats","volume":"39","author":"Fisher","year":"1989","journal-title":"Teratology"},{"issue":"2","key":"10.1016\/j.fct.2016.09.001_bib30","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/rtph.1999.1362","article-title":"Criteria for development of a database for safety evaluation of fragrance ingredients","volume":"31","author":"Ford","year":"2000","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"12","key":"10.1016\/j.fct.2016.09.001_bib31","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1271\/bbb.66.2687","article-title":"Identification of a toxic mechanism of the plasticizers, phthahlic acid esters, which are putative endocrine disrupters: time-dependent increase in quinolinic acid and its metabolites in rats fed di(2-ethylhexyl)phthalate","volume":"66","author":"Fukuwatari","year":"2002","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.fct.2016.09.001_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1289\/ehp.824577","article-title":"Testicular effects of phthalate esters","volume":"45","author":"Gangolli","year":"1982","journal-title":"Environ. Health Perspect."},{"issue":"2\u20133","key":"10.1016\/j.fct.2016.09.001_bib33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0378-4274(82)90087-X","article-title":"Peroxisome proliferation in cultured rat hepatocytes produced by clofibrate and phthalate ester metabolites","volume":"10","author":"Gray","year":"1982","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2016.09.001_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0300-483X(83)90115-4","article-title":"Peroxisomal effects of phthalate esters in primary cultures of rat hepatocytes","volume":"28","author":"Gray","year":"1983","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.fct.2016.09.001_bib35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0278-6915(84)90092-9","article-title":"Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells","volume":"22","author":"Gray","year":"1984","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.09.001_bib36","first-page":"229","article-title":"Aspects of the testicular toxicity of phthalate esters","volume":"65","author":"Gray","year":"1986","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib37","first-page":"29","article-title":"Evaluation of 60 chemicals in a preliminary developmental toxicity test. Teratogenesis","volume":"7","author":"Hardin","year":"1987","journal-title":"Carcinog. Mutagen."},{"issue":"5","key":"10.1016\/j.fct.2016.09.001_bib38","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0278-6915(97)00007-0","article-title":"Differential prenatal toxicity of one straight-chain and five branched-chain primary alcohols in rats","volume":"35","author":"Hellwig","year":"1997","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jphotobiol.2009.04.005","article-title":"Can light absorption and photostability data be used to assess the photosafety risks in patients for a new drug molecule?","volume":"96","author":"Henry","year":"2009","journal-title":"J.\u00a0Photochem. Photobiol. B Biol."},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib40","first-page":"388","article-title":"Evaluation of di-(2-ethylhexyl) phthalate and its major metabolites in the primary rat hepatocyte unscheduled DNA synthesis assay","volume":"4","author":"Hodgson","year":"1982","journal-title":"Environ. Mutagen."},{"issue":"2","key":"10.1016\/j.fct.2016.09.001_bib41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/074823378700300205","article-title":"Results of peroxisome induction studies on tri(2-ethylhexyl) trimellitate and 2-ethylhexanol","volume":"3","author":"Hodgson","year":"1987","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.fct.2016.09.001_bib42","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/bj0530129","article-title":"Studies in detoxication. 46. The metabolism of aliphatic alcohols. The glucuronic acid conjugation of acyclic aliphatic alcohols","volume":"53","author":"Kamil","year":"1953","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib43","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/bj0530137","article-title":"Studies in detoxication. 47. The formation of ester glucuronides of aliphatic acids during the metabolism of 2-ethylbutanol and 2-ethylhexanol","volume":"53","author":"Kamil","year":"1953","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.fct.2016.09.001_bib44","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/096032718500400540","article-title":"Peroxisome proliferation due to di-(2-ethylhexyl)adipate and 2-ethylhexanol","volume":"4","author":"Keith","year":"1985","journal-title":"Hum. Toxicol."},{"key":"10.1016\/j.fct.2016.09.001_bib45","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/978-3-642-73113-6_45","article-title":"Di-(2-ethylhexyl) adipate and peroxisome proliferation: identification of proximate peroxisomal proliferator in\u00a0vivo and in\u00a0vitro","author":"Keith","year":"1988","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.fct.2016.09.001_bib46","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF01973626","article-title":"Peroxisome proliferation due to di(2-ethylhexyl) adipate, 2-ethylhexanol and 2-ethylhexanoic acid","volume":"66","author":"Keith","year":"1992","journal-title":"Arch. Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib47","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0022-3565(25)20202-6","article-title":"O(2)-Dependent hepatotoxicity due to ethylhexanol in the perfused rat liver: mitochondria as a site of action","volume":"252","author":"Keller","year":"1990","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0378-4274(91)90125-P","article-title":"2-Ethylhexanol uncouples oxidative phosphorylation in rat liver mitochondria","volume":"57","author":"Keller","year":"1991","journal-title":"Toxicol. Lett."},{"issue":"1\u20132","key":"10.1016\/j.fct.2016.09.001_bib49","first-page":"49","article-title":"Inhibition of mitochondrial respiration and oxygen-dependent hepatotoxicity by six structurally dissimilar peroxisomal proliferating agents","volume":"71","author":"Keller","year":"1992","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.fct.2016.09.001_bib50","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/em.2860050504","article-title":"Evaluation of di-(2-ethylhexyl)phthalate and its major metabolites in the Ames test and L5178Y mouse lymphoma mutagenicity assay","volume":"5","author":"Kirby","year":"1983","journal-title":"Environ. Mutagen."},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0278-6915(97)00134-8","article-title":"Subchronic inhalation toxicity study of 2-ethylhexanol vapour in rats","volume":"36","author":"Klimisch","year":"1998","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.fct.2016.09.001_bib52","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0041-008X(75)90226-4","article-title":"Studies on the hepatic effects of orally administered di-(2-ethylhexyl) phthalate in the rat","volume":"32","author":"Lake","year":"1975","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib53","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.tox.2004.09.008","article-title":"Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver","volume":"207","author":"Lapinskas","year":"2005","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib54","first-page":"64","article-title":"In\u00a0vitro interaction between glutathione s-transferases and phthalate ester derived peroxisome proliferators","volume":"9","author":"Law","year":"1989","journal-title":"Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib55","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0887-2333(91)90019-A","article-title":"In\u00a0vitro inhibition of mouse and rat glutathione S-transferases by di(2-ethylhexyl) phthalate, mono(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid and clofibric acid","volume":"5","author":"Law","year":"1991","journal-title":"Toxicol. Vitro"},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib56","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/taap.2000.8972","article-title":"A\u00a0single dose of di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces sertoli cell proliferation, and decreases cyclin D2 expression","volume":"166","author":"Li","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3\u20134","key":"10.1016\/j.fct.2016.09.001_bib57","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0009-2797(88)90018-X","article-title":"Induction of cytosolic and microsomal epoxide hydrolases in mouse liver by peroxisome proliferators, with special emphasis on structural analogues of 2-ethylhexanoic acid","volume":"68","author":"Lundgren","year":"1988","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.fct.2016.09.001_bib58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/taap.1999.8809","article-title":"trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals","volume":"161","author":"Maloney","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"Suppl.\u00a04","key":"10.1016\/j.fct.2016.09.001_bib59","first-page":"S60","article-title":"Fragrance material review on 2-methylundecanol. Food and chemical toxicology","volume":"48","author":"McGinty","year":"2010"},{"issue":"Suppl.\u00a04","key":"10.1016\/j.fct.2016.09.001_bib60","first-page":"S85","article-title":"Fragrance material review on 2-ethyl-1-butanol. Food and chemical toxicology","volume":"48","author":"McGinty","year":"2010"},{"issue":"Suppl.\u00a04","key":"10.1016\/j.fct.2016.09.001_bib61","first-page":"S115","article-title":"Fragrance material review on 2-ethyl-1-hexanol. Food and chemical toxicology","volume":"48","author":"McGinty","year":"2010"},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib62","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0041-008X(85)90097-3","article-title":"Identification of the proximate peroxisome proliferators derived from di(2-ethylhexyl)phthalate","volume":"80","author":"Mitchell","year":"1985","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1 pt. 2","key":"10.1016\/j.fct.2016.09.001_bib63","first-page":"A125","article-title":"Effects of dietary di(2-ethylhexyl)phthalate (DEHP), and its primary metabolites, mono(2-ethylhexyl)phthalate (MEHP) and 2-ethyl hexanol (2-EH) on hepatic lipid metabolism","volume":"48","author":"Morton","year":"1979","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib64","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0378-4274(88)90185-3","article-title":"The effect of mono-(2-ethylhexyl) phthalate and other phthalate esters on lactate production by sertoli cells in\u00a0vitro","volume":"40","author":"Moss","year":"1988","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2016.09.001_bib65","series-title":"NTP Study ID 463951_CA: 2-Ethylhexanol","author":"National Toxicology Program (NTP)","year":"2007"},{"issue":"5","key":"10.1016\/j.fct.2016.09.001_bib66","first-page":"479","article-title":"Teratological evaluation of 1-pentanol 1-hexanol and 2 ethyl-1-hexanol administered by inhalation to rats","volume":"37","author":"Nelson","year":"1988","journal-title":"Teratology"},{"issue":"2","key":"10.1016\/j.fct.2016.09.001_bib67","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3109\/10915818909019562","article-title":"Developmental toxicology evaluation of 1-pentanol, 1-hexanol, and 2-ethyl-1-hexanol administered by inhalation to rats","volume":"8","author":"Nelson","year":"1989","journal-title":"J.\u00a0Am. Coll. Toxicol."},{"key":"10.1016\/j.fct.2016.09.001_bib68","series-title":"The OECD QSAR Toolbox","author":"OECD","year":"2012"},{"key":"10.1016\/j.fct.2016.09.001_bib69","series-title":"SIAM 3, 13\u201315 February 1995. SIDS Initial Assessment Profile:","author":"OECD SIDS","year":"1995"},{"key":"10.1016\/j.fct.2016.09.001_bib70","series-title":"Oxo Alcohols. SIAM 22, 18\u201321 April 2006. SIDS Initial Assessment Profile:","author":"OECD SIDS","year":"2006"},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib71","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0165-1218(82)90139-2","article-title":"Genotoxicity studies of di(2-ethylhexyl)phthalate and its metabolites in CHO cells","volume":"102","author":"Phillips","year":"1982","journal-title":"Mutat. Res. Gen. Toxicol."},{"key":"10.1016\/j.fct.2016.09.001_bib72","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ecoenv.2011.12.008","article-title":"Effects of di-(2-ethylhexyl) phthalate and four of its metabolites on steroidogenesis in MA-lO cells","volume":"79","author":"Piche","year":"2012","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.fct.2016.09.001_bib73","first-page":"457","article-title":"Developmental toxicity evaluation of DEHP metabolites in Swiss mice","volume":"43","author":"Price","year":"1991","journal-title":"Teratology"},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib74","first-page":"387","article-title":"Cytogenetic evaluation of di-(2-ethylhexyl)phthalate and its major metabolites in Fischer 344 rats","volume":"4","author":"Putman","year":"1982","journal-title":"Environ. Mutagen."},{"issue":"2","key":"10.1016\/j.fct.2016.09.001_bib75","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/em.2860050211","article-title":"Cytogenetic evaluation of DEHP and its major metabolites in Fischer 344 rats","volume":"5","author":"Putman","year":"1983","journal-title":"Environ. Mutagen."},{"key":"10.1016\/j.fct.2016.09.001_bib76","first-page":"38","article-title":"Effects on rat embryonic development in\u00a0vitro of di-(2-ethylhexyl) phthalate (DEHP) and its metabolites","author":"Regnier","year":"2004","journal-title":"Toxicol."},{"key":"10.1016\/j.fct.2016.09.001_bib77","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-4274(84)90230-3","article-title":"The absence of testicular atrophy & in\u00a0vivo & in\u00a0vitro effects on hepatocyte morphology and peroxisomal enzyme activities in male rats following the administration of several alkanols","volume":"21","author":"Rhodes","year":"1984","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2016.09.001_bib78","series-title":"Report on Human Maximization Studies","author":"RIFM (Research Institute for Fragrance Materials, Inc)","year":"1976"},{"key":"10.1016\/j.fct.2016.09.001_bib79","series-title":"Submission to EPA. Unpublished Report from the Chemical Manufacturers Association (CMA)","author":"RIFM (Research Institute for Fragrance Materials, Inc)","year":"1983"},{"key":"10.1016\/j.fct.2016.09.001_bib80","series-title":"Mutagenicity Study of 2-ethyl-1-hexanol (Isooctanol) in the Salmonella typhimurium\/mammalian Microsome Reverse Mutation Assay (Ames-Test)","author":"RIFM (Research Institute for Fragrance Materials, Inc)","year":"1986"},{"key":"10.1016\/j.fct.2016.09.001_bib81","series-title":"Developmental Toxicity of 2 Ethylhexanol in CD-1-swiss Mice. Unpublished from the National Toxicology Program (NTP)","author":"RIFM (Research Institute for Fragrance Materials, Inc)","year":"1991"},{"key":"10.1016\/j.fct.2016.09.001_bib82","series-title":"Submission to EPA. Unpublished Report from Shell Oil Company","author":"RIFM (Research Institute for Fragrance Materials, Inc)","year":"1992"},{"key":"10.1016\/j.fct.2016.09.001_bib83","series-title":"Submission to EPA. Unpublished Report from Shell Oil Company","author":"RIFM (Research Institute for Fragrance Materials, Inc)","year":"1992"},{"key":"10.1016\/j.fct.2016.09.001_bib84","series-title":"Submission to EPA. Unpublished Report from Shell Oil Company","author":"RIFM (Research Institute for Fragrance Materials, Inc)","year":"1992"},{"key":"10.1016\/j.fct.2016.09.001_bib85","series-title":"Submission to EPA. Unpublished Report from the Union Carbide Corporation","author":"RIFM (Research Institute for Fragrance Materials, Inc)","year":"1992"},{"key":"10.1016\/j.fct.2016.09.001_bib86","series-title":"1-Heptanol, 2-propyl (Propylheptanol): Subchronic Oral Toxicity Study in Fischer F-344 Rats. Unpublished Report from BASF","author":"RIFM (Research Institute for Fragrance Materials, Inc)","year":"1996"},{"key":"10.1016\/j.fct.2016.09.001_bib87","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/tera.1420350107","article-title":"Teratogenicity of di(2-ethylhexyl)Phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, & valproic acid, & potentiation by caffeine","volume":"35","author":"Ritter","year":"1987","journal-title":"Teratology"},{"issue":"7","key":"10.1016\/j.fct.2016.09.001_bib88","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/tx700024w","article-title":"Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization","volume":"20","author":"Roberts","year":"2007","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.fct.2016.09.001_bib89","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1021\/ci100050t","article-title":"Extended-connectivity fingerprints","volume":"50","author":"Rogers","year":"2010","journal-title":"J.\u00a0Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib90","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/carcin\/20.1.27","article-title":"Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators","volume":"20","author":"Rose","year":"1999","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib91","first-page":"387","article-title":"Dominant lethal study of di-(2-ethylhexyl) phthalate and its major metabolites in ICR\/SIM mice","volume":"4","author":"Rushbrook","year":"1982","journal-title":"Environ. Mutagen."},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib92","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/BF03218349","article-title":"Thermal decomposition products of phthalates with poly(vinyl chloride) and their mutagenicity","volume":"11","author":"Saido","year":"2003","journal-title":"Macromol. Res."},{"key":"10.1016\/j.fct.2016.09.001_bib93","first-page":"15","article-title":"The influence of phthalates on chick embryos","volume":"11","author":"Sakagami","year":"1977","journal-title":"Osaka-furitsu Koshu Eisei Kenkyu Hokoku Shokuhin Eisei Hen"},{"issue":"6","key":"10.1016\/j.fct.2016.09.001_bib94","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/etc.5620210627","article-title":"A\u00a0Framework for prioritizing fragrance materials for aquatic risk assessment","volume":"21","author":"Salvito","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"issue":"11","key":"10.1016\/j.fct.2016.09.001_bib95","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/0002889738506887","article-title":"Acute toxicity of a homologous series of branched-chain primary alcohols","volume":"34","author":"Scala","year":"1973","journal-title":"Am. Ind. Hyg. Assoc. J. (AIHAJ)"},{"issue":"7","key":"10.1016\/j.fct.2016.09.001_bib96","first-page":"485","article-title":"Toxicity of various C8 aldehydes and alcohols","volume":"19","author":"Schmidt","year":"1973","journal-title":"Z.\u00a0Ges. Hyg. Grezgeb."},{"key":"10.1016\/j.fct.2016.09.001_bib97","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1289\/ehp.8245111","article-title":"Mutagenic activity of phthalate esters in bacterial liquid suspension assays","volume":"45","author":"Seed","year":"1982","journal-title":"Environ. Health Perspect."},{"issue":"12","key":"10.1016\/j.fct.2016.09.001_bib98","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.fct.2014.09.015","article-title":"An in silico skin absorption model for fragrance materials","volume":"74","author":"Shen","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.fct.2016.09.001_bib99","first-page":"400","article-title":"The results of microbial mutation test for forty-three industrial chemicals","volume":"27","author":"Shimizu","year":"1985","journal-title":"Jpn. J. Ind. Health"},{"key":"10.1016\/j.fct.2016.09.001_bib100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0773.1986.tb00098.x","article-title":"Effects of di-(2-ethylhexyl) phthalate and five of its metabolites on rat testis in\u00a0vivo and in in\u00a0vitro","volume":"58","author":"Sjoberg","year":"1986","journal-title":"Acta Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.fct.2016.09.001_bib101","first-page":"88","article-title":"Maternal exposure to 2-ethylhexanoic acid (EHXA), 2-ethylhexanol (EHXO), and valproic acid (VPA) results in alterations in maternal and embryonic zinc status","volume":"53","author":"Taubeneck","year":"1996","journal-title":"Teratology"},{"key":"10.1016\/j.fct.2016.09.001_bib102","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1289\/ehp.8245119","article-title":"Mutagenic\/carcinogenic potential of DEHP and MEHP","volume":"45","author":"Tomita","year":"1982","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.fct.2016.09.001_bib103","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0272-0590(92)90149-C","article-title":"The developmental toxicity of 2-ethylhexanol applied dermally to pregnant Fischer 344 rats","volume":"19","author":"Tyl","year":"1992","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.fct.2016.09.001_bib104","series-title":"Estimation Programs Interface Suite\u2122 for Microsoft\u00ae Windows, V. 4.11","author":"USEPA","year":"2012"},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib105","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.etap.2004.12.024","article-title":"An integrative approach considering acute symptoms and intensity ratings of chemosensory sensations during experimental exposures","volume":"19","author":"van Thriel","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib106","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0041-008X(84)90089-9","article-title":"Investigation of the potential for binding of di(2-ethylhexyl)phthalate (DEHP) and di(2-ethylhexyl) adipate (DEHA) to liver DNA in\u00a0vivo","volume":"73","author":"von Daniken","year":"1984","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2016.09.001_bib107","first-page":"279","article-title":"Tumor initiating and -promoting activities of di(2-ethylhexyl)phthalate in\u00a0vivo and in\u00a0vitro","volume":"65","author":"Ward","year":"1986","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2016.09.001_bib108","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1289\/ehp.824535","article-title":"Phthalate esters as peroxisome proliferator carcinogens","volume":"45","author":"Warren","year":"1982","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.fct.2016.09.001_bib109","first-page":"247","article-title":"Comparative toxicity of 2-ethylhexanol (2EH) in the fischer 344 rat by different routes of administration","volume":"9","author":"Weaver","year":"1989","journal-title":"Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib110","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3382\/ps.0630469","article-title":"The effect of feeding di-(2-ethylhexyl) phthalate and related compounds on lipids in the laying hen","volume":"63","author":"Wood","year":"1984","journal-title":"Poult. Sci."},{"issue":"3","key":"10.1016\/j.fct.2016.09.001_bib111","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3358\/shokueishi.15.147","article-title":"Toxicity of phthalic acid esters and hepatotoxicity of di-(2-ethyl hexyl) phthalate","volume":"15","author":"Yamada","year":"1974","journal-title":"Shokuhin Eiseigaku Zasshi"},{"key":"10.1016\/j.fct.2016.09.001_bib112","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1289\/ehp.824599","article-title":"Phthalate ester testing in the National Toxicology Program's environmental mutagenesis test development program","volume":"45","author":"Zeiger","year":"1982","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2016.09.001_bib113","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/em.2860070209","article-title":"Mutagenicity testing of di(2-ethylhexyl)phthalate and related chemicals in Salmonella","volume":"7","author":"Zeiger","year":"1985","journal-title":"Environ. Mutagen."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516303155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516303155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:32:14Z","timestamp":1759527134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691516303155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":112,"alternative-id":["S0278691516303155"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2016.09.001","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2016.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}