{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:37:30Z","timestamp":1780580250445,"version":"3.54.1"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.fct.2016.10.011","type":"journal-article","created":{"date-parts":[[2016,10,16]],"date-time":"2016-10-16T17:13:48Z","timestamp":1476638028000},"page":"89-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"PB","title":["In\u00a0vivo and in\u00a0vitro evaluation for nutraceutical purposes of\u00a0capsaicin,\u00a0capsanthin, lutein and four pepper varieties"],"prefix":"10.1016","volume":"98","author":[{"given":"Zahira","family":"Fern\u00e1ndez-Bedmar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeles","family":"Alonso-Moraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2016.10.011_bib1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/mutage\/9.4.383","article-title":"Antigenotoxicity of coffee in the Drosophila assay for somatic mutation and recombination","volume":"9","author":"Abraham","year":"1994","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2016.10.011_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-011-0743-3","article-title":"A\u00a0Drosophila model for the screening of bioavailable NADPH oxidase inhibitors and antioxidants","volume":"352","author":"Anh","year":"2011","journal-title":"Mol. Cell.. Biochem."},{"key":"10.1016\/j.fct.2016.10.011_bib3","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1089\/jmf.2010.0139","article-title":"Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid","volume":"14","author":"Anter","year":"2011","journal-title":"J.\u00a0Med. Food"},{"key":"10.1016\/j.fct.2016.10.011_bib4","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0306-9877(02)00152-4","article-title":"Capsaicin pepper, cancer and ethnicity","volume":"59","author":"Archer","year":"2002","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.fct.2016.10.011_bib5","doi-asserted-by":"crossref","first-page":"736","DOI":"10.5897\/AJPP12.031","article-title":"Evaluation of cytotoxic properties of Curcuma longa and Tagetes erecta on cancer cell line (Hep2)","volume":"7","author":"Ayyadurai","year":"2013","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"10.1016\/j.fct.2016.10.011_bib6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cmet.2007.09.002","article-title":"Diabetic larvae and obese flies\u2014emerging studies of metabolism in Drosophila","volume":"6","author":"Baker","year":"2007","journal-title":"Cell. Metab."},{"key":"10.1016\/j.fct.2016.10.011_bib7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.disamonth.2009.03.008","article-title":"Pepper and capsaicin (Capsicum and piper species)","volume":"55","author":"Barceloux","year":"2009","journal-title":"Dis. Mon."},{"key":"10.1016\/j.fct.2016.10.011_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jep.2010.02.016","article-title":"Pharmaceutical ethnobotany in the western part of Granada province (southern Spain): ethnopharmacological synthesis","volume":"129","author":"Ben\u00edtez","year":"2010","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.fct.2016.10.011_bib9","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1158\/0008-5472.CAN-10-3756","article-title":"The two faces of capsaicin","volume":"71","author":"Bode","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2016.10.011_bib10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/1011-1344(91)80266-K","article-title":"The singlet oxygen and carotenoid interaction","volume":"11","author":"Conn","year":"1991","journal-title":"J.\u00a0Photochem. Photobiol."},{"key":"10.1016\/j.fct.2016.10.011_bib11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/excr.1993.1005","article-title":"Effect of hydrogen peroxide on cytoskeletal proteins of Drosophila cells: comparison with heat shock and other stresses","volume":"204","author":"Courgeon","year":"1993","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.fct.2016.10.011_bib12","doi-asserted-by":"crossref","first-page":"10521","DOI":"10.1021\/jf802111x","article-title":"Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells","volume":"56","author":"Cha","year":"2008","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.fct.2016.10.011_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mrgentox.2003.10.001","article-title":"Genotoxicity studies with pure trans-capsaicin","volume":"557","author":"Chanda","year":"2004","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.fct.2016.10.011_bib14","doi-asserted-by":"crossref","first-page":"14814","DOI":"10.1073\/pnas.251446498","article-title":"Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase","volume":"98","author":"Chavous","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fct.2016.10.011_bib15","first-page":"3333","article-title":"Dietary lutein inhibits mouse mammary tumor growth by regulating angiogenesis and apoptosis","volume":"23","author":"Chew","year":"2002","journal-title":"Anticancer Res."},{"key":"10.1016\/j.fct.2016.10.011_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.foodchem.2008.03.022","article-title":"Effect of cooking on the antioxidant properties of coloured peppers","volume":"111","author":"Chuah","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2016.10.011_bib17","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.foodres.2011.01.006","article-title":"Effect of heat treatment on the content of some bioactive compounds and free radical-scavenging activity in pungent and non-pungent peppers","volume":"50","author":"de Jes\u00fas Ornelas-Paz","year":"2013","journal-title":"Food Res. Int."},{"key":"10.1016\/j.fct.2016.10.011_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1383-5718(98)00070-9","article-title":"Antimutagenic activity of carotenoids in green peppers against some nitroarenes","volume":"416","author":"de Mej\u0131\u0301a","year":"1998","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.fct.2016.10.011_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1475-2891-3-19","article-title":"Nutrition and cancer: a review of the evidence for an anti-cancer diet","volume":"3","author":"Donaldson","year":"2004","journal-title":"Nutr. J."},{"key":"10.1016\/j.fct.2016.10.011_bib20","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1677\/ERC-09-0020","article-title":"Hydrogen peroxide induces DNA single-and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organ","volume":"16","author":"Driessens","year":"2009","journal-title":"Endocr.-Relat. Cancer"},{"key":"10.1016\/j.fct.2016.10.011_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0278-6915(02)00216-8","article-title":"Antimutagenic properties of bell and black peppers","volume":"41","author":"El Hamss","year":"2003","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.10.011_bib22","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0304-4238(99)00029-1","article-title":"Pungency level in fruits of the Padr\u00f3n pepper with different water supply","volume":"81","author":"Estrada","year":"1999","journal-title":"Sci. Hortic."},{"key":"10.1016\/j.fct.2016.10.011_bib23","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1080\/15287394.2011.582306","article-title":"Role of citrus juices and distinctive components in the modulation of degenerative processes: genotoxicity, antigenotoxicity, cytotoxicity, and longevity in Drosophila","volume":"74","author":"Fern\u00e1ndez-Bedmar","year":"2011","journal-title":"J.\u00a0Toxicol. Environ. Health A"},{"key":"10.1016\/j.fct.2016.10.011_bib24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0921-8734(92)90031-J","article-title":"Role of oxidative stress in Drosophila aging","volume":"275","author":"Fleming","year":"1992","journal-title":"Mutat. Res.-DNAging"},{"key":"10.1016\/j.fct.2016.10.011_bib98","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0165-1161(88)90019-2","article-title":"Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila","volume":"203","author":"Frei","year":"1988","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2016.10.011_bib25","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/S0161-6420(01)00833-8","article-title":"Plasma antioxidant vitamins and carotenoids and age-related cataract","volume":"108","author":"Gale","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.fct.2016.10.011_bib26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbagen.2011.02.008","article-title":"Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells","volume":"1810","author":"Ganesan","year":"2011","journal-title":"BBA-Gen. Subj."},{"key":"10.1016\/j.fct.2016.10.011_bib27","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.lfs.2008.02.020","article-title":"Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cells","volume":"82","author":"Gil","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2016.10.011_bib28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jnci\/94.5.391","article-title":"A\u00a0prospective study of tomato products, lycopene, and prostate Cancer risk","volume":"94","author":"Giovannucci","year":"2002","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.fct.2016.10.011_bib29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0027-5107(97)00298-4","article-title":"Antigenotoxicity studies in Drosophila melanogaster","volume":"402","author":"Graf","year":"1998","journal-title":"Mutat. Res. Fund. Mol. M."},{"key":"10.1016\/j.fct.2016.10.011_bib30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/em.2860060206","article-title":"Somatic mutation and recombination test in Drosophila melanogaster","volume":"6","author":"Graf","year":"1984","journal-title":"Environ. Mutagen"},{"key":"10.1016\/j.fct.2016.10.011_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/01635589709514520","article-title":"Induction of HL-60 cell differentiation by carotenoids","volume":"27","author":"Gross","year":"1997","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.fct.2016.10.011_bib32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/35041700","article-title":"Genetic pathways that regulate ageing in model organisms","volume":"408","author":"Guarente","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.fct.2016.10.011_bib33","first-page":"338","article-title":"Capsaicin: a review of its pharmacology and clinical applications","volume":"19","author":"Hayman","year":"2008","journal-title":"Curr. Anaesth. Crit. Care"},{"key":"10.1016\/j.fct.2016.10.011_bib34","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/aje\/kwf072","article-title":"Dietary carotenoids, serum \u03b2-carotene, and retinol and risk of lung cancer in the Alpha-Tocopherol, Beta-Carotene cohort study","volume":"156","author":"Holick","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.fct.2016.10.011_bib35","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1021\/jf991020r","article-title":"Carotenoid biosynthesis changes in five red pepper (Capsicum annuum L.) cultivars during ripening. Cultivar selection for breeding","volume":"48","author":"Hornero-M\u00e9ndez","year":"2000","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.fct.2016.10.011_bib36","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1158\/0008-5472.CAN-03-1670","article-title":"Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species","volume":"64","author":"Ito","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2016.10.011_bib37","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.fct.2006.10.011","article-title":"Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2","volume":"45","author":"Jun","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.10.011_bib38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0304-3835(01)00426-8","article-title":"Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation","volume":"165","author":"Jung","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2016.10.011_bib39","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/02713680903046855","article-title":"Genotoxic effects of carotenoid breakdown products in human retinal pigment epithelial cells","volume":"34","author":"Kalariya","year":"2009","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.fct.2016.10.011_bib40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-2999(01)00994-3","article-title":"Capsaicin potentiates 1, 25-dihydoxyvitamin D 3-and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells","volume":"420","author":"Kang","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2016.10.011_bib41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/jmf.2004.7.267","article-title":"Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor \u03b3 in HT-29 human colon cancer cells","volume":"7","author":"Kim","year":"2004","journal-title":"J.\u00a0Med. Food"},{"key":"10.1016\/j.fct.2016.10.011_bib42","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0304-3835(97)00321-2","article-title":"Capsaicin can alter the expression of tumor forming-related genes which might be followed by induction of apoptosis of a Korean stomach cancer cell line, SNU-1","volume":"120","author":"Kim","year":"1997","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2016.10.011_bib43","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1093\/jn\/131.12.3303","article-title":"Carotenoids affect proliferation of human prostate cancer cells","volume":"131","author":"Kotake-Nara","year":"2001","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.fct.2016.10.011_bib44","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.fct.2010.04.011","article-title":"Antioxidant and cytotoxic effect of oxidized lutein in human cervical carcinoma cells (HeLa)","volume":"48","author":"Lakshminarayana","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.10.011_bib45","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.fct.2006.02.013","article-title":"Effect of different Thai traditional processing of various hot chili peppers on urethane-induced somatic mutation and recombination in Drosophila melanogaster: assessment of the role of glutathione transferase activity","volume":"44","author":"Laohavechvanich","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.10.011_bib46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3835(00)00608-X","article-title":"Induction of apoptosis by capsaicin in A172 human glioblastoma cells","volume":"161","author":"Lee","year":"2000","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2016.10.011_bib47","series-title":"Edible Medicinal and Non-medicinal Plants","author":"Lim","year":"2012"},{"key":"10.1016\/j.fct.2016.10.011_bib48","series-title":"The Genome of Drosophila melanogaster","author":"Lindsley","year":"2012"},{"key":"10.1016\/j.fct.2016.10.011_bib49","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.3748\/wjg.v11.i40.6254","article-title":"Capsaicin-induced cell death in a human gastric adenocarcinoma cell line","volume":"11","author":"Lo","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2016.10.011_bib50","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/oxfordjournals.aje.a116993","article-title":"Chili pepper consumption and gastric cancer in Mexico: a case-control study","volume":"139","author":"L\u00f3pez-Carnllo","year":"1994","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.fct.2016.10.011_bib51","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1383-5718(01)00325-4","article-title":"Germ cells microsatellite instability: the effect of different mutagens in a mismatch repair mutant of Drosophila (spel1)","volume":"514","author":"L\u00f3pez","year":"2002","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.fct.2016.10.011_bib52","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jnutbio.2004.08.003","article-title":"Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances","volume":"16","author":"Lu","year":"2005","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.fct.2016.10.011_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2010.09.074","article-title":"Recent advances in the study on capsaicinoids and capsinoids","volume":"650","author":"Luo","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2016.10.011_bib54","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/jcb.22469","article-title":"Capsaicin induces apoptosis through ubiquitin\u2013proteasome system dysfunction","volume":"109","author":"Maity","year":"2010","journal-title":"J.\u00a0Cell.. Biochem."},{"key":"10.1016\/j.fct.2016.10.011_bib55","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0304-3835(01)00635-8","article-title":"Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L","volume":"172","author":"Maoka","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2016.10.011_bib56","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1383-5718(02)00040-2","article-title":"Micronuclei and sister chromatid exchanges induced by capsaicin in human lymphocytes","volume":"517","author":"Marques","year":"2002","journal-title":"Mutat. Res.-Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.fct.2016.10.011_bib57","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/aje\/153.5.424","article-title":"Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey","volume":"153","author":"Marse-Perlman","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.fct.2016.10.011_bib58","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.arr.2005.08.001","article-title":"How should we assess the impact of genetic changes on ageing in model species?","volume":"5","author":"Minois","year":"2006","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.fct.2016.10.011_bib59","first-page":"237","article-title":"Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids","volume":"18","author":"Molnar","year":"2004","journal-title":"In\u00a0vivo"},{"key":"10.1016\/j.fct.2016.10.011_bib60","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1158\/0008-5472.CAN-05-0087","article-title":"Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells","volume":"66","author":"Mori","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2016.10.011_bib61","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/ptr.1144","article-title":"Cytotoxic and multidrug resistance reversal activity of a vegetable,\u2018Anastasia Red\u2019, a variety of sweet pepper","volume":"17","author":"Motohashi","year":"2003","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fct.2016.10.011_bib62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0304-3835(99)00351-1","article-title":"Modifying effects of carotenoids on superoxide and nitric oxide generation from stimulated leukocytes","volume":"149","author":"Murakami","year":"2000","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2016.10.011_bib63","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jfca.2008.07.006","article-title":"Xanthophyll (lutein, zeaxanthin) content in fruits, vegetables and corn and egg products","volume":"22","author":"Perry","year":"2009","journal-title":"J.\u00a0Food Comp. Anal."},{"key":"10.1016\/j.fct.2016.10.011_bib64","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jep.2005.04.028","article-title":"Traditional pharmacopoeias and medicines among Albanians and Italians in southern Italy: a comparison","volume":"101","author":"Pieroni","year":"2005","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.fct.2016.10.011_bib65","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jep.2004.08.012","article-title":"Folk pharmaceutical knowledge in the territory of the Dolomiti Lucane, inland southern Italy","volume":"95","author":"Pieroni","year":"2004","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.fct.2016.10.011_bib66","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.foodchem.2006.12.067","article-title":"Characterization of total capsaicinoids, colour and volatile compounds of Habanero chilli pepper (Capsicum chinense Jack.) cultivars grown in Yucatan","volume":"104","author":"Pino","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2016.10.011_bib67","doi-asserted-by":"crossref","first-page":"e20151","DOI":"10.1371\/journal.pone.0020151","article-title":"Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells","volume":"6","author":"Pramanik","year":"2011","journal-title":"Plos One"},{"key":"10.1016\/j.fct.2016.10.011_bib68","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1089\/jmf.2014.0003","article-title":"Dietary lutein modulates growth and survival genes in prostate Cancer cells","volume":"18","author":"Rafi","year":"2015","journal-title":"J.\u00a0Med. Food"},{"key":"10.1016\/j.fct.2016.10.011_bib69","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1383-5718(01)00217-0","article-title":"Antimutagenic effect of one variety of green pepper (Capsicum spp.) and its possible interference with the nitrosation process","volume":"496","author":"Ramirez-Victoria","year":"2001","journal-title":"Mutat. Res.-Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.fct.2016.10.011_bib70","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1016\/j.fct.2011.08.011","article-title":"Safety assessment of lutein and zeaxanthin (Lutemax\u2122 2020): subchronic toxicity and mutagenicity studies","volume":"49","author":"Ravikrishnan","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.10.011_bib71","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1534\/genetics.107.072959","article-title":"The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells","volume":"176","author":"Ren","year":"2007","journal-title":"Genetics"},{"key":"10.1016\/j.fct.2016.10.011_bib72","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s002040050680","article-title":"Cytotoxicity and genotoxicity of capsaicin in human neuroblastoma cells SHSY-5Y","volume":"73","author":"Richeux","year":"1999","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2016.10.011_bib73","article-title":"The health potential of fruits and vegetables phytochemicals: notable examples","author":"Rodriguez-Casado","year":"2014","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fct.2016.10.011_bib74","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mrgentox.2005.05.004","article-title":"Genotoxicity and anti-genotoxicity of some traditional medicinal herbs","volume":"585","author":"Romero-Jimenez","year":"2005","journal-title":"Mutat. Res.-Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.fct.2016.10.011_bib75","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s10495-007-0119-z","article-title":"Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation","volume":"12","author":"S\u00e1nchez","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.fct.2016.10.011_bib76","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1086\/physzool.58.4.30156013","article-title":"Resistance to environmental stress in Drosophila melanogaster selected for postponed senescence","author":"Service","year":"1985","journal-title":"Physiol. Zool."},{"key":"10.1016\/j.fct.2016.10.011_bib77","first-page":"273","article-title":"The Antimutagenic and Antioxidant effects of red pepper seed and red pepper pericarp (Capsicum annuum L.)","volume":"12","author":"Sim","year":"2007","journal-title":"J.\u00a0Food Sci. Nutr"},{"key":"10.1016\/j.fct.2016.10.011_bib78","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.mad.2007.08.004","article-title":"Dietary restriction in Drosophila is dependent on mitochondrial efficiency and constrained by pre-existing extended longevity","volume":"128","author":"Soh","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.fct.2016.10.011_bib79","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.foodres.2004.09.001","article-title":"Spices as influencers of body metabolism: an overview of three decades of research","volume":"38","author":"Srinivasan","year":"2005","journal-title":"Food Res. Int."},{"key":"10.1016\/j.fct.2016.10.011_bib80","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1111\/j.1750-3841.2006.00245.x","article-title":"Antioxidant activities of different colored sweet bell peppers (Capsicum annuum L.)","volume":"72","author":"Sun","year":"2007","journal-title":"J.\u00a0Food Sci."},{"key":"10.1016\/j.fct.2016.10.011_bib81","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.aca.2005.05.051","article-title":"Chromatographic and electrophoretic procedures for analyzing plant pigments of pharmacologically interests","volume":"547","author":"Sun","year":"2005","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.fct.2016.10.011_bib82","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/0024-3205(95)00159-4","article-title":"Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential","volume":"56","author":"Surh","year":"1995","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2016.10.011_bib83","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0027-5107(01)00177-4","article-title":"Preventive effects of anthraquinone food pigments on the DNA damage induced by carcinogens in Drosophila","volume":"480","author":"Takahashi","year":"2001","journal-title":"Mutat. Res.-Fund. Mol. M."},{"key":"10.1016\/j.fct.2016.10.011_bib84","doi-asserted-by":"crossref","first-page":"e56986","DOI":"10.1371\/journal.pone.0056986","article-title":"Protective effect of borage seed oil and gamma linolenic acid on DNA: in\u00a0vivo and in\u00a0vitro studies","volume":"8","author":"Tasset-Cuevas","year":"2013","journal-title":"Plos One"},{"key":"10.1016\/j.fct.2016.10.011_bib85","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jfca.2007.03.007","article-title":"Assessment of carotenoids, capsaicinoids and ascorbic acid composition of some selected pepper cultivars (Capsicum annuum L.) grown in Turkey","volume":"20","author":"Topuz","year":"2007","journal-title":"J.\u00a0Food Comp. Anal."},{"key":"10.1016\/j.fct.2016.10.011_bib86","first-page":"1127","article-title":"The retinal carotenoids zeaxanthin and lutein scavenge superoxide and hydroxyl radicals: a chemiluminescence and ESR study","volume":"12","author":"Trevithick-Sutton","year":"2006","journal-title":"Mol. Vis."},{"key":"10.1016\/j.fct.2016.10.011_bib87","first-page":"1965","article-title":"Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells","volume":"26","author":"Tsou","year":"2006","journal-title":"Anticancer Res."},{"key":"10.1016\/j.fct.2016.10.011_bib88","first-page":"471","article-title":"Mutagenicity and mutagens of the red chili pepper as gallbladder cancer risk factor in Chilean women","volume":"12","author":"Tsuchiya","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.fct.2016.10.011_bib89","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0027-5107(02)00194-X","article-title":"Mitotic recombination is an important mutational event following oxidative damage","volume":"522","author":"Turner","year":"2003","journal-title":"Mutat. Res.-Fund. Mol. M."},{"key":"10.1016\/j.fct.2016.10.011_bib90","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.atherosclerosis.2013.01.021","article-title":"Lutein supplementation reduces plasma lipid peroxidation and C-reactive protein in healthy nonsmokers","volume":"227","author":"Wang","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fct.2016.10.011_bib91","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.fct.2006.04.005","article-title":"Antioxidant activity, mutagenicity\/anti-mutagenicity, and clastogenicity\/anti-clastogenicity of lutein from marigold flowers","volume":"44","author":"Wang","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.10.011_bib92","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mrfmmm.2006.06.015","article-title":"Capsaicin induced cell cycle arrest and apoptosis in human esophagus epidermoid carcinoma CE 81T\/VGH cells through the elevation of intracellular reactive oxygen species and Ca 2+ productions and caspase-3 activation","volume":"601","author":"Wu","year":"2006","journal-title":"Mutat. Res.-Fund. Mol. M."},{"key":"10.1016\/j.fct.2016.10.011_bib93","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1534\/genetics.108.091314","article-title":"The multiple-wing-hairs gene encodes a novel GBD\u2013FH3 domain-containing protein that functions both prior to and after wing hair initiation","volume":"180","author":"Yan","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.fct.2016.10.011_bib94","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2478\/s11658-009-0016-2","article-title":"Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines","volume":"14","author":"Yang","year":"2009","journal-title":"Cell.. Mol. Biol. Lett."},{"key":"10.1016\/j.fct.2016.10.011_bib95","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.abb.2011.05.004","article-title":"Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPAR\u03b3) in K562 cancer cells","volume":"512","author":"Zhang","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.fct.2016.10.011_bib96","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jff.2012.01.001","article-title":"Bioactive characteristics and antioxidant activities of nine peppers","volume":"4","author":"Zhuang","year":"2012","journal-title":"J.\u00a0Funct. Foods"},{"key":"10.1016\/j.fct.2016.10.011_bib97","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0165-7992(91)90092-I","article-title":"The genotoxicity of nitrilotriacetic acid (NTA) in a somatic mutation and recombination test in Drosophila melanogaster","volume":"262","author":"Zordan","year":"1991","journal-title":"Mutat. Res. Lett."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516303611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516303611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:28:37Z","timestamp":1759526917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691516303611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":98,"alternative-id":["S0278691516303611"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2016.10.011","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0vivo and in\u00a0vitro evaluation for nutraceutical purposes of\u00a0capsaicin,\u00a0capsanthin, lutein and four pepper varieties","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2016.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}