{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T23:35:55Z","timestamp":1784417755317,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Cooperative Research Program for Agriculture Science & Technology Development","award":["PJ00995002"],"award-info":[{"award-number":["PJ00995002"]}]},{"name":"Research Institute for Veterinary Science"},{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BK21 PLUS Program for Creative Veterinary Science Research"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.fct.2016.10.024","type":"journal-article","created":{"date-parts":[[2016,10,23]],"date-time":"2016-10-23T09:46:35Z","timestamp":1477215995000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"PB","title":["Benomyl-induced effects of ORMDL3 overexpression via oxidative stress in human bronchial epithelial cells"],"prefix":"10.1016","volume":"98","author":[{"given":"Yoonjeong","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hee","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Haing","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2016.10.024_bib1","first-page":"RA141","article-title":"Pesticides and oxidative stress: a review","volume":"10","author":"Abdollahi","year":"2004","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.fct.2016.10.024_bib2","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1172\/JCI36130","article-title":"The cytokine network in asthma and chronic obstructive pulmonary disease","volume":"118","author":"Barnes","year":"2008","journal-title":"J.\u00a0Clin. investig."},{"key":"10.1016\/j.fct.2016.10.024_bib3","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1164\/ajrccm.161.5.9903102","article-title":"Asthma: from bronchoconstriction to airways inflammation and remodeling","volume":"161","author":"Bousquet","year":"2000","journal-title":"Am. J. Respir. Crit. care Med."},{"key":"10.1016\/j.fct.2016.10.024_bib4","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMoa0806604","article-title":"Effect of 17q21 variants and smoking exposure in early-onset asthma","volume":"359","author":"Bouzigon","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.fct.2016.10.024_bib5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jaci.2011.12.968","article-title":"Advances in mechanisms of asthma, allergy, and immunology in 2011","volume":"129","author":"Boyce","year":"2012","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.fct.2016.10.024_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/hmg\/ddp471","article-title":"The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress","volume":"19","author":"Cantero-Recasens","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.fct.2016.10.024_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11882-010-0092-4","article-title":"Occupational rhinitis and asthma: where do we stand, where do we go?","volume":"10","author":"Castano","year":"2010","journal-title":"Curr. Allerg. Asthma Rep."},{"key":"10.1016\/j.fct.2016.10.024_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4168\/aair.2010.2.3.183","article-title":"The role of oxidative stress in the pathogenesis of asthma","volume":"2","author":"Cho","year":"2010","journal-title":"Allergy, asthma & Immunol. Res."},{"key":"10.1016\/j.fct.2016.10.024_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1165\/ajrcmb.10.1.7507342","article-title":"CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells","volume":"10","author":"Cozens","year":"1994","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.fct.2016.10.024_bib10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.coph.2004.12.005","article-title":"Matrix metalloproteinases in asthma and COPD","volume":"5","author":"Demedts","year":"2005","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.fct.2016.10.024_bib11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.109.214601","article-title":"Therapeutic targeting of mitochondrial superoxide in hypertension","volume":"107","author":"Dikalova","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.fct.2016.10.024_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1136\/oem.60.1.76","article-title":"Occupational asthma from fungicides fluazinam and chlorothalonil","volume":"60","author":"Draper","year":"2003","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.fct.2016.10.024_bib13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1083\/jcb.201401050","article-title":"The cell biology of asthma","volume":"205","author":"Erle","year":"2014","journal-title":"J.\u00a0cell Biol."},{"key":"10.1016\/j.fct.2016.10.024_bib14","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jaci.2006.12.665","article-title":"Increased expression of ADAM33 and ADAM8 with disease progression in asthma","volume":"119","author":"Foley","year":"2007","journal-title":"J.\u00a0Allerg. Clin. Immunol."},{"key":"10.1016\/j.fct.2016.10.024_bib15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/ACI.0b013e32831f8ee0","article-title":"Novel biomarkers in asthma: chemokines and chitinase-like proteins","volume":"9","author":"Hartl","year":"2009","journal-title":"Curr. Opin. allerg. Clin. Immunol."},{"key":"10.1016\/j.fct.2016.10.024_bib16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/icb.2011.112","article-title":"The interplay between endoplasmic reticulum stress and inflammation","volume":"90","author":"Hasnain","year":"2012","journal-title":"Immunol. cell Biol."},{"key":"10.1016\/j.fct.2016.10.024_bib17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00420-013-0881-x","article-title":"Exacerbation of symptoms in agricultural pesticide applicators with asthma","volume":"87","author":"Henneberger","year":"2014","journal-title":"Int. Archiv. Occup. Environ. Health"},{"key":"10.1016\/j.fct.2016.10.024_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.pupt.2005.02.008","article-title":"ADAM33: a newly identified protease involved in airway remodelling","volume":"19","author":"Holgate","year":"2006","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2016.10.024_bib19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1710-1492-9-4","article-title":"Functional analysis of the impact of ORMDL3 expression on inflammation and activation of the unfolded protein response in human airway epithelial cells","volume":"9","author":"Hsu","year":"2013","journal-title":"Allerg. Asthma Clin. Immunol."},{"key":"10.1016\/j.fct.2016.10.024_bib20","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jaci.2013.08.041","article-title":"Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor \u03baB activation","volume":"132","author":"Kim","year":"2013","journal-title":"J.\u00a0Allerg. Clin. Immunol."},{"key":"10.1016\/j.fct.2016.10.024_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0014-2999(01)01320-6","article-title":"Oxidative stress and lung inflammation in airways disease","volume":"429","author":"MacNee","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2016.10.024_bib22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jps.2600690244","article-title":"Antiasthmatic drug therapy and calcium ions: review of pathogenesis and role of calcium","volume":"69","author":"Middleton","year":"1980","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.fct.2016.10.024_bib23","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.4049\/jimmunol.1303047","article-title":"ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma","volume":"192","author":"Miller","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.fct.2016.10.024_bib24","doi-asserted-by":"crossref","first-page":"16648","DOI":"10.1073\/pnas.1204151109","article-title":"ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6","volume":"109","author":"Miller","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.fct.2016.10.024_bib25","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A\u00a0large-scale, consortium-based genomewide association study of asthma","volume":"363","author":"Moffatt","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.fct.2016.10.024_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.taap.2013.01.025","article-title":"Pesticides and human chronic diseases: evidences, mechanisms, and perspectives","volume":"268","author":"Mostafalou","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2016.10.024_bib27","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1164\/ajrccm.161.4.9812061","article-title":"Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: clinical and biologic significance","volume":"161","author":"Ordonez","year":"2000","journal-title":"Am. J. Respir. Crit. care Med."},{"key":"10.1016\/j.fct.2016.10.024_bib28","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1056\/NEJMcibr022144","article-title":"ADAM-33 surfaces as an asthma gene","volume":"347","author":"Shapiro","year":"2002","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.fct.2016.10.024_bib29","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ni805","article-title":"Human epithelial cells trigger dendritic cell\u2013mediated allergic inflammation by producing TSLP","volume":"3","author":"Soumelis","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fct.2016.10.024_bib30","article-title":"Cytokines and chemokines in asthma: anoverview","volume":"453","author":"Tulic","year":"2005","journal-title":"Physiol. Basis Respir. Dis."},{"key":"10.1016\/j.fct.2016.10.024_bib31","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature00878","article-title":"Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness","volume":"418","author":"Van Eerdewegh","year":"2002","journal-title":"Nature"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516303933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516303933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:28:25Z","timestamp":1759526905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691516303933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":31,"alternative-id":["S0278691516303933"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2016.10.024","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benomyl-induced effects of ORMDL3 overexpression via oxidative stress in human bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2016.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}