{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:13:02Z","timestamp":1783548782474,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.fct.2016.12.030","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T07:31:12Z","timestamp":1482478272000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Prepubertal subchronic exposure to soy milk and glyphosate leads to endocrine disruption"],"prefix":"10.1016","volume":"100","author":[{"given":"Jessica","family":"Nardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Bonamigo","family":"Moras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Koeppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Dallegrave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna Bainy","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Grazziotin","family":"Rossato-Grando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2016.12.030_bib1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.neuint.2012.09.003","article-title":"The oxidative damage and inflammation caused by pesticides are reverted by lipoic acid in rat brain","volume":"61","author":"Astiz","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.fct.2016.12.030_bib2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1590\/S0101-20612008000500030","article-title":"Residues of glyphosate and aminomethylphosphonic acid and levels of isoflavones in BRS 244 RR and BRS 154 soybean","volume":"28","author":"Bohm","year":"2008","journal-title":"Food Sci. Technol."},{"key":"10.1016\/j.fct.2016.12.030_bib3","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/and.12394","article-title":"Isoflavones and their effects on the onset of puberty in male Wistar rats","volume":"47","author":"Caceres","year":"2015","journal-title":"Andrologia"},{"key":"10.1016\/j.fct.2016.12.030_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.etap.2007.08.011","article-title":"The effect of sub-acute and sub-chronic exposure of rats to the glyphosate-based herbicide Roundup","volume":"25","author":"\u00c7a\u011flar","year":"2008","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.fct.2016.12.030_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tox.2014.03.001","article-title":"Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: involvement of glutamate excitotoxicity","volume":"5","author":"Cattani","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2016.12.030_bib6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.freeradbiomed.2013.06.043","article-title":"Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells","volume":"65","author":"Cavalli","year":"2013","journal-title":"Free Radic. Bio Med."},{"key":"10.1016\/j.fct.2016.12.030_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tiv.2011.12.009","article-title":"A\u00a0glyphosate-based herbicide induces necrosis and apoptosis in mature rat testicular cells in\u00a0vitro, and testosterone decrease at lower levels","volume":"26","author":"Clair","year":"2012","journal-title":"Toxicol. in\u00a0vitro"},{"key":"10.1016\/j.fct.2016.12.030_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/019262339702500201","article-title":"Evaluation of testicular toxicity in safety evaluation studies: the appropriate use of spermatogenic staging","volume":"25","author":"Creasy","year":"1997","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.fct.2016.12.030_bib9","first-page":"29","article-title":"Oral acute toxicity of glyphosate in Wistar rats","volume":"1","author":"Dallegrave","year":"2002","journal-title":"Online J. Veterinary Res."},{"key":"10.1016\/j.fct.2016.12.030_bib10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00204-006-0170-5","article-title":"Pre-and postnatal toxicity of the commercial glyphosate formulation in Wistar rats","volume":"81","author":"Dallegrave","year":"2007","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2016.12.030_bib11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1191\/096032799678845124","article-title":"Reproductive effects of endosulfan on male offspring of rats exposed during pregnancy and lactation","volume":"18","author":"Dalsenter","year":"1999","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.fct.2016.12.030_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.etap.2009.06.001","article-title":"Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate","volume":"28","author":"El-Shenavy","year":"2009","journal-title":"Environ. Toxicol. Phar"},{"key":"10.1016\/j.fct.2016.12.030_bib13","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tox.2009.06.006","article-title":"Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines","volume":"262","author":"Gasnier","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2016.12.030_bib14","series-title":"Textbook of Medical Phisiology","author":"Guyton","year":"1988"},{"key":"10.1016\/j.fct.2016.12.030_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/ilar.45.4.443","article-title":"Behavioral effects of endocrine-disrupting substances: phytoestrogens","volume":"45","author":"Lephart","year":"2004","journal-title":"ILAR J."},{"key":"10.1016\/j.fct.2016.12.030_bib16","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0006-8993(01)02793-7","article-title":"Dietary soy phytoestrogens produce anxiolytic effects in the elevated plus-maze","volume":"913","author":"Lund","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.fct.2016.12.030_bib17","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.foodchem.2014.07.036","article-title":"Physicochemical and acid gelation properties of commercial UHT-treated plant-based milk substitutes and lactose free bovine milk","volume":"168","author":"M\u00e4kinen","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2016.12.030_bib18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1590\/S0104-42302010000200025","article-title":"Lactose intolerance: changing paradigms due to molecular biology","volume":"56","author":"Mattar","year":"2010","journal-title":"Rev. Assoc. Med. Bras."},{"key":"10.1016\/j.fct.2016.12.030_bib19","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jat.2712","article-title":"Cytotoxicity on human cells of Cry1Sb and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide","volume":"33","author":"Mesnage","year":"2012","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.fct.2016.12.030_bib20","first-page":"1","article-title":"Testicular development in male rats is sensitive to a soy-based diet in the neonatal period","volume":"40","author":"Napier","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.fct.2016.12.030_bib21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.beem.2015.04.006","article-title":"Androgen receptor roles in spermatogenesis and infertility","volume":"29","author":"O'Hara","year":"2015","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.fct.2016.12.030_bib22","first-page":"260","volume":"9","author":"OECD-Organisation for Economic Co-operation and Development","year":"2010","journal-title":"Guid. Doc. Assess. Chem. Endocr. Disrupt."},{"key":"10.1016\/j.fct.2016.12.030_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2164\/jandrol.107.003392","article-title":"Exposure of juvenile rats to the phytoestrogen daidzein impairs erectile function in a dose-related manner in adulthood","volume":"29","author":"Pan","year":"2008","journal-title":"J.\u00a0Androl."},{"key":"10.1016\/j.fct.2016.12.030_bib24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00204-011-0788-9","article-title":"Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression","volume":"86","author":"Romano","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2016.12.030_bib25","first-page":"481","article-title":"Glyphosate-roundup exposure delays puberty onset in male rats","volume":"45","author":"Romano","year":"2008","journal-title":"Braz J. Vet. Res. Anim. Sci."},{"key":"10.1016\/j.fct.2016.12.030_bib26","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.3945\/jn.109.119776","article-title":"Equol: history, chemistry, and formation","volume":"140","author":"Setchell","year":"2010","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.fct.2016.12.030_bib27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.fct.2013.05.057","article-title":"Glyphosate induces human breast cancer cells growth via estrogen receptors","volume":"59","author":"Thongprakaisang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.12.030_bib29","first-page":"1","article-title":"Possible developmental early effects of endocrine disrupters on child health","author":"WHO- World Health Organization","year":"2012","journal-title":"Endocr. disrupt. child health"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516304896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516304896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:33:38Z","timestamp":1759527218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691516304896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":28,"alternative-id":["S0278691516304896"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2016.12.030","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prepubertal subchronic exposure to soy milk and glyphosate leads to endocrine disruption","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2016.12.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}