{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:22:51Z","timestamp":1791325371700,"version":"4.3.1"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T00:00:00Z","timestamp":1529712000000},"content-version":"am","delay-in-days":295,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"United States Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["USDA-NIFA-EXCA-005457"],"award-info":[{"award-number":["USDA-NIFA-EXCA-005457"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute of Computational Comparative Medicine (ICCM)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.fct.2017.06.023","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T19:18:03Z","timestamp":1497467883000},"page":"74-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"PA","title":["Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment"],"prefix":"10.1016","volume":"107","author":[{"given":"Miao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronette","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim E.","family":"Riviere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-8366","authenticated-orcid":false,"given":"Zhoumeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2017.06.023_bib1","first-page":"E1","article-title":"Oxytetracycline and penicillin-G residues in cattle slaughtered in south-western Nigeria: implications for livestock disease management and public health","volume":"84","author":"Adesokan","year":"2013","journal-title":"J.\u00a0S Afr. Vet. Assoc."},{"key":"10.1016\/j.fct.2017.06.023_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-4274(02)00375-2","article-title":"Toxicokinetic modeling and its applications in chemical risk assessment","volume":"138","author":"Andersen","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2017.06.023_bib3","first-page":"07","article-title":"Pharmacokinetics and tissue residues of procaine penicillin G in sows after administration of 33,000 IU\/kg intramuscularly and by needle-free injection in the hip","author":"Apley","year":"2009","journal-title":"Natl. Pork Board Res. Rep. NPB"},{"key":"10.1016\/j.fct.2017.06.023_bib4","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1152\/jappl.1987.62.3.1285","article-title":"Distribution of blood flow in muscles of miniature swine during exercise","volume":"62","author":"Armstrong","year":"1987","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.fct.2017.06.023_bib5","first-page":"1","article-title":"A\u00a0prolonged release parenteral drug delivery system\u2014an overview","volume":"3","author":"Bari","year":"2010","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"10.1016\/j.fct.2017.06.023_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2165\/00003088-197601040-00004","article-title":"Pharmacokinetics of the penicillins in man","volume":"1","author":"Barza","year":"1976","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.fct.2017.06.023_bib7","first-page":"689","article-title":"An evaluation of antimicrobial therapy for undifferentiated bovine respiratory disease","volume":"31","author":"Bateman","year":"1990","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.fct.2017.06.023_bib8","series-title":"Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management, and Testing","first-page":"1","article-title":"Importance of veterinary drug residues","author":"Baynes","year":"2014"},{"key":"10.1016\/j.fct.2017.06.023_bib9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.fct.2015.12.020","article-title":"Health concerns and management of select veterinary drug residues","volume":"88","author":"Baynes","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2017.06.023_bib10","first-page":"645","article-title":"An oxytetracycline residue depletion study to assess the physiologically based pharmokinetic (PBPK) model in farmed Atlantic salmon","volume":"38","author":"Brocklebank","year":"1997","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.fct.2017.06.023_bib11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.yrtph.2005.05.009","article-title":"Demystifying 21 CFR Part 556\u2013tolerances for residues of new animal drugs in food","volume":"42","author":"Brynes","year":"2005","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib12","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1128\/AAC.01355-05","article-title":"Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine","volume":"50","author":"Buur","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.fct.2017.06.023_bib13","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.2460\/ajvr.2005.66.1686","article-title":"Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues","volume":"66","author":"Buur","year":"2005","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.fct.2017.06.023_bib14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.yrtph.2008.05.003","article-title":"Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model","volume":"51","author":"Buur","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.rvsc.2008.07.003","article-title":"A\u00a0physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition","volume":"86","author":"Buur","year":"2009","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.fct.2017.06.023_bib16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10928-012-9280-2","article-title":"Applications of minimal physiologically-based pharmacokinetic models","volume":"39","author":"Cao","year":"2012","journal-title":"J.\u00a0Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.fct.2017.06.023_bib17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2885.2006.00747.x","article-title":"Bovine kidney tissue\/biological fluid correlation for penicillin","volume":"29","author":"Chiesa","year":"2006","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.fct.2017.06.023_bib18","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1289\/ehp.00108s2283","article-title":"Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment","volume":"108","author":"Clewell","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2017.06.023_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yrtph.2007.10.012","article-title":"Development and specification of physiologically based pharmacokinetic models for use in risk assessment","volume":"50","author":"Clewell","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1128\/AAC.3.4.463","article-title":"Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption","volume":"3","author":"Cole","year":"1973","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.fct.2017.06.023_bib21","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2885.2009.01073.x","article-title":"A\u00a0PBPK model for midazolam in four avian species","volume":"32","author":"Cortright","year":"2009","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yrtph.2006.06.008","article-title":"The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene","volume":"47","author":"Covington","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-2885.2003.00451.x","article-title":"A\u00a0physiologically based pharmacokinetic model for oxytetracycline residues in sheep","volume":"26","author":"Craigmill","year":"2003","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib24","series-title":"Tabulation of FARAD Comparative and Veterinary Pharmacokinetic Data","first-page":"1","author":"Craigmill","year":"2006"},{"key":"10.1016\/j.fct.2017.06.023_bib25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0378-1135(93)90146-X","article-title":"Allergy to antimicrobial residues in food: assessment of the risk to man","volume":"35","author":"Dayan","year":"1993","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.fct.2017.06.023_bib26","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.2527\/jas1986.6261675x","article-title":"Relationships among serum characteristics and performance and carcass traits in growing pigs","volume":"62","author":"Doornenbal","year":"1986","journal-title":"J.\u00a0Anim. Sci."},{"key":"10.1016\/j.fct.2017.06.023_bib27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1161\/01.RES.8.1.4","article-title":"Observations on the circulation of domestic cattle","volume":"8","author":"Doyle","year":"1960","journal-title":"Circ. Res."},{"key":"10.1016\/j.fct.2017.06.023_bib28","series-title":"Benzylpenicillin","author":"DrugBank","year":"2016"},{"key":"10.1016\/j.fct.2017.06.023_bib29","series-title":"Guidance for Industry #209, the Judicious Use of Medically Important Antimicrobial Drugs in Food-producing Animals","author":"FDA","year":"2013"},{"key":"10.1016\/j.fct.2017.06.023_bib30","series-title":"Penicillin G Procaine Implantation and Injectable Dosage Forms","author":"FDA","year":"2013"},{"key":"10.1016\/j.fct.2017.06.023_bib31","author":"FDA","year":"2015"},{"key":"10.1016\/j.fct.2017.06.023_bib32","series-title":"FDA Reminds Retail Establishments of Upcoming Changes to the Use of Antibiotics in Food Animals","author":"FDA","year":"2016"},{"key":"10.1016\/j.fct.2017.06.023_bib33","series-title":"Guidance for Industry #3, General Principles for Evaluating the Human Food Safety of New Animal Drugs Used in Food-producing Animals","author":"FDA","year":"2016"},{"key":"10.1016\/j.fct.2017.06.023_bib34","series-title":"Code of Federal Regulations 21, CFR Parts 530.3","author":"FDA","year":"2017"},{"key":"10.1016\/j.fct.2017.06.023_bib35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2885.1990.tb00766.x","article-title":"The effect of phenylbutazone on the plasma disposition of penicillin G in the horse","volume":"13","author":"Firth","year":"1990","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1289\/ehp.00108s2265","article-title":"Physiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites","volume":"108","author":"Fisher","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2017.06.023_bib37","series-title":"Screening and Confirmation of Animal Drug Residues by UHPLC-MS-MS","author":"FSIS","year":"2013"},{"key":"10.1016\/j.fct.2017.06.023_bib38","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1080\/01621459.1996.10476708","article-title":"Physiological pharmacokinetic analysis using population modeling and informative prior distributions","volume":"91","author":"Gelman","year":"1996","journal-title":"J.\u00a0Am. Stat. Assoc."},{"key":"10.1016\/j.fct.2017.06.023_bib39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/01.all.0000173785.81024.33","article-title":"Epidemiology of hypersensitivity drug reactions","volume":"5","author":"Gomes","year":"2005","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.fct.2017.06.023_bib40","series-title":"Measurement and Measurement Uncertainty, Systems Analysis for Water Technology","first-page":"237","author":"Gujer","year":"2008"},{"key":"10.1016\/j.fct.2017.06.023_bib41","series-title":"Parameter Identification, Sensitivity and Error Propagation, Systems Analysis for Water Technology","first-page":"257","author":"Gujer","year":"2008"},{"key":"10.1016\/j.fct.2017.06.023_bib42","first-page":"293","article-title":"Normal physiological values for conscious pigs used in biomedical research","volume":"40","author":"Hannon","year":"1990","journal-title":"Lab. Anim. Sci."},{"key":"10.1016\/j.fct.2017.06.023_bib43","article-title":"A\u00a0physiologically based pharmacokinetic model for chickens exposed to feed supplemented with monensin during their lifetime","author":"Henri","year":"2016","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib44","first-page":"2002","article-title":"Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modelling","volume":"32","author":"Huang","year":"2015","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"10.1016\/j.fct.2017.06.023_bib45","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1476-5381.1965.tb02068.x","article-title":"The binding of three penicillins in the plasma of several mammalian species as studied by ultrafiltration at body temperature","volume":"25","author":"Keen","year":"1965","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.fct.2017.06.023_bib46","article-title":"Fast Monte Carlo simulation methods for biological reaction-diffusion systems in solution and on surfaces SIAM","volume":"30","author":"Kerr","year":"2008","journal-title":"J.\u00a0Sci. Comput."},{"key":"10.1016\/j.fct.2017.06.023_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40780-016-0043-x","article-title":"Population pharmacokinetic analysis and dosing regimen optimization of penicillin G in patients with infective endocarditis","volume":"2","author":"Komatsu","year":"2016","journal-title":"J.\u00a0Pharm. Health Care Sci."},{"key":"10.1016\/j.fct.2017.06.023_bib109","first-page":"223","article-title":"Depletion of intramuscularly and subcutaneously injected procaine penicillin G from tissues and plasma of yearling beef steers","volume":"57","author":"Korsrud","year":"1993","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.fct.2017.06.023_bib110","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/02652039609374410","article-title":"Residue depletion in tissues and fluids from swine fed sulfamethazine, chlortetracycline and penicillin G in combination","volume":"13","author":"Korsrud","year":"1996","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.fct.2017.06.023_bib111","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/02652039809374662","article-title":"Depletion of penicillin G residues in tissues, plasma and injection sites of market pigs injected intramuscularly with procaine penicillin G","volume":"15","author":"Korsrud","year":"1998","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.fct.2017.06.023_bib48","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1038\/psp.2014.13","article-title":"Visualization and communication of pharmacometric models with berkeley madonna","volume":"3","author":"Krause","year":"2014","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib49","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2193-9616-1-6","article-title":"Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification","volume":"1","author":"Krauss","year":"2013","journal-title":"Silico Pharmacol"},{"key":"10.1016\/j.fct.2017.06.023_bib50","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/jat.1455","article-title":"Physiologically based pharmacokinetic modeling of cyclotrimethylenetrinitramine in male rats","volume":"29","author":"Krishnan","year":"2009","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.fct.2017.06.023_bib51","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.2460\/javma.2005.227.1574","article-title":"Effect of formulation and route of administration on tissue residues and withdrawal times","volume":"227","author":"KuKanich","year":"2005","journal-title":"J.\u00a0Am. Vet. Med. Assoc."},{"key":"10.1016\/j.fct.2017.06.023_bib52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2885.2011.01304.x","article-title":"Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats","volume":"35","author":"Leavens","year":"2012","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib53","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1080\/19440049.2014.938363","article-title":"Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus)","volume":"31","author":"Leavens","year":"2014","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"10.1016\/j.fct.2017.06.023_bib54","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1051\/rnd:19960202","article-title":"Quantitative aspects of blood and amino acid flows in cattle","volume":"36","author":"Lescoat","year":"1996","journal-title":"Reprod. Nutr. Dev."},{"key":"10.1016\/j.fct.2017.06.023_bib55","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/jps.24341","article-title":"A\u00a0framework for meta-analysis of veterinary drug pharmacokinetic data using mixed effect modeling","volume":"104","author":"Li","year":"2015","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.fct.2017.06.023_bib56","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1128\/AAC.02806-14","article-title":"Interspecies mixed-effect pharmacokinetic modeling of penicillin G in cattle and swine","volume":"58","author":"Li","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.fct.2017.06.023_bib57","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.taap.2010.11.009","article-title":"A\u00a0physiologically based pharmacokinetic model for atrazine and its main metabolites in the adult male C57BL\/6 mouse","volume":"251","author":"Lin","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib58","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.taap.2013.08.010","article-title":"Estimation of placental and lactational transfer and tissue distribution of atrazine and its main metabolites in rodent dams, fetuses, and neonates with physiologically based pharmacokinetic modeling","volume":"273","author":"Lin","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib59","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/jvp.12311","article-title":"Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment","volume":"39","author":"Lin","year":"2016","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib60","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfx070","article-title":"Performance assessment and translation of physiologically based pharmacokinetic models from acslX to berkeley madonna, MATLAB(R), and R language: oxytetracycline and gold nanoparticles as case examples","author":"Lin","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2017.06.023_bib61","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jps.24244","article-title":"Development and application of a multiroute physiologically based pharmacokinetic model for oxytetracycline in dogs and humans","volume":"104","author":"Lin","year":"2015","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.fct.2017.06.023_bib62","doi-asserted-by":"crossref","first-page":"27907","DOI":"10.1038\/srep27907","article-title":"Human food safety implications of variation in food animal drug metabolism","volume":"6","author":"Lin","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2017.06.023_bib63","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1213\/00000539-198305000-00008","article-title":"Systemic distribution of blood flow in swine while awake and during 1.0 and 1.5 MAC isoflurane anesthesia with or without 50% nitrous oxide","volume":"62","author":"Lundeen","year":"1983","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.fct.2017.06.023_bib64","doi-asserted-by":"crossref","first-page":"7577","DOI":"10.1021\/jf501492v","article-title":"Depletion of penicillin G residues in heavy sows after intramuscular injection. Part I: tissue residue depletion","volume":"62","author":"Lupton","year":"2014","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.fct.2017.06.023_bib65","series-title":"Berkeley Madonna User's Guide Version 8.0.2","first-page":"1","author":"Macey","year":"2009"},{"key":"10.1016\/j.fct.2017.06.023_bib66","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1365-2885.1998.00121.x","article-title":"Population pharmacokinetics in veterinary medicine: potential use for therapeutic drug monitoring and prediction of tissue residues","volume":"21","author":"Martin-Jimenez","year":"1998","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib67","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fphar.2011.00031","article-title":"A\u00a0workflow for global sensitivity analysis of PBPK models","volume":"2","author":"McNally","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib68","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/toxsci\/kfl056","article-title":"Development of a physiologically based pharmacokinetic model for deltamethrin in the adult male sprague-dawley rat","volume":"93","author":"Mirfazaelian","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2017.06.023_bib69","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.4238\/vol10-3gmr1302","article-title":"Modeling of crossbred cattle growth, comparison between cubic and piecewise random regression models","volume":"10","author":"Mirzaei","year":"2011","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.fct.2017.06.023_bib70","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2460\/javma.2001.219.346","article-title":"Tissue disposition and depletion of penicillin G after oral administration with milk in unweaned dairy calves","volume":"219","author":"Musser","year":"2001","journal-title":"J.\u00a0Am. Vet. Med. Assoc."},{"key":"10.1016\/j.fct.2017.06.023_bib71","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1023272707390","article-title":"Lumping of whole-body physiologically based pharmacokinetic models","volume":"26","author":"Nestorov","year":"1998","journal-title":"J.\u00a0Pharmacokinet. Biopharm."},{"key":"10.1016\/j.fct.2017.06.023_bib72","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1365-2885.1990.tb00780.x","article-title":"Comparative benzylpenicillin pharmacokinetics in the dromedary Camelus dromedarius and in sheep","volume":"13","author":"Oukessou","year":"1990","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib73","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2885.1993.tb00178.x","article-title":"A\u00a0study of the disposition of procaine penicillin G in feedlot steers following intramuscular and subcutaneous injection","volume":"16","author":"Papich","year":"1993","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib74","series-title":"Veterinary Pharmacology and Therapeutics","first-page":"866","article-title":"Lactam antibiotics: PENICILLINS, cephalosporins, and related drugs","author":"Papich","year":"2009"},{"key":"10.1016\/j.fct.2017.06.023_bib75","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2460\/javma.229.9.1401","article-title":"Extralabel use of penicillin in food animals","volume":"229","author":"Payne","year":"2006","journal-title":"J.\u00a0Am. Vet. Med. Assoc."},{"key":"10.1016\/j.fct.2017.06.023_bib76","first-page":"11","article-title":"A\u00a0molasses in diets for growing pigs","volume":"5","author":"Phuc","year":"1993","journal-title":"Livest. Res. Rural Dev."},{"key":"10.1016\/j.fct.2017.06.023_bib77","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yrtph.2015.12.020","article-title":"Using physiologically based pharmacokinetic modeling and benchmark dose methods to derive an occupational exposure limit for N-methylpyrrolidone","volume":"76","author":"Poet","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib78","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1177\/1040638712457559","article-title":"A\u00a0ten-year (2000-2009) study of antimicrobial susceptibility of bacteria that cause bovine respiratory disease complex\u2013mannheimia haemolytica, pasteurella multocida, and histophilus somni\u2013in the United States and Canada","volume":"24","author":"Portis","year":"2012","journal-title":"J.\u00a0Vet. Diagn. Invest"},{"key":"10.1016\/j.fct.2017.06.023_bib79","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1034\/j.1398-9995.2001.056008796.x","article-title":"Anaphylaxis to beef in penicillin-allergic patient","volume":"56","author":"Raison-Peyron","year":"2001","journal-title":"Allergy"},{"key":"10.1016\/j.fct.2017.06.023_bib80","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1023\/A:1020590408947","article-title":"Benzathine penicillin G and procaine penicillin G in piglets: comparison of intramuscular and subcutaneous injection","volume":"26","author":"Ranheim","year":"2002","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.fct.2017.06.023_bib81","doi-asserted-by":"crossref","first-page":"826","DOI":"10.4315\/0362-028X-49.10.826","article-title":"Food animal residue avoidance Databank (FARAD): an automated pharmacologic Databank for drug and chemical residue avoidance","volume":"49","author":"Riviere","year":"1986","journal-title":"J.\u00a0Food Prot."},{"key":"10.1016\/j.fct.2017.06.023_bib82","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2460\/javma.250.10.1131","article-title":"Guide to FARAD resources: historical and future perspectives","volume":"250","author":"Riviere","year":"2017","journal-title":"J.\u00a0Am. Vet. Med. Assoc."},{"key":"10.1016\/j.fct.2017.06.023_bib83","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.taap.2013.05.024","article-title":"Physiologically-based pharmacokinetic model for fentanyl in support of the development of provisional advisory levels","volume":"273","author":"Shankaran","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib84","doi-asserted-by":"crossref","first-page":"e0161131","DOI":"10.1371\/journal.pone.0161131","article-title":"An agent-based model of a hepatic inflammatory response to Salmonella: a computational study under a large set of experimental data","volume":"11","author":"Shi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2017.06.023_bib85","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00204-012-0987-z","article-title":"A\u00a0physiologically based pharmacokinetic model for the oxime TMB-4: simulation of rodent and human data","volume":"87","author":"Sterner","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2017.06.023_bib86","series-title":"Variations Recorded in the Study of the Conformation and Anatomy of 318 Dairy Cows Having Records of Production","author":"Swett WW","year":"1933"},{"key":"10.1016\/j.fct.2017.06.023_bib87","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1080\/15287390600631367","article-title":"Use of a physiologically based pharmacokinetic model to identify exposures consistent with human biomonitoring data for chloroform","volume":"69","author":"Tan","year":"2006","journal-title":"J.\u00a0Toxicol. Environ. Health Part A"},{"key":"10.1016\/j.fct.2017.06.023_bib88","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2460\/ajvr.1982.43.05.895","article-title":"Organ blood flow and distribution of cardiac output in nonanesthetized swine","volume":"43","author":"Tranquilli","year":"1982","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.fct.2017.06.023_bib112","article-title":"Blood levels, pharmacokinetics and residualization of benzylpenicillin Ursopen 100000 in calves following subcutaneous injection","volume":"41","author":"Trolldenier","year":"1986","journal-title":"Monatsh. Veterinarmed."},{"key":"10.1016\/j.fct.2017.06.023_bib89","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.2042-7158.1979.tb13448.x","article-title":"Physiological pharmacokinetics of Mactam antibiotics: penicillin V distribution and elimination after intravenous administration in rats","volume":"31","author":"Tsuji","year":"1979","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib90","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/jps.2600721103","article-title":"Physiologically based pharmacokinetic model for \u03b2-lactam antibiotics I: tissue distribution and elimanation rates","volume":"72","author":"Tsuji","year":"1983","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.fct.2017.06.023_bib91","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2460\/ajvr.2000.61.811","article-title":"Pharmacokinetics of penicillin G procaine versus penicillin G potassium and procaine hydrochloride in horses","volume":"61","author":"Uboh","year":"2000","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.fct.2017.06.023_bib92","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.vascn.2008.08.001","article-title":"Organ weights and blood flows of sheep and pig for physiological pharmacokinetic modelling","volume":"58","author":"Upton","year":"2008","journal-title":"J.\u00a0Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.fct.2017.06.023_bib93","series-title":"U.S. National Residue Program: 2014 Residue Sample Results","author":"USDA","year":"2015"},{"key":"10.1016\/j.fct.2017.06.023_bib94","series-title":"PENICILLIN G (Veterinary\u2014systemic) Veterinary Antibiotic Monographs","author":"USP","year":"2007"},{"key":"10.1016\/j.fct.2017.06.023_bib95","first-page":"341","article-title":"Pneumonia in calves: characterization of the bacterial spectrum and the resistance patterns to antimicrobial drugs","volume":"143","author":"Vogel","year":"2001","journal-title":"Schweiz. Arch. Tierheilkd"},{"key":"10.1016\/j.fct.2017.06.023_bib96","series-title":"Characterization and Application of Physiologically Based Pharmacokinetic Models in Risk Assessment","first-page":"1","author":"WHO","year":"2010"},{"key":"10.1016\/j.fct.2017.06.023_bib97","doi-asserted-by":"crossref","first-page":"D668","DOI":"10.1093\/nar\/gkj067","article-title":"DrugBank: a comprehensive resource for in silico drug discovery and exploration","volume":"34","author":"Wishart","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fct.2017.06.023_bib98","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/jvp.12053","article-title":"A\u00a0physiologically based pharmacokinetic model for the prediction of the depletion of methyl-3-quinoxaline-2-carboxylic acid, the marker residue of olaquindox, in the edible tissues of pigs","volume":"37","author":"Yang","year":"2014","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib99","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/19440049.2011.624126","article-title":"Use of a Monte Carlo analysis within a physiologically based pharmacokinetic model to predict doxycycline residue withdrawal time in edible tissues in swine","volume":"29","author":"Yang","year":"2012","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"10.1016\/j.fct.2017.06.023_bib100","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/jvp.12162","article-title":"Estimating danofloxacin withdrawal time in broiler chickens based on physiologically based pharmacokinetics modeling","volume":"38","author":"Yang","year":"2015","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib101","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1365-2885.2012.01419.x","article-title":"A\u00a0physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolation","volume":"36","author":"Yang","year":"2013","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib102","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/jvp.12137.","article-title":"Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model","volume":"37","author":"Yang","year":"2014","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib103","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.taap.2015.10.016","article-title":"Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A","volume":"289","author":"Yang","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2017.06.023_bib104","doi-asserted-by":"crossref","first-page":"e0164641","DOI":"10.1371\/journal.pone.0164641","article-title":"Application of physiologically based absorption modeling to characterize the pharmacokinetic profiles of oral extended release methylphenidate products in adults","volume":"11","author":"Yang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2017.06.023_bib105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/jvp.12143","article-title":"A\u00a0physiologically based pharmacokinetic model for quinoxaline-2-carboxylic acid in rats, extrapolation to pigs","volume":"38","author":"Yang","year":"2015","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib106","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/toxsci\/kfp198","article-title":"Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposures with a PBPK model","volume":"112","author":"Yoon","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2017.06.023_bib107","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2885.2010.01230.x","article-title":"A\u00a0physiologically based pharmacokinetic model for valnemulin in rats and extrapolation to pigs","volume":"34","author":"Yuan","year":"2011","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.06.023_bib108","first-page":"192","article-title":"Physiologically based pharmacokinetic model for quinocetone in pigs and extrapolation to mequindox","volume":"34","author":"Zhu","year":"2017","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691517303319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691517303319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:33:08Z","timestamp":1759527188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691517303319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":112,"alternative-id":["S0278691517303319"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2017.06.023","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2017.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}