{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:27:20Z","timestamp":1783078040919,"version":"3.54.6"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.fct.2017.07.027","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T15:21:37Z","timestamp":1499959297000},"page":"63-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"PA","title":["Phytochemical analysis and effects on ingestive behaviour of a Caralluma fimbriata extract"],"prefix":"10.1016","volume":"108","author":[{"given":"Annabella","family":"Vitalone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7467-1689","authenticated-orcid":false,"given":"Antonella","family":"Di Sotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina Loredana","family":"Mammola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Heyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selenia","family":"Miglietta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Sciubba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Passarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Nativio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Mazzanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2017.07.027_bib1","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.phytochem.2008.05.017","article-title":"Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity","volume":"69","author":"Abdel-Sattar","year":"2008","journal-title":"Phytochem"},{"key":"10.1016\/j.fct.2017.07.027_bib2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1248\/cpb.48.1017","article-title":"Pregnane Glycosides from the roots of Asclepias tuberose","volume":"48","author":"Abe","year":"2000","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.fct.2017.07.027_bib3","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1210\/en.2013-1251","article-title":"The orexigenic effect of orexin-A revisited: dependence of an intact growth hormone axis","volume":"154","author":"\u00c1lvarez-Crespo","year":"2013","journal-title":"Endocrinol"},{"key":"10.1016\/j.fct.2017.07.027_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11130-013-0361-1","article-title":"Plant extracts with appetite suppressing properties for body weight control: a systematic review of double blind randomized controlled clinical trials","volume":"68","author":"Astell","year":"2013","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.fct.2017.07.027_bib5","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0031-9422(02)00678-7","article-title":"Further constituents from Caralluma negevensis","volume":"62","author":"Bader","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fct.2017.07.027_bib6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrn2400","article-title":"Central mechanisms of osmosensation and systemic osmoregulation","volume":"9","author":"Bourque","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.fct.2017.07.027_bib7","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0045-6535(03)00471-5","article-title":"Some aspects of toxic contaminants in herbal medicines","volume":"52","author":"Chan","year":"2003","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2017.07.027_bib8","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.foodchem.2015.05.068","article-title":"Polyphenols rich fraction from Geoffroea decorticans fruits flour affects key enzymes involved in metabolic syndrome, oxidative stress and inflammatory process","volume":"190","author":"Costamagna","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2017.07.027_bib9","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.3748\/wjg.14.6999","article-title":"Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements","volume":"14","author":"Dara","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2017.07.027_bib10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1089\/jmf.2010.1555","article-title":"Pharmacological review of Caralluma R.Br. with special reference to appetite suppression and anti-obesity","volume":"15","author":"Dutt","year":"2012","journal-title":"J.\u00a0Med. Food"},{"key":"10.1016\/j.fct.2017.07.027_bib11","unstructured":"EMEA\/HMPC\/253629\/2007. Reflection paper on references used for quantitative and qualitative analysis of herbal medicinal products and traditional herbal medicinal products. Available at http:\/\/www.gmp-compliance.org\/guidemgr\/files\/25362907ENFIN.PDF."},{"key":"10.1016\/j.fct.2017.07.027_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1651-2227.2005.tb02128.x","article-title":"Appetite regulation and energy balance","volume":"94","author":"Erlanson-Albertsson","year":"2005","journal-title":"Acta Paediatr. Suppl."},{"key":"10.1016\/j.fct.2017.07.027_bib13","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.4161\/cc.9.16.12601","article-title":"Nutrient sensing and insulin signaling in neuropeptide-expressing immortalized, hypothalamic neurons: a cellular model of insulin resistance","volume":"9","author":"Fick","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.fct.2017.07.027_bib14","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3736\/jcim20121002","article-title":"Facts about standardization of herbal medicine: a review","volume":"10","author":"Garg","year":"2012","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"10.1016\/j.fct.2017.07.027_bib15","first-page":"436039","article-title":"Plants' metabolites as potential antiobesity agents","author":"Gooda Sahib","year":"2012","journal-title":"Sci. World J."},{"key":"10.1016\/j.fct.2017.07.027_bib16","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1073\/pnas.1011508108","article-title":"Bitter taste receptors and \u03b1-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying","volume":"108","author":"Janssen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fct.2017.07.027_bib17","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2016.06.046","article-title":"Coupled sensing of hunger and thirst signals balances sugar and water consumption","volume":"166","author":"Jourjine","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.fct.2017.07.027_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.npep.2012.09.007","article-title":"Neuronal circuits involving neuropeptide Y in hypothalamic arcuate nucleus-mediated feeding regulation","volume":"46","author":"Kageyama","year":"2012","journal-title":"Neuropeptides"},{"key":"10.1016\/j.fct.2017.07.027_bib19","first-page":"285301","article-title":"Antiobesogenic and antiatherosclerotic properties of Caralluma fimbriata extract","volume":"2010","author":"Kamalakkannan","year":"2010","journal-title":"J.\u00a0Nutr. Metab."},{"key":"10.1016\/j.fct.2017.07.027_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neulet.2014.05.063","article-title":"Orexin-1 receptor mediates the increased food and water intake induced by intracerebroventricular injection of the stable somatostatin pan-agonist, ODT8-SST in rats","volume":"576","author":"Karasawa","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.fct.2017.07.027_bib21","doi-asserted-by":"crossref","first-page":"17610","DOI":"10.1523\/JNEUROSCI.3452-13.2013","article-title":"Food for thought: hormonal, experiential, and neural influences on feeding and obesity","volume":"33","author":"Karatsoreos","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.fct.2017.07.027_bib22","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1021\/jf3033649","article-title":"Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model","volume":"61","author":"Komarnytsky","year":"2013","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.fct.2017.07.027_bib23","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.appet.2006.09.013","article-title":"Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women","volume":"48","author":"Kuriyan","year":"2007","journal-title":"Appetite"},{"key":"10.1016\/j.fct.2017.07.027_bib24","doi-asserted-by":"crossref","first-page":"785","DOI":"10.13005\/bbra\/1338","article-title":"HPTLC fingerprinting method to Distinguish total extract of Caralluma fimbriata from the modified extracts of Caralluma fimbriata","volume":"11","author":"Lakshmi","year":"2014","journal-title":"Biosci. Biotechnol. Res. Asia"},{"key":"10.1016\/j.fct.2017.07.027_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2004.04.041","article-title":"Increased ATP content\/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside","volume":"1020","author":"MacLean","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.fct.2017.07.027_bib26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1055\/s-0029-1185949","article-title":"Characterization of in\u00a0vitro pharmacokinetic properties of hoodigogenin A from Hoodia gordonii","volume":"76","author":"Madgula","year":"2010","journal-title":"Planta Med."},{"key":"10.1016\/j.fct.2017.07.027_bib27","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1079\/BJN20051650","article-title":"Asparagus adscendens (Shweta musali) stimulates insulin secretion, insulin action and inhibits starch digestion","volume":"95","author":"Mathews","year":"2006","journal-title":"Brit. J. Nutr."},{"key":"10.1016\/j.fct.2017.07.027_bib28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jep.2009.09.004","article-title":"Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 week feeding experiment","volume":"126","author":"Mazzanti","year":"2009","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.fct.2017.07.027_bib29","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.foodchem.2004.10.006","article-title":"Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity","volume":"91","author":"Meda","year":"2005","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2017.07.027_bib30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.yfrne.2011.06.001","article-title":"The role of NPY in hypothalamic mediated food intake","volume":"32","author":"Mercer","year":"2011","journal-title":"Front. Neuroendocrinol"},{"key":"10.1016\/j.fct.2017.07.027_bib31","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1111\/j.1460-9568.2004.03255.x","article-title":"Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus","volume":"19","author":"Muroya","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.fct.2017.07.027_bib32","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3109\/10253890.2011.627071","article-title":"Effect of stress on hippocampal nociceptin expression in rat","volume":"15","author":"Nativio","year":"2012","journal-title":"Stress"},{"key":"10.1016\/j.fct.2017.07.027_bib33","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S2221-1691(12)60219-6","article-title":"Inhibition of \u03b1-amylase and \u03b1-glucosidase activities by ethanolic extract of Telfairia occidentalis (fluted pumpkin) leaf","volume":"2","author":"Oboh","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.fct.2017.07.027_bib34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/1091581813492827","article-title":"Safety assessment of a hydroethanolic extract of Caralluma fimbriata","volume":"32","author":"Odendaal","year":"2013","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.fct.2017.07.027_bib35","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0031-9384(88)90065-0","article-title":"Characterization of central actions of neuropeptide Y on food and water intake in rabbits","volume":"44","author":"Pau","year":"1988","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.fct.2017.07.027_bib36","series-title":"A\u00a0Stereotaxic Atlas of the Rat Brain","author":"Pellegrino","year":"1979"},{"key":"10.1016\/j.fct.2017.07.027_bib37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-8993(92)90089-R","article-title":"Feeding and drinking responses to neuropeptide Y injections in the paraventricular hypothalamic nucleus of aged rats","volume":"575","author":"Pich","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.fct.2017.07.027_bib38","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1021\/jf0502810","article-title":"Effect of ascorbic acid and dehydration on concentrations of total phenolics, antioxidant capacity, anthocyanins, and color in fruits","volume":"53","author":"Rababah","year":"2005","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.fct.2017.07.027_bib39","first-page":"147","article-title":"Nootropic activity of Caralluma fimbriata extract in mice","volume":"5","author":"Rajendran","year":"2014","journal-title":"Food Nutr. Sci."},{"key":"10.1016\/j.fct.2017.07.027_bib40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0305-1978(98)00069-6","article-title":"Flavone glycoside from three Caralluma species","volume":"27","author":"Ramesh","year":"1999","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.fct.2017.07.027_bib50","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1083\/jcb.17.1.208","article-title":"The use of lead citrate at high pH as an electron-opaque stain in electron microscopy","volume":"17","author":"Reynolds","year":"1963","journal-title":"J. Cell. Biol."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.fct.2017.07.027_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/nutrit\/nuv033","article-title":"Determinants of water and sodium intake and output","volume":"73","author":"Stanhewicz","year":"2015","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.fct.2017.07.027_bib42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s13105-013-0304-1","article-title":"Beneficial effects of hydro-alcoholic extract of Caralluma fimbriata against high-fat diet-induced insulin resistance and oxidative stress in Wistar male rats","volume":"70","author":"Sudhakara","year":"2014","journal-title":"Physiol. Biochem."},{"key":"10.1016\/j.fct.2017.07.027_bib43","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1021\/pr500748r","article-title":"1H NMR-based urinary metabolic profiling reveals changes in nicotinamide pathway intermediates due to postnatal stress model in rat","volume":"13","author":"Tomassini","year":"2014","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.fct.2017.07.027_bib44","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0367-326X(03)00021-2","article-title":"Antihyperglycemic activity of Caralluma attenuata","volume":"74","author":"Venkatesh","year":"2003","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fct.2017.07.027_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00228-010-0981-4","article-title":"Suspected adverse reactions associated with herbal products used for weight loss: a case series reported to the Italian National Institute of Health","volume":"67","author":"Vitalone","year":"2011","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.fct.2017.07.027_bib46","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0031-9384(01)00612-6","article-title":"The hypothalamus and the control of energy homeostasis: different circuits, different purposes","volume":"74","author":"Williams","year":"2001","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.fct.2017.07.027_bib47","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.amjmed.2005.01.076","article-title":"Lack of herbal supplement characterization in published randomized controlled trials","volume":"118","author":"Wolsko","year":"2005","journal-title":"Am. J. Med."},{"key":"10.1016\/j.fct.2017.07.027_bib48","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1248\/cpb.44.1212","article-title":"Medicinal foodstuff. III. Sugar beet. Hypoglycemic oleanolic acid oligoglycosides, betavulgarosides I, II, III, and IV, from the root of Beta vulgaris L. (Chenopodiaceae)","volume":"44","author":"Yoshikawa","year":"1996","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.fct.2017.07.027_bib49","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1467-789X.2010.00790.x","article-title":"Comprehensive review on herbal medicine for energy intake suppression","volume":"12","author":"Yuliana","year":"2011","journal-title":"Obes. Rev."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869151730399X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869151730399X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:33:25Z","timestamp":1759527205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869151730399X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":50,"alternative-id":["S027869151730399X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2017.07.027","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phytochemical analysis and effects on ingestive behaviour of a Caralluma fimbriata extract","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2017.07.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}