{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:07:16Z","timestamp":1769267236874,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Italian Ministry of Health","award":["RF-2010-2311608"],"award-info":[{"award-number":["RF-2010-2311608"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.fct.2017.07.041","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T14:47:22Z","timestamp":1500648442000},"page":"74-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"PA","title":["Relative toxicological ranking of eight polybrominated diphenyl ether congeners using cytotoxicity, chemical properties and exposure data"],"prefix":"10.1016","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8029-8625","authenticated-orcid":false,"given":"Sabrina","family":"Tait","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4294-9866","authenticated-orcid":false,"given":"Monia","family":"Perugini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"La Rocca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2017.07.041_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ecoenv.2013.05.028","article-title":"Histopathological effects of 2, 2\u2032, 4, 4\u2032-tetrabromodiphenyl ether (BDE-47) in the gills, intestine and liver of turbot (Psetta maxima)","volume":"95","author":"Barja-Fern\u00e1ndez","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2017.07.041_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1387-2656(05)11004-7","article-title":"Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction","volume":"11","author":"Berridge","year":"2005","journal-title":"Biotechnol. Annu. Rev."},{"key":"10.1016\/j.fct.2017.07.041_bib3","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.envint.2016.02.017","article-title":"Associations between human exposure to polybrominated diphenyl ether flame retardants via diet and indoor dust, and internal dose: a systematic review","volume":"92","author":"Bramwell","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2017.07.041_bib4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.toxlet.2013.11.011","article-title":"A\u00a0mechanistic view of polybrominated diphenyl ether (PBDE) developmental neurotoxicity","volume":"230","author":"Costa","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2017.07.041_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0022-1759(93)90011-U","article-title":"The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity","volume":"160","author":"Crouch","year":"1993","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.fct.2017.07.041_bib6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.etap.2014.07.021","article-title":"Cadmium and decabrominated diphenyl ether mixture: in\u00a0vitro evaluation of cytotoxic, prooxidative and genotoxic effects","volume":"38","author":"Curcic","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2017.07.041_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.taap.2010.10.016","article-title":"Introduction to benchmark dose methods and US EPA's benchmark dose software (BMDS) version 2.1.1","volume":"254","author":"Davis","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.fct.2017.07.041_bib8","first-page":"2156","article-title":"Scientific opinion on polybrominated diphenyl ethers (PBDEs) in food","volume":"9","author":"EFSA","year":"2011","journal-title":"EFSA J."},{"key":"10.1016\/j.fct.2017.07.041_bib9","series-title":"Ecological State of the Science Report on Decabromodiphenyl Ether (decaBDE) - Bioaccumulation and Transformation. 2010","author":"Environment Canada","year":"2010"},{"key":"10.1016\/j.fct.2017.07.041_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijheh.2015.08.004","article-title":"Brominated flame retardants\u2013Exposure and risk assessment for the general population","volume":"219","author":"Fromme","year":"2016","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.fct.2017.07.041_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/toxsci\/kfj187","article-title":"In\u00a0vitro profiling of the endocrine-disrupting potency of brominated flame retardants","volume":"92","author":"Hamers","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2017.07.041_bib12","article-title":"Update: use of the benchmark dose approach in risk assessment","volume":"15","author":"Hardy","year":"2017","journal-title":"EFSA J."},{"key":"10.1016\/j.fct.2017.07.041_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.toxlet.2007.04.002","article-title":"Apoptosis induction on human hepatoma cells Hep G2 of decabrominated diphenyl ether (PBDE-209)","volume":"171","author":"Hu","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2017.07.041_bib14","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.tiv.2014.07.004","article-title":"Effect on metabolic enzymes and thyroid receptors induced by BDE-47 by activation the pregnane X receptor in HepG2, a human hepatoma cell line","volume":"28","author":"Hu","year":"2014","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2017.07.041_bib15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/toxsci\/kfp296","article-title":"Comparative cytotoxicity and intracellular accumulation of five polybrominated diphenyl ether congeners in mouse cerebellar granule neurons","volume":"114","author":"Huang","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2017.07.041_bib16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jprot.2013.08.004","article-title":"Proteomic and metabolomic analysis of earthworm Eisenia fetida exposed to different concentrations of 2, 2\u2032, 4, 4\u2032-tetrabromodiphenyl ether","volume":"91","author":"Ji","year":"2013","journal-title":"J.\u00a0proteomics"},{"key":"10.1016\/j.fct.2017.07.041_bib17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.aquatox.2013.07.009","article-title":"Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2, 2\u2032, 4, 4\u2032-tetrabromodiphenyl ether (BDE 47)","volume":"140","author":"Ji","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fct.2017.07.041_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0022-1759(01)00404-5","article-title":"Sensitive determination of cell number using the CyQUANT\u00ae cell proliferation assay","volume":"254","author":"Jones","year":"2001","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.fct.2017.07.041_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ecoenv.2016.08.017","article-title":"In\u00a0vitro digestion and absorption of BDE-28, -47, -99 and -153 in indoor dust and its implication in risk assessment","volume":"134","author":"Kang","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2017.07.041_bib20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.chemosphere.2008.04.081","article-title":"New insights into the endocrine disrupting effects of brominated flame retardants","volume":"73","author":"Legler","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2017.07.041_bib21","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1021\/es200383a","article-title":"Derivation by infrared spectroscopy with multivariate analysis of bimodal contaminant-induced dose-response effects in MCF-7 cells","volume":"45","author":"Llabjani","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2017.07.041_bib22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3109\/15376516.2014.974233","article-title":"Toxicity of brominated flame retardants, BDE-47 and BDE-99 stems from impaired mitochondrial bioenergetics","volume":"25","author":"Pazin","year":"2015","journal-title":"Toxicol. Mech. methods"},{"key":"10.1016\/j.fct.2017.07.041_bib23","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/bcpt.12046","article-title":"Polybrominated diphenyl ether congener (BDE-100) induces mitochondrial impairment","volume":"112","author":"Pereira","year":"2013","journal-title":"Basic & Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.fct.2017.07.041_bib24","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1582-4934.2010.01013.x","article-title":"Discrepancies between metabolic activity and DNA content as tool to assess cell proliferation in cancer research","volume":"14","author":"Quent","year":"2010","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.fct.2017.07.041_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/bioinformatics\/bts686","article-title":"ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence","volume":"29","author":"Reif","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fct.2017.07.041_bib26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0167-4889(03)00105-8","article-title":"Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells","volume":"1642","author":"Renner","year":"2003","journal-title":"Biochimica Biophysica Acta (BBA)-Molecular Cell Res."},{"key":"10.1016\/j.fct.2017.07.041_bib27","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1002\/jps.21730","article-title":"Ionization-specific analysis of human intestinal absorption","volume":"98","author":"Reynolds","year":"2009","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.fct.2017.07.041_bib28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/bcpt.12598","article-title":"Evaluation of polybrominated diphenyl ether toxicity on HepG2 cells-hexa-brominated congener (BDE-154) is less toxic than tetra-brominated congener (BDE-47)","volume":"119","author":"Souza","year":"2016","journal-title":"Basic & Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.fct.2017.07.041_bib29","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.tiv.2012.09.022","article-title":"BDE-99 congener induces cell death by apoptosis of human hepatoblastoma cell line\u2013HepG2","volume":"27","author":"Souza","year":"2013","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2017.07.041_bib30","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tiv.2016.04.009","article-title":"Development of an in\u00a0vitro test battery model based on liver and colon cancer cell lines to discriminate PCB mixtures by transcription factors gene expression analysis","volume":"34","author":"Stecca","year":"2016","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2017.07.041_bib31","series-title":"An Exposure Assessment of Polybrominated Diphenyl Ethers (PBDE)","author":"U.S. Environmental Protection Agency","year":"2010"},{"key":"10.1016\/j.fct.2017.07.041_bib32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tiv.2007.08.006","article-title":"The MTT assay yields a relatively lower result of growth inhibition than the ATP assay depending on the chemotherapeutic drugs tested","volume":"22","author":"Ulukaya","year":"2008","journal-title":"Toxicol. vitro"},{"key":"10.1016\/j.fct.2017.07.041_bib33","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/toxsci\/kfl055","article-title":"The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds","volume":"93","author":"Van den Berg","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2017.07.041_bib34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.toxlet.2011.12.014","article-title":"The hormesis effect of BDE-47 in HepG 2 cells and the potential molecular mechanism","volume":"209","author":"Wang","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2017.07.041_bib35","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.tiv.2010.03.015","article-title":"Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in\u00a0vitro toxicological studies","volume":"24","author":"Wei","year":"2010","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2017.07.041_bib36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ijpharm.2004.09.018","article-title":"A\u00a0practical note on the use of cytotoxicity assays","volume":"288","author":"Weyermann","year":"2005","journal-title":"Int. J. Pharm."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691517304234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691517304234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:33:29Z","timestamp":1759527209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691517304234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":36,"alternative-id":["S0278691517304234"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2017.07.041","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relative toxicological ranking of eight polybrominated diphenyl ether congeners using cytotoxicity, chemical properties and exposure data","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2017.07.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}