{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:41:35Z","timestamp":1787773295927,"version":"build-2784847793"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"am","delay-in-days":323,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"NCTR-US-FDA","award":["E0756401"],"award-info":[{"award-number":["E0756401"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.fct.2017.09.004","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T17:45:26Z","timestamp":1504547126000},"page":"253-263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"P1","title":["Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells"],"prefix":"10.1016","volume":"109","author":[{"given":"Kuppan","family":"Gokulan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E.","family":"Cerniglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia A.","family":"Pineiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Khare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2017.09.004_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.drup.2004.04.002","article-title":"Chemically modified tetracyclines as inhibitors of matrix metalloproteinases","volume":"7","author":"Acharya","year":"2004","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.fct.2017.09.004_bib2","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.4049\/jimmunol.150.6.2356","article-title":"IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding","volume":"150","author":"Adams","year":"1993","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.fct.2017.09.004_bib3","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1128\/MCB.02342-05","article-title":"Role of the Cldn6 cytoplasmic tail domain in membrane targeting and epidermal differentiation in\u00a0vivo","volume":"26","author":"Arabzadeh","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.fct.2017.09.004_bib4","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"Backhed","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.fct.2017.09.004_bib5","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1053\/gast.1997.v113.pm9352853","article-title":"Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation","volume":"113","author":"Basora","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2017.09.004_bib6","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.4049\/jimmunol.171.11.6164","article-title":"Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms","volume":"171","author":"Bruewer","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.fct.2017.09.004_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12703\/P6-1","article-title":"Epithelial adhesive junctions","volume":"6","author":"Capaldo","year":"2014","journal-title":"F1000Prime Rep."},{"key":"10.1016\/j.fct.2017.09.004_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.yrtph.2005.06.005","article-title":"Antibiotics in the human food chain: establishing no effect levels of tetracycline, neomycin, and erythromycin using a chemostat model of the human colonic microflora","volume":"43","author":"Carman","year":"2005","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2017.09.004_bib9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/rtph.1999.1300","article-title":"Evaluation of veterinary drug residues in food for their potential to affect human intestinal microflora","volume":"29","author":"Cerniglia","year":"1999","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2017.09.004_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2885.2004.00595.x","article-title":"Approaches in the safety evaluations of veterinary antimicrobial agents in food to determine the effects on the human intestinal microflora","volume":"28","author":"Cerniglia","year":"2005","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2017.09.004_bib11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/dta.2024","article-title":"An update discussion on the current assessment of the safety of veterinary antimicrobial drug residues in food with regard to their impact on the human intestinal microbiome","volume":"8","author":"Cerniglia","year":"2016","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.fct.2017.09.004_bib12","series-title":"On Pharmacologically Active Substances and Their Classification Regarding Maximum Residue Limits in Foodstuffs of Animal Origin","first-page":"1","author":"Commission","year":"2009"},{"key":"10.1016\/j.fct.2017.09.004_bib13","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1128\/AEM.71.7.4108-4111.2005","article-title":"Prevalence and antimicrobial resistance of Campylobacter spp. and Salmonella serovars in organic chickens from Maryland retail stores","volume":"71","author":"Cui","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fct.2017.09.004_bib14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-61779-191-8_8","article-title":"Studying permeability in a commonly used epithelial cell line: T84 intestinal epithelial cells","volume":"763","author":"Donato","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.fct.2017.09.004_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/jac\/34.1.127","article-title":"The relationship between an increase in beta-lactamase activity after oral administration of three new cephalosporins and protection against intestinal ecological disturbances","volume":"34","author":"Edlund","year":"1994","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.fct.2017.09.004_bib16","series-title":"Pharmacologically Active Substances and Their Classification Regarding Maximum Residue Limits in Foodstuffs of Animal Origin","author":"EU-Commission-Regulation","year":"2010"},{"key":"10.1016\/j.fct.2017.09.004_bib17","series-title":"# 152, Guidance for Industry. \u201c Evaluating the Safety of Antimicrobial New Animal Drugs with Regard to Their Microbiological Effects on Bacteria of Human Health Concern\u201d","author":"FDA","year":"2003"},{"key":"10.1016\/j.fct.2017.09.004_bib18","series-title":"Summary Report on Antimicrobials Sold or Distributed for Use in Food Producting Animals","first-page":"1","author":"FDA","year":"2016"},{"key":"10.1016\/j.fct.2017.09.004_bib19","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nature03589","article-title":"Notch signals control the fate of immature progenitor cells in the intestine","volume":"435","author":"Fre","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.fct.2017.09.004_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0014-5793(00)01744-0","article-title":"Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein","volume":"476","author":"Fujita","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.fct.2017.09.004_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ijfoodmicro.2006.07.015","article-title":"Direct detection of antibiotic resistance genes in specimens of chicken and pork meat","volume":"113","author":"Garofalo","year":"2007","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.fct.2017.09.004_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1534-5807(03)00034-0","article-title":"A\u00a0structural view of integrin activation and signaling","volume":"4","author":"Giancotti","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.fct.2017.09.004_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.cellbio.19.031103.133334","article-title":"Positional control of cell fate through joint integrin\/receptor protein kinase signaling","volume":"19","author":"Giancotti","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.fct.2017.09.004_bib25","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1096\/fj.99-0898com","article-title":"Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis","volume":"14","author":"Gitter","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.fct.2017.09.004_bib26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1089\/dna.2015.3142","article-title":"Transmissible plasmid containing Salmonella enterica Heidelberg isolates modulate cytokine production during early stage of interaction with intestinal epithelial cells","volume":"35","author":"Gokulan","year":"2016","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.fct.2017.09.004_bib27","first-page":"318","article-title":"Caco 2 cell culture as intestinal epithelium model for hexose transport studying","volume":"54","author":"Grefner","year":"2012","journal-title":"Tsitologiia"},{"key":"10.1016\/j.fct.2017.09.004_bib28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/ibd.21379","article-title":"Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease","volume":"17","author":"Henderson","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.fct.2017.09.004_bib29","series-title":"Evaluation of Certain Veterinary Drug Residues in Food: Thirty-eighth Report of the Joint FAO\/WHO Expert Committee on Food Additives","author":"JECFA","year":"1991"},{"key":"10.1016\/j.fct.2017.09.004_bib30","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4291\/wjgp.v4.i4.94","article-title":"Intestinal barrier: molecular pathways and modifiers","volume":"4","author":"Jeon","year":"2013","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1016\/j.fct.2017.09.004_bib31","first-page":"1","article-title":"Cigarette smoke and decreased oxygen tension inhibit pulmonary claudin-6 expression","author":"Jimenez","year":"2016","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.fct.2017.09.004_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/328134","article-title":"Tetracycline and glutathione inhibit matrix metalloproteinase activity: an in\u00a0vitro study using culture supernatants of L929 and dalton lymphoma cell lines","author":"Kendre","year":"2013","journal-title":"J.\u00a0Cancer Res."},{"key":"10.1016\/j.fct.2017.09.004_bib32","doi-asserted-by":"crossref","first-page":"e42127","DOI":"10.1371\/journal.pone.0042127","article-title":"Systems biology analysis of gene expression during in\u00a0vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance","volume":"7","author":"Khare","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2017.09.004_bib33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/1270","article-title":"Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4","volume":"19","author":"Korinek","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.fct.2017.09.004_bib34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/BJ20051922","article-title":"Life cycle of connexins in health and disease","volume":"394","author":"Laird","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.fct.2017.09.004_bib35","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1053\/j.gastro.2007.03.029","article-title":"Interferon-gamma inhibits intestinal restitution by preventing gap junction communication between enterocytes","volume":"132","author":"Leaphart","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2017.09.004_bib36","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/30597","article-title":"Notch signalling. A short cut to the nucleus","volume":"393","author":"Lewis","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.fct.2017.09.004_bib64","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1981.61.4.829","article-title":"Junctional intercellular communication: the cell-to-cell membrane channel","volume":"61","author":"Loewenstein","year":"1981","journal-title":"Physiol. Rev."},{"issue":"Suppl.\u00a03","key":"10.1016\/j.fct.2017.09.004_bib37","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1086\/340246","article-title":"Antimicrobial use and resistance in animals","volume":"34","author":"McEwen","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.fct.2017.09.004_bib38","series-title":"Hogging it: Estimates of Antimicrobial Abuse in Livestock","author":"Mellon","year":"2001"},{"key":"10.1016\/j.fct.2017.09.004_bib39","series-title":"Principles and Practice of Infectious Disease","first-page":"206","article-title":"Principles of anti-infective therapy","author":"Moellering","year":"1990"},{"key":"10.1016\/j.fct.2017.09.004_bib40","doi-asserted-by":"crossref","first-page":"33485","DOI":"10.1038\/srep33485","article-title":"Investigating the responses of human epithelial cells to predatory bacteria","volume":"6","author":"Monnappa","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2017.09.004_bib41","doi-asserted-by":"crossref","first-page":"25207","DOI":"10.1074\/jbc.275.33.25207","article-title":"Regulation of connexin degradation as a mechanism to increase gap junction assembly and function","volume":"275","author":"Musil","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fct.2017.09.004_bib42","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1462-5822.2004.00404.x","article-title":"Enteropathogenic Escherichia coli infection leads to appearance of aberrant tight junctions strands in the lateral membrane of intestinal epithelial cells","volume":"6","author":"Muza-Moons","year":"2004","journal-title":"Cell Microbiol."},{"issue":"Suppl.\u00a03","key":"10.1016\/j.fct.2017.09.004_bib43","doi-asserted-by":"crossref","first-page":"S244","DOI":"10.1093\/clinids\/9.Supplement_3.S244","article-title":"Resistance of bacteria to antibacterial agents: report of Task Force 2","volume":"9","author":"O'Brien","year":"1987","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/j.fct.2017.09.004_bib44","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.cgh.2013.07.001","article-title":"Intestinal permeability defects: is it time to treat?","volume":"11","author":"Odenwald","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.fct.2017.09.004_bib45","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fimmu.2013.00280","article-title":"Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics","volume":"4","author":"Pastorelli","year":"2013","journal-title":"Front. Immunol."},{"issue":"1230\u20131240","key":"10.1016\/j.fct.2017.09.004_bib46","first-page":"e1231","article-title":"Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells","volume":"140","author":"Pellegrinet","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2017.09.004_bib47","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1007\/s00216-010-3819-0","article-title":"Determination of fluoroquinolone residues in poultry muscle in Portugal","volume":"397","author":"Pena","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.fct.2017.09.004_bib48","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1083\/jcb.109.6.3027","article-title":"Junctional communication is induced in migrating capillary endothelial cells","volume":"109","author":"Pepper","year":"1989","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.fct.2017.09.004_bib49","doi-asserted-by":"crossref","first-page":"223","DOI":"10.4315\/0362-028X-71.1.223","article-title":"Antibiotic residues distribute uniformly in broiler chicken breast muscle tissue","volume":"71","author":"Reyes-Herrera","year":"2008","journal-title":"J.\u00a0Food Prot."},{"key":"10.1016\/j.fct.2017.09.004_bib50","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1086\/367622","article-title":"Tetracycline therapy: update","volume":"36","author":"Roberts","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.fct.2017.09.004_bib51","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1242\/jcs.060665","article-title":"Claudin-2, a component of the tight junction, forms a paracellular water channel","volume":"123","author":"Rosenthal","year":"2010","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.fct.2017.09.004_bib52","series-title":"Principles and Practice of Infectious Diseases","first-page":"284","article-title":"Tetracyclines and chloramphenicol","author":"Standiford","year":"1990"},{"key":"10.1016\/j.fct.2017.09.004_bib53","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2010.08.006","article-title":"Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine","volume":"140","author":"Tamura","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2017.09.004_bib54","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fct.2017.09.004_bib55","series-title":"Tolerance for Residues of New Animal Drugs in Food","author":"US-FDA","year":"2012"},{"key":"10.1016\/j.fct.2017.09.004_bib56","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.molmed.2005.09.008","article-title":"Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease","volume":"11","author":"van Es","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.fct.2017.09.004_bib57","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.physiol.68.040104.131404","article-title":"Claudins and epithelial paracellular transport","volume":"68","author":"Van Itallie","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.fct.2017.09.004_bib58","first-page":"684","article-title":"[The problem of tetracycline excretion in stools]","volume":"100","author":"Van Marwyck","year":"1958","journal-title":"Munch Med. Wochenschr"},{"key":"10.1016\/j.fct.2017.09.004_bib59","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.tvjl.2008.08.011","article-title":"Role of connexin-43 hemichannels in the pathogenesis of Yersinia enterocolitica","volume":"182","author":"Velasquez Almonacid","year":"2009","journal-title":"Vet. J."},{"key":"10.1016\/j.fct.2017.09.004_bib60","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1289\/ehp.1408852","article-title":"Novel roles for Notch3 and Notch4 receptors in gene expression and susceptibility to ozone-induced lung inflammation in mice","volume":"123","author":"Verhein","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2017.09.004_bib61","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1128\/AAC.00852-07","article-title":"In vitro model of colonization resistance by the enteric microbiota: effects of antimicrobial agents used in food-producing animals","volume":"52","author":"Wagner","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.fct.2017.09.004_bib62","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/17435390.2014.921346","article-title":"Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats","volume":"9","author":"Williams","year":"2015","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.fct.2017.09.004_bib63","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12951-016-0214-9","article-title":"Size and dose dependent effects of silver nanoparticle exposure on intestinal permeability in an in\u00a0vitro model of the human gut epithelium","volume":"14","author":"Williams","year":"2016","journal-title":"J.\u00a0Nanobiotech."},{"key":"10.1016\/j.fct.2017.09.004_bib65","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1462-5822.2000.00025.x","article-title":"Distinct effects of Vibrio cholerae haemagglutinin\/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1","volume":"2","author":"Wu","year":"2000","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.fct.2017.09.004_bib66","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.yexcr.2011.04.008","article-title":"Numb modulates intestinal epithelial cells toward goblet cell phenotype by inhibiting the Notch signaling pathway","volume":"317","author":"Yang","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.fct.2017.09.004_bib67","first-page":"G1279","article-title":"Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin","volume":"276","author":"Youakim","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.fct.2017.09.004_bib68","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/ibd.21611","article-title":"Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis","volume":"17","author":"Zheng","year":"2011","journal-title":"Inflamm. Bowel Dis."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869151730515X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869151730515X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:35:36Z","timestamp":1759527336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869151730515X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":68,"alternative-id":["S027869151730515X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2017.09.004","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2017.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}