{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:19:13Z","timestamp":1792293553795,"version":"4.4.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/149(0656)\/2014 EMR-1"],"award-info":[{"award-number":["09\/149(0656)\/2014 EMR-1"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.fct.2018.02.011","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T20:43:39Z","timestamp":1518036219000},"page":"322-327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Tartrazine induced neurobiochemical alterations in rat brain sub-regions"],"prefix":"10.1016","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-7960","authenticated-orcid":false,"given":"Diksha","family":"Bhatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krati","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakuntala","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderpal","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2018.02.011_bib1","first-page":"673","volume":"vol. 2","author":"Aebi","year":"1974"},{"issue":"10","key":"10.1016\/j.fct.2018.02.011_bib2","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1016\/j.fct.2010.07.039","article-title":"Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats","volume":"48","author":"Amin","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2018.02.011_bib3","first-page":"117","article-title":"Age-related changes in lipid peroxidation and protective enzymes in the central nervous system","volume":"53","author":"Ansari","year":"1989","journal-title":"Growth Dev. Aging"},{"key":"10.1016\/j.fct.2018.02.011_bib4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF02979058","article-title":"Regional difference of ROS generation, lipid peroxidation, and antioxidant enzyme activity in rat brain and their dietary modulation","volume":"22","author":"Baek","year":"1999","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.fct.2018.02.011_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1191\/0960327105ht533oa","article-title":"Modulation of N-nitrosodiethylamine induced oxidative stress by vitamin E in rat erythrocytes","volume":"24","author":"Bansal","year":"2005","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.fct.2018.02.011_bib6","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/adc.2003.031435","article-title":"The effects of a double blind, placebo controlled, artificial food colorings and benzoate preservative challenge on hyperactivity in a general population sample of preschool children","volume":"89","author":"Bateman","year":"2004","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.fct.2018.02.011_bib7","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.fct.2018.02.011_bib8","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1471-4159.1980.tb07102.x","article-title":"Regional distribution of glutathione peroxidase in the adult rat brain","volume":"35","author":"Brannan","year":"1980","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.fct.2018.02.011_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0165-7992(86)90138-7","article-title":"Mutagenic activation of the benzidine-based dye Direct Black 38 by human intestinal microflora","volume":"175","author":"Cerniglia","year":"1986","journal-title":"Mutat. Res."},{"issue":"2","key":"10.1016\/j.fct.2018.02.011_bib10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/19440040903268062","article-title":"Usage pattern and exposure assessment of food colours in different age groups of consumers in the State of Uttar Pradesh, India","volume":"27","author":"Dixit","year":"2010","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"issue":"8","key":"10.1016\/j.fct.2018.02.011_bib11","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1080\/19440049.2011.580011","article-title":"Usage pattern of synthetic food colours in different states of India and exposure assessment through commodities preferentially consumed by children","volume":"28","author":"Dixit","year":"2011","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"issue":"7","key":"10.1016\/j.fct.2018.02.011_bib12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1177\/0748233712436638","article-title":"Effects of maternally exposed colouring food additives on cognitive performance in rats","volume":"29","author":"Doguc","year":"2013","journal-title":"Toxicol. Ind. Health"},{"issue":"47","key":"10.1016\/j.fct.2018.02.011_bib13","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1038\/sj.onc.1206940","article-title":"The role of glutathione S-transferase on anticancer drug resistance","volume":"22","author":"Dynyelle","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.fct.2018.02.011_bib15","doi-asserted-by":"crossref","unstructured":"EFSA Journal, 2009. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the reevaluation Tartrazine (E 102) on request from the European Commission. http:\/\/dx.doi.org\/10.2903\/j.efsa.2009.1331.","DOI":"10.2903\/j.efsa.2009.1331"},{"key":"10.1016\/j.fct.2018.02.011_bib14","first-page":"40","article-title":"Effect of Zingiber officinale on liver function of mercuric chloride induced hepatotoxicity in adult male Wistar rats","volume":"3","author":"Ezeuko","year":"2007","journal-title":"Electron. J. Biomed."},{"issue":"6","key":"10.1016\/j.fct.2018.02.011_bib16","doi-asserted-by":"crossref","first-page":"T125","DOI":"10.1111\/j.1750-3841.2011.02267.x","article-title":"Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved","volume":"76","author":"Gao","year":"2011","journal-title":"J. Food Sci."},{"issue":"1","key":"10.1016\/j.fct.2018.02.011_bib17","first-page":"43","article-title":"Sulfanilic acid: behavioral change related to azo food dyes in developing rats","volume":"4","author":"Goldenring","year":"1982","journal-title":"Neurobehav. Toxicol. Teratol."},{"key":"10.1016\/j.fct.2018.02.011_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0022-510X(88)90051-2","article-title":"Longitudinal studies of the neurobiology of Vitamin E and other antioxidant systems, and neurological function in the Vitamin E deficient rat","volume":"87","author":"Goss-Sampson","year":"1988","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.fct.2018.02.011_bib19","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione-S-tranferase, the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2018.02.011_bib20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/02652030500429125","article-title":"Estimates of dietary exposure of children to artificial food colours in Kuwait","volume":"23","author":"Husain","year":"2006","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.fct.2018.02.011_bib21","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0736-5748(95)00071-2","article-title":"Age-related changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione in different regions of mouse brain","volume":"13","author":"Hussain","year":"1995","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.fct.2018.02.011_bib22","series-title":"Nutrition Division, Agriculture and Consumer Protection","author":"JECFA","year":"2016"},{"key":"10.1016\/j.fct.2018.02.011_bib23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.fct.2018.02.011_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"issue":"9598","key":"10.1016\/j.fct.2018.02.011_bib25","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/S0140-6736(07)61306-3","article-title":"Food additives and hyperactive behaviour in 3-year-old and 8\/9-year-old children in the community a randomized, double-blinded, placebocontrolled trial","volume":"370","author":"McCann","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.fct.2018.02.011_bib26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1590\/S1519-69842007000100019","article-title":"Prolonged use of the food dye tartrazine (FD&C Yellow n degrees 5) and its effects on the gastric mucosa of Wistar rats","volume":"67","author":"Moutinho","year":"2007","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.fct.2018.02.011_bib27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2018.02.011_bib28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.phymed.2008.08.005","article-title":"Chinese medicinal formula Guan-Xin-Er-Hao protects the heart against oxidative stress induced by acute ischemic myocardial injury in rats","volume":"16","author":"Qin","year":"2009","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.fct.2018.02.011_bib29","first-page":"59","article-title":"Alachlor 50% EC induced biochemical alterations in Clarias batrachus during and after cessation of exposure","volume":"2","author":"Rajini","year":"2014","journal-title":"Int. J. Fish. Aquat. Stud."},{"issue":"5","key":"10.1016\/j.fct.2018.02.011_bib30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/02652030410001668772","article-title":"Exposure assessment to synthetic food colours of a selected population in Hyderabad, India","volume":"21","author":"Rao","year":"2004","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.fct.2018.02.011_bib31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.fct.2015.05.003","article-title":"Sodium tungstate induced neurological alterations in rat brain regions and their response to antioxidants","volume":"82","author":"Sachdeva","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2018.02.011_bib32","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00004703-200412000-00007","article-title":"Do artificial food colours promote hyperactivity in children with hyperactivity in children with hyperactive syndromes? A meta analysis of double-blind placebo-controlled trials","volume":"25","author":"Schab","year":"2004","journal-title":"J. Dev. Behav. Pediatr."},{"key":"10.1016\/j.fct.2018.02.011_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/026010608400300202","article-title":"Nutrition and behavior: complex interdisciplinary research","volume":"3","author":"Schauss","year":"1984","journal-title":"Nutr. Health"},{"issue":"1","key":"10.1016\/j.fct.2018.02.011_bib34","first-page":"85","article-title":"The regional distribution of lead in normal rat brain","volume":"3","author":"Scheuhammer","year":"1982","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.fct.2018.02.011_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0272-0590(88)90147-9","article-title":"Glutathione status and cadmium neurotoxicity: studies in discrete brain regions of growing rats","volume":"11","author":"Shukla","year":"1988","journal-title":"Fund. Appl. Toxicol."},{"issue":"6","key":"10.1016\/j.fct.2018.02.011_bib36","first-page":"119","article-title":"Evidence for direct-acting oxidative genotoxicity by reduction products of azo dyes","volume":"102","author":"Sweeney","year":"1994","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.fct.2018.02.011_bib37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.fct.2005.06.011","article-title":"Reproductive and neurobehavioural toxicity study of tartrazine administered to mice in the diet","volume":"44","author":"Tanaka","year":"2006","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.fct.2018.02.011_bib38","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.reprotox.2008.07.001","article-title":"Effects of tartrazine on exploratory behavior in a three-generation toxicity study in mice","volume":"26","author":"Tanaka","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.fct.2018.02.011_bib39","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0003-9861(92)90453-4","article-title":"Hexachlorocyclohexane pesticides reduce survival and alter plasma membrane structure of Chinese hamster V79 cells","volume":"298","author":"Verma","year":"1992","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.fct.2018.02.011_bib40","first-page":"261","volume":"vol. 2","author":"Wood","year":"1970"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518300760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518300760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:20:45Z","timestamp":1788297645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691518300760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":40,"alternative-id":["S0278691518300760"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2018.02.011","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tartrazine induced neurobiochemical alterations in rat brain sub-regions","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2018.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}