{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:48:54Z","timestamp":1790725734488,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Philip Morris International R&D"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.fct.2018.02.013","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T11:48:30Z","timestamp":1518522510000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes"],"prefix":"10.1016","volume":"115","author":[{"given":"Dominika","family":"Malinska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u0119drzej","family":"Szyma\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Patalas-Krawczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadeta","family":"Michalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Wojtala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Prill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Partyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Drabik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Walczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Sewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Johne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsta","family":"Luettich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel C.","family":"Peitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hoeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Duszy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Szczepanowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"van der Toorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz R.","family":"Wieckowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2018.02.013_bib1","doi-asserted-by":"crossref","first-page":"L889","DOI":"10.1152\/ajplung.00219.2012","article-title":"Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs. American journal of physiology","volume":"303","author":"Agarwal","year":"2012","journal-title":"Lung cellular and molecular physiology"},{"key":"10.1016\/j.fct.2018.02.013_bib2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1165\/rcmb.2013-0523OC","article-title":"Short-term cigarette smoke exposure leads to metabolic alterations in lung alveolar cells","volume":"51","author":"Agarwal","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.fct.2018.02.013_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1615\/JEnvPathToxOncol.v24.i3.80","article-title":"Protective effect of bacoside A on cigarette smoking-induced brain mitochondrial dysfunction in rats","volume":"24","author":"Anbarasi","year":"2005","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.fct.2018.02.013_bib4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/1617-9625-1-3-219","article-title":"Oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke","volume":"1","author":"Aoshiba","year":"2003","journal-title":"Tob. Induc. Dis."},{"key":"10.1016\/j.fct.2018.02.013_bib5","doi-asserted-by":"crossref","first-page":"L840","DOI":"10.1152\/ajplung.00155.2013","article-title":"Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle. American journal of physiology","volume":"306","author":"Aravamudan","year":"2014","journal-title":"Lung cellular and molecular physiology"},{"key":"10.1016\/j.fct.2018.02.013_bib6","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1165\/rcmb.2013-0377OC","article-title":"Alterations of bronchial epithelial metabolome by cigarette smoke are reversible by an antioxidant, O-methyl-L-tyrosinyl-gamma-L-glutamyl-L-cysteinylglycine","volume":"51","author":"Aug","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.fct.2018.02.013_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/247405a0","article-title":"Temperature distribution inside a burning cigarette","volume":"247","author":"Baker","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.fct.2018.02.013_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/mrc.1939","article-title":"Tobacco smoke particulate matter chemistry by NMR","volume":"45","author":"Barsanti","year":"2007","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.fct.2018.02.013_bib9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","author":"Benjamini","year":"1995","journal-title":"J. Roy. Stat. Soc. B"},{"key":"10.1016\/j.fct.2018.02.013_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7808576","article-title":"The role of mitochondria and oxidative\/antioxidative imbalance in pathobiology of chronic obstructive pulmonary disease","volume":"2016","author":"Bialas","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.fct.2018.02.013_bib11","doi-asserted-by":"crossref","first-page":"E171","DOI":"10.1152\/ajpendo.00260.2003","article-title":"Maternal smoking is associated with mitochondrial DNA depletion and respiratory chain complex III deficiency in placenta","volume":"288","author":"Bouhours-Nouet","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.fct.2018.02.013_bib12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1081\/COPD-200027031","article-title":"The role of oxidative stress in chronic obstructive pulmonary disease","volume":"1","author":"Bowler","year":"2004","journal-title":"COPD"},{"key":"10.1016\/j.fct.2018.02.013_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2018.02.013_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1081\/CLT-120021102","article-title":"Effect of smoking cessation on mitochondrial respiratory chain function","volume":"41","author":"Cardellach","year":"2003","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.fct.2018.02.013_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.lungcan.2015.08.017","article-title":"The relationship between COPD and lung cancer","volume":"90","author":"Durham","year":"2015","journal-title":"Lung Canc."},{"key":"10.1016\/j.fct.2018.02.013_bib16","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1111\/bph.12054","article-title":"Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity","volume":"168","author":"Guan","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fct.2018.02.013_bib17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/biof.5520100107","article-title":"Captopril increased mitochondrial coenzyme Q10 level, improved respiratory chain function and energy production in the left ventricle in rabbits with smoke mitochondrial cardiomyopathy","volume":"10","author":"Gvozdjakova","year":"1999","journal-title":"Biofactors"},{"key":"10.1016\/j.fct.2018.02.013_bib18","series-title":"Health Canada Test Method T-115, Determination of \u2018\u2018Tar\u2019\u2019 and Nicotine in Sidestream Tobacco Smoke","author":"Health Canada","year":"1999"},{"key":"10.1016\/j.fct.2018.02.013_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1465-9921-14-97","article-title":"Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells","volume":"14","author":"Hoffmann","year":"2013","journal-title":"Respir. Res."},{"key":"10.1016\/j.fct.2018.02.013_bib20","series-title":"Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-attributable Disease: a Report of the Surgeon General, Atlanta (GA)","author":"CDC","year":"2010"},{"key":"10.1016\/j.fct.2018.02.013_bib21","series-title":"ISO 3402: 1999\u2013Tobacco and Tobacco Products \u2013 Atmosphere for Conditioning and Testing","author":"International Organization for Standardization","year":"2010"},{"key":"10.1016\/j.fct.2018.02.013_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.biocel.2012.07.020","article-title":"Disrupted ATP synthase activity and mitochondrial hyperpolarisation-dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients","volume":"45","author":"Lebiedzinska","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.fct.2018.02.013_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.fct.2018.02.013_bib24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3109\/15376516.2014.956909","article-title":"Cigarette smoke extract-induced BEAS-2B cell apoptosis and anti-oxidative Nrf-2 up-regulation are mediated by ROS-stimulated p38 activation","volume":"24","author":"Lin","year":"2014","journal-title":"Toxicol. Mech. Meth."},{"key":"10.1016\/j.fct.2018.02.013_bib25","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1093\/carcin\/20.7.1331","article-title":"Smoking disturbs mitochondrial respiratory chain function and enhances lipid peroxidation on human circulating lymphocytes","volume":"20","author":"Miro","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2018.02.013_bib26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/jat.923","article-title":"Toxicological evaluation of an electrically heated cigarette. Part 1: overview of technical concepts and summary of findings","volume":"23","author":"Patskan","year":"2003","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.fct.2018.02.013_bib27","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0891-5849(96)00155-4","article-title":"Role of oxidants\/antioxidants in smoking-induced lung diseases","volume":"21","author":"Rahman","year":"1996","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.fct.2018.02.013_bib28","first-page":"L1067","article-title":"Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease","volume":"277","author":"Rahman","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.fct.2018.02.013_bib29","series-title":"The Chemical Components of Tobacco and Tobacco Smoke","first-page":"2238","author":"Rodgman","year":"2013"},{"issue":"Suppl. 2","key":"10.1016\/j.fct.2018.02.013_bib30","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.yrtph.2016.07.006","article-title":"Evaluation of the tobacco heating system 2.2. Part 1: description of the system and the scientific assessment program","volume":"81","author":"Smith","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2018.02.013_bib31","series-title":"Limma: Linear Models for Microarray Data. Bioinformatics and Computational Biology Solutions Using R and Bioconductor","first-page":"397","author":"Smyth","year":"2005"},{"key":"10.1016\/j.fct.2018.02.013_bib32","doi-asserted-by":"crossref","first-page":"L1211","DOI":"10.1152\/ajplung.00291.2006","article-title":"Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis. American journal of physiology","volume":"292","author":"van der Toorn","year":"2007","journal-title":"Lung cellular and molecular physiology"},{"key":"10.1016\/j.fct.2018.02.013_bib33","doi-asserted-by":"crossref","first-page":"L109","DOI":"10.1152\/ajplung.90461.2008","article-title":"Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells. American journal of physiology","volume":"297","author":"van der Toorn","year":"2009","journal-title":"Lung cellular and molecular physiology"},{"key":"10.1016\/j.fct.2018.02.013_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2018.02.019","article-title":"The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product","author":"van der Toorn","year":"2018","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2018.02.013_bib35","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.tiv.2010.11.011","article-title":"Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B","volume":"25","author":"Veljkovic","year":"2011","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2018.02.013_bib36","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.bbabio.2010.01.035","article-title":"Antioxidant defence systems and generation of reactive oxygen species in osteosarcoma cells with defective mitochondria: effect of selenium","volume":"1797","author":"Wojewoda","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fct.2018.02.013_bib37","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.biocel.2011.04.011","article-title":"NARP mutation and mtDNA depletion trigger mitochondrial biogenesis which can be modulated by selenite supplementation","volume":"43","author":"Wojewoda","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"Suppl. 2","key":"10.1016\/j.fct.2018.02.013_bib38","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/j.yrtph.2016.10.015","article-title":"Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke","volume":"81","author":"Wong","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2018.02.013_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128778","article-title":"Mechanisms of cigarette smoke effects on human airway smooth muscle","volume":"10","author":"Wylam","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2018.02.013_bib40","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.etap.2017.06.023","article-title":"Evaluation of whole cigarette smoke induced oxidative stress in A549 and BEAS-2B cells","volume":"54","author":"Zhang","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518300784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518300784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:41:20Z","timestamp":1759527680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691518300784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":40,"alternative-id":["S0278691518300784"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2018.02.013","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2018.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}