{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:26:52Z","timestamp":1782221212567,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"China National Natural Science Foundation","doi-asserted-by":"publisher","award":["31001089"],"award-info":[{"award-number":["31001089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovative Talents of Higher Learning Institutions of Shanxi","award":["2010"],"award-info":[{"award-number":["2010"]}]},{"name":"Shanxi Province Science and Technology Bureau Program","award":["2014011027-3"],"award-info":[{"award-number":["2014011027-3"]}]},{"name":"Technological innovation Foundation of Shanxi Agricultural University","award":["20100017"],"award-info":[{"award-number":["20100017"]}]},{"name":"Shanxi Agricultural University","award":["XB2009014"],"award-info":[{"award-number":["XB2009014"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.fct.2018.04.013","type":"journal-article","created":{"date-parts":[[2018,4,8]],"date-time":"2018-04-08T09:43:42Z","timestamp":1523180622000},"page":"189-195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"PB","title":["Effects of different Ca2+ level on fluoride-induced apoptosis pathway of endoplasmic reticulum in the rabbit osteoblast in vitro"],"prefix":"10.1016","volume":"116","author":[{"given":"Jinming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Kumar","family":"Manthari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4320-0347","authenticated-orcid":false,"given":"Jundong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2018.04.013_bib1","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.tiv.2011.06.006","article-title":"Fluoride-induced death of rat erythrocytes in vitro","volume":"25","author":"Agalakova","year":"2011","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2018.04.013_bib2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3760\/cma.j.issn.0366-6999.2010.06.007","article-title":"Serum calciotropic hormone levels, and dental fluorosis in children exposed to different concentrations of fluoride and iodine in drinking water","volume":"123","author":"Ba","year":"2010","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.fct.2018.04.013_bib3","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.3390\/ijms17091558","article-title":"ER stress-mediated signaling: action potential and Ca2+ as key players","volume":"17","author":"Bahar","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2018.04.013_bib4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cbi.2010.07.011","article-title":"Molecular mechanisms of fluoride toxicity","volume":"188","author":"Barbier","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2018.04.013_bib5","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.chemosphere.2016.06.106","article-title":"Fluoride exposure changed the structure and the expressions of Y chromosome related genes in testes of mice","volume":"161","author":"Cao","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2018.04.013_bib6","first-page":"3552","article-title":"Sodium fluoride (NaF) induces the splenic apoptosis via endoplasmic reticulum (ER) stress pathway in vivo and in vitro","volume":"8","author":"Deng","year":"2016","journal-title":"Aging (N Y)"},{"key":"10.1016\/j.fct.2018.04.013_bib7","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.18632\/aging.101150","article-title":"Sodium fluoride (NaF) induces the splenic apoptosis via endoplasmic reticulum (ER) stress pathway in vivo and in vitro","volume":"8","author":"Deng","year":"2016","journal-title":"Aging"},{"key":"10.1016\/j.fct.2018.04.013_bib8","first-page":"211","article-title":"Fluoride in drinking-water","volume":"8","author":"Fawell","year":"2006","journal-title":"Community Dent. Oral Epidemiol."},{"key":"10.1016\/j.fct.2018.04.013_bib9","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bone.2010.05.042","article-title":"Elevated extracellular calcium increases fibroblast growth factor-2 gene and protein expression levels via a cAMP\/PKA dependent pathway in cementoblasts","volume":"47","author":"Kanaya","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.fct.2018.04.013_bib10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/lsm.22439","article-title":"Effect of silver diamine fluoride and ammonium hexafluorosilicate applications with and without Er:YAG laser irradiation on the microtensile bond strength in sound and caries-affected dentin","volume":"48","author":"Kucukyilmaz","year":"2016","journal-title":"Laser Surg. Med."},{"key":"10.1016\/j.fct.2018.04.013_bib11","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tox.2007.10.026","article-title":"Involvement of both mitochondrial- and death receptor-dependent apoptotic pathways regulated by Bcl-2 family in sodium fluoride-induced apoptosis of the human gingival fibroblasts","volume":"243","author":"Lee","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2018.04.013_bib12","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1002\/jbm.a.36159","article-title":"Effects of fluoride-modified titanium surfaces with the similar roughness on RUNX2 gene expression of osteoblast-like MG63 cells","volume":"105","author":"Lee","year":"2017","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.fct.2018.04.013_bib13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12011-017-0930-5","article-title":"Micromolar levels of sodium fluoride promote osteoblast differentiation through Runx2 signaling","volume":"178","author":"Lee","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fct.2018.04.013_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12011-014-9897-7","article-title":"Role of unfolded protein response in affecting osteoblast differentiation induced by fluoride","volume":"158","author":"Li","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fct.2018.04.013_bib15","first-page":"1623","article-title":"Sodium fluoride causes oxidative stress and apoptosis in the mouse liver","volume":"9","author":"Lu","year":"2017","journal-title":"Aging (N Y)"},{"key":"10.1016\/j.fct.2018.04.013_bib1a","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00210-003-0802-8","article-title":"The mechanism of honokiol-induced and magnolol-induced inhibition on muscle contraction and ca2+ mobilization in rat uterus","volume":"368","author":"Lu","year":"2003","journal-title":"N-S Arch Pharmacol."},{"key":"10.1016\/j.fct.2018.04.013_bib16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0142-9612(95)98269-K","article-title":"Effects of high levels of fluoride on bone formation: an in vitro model system","volume":"16","author":"Mehta","year":"1995","journal-title":"Biomaterials"},{"key":"10.1016\/j.fct.2018.04.013_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3413\/Nukmed-0867-16-12","article-title":"Differences in sodium fluoride-18 uptake in the normal skeleton depending on the location and characteristics of the bone","volume":"56","author":"Nawata","year":"2017","journal-title":"Nuklearmedizin"},{"key":"10.1016\/j.fct.2018.04.013_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.taap.2012.01.010","article-title":"Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and Caspase- and JNK-mediated pathways","volume":"259","author":"Nguyen Ngoc","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2018.04.013_bib19","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.envpol.2017.09.015","article-title":"Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity","volume":"233","author":"Niu","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2018.04.013_bib20","first-page":"S223","article-title":"Fluoride therapy for the vertebral crush fracture syndrome: a status report","volume":"5","author":"Robert","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.fct.2018.04.013_bib21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1590\/S0103-64402012000600002","article-title":"Fluoride modulates preosteoblasts viability and matrix metalloproteinases-2 and -9 activities","volume":"23","author":"Slompo","year":"2012","journal-title":"Braz. Dent. J."},{"key":"10.1016\/j.fct.2018.04.013_bib22","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41598-017-00796-3","article-title":"Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway","volume":"7","author":"Song","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2018.04.013_bib23","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00204-009-0508-x","article-title":"Effects of sodium fluoride on hyperactivation and Ca2+ signaling pathway in sperm from mice: an in vivo study","volume":"84","author":"Sun","year":"2010","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2018.04.013_bib24","first-page":"18","article-title":"Effects of protein and calcium on bone metabolism and biomechanical indexes in nutritionally deficient rabbits exposed to high fluoride","volume":"41","author":"Wang","year":"2008","journal-title":"Fluoride"},{"key":"10.1016\/j.fct.2018.04.013_bib25","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.chemosphere.2017.08.068","article-title":"Fluoride-induced oxidative stress and apoptosis are involved in the reducing of oocytes development potential in mice","volume":"186","author":"Wang","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2018.04.013_bib26","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.cell.2016.04.051","article-title":"TMCO1 is an ER Ca2+ load-activated Ca2+ channel","volume":"165","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.fct.2018.04.013_bib27","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s00204-011-0697-y","article-title":"Sodium fluoride suppress proliferation and induce apoptosis through decreased insulin-like growth factor-I expression and oxidative stress in primary cultured mouse osteoblasts","volume":"85","author":"Wang","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2018.04.013_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2010.08.006","article-title":"Activation of PERK signaling through fluoride-mediated endoplasmic reticulum stress in OS732 cells","volume":"277","author":"Xu","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2018.04.013_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00204-008-0365-z","article-title":"Effects of sodium fluoride treatment in vitro on cell proliferation, apoptosis and caspase-3 and caspase-9 mRNA expression by neonatal rat osteoblasts","volume":"83","author":"Yan","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2018.04.013_bib30","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.bbrc.2011.06.094","article-title":"Sodium fluoride induces apoptosis and alters bcl-2 family protein expression in MC3T3-E1 osteoblastic cells","volume":"410","author":"Yang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2018.04.013_bib31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.taap.2013.04.033","article-title":"Fluoride-elicited developmental testicular toxicity in rats: roles of endoplasmic reticulum stress and inflammatory response","volume":"271","author":"Zhang","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2018.04.013_bib32","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.plaphy.2015.08.007","article-title":"Ca(2+) and CaM are involved in Al(3+) pretreatment-promoted fluoride accumulation in tea plants (Camellia sinesis L.)","volume":"96","author":"Zhang","year":"2015","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.fct.2018.04.013_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/ijms17010057","article-title":"Anion channel inhibitor NPPB-inhibited fluoride accumulation in tea plant (Camellia sinensis) is related to the regulation of Ca2+, CaM and depolarization of plasma membrane potential","volume":"17","author":"Zhang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2018.04.013_bib34","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1021\/acs.chemrestox.7b00047","article-title":"Do environmental fluoride exposure and ESRalpha genetic variation modulate methylation modification on bone changes in Chinese farmers?","volume":"30","author":"Zhang","year":"2017","journal-title":"Chem. Res. Toxicol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518302151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518302151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:41:03Z","timestamp":1759527663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691518302151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":35,"alternative-id":["S0278691518302151"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2018.04.013","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of different Ca2+ level on fluoride-induced apoptosis pathway of endoplasmic reticulum in the rabbit osteoblast in vitro","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2018.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}