{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:20:31Z","timestamp":1779351631368,"version":"3.51.4"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.fct.2018.07.036","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T12:36:28Z","timestamp":1532522188000},"page":"448-461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Potential synergistic effects of quercetin with other phytoconstituents of Costus pictus (insulin plant) extract in the control of hyperglycemia and prevention of NSAID-induced gastroenteropathy in diabetic rats"],"prefix":"10.1016","volume":"120","author":[{"given":"Swapnil P.","family":"Borse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devendra Pratap","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilawar","family":"Upadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Nivsarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2018.07.036_bib1","series-title":"IDF Diabetes Atlas","author":"Aguiree","year":"2013"},{"key":"10.1016\/j.fct.2018.07.036_bib2","doi-asserted-by":"crossref","first-page":"091","DOI":"10.7324\/JAPS.2016.60616","article-title":"Efficacy and safety of metformin in weight loss in bahraini population","volume":"6","author":"Al-qallaf","year":"2016","journal-title":"J. Appl. Pharmaceut. Sci."},{"key":"10.1016\/j.fct.2018.07.036_bib3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.abb.2017.04.005","article-title":"Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity","volume":"621","author":"Alam","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.fct.2018.07.036_bib4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/ptr.2313","article-title":"Antiviral and immunomodulatory effect of a lyophilized extract of Capparis spinosa L. buds","volume":"22","author":"Arena","year":"2008","journal-title":"Phytother Res."},{"key":"10.1016\/j.fct.2018.07.036_bib5","first-page":"3217","article-title":"Comparative anti-diabetic effect of methanolic extract of insulin plant (Costus pictus) leaves and its silver nanoparticle","volume":"4","author":"Aruna","year":"2014","journal-title":"Indo Am. J. Pharmaceut. Res."},{"key":"10.1016\/j.fct.2018.07.036_bib6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jff.2015.06.024","article-title":"Insulin plant (Costus pictus) extract improves insulin sensitivity and ameliorates atherogenic dyslipidaemia in fructose induced insulin resistant rats: molecular mechanism","volume":"17","author":"Ashwini","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fct.2018.07.036_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/0974-8490.199766","article-title":"Insulin Plant (Costus pictus) extract restores thyroid hormone levels in experimental hypothyroidism","volume":"9","author":"Ashwini","year":"2017","journal-title":"Pharmacogn. Res."},{"key":"10.1016\/j.fct.2018.07.036_bib8","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1053\/gast.2000.20186","article-title":"Drug enterocyte adducts: possible causal factor for diclofenac enteropathy in rats","volume":"119","author":"Atchison","year":"2000","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.fct.2018.07.036_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/jdi.12673","article-title":"Understanding the role of the gut ecosystem in Diabetes Mellitus","volume":"9","author":"Aw","year":"2017","journal-title":"J. Diabetes Invest."},{"key":"10.1016\/j.fct.2018.07.036_bib10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4103\/0973-8258.108204","article-title":"Emblica officinalis (Amla): a review of potential therapeutic applications","volume":"6","author":"Bhandari","year":"2012","journal-title":"Int. J. Green Pharm."},{"key":"10.1016\/j.fct.2018.07.036_bib11","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0031-6989(85)90041-4","article-title":"Inhibitory action of quercetin on xanthine oxidase and xanthine dehydrogenase activity","volume":"17","author":"Bindoli","year":"1985","journal-title":"Pharmacol. Res. Commun."},{"key":"10.1016\/j.fct.2018.07.036_bib12","first-page":"137","article-title":"Over the counter non-steroidal anti-inflammatory drugs and risk of gastrointenstinal bleeding","volume":"5","author":"Blot","year":"2000","journal-title":"J. Epidemiol. Biostat."},{"key":"10.1016\/j.fct.2018.07.036_bib13","first-page":"643","article-title":"Prevalence of silent gastric ulcer, erosions or severe acute gastritis in patients with type 2 diabetes mellitus\u2013a cross-sectional study","volume":"54","author":"Boehme","year":"2007","journal-title":"Hepato-Gastroenterology"},{"key":"10.1016\/j.fct.2018.07.036_bib14","series-title":"SFEC - 2016: 3rd International Congress of the Society for Ethnopharmacology. National Center for Natural Resources (NCNR)","article-title":"Ayurnization of non ayurvedic substance and modernization of ayurvedic research with special reference to insulin plant","author":"Borse","year":"2016"},{"key":"10.1016\/j.fct.2018.07.036_bib15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/0257-7941.195407","article-title":"Is redefining the ayurvedic proprietary medicine required?","volume":"36","author":"Borse","year":"2016","journal-title":"Ancient Sci. Life"},{"key":"10.1016\/j.fct.2018.07.036_bib16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/JPR.S75160","article-title":"New insights into the use of currently available non-steroidal anti-inflammatory drugs","volume":"8","author":"Brune","year":"2015","journal-title":"J. Pain Res."},{"key":"10.1016\/j.fct.2018.07.036_bib17","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.jnutbio.2013.05.001","article-title":"Benefits of polyphenols on gut microbiota and implications in human health","volume":"24","author":"Cardona","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2018.07.036_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.diabet.2016.09.004","article-title":"Increased intestinal permeability as a risk factor for type 2 diabetes","volume":"43","author":"Cox","year":"2017","journal-title":"Diabetes Metabol."},{"key":"10.1016\/j.fct.2018.07.036_bib19","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2337\/db09-9028","article-title":"From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus","volume":"58","author":"DeFronzo","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.fct.2018.07.036_bib20","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrd4275","article-title":"Targeting inflammation in the treatment of type 2 diabetes: time to start","volume":"13","author":"Donath","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.fct.2018.07.036_bib21","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.2337\/diabetes.54.suppl_2.S108","article-title":"Mechanisms of \u03b2-cell death in type 2 diabetes","volume":"54","author":"Donath","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.fct.2018.07.036_bib22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fct.2018.07.036_bib23","first-page":"80","article-title":"Low back pain in diabetes mellitus and importance of preventive approach","volume":"2","author":"Eivazi","year":"2012","journal-title":"Health Promot. Perspect."},{"key":"10.1016\/j.fct.2018.07.036_bib24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jnutbio.2015.01.002","article-title":"Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats","volume":"26","author":"Etxeberria","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2018.07.036_bib25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/jpet.113.207118","article-title":"NSAID-induced enteropathy: are the currently available selective COX-2 inhibitors all the same?","volume":"348","author":"Fornai","year":"2014","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.fct.2018.07.036_bib26","series-title":"Arthritis & Diabetes: what Do Diabetes and Arthritis Have in Common?","author":"Foundation","year":"2017"},{"key":"10.1016\/j.fct.2018.07.036_bib27","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jep.2009.03.026","article-title":"Antihyperglycemic and insulin secretory activity of Costus pictus leaf extract in streptozotocin induced diabetic rats and in in vitro pancreatic islet culture","volume":"123","author":"Gireesh","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2018.07.036_bib28","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.jpain.2006.04.013","article-title":"Burden of illness in painful diabetic peripheral neuropathy: the patients' perspectives","volume":"7","author":"Gore","year":"2006","journal-title":"J. Pain"},{"key":"10.1016\/j.fct.2018.07.036_bib29","first-page":"1031","article-title":"Gastrointestinal manifestations of diabetes mellitus","volume":"55","author":"Goyal","year":"1971","journal-title":"Med. Clin."},{"key":"10.1016\/j.fct.2018.07.036_bib30","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: the evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.fct.2018.07.036_bib31","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.4314\/tjpr.v16i8.10","article-title":"Anti-inflammatory effects of kaempferol, myricetin, fisetin and ibuprofen in neonatal rats","volume":"16","author":"Guo","year":"2017","journal-title":"Trop. J. Pharmaceut. Res."},{"key":"10.1016\/j.fct.2018.07.036_bib32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2152\/jmi.51.43","article-title":"Role of unbalanced growth of gram-negative bacteria in ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug","volume":"51","author":"Hagiwara","year":"2004","journal-title":"J. Med. Invest."},{"key":"10.1016\/j.fct.2018.07.036_bib33","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/0003-2697(74)90175-4","article-title":"A new spectrophotometric assay method of xanthine oxidase in crude tissue homogenate","volume":"62","author":"Hashimoto","year":"1974","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2018.07.036_bib34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/0973-7847.125536","article-title":"A review on insulin plant (Costus igneus Nak)","volume":"8","author":"Hegde","year":"2014","journal-title":"Phcog. Rev."},{"key":"10.1016\/j.fct.2018.07.036_bib35","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.foodchem.2011.11.016","article-title":"Prebiotic effect of diosgenin, an immunoactive steroidal sapogenin of the Chinese yam","volume":"132","author":"Huang","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2018.07.036_bib36","series-title":"4 Ways to Break Down Diabetes, Food Tips to Prevent, Manage and Control the Blood Sugar Disease., IndiaToday.in","author":"IndiaToday.in","year":"2016"},{"key":"10.1016\/j.fct.2018.07.036_bib37","first-page":"3628","article-title":"Comparative study of hypoglycemic activity of Costus pictus and Costus igneus in streptozotocin induced diabetic rat","volume":"4","author":"Isaac","year":"2011","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.fct.2018.07.036_bib38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/cbf.1055","article-title":"Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis","volume":"22","author":"Kamanl\u0131","year":"2004","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.fct.2018.07.036_bib39","first-page":"352","article-title":"A comparison of gastrointestinal permeability induced by diclofenac phospholipid complex with diclofenac acid and its sodium salt","volume":"6","author":"Khazaeinia","year":"2003","journal-title":"J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.fct.2018.07.036_bib40","first-page":"103","article-title":"Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats","volume":"14","author":"Kim","year":"2005","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"10.1016\/j.fct.2018.07.036_bib41","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000356149","article-title":"Metformin-induced hemolytic anemia","volume":"23","author":"Kirkiz","year":"2014","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.fct.2018.07.036_bib42","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/MEG.0b013e3282f5f75e","article-title":"Are gastrointestinal symptoms related to diabetes mellitus and glycemic control?","volume":"20","author":"Koch","year":"2008","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.fct.2018.07.036_bib43","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.drudis.2014.08.006","article-title":"Multi-target approach for natural products in inflammation","volume":"19","author":"Koeberle","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.fct.2018.07.036_bib44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1476-511X-12-115","article-title":"The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits","volume":"12","author":"Kong","year":"2013","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.fct.2018.07.036_bib45","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2174\/138161210791164063","article-title":"Multi-targeted natural products evaluation based on biological activity prediction with PASS","volume":"16","author":"Lagunin","year":"2010","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.fct.2018.07.036_bib46","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2036.2012.05213.x","article-title":"Risk factors associated with a decrease\u2265 2 g\/dL in haemoglobin and\/or\u2265 10% haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial (CONDOR)","volume":"36","author":"Lanas","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2018.07.036_bib47","first-page":"290","article-title":"Study on chemical composition of Phyllanthus emblica","volume":"38","author":"Li","year":"2015","journal-title":"Zhong yao cai= Zhongyaocai= J. Chin. Med. Mater."},{"key":"10.1016\/j.fct.2018.07.036_bib48","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.fitote.2011.10.012","article-title":"Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC\u2013MS method","volume":"83","author":"Li","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fct.2018.07.036_bib49","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1124\/jpet.111.191122","article-title":"Pharmacologic targeting of bacterial \u03b2-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice","volume":"341","author":"LoGuidice","year":"2012","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.fct.2018.07.036_bib50","series-title":"World Diabetes Day - 1 in 2 Adults with Diabetes is Undiagnosed, World Diabetes Day Highlights Urgent Need for Early Diagnosis and Treatment","author":"Lorenzo Piemonte","year":"2016"},{"key":"10.1016\/j.fct.2018.07.036_bib51","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/aps.2010.225","article-title":"A protective effect of melatonin on intestinal permeability is induced by diclofenac via regulation of mitochondrial function in mice","volume":"32","author":"Mei","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.fct.2018.07.036_bib52","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/biof.1042","article-title":"Curcumin uptake and metabolism","volume":"39","author":"Metzler","year":"2013","journal-title":"Biofactors"},{"key":"10.1016\/j.fct.2018.07.036_bib53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1515\/JBCPP.2010.21.1.93","article-title":"Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder","volume":"21","author":"Mirunalini","year":"2010","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.fct.2018.07.036_bib54","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/0975-9476.65077","article-title":"Ethnopharmacology and integrative medicine-Let the history tell the future","volume":"1","author":"Mukherjee","year":"2010","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.fct.2018.07.036_bib55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0021-9150(99)00214-2","article-title":"Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?","volume":"148","author":"Nieto","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fct.2018.07.036_bib56","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2018.07.036_bib57","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/jgh.12190","article-title":"Diabetes is an independent risk factor for peptic ulcer bleeding: a nationwide population-based cohort study","volume":"28","author":"Peng","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.fct.2018.07.036_bib58","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0140-6736(15)00132-4","article-title":"Type 2 diabetes: multimodal treatment of a complex disease","volume":"386","author":"Pournaras","year":"2015","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.fct.2018.07.036_bib59","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Canc. Res. Treat."},{"key":"10.1016\/j.fct.2018.07.036_bib60","article-title":"Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities","volume":"6","author":"Rahmani","year":"2014","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.fct.2018.07.036_bib61","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1211\/002235703765344577","article-title":"Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indometacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease","volume":"55","author":"Rainsford","year":"2003","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.fct.2018.07.036_bib62","first-page":"19","article-title":"Indian gooseberry (Phyllanthus emblica l.)\u2013phytochemistry. Pharmacology, and therapeutics","volume":"vol. 2","author":"Ramakrishna","year":"2011"},{"key":"10.1016\/j.fct.2018.07.036_bib63","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ddr.10417","article-title":"Attenuated gastropathy but not enteropathy of diclofenac\u2013cholestyramine complex in rats","volume":"64","author":"Ram\u0131rez-Alc\u00e1ntara","year":"2005","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.fct.2018.07.036_bib64","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0016-5085(97)70225-7","article-title":"Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation","volume":"112","author":"Reuter","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2018.07.036_bib65","article-title":"Reigniting pharmaceutical innovation through holistic drug targeting","volume":"45","author":"Roy","year":"2016","journal-title":"Drug Discov."},{"key":"10.1016\/j.fct.2018.07.036_bib66","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.canlet.2009.04.033","article-title":"Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene","volume":"285","author":"Saleem","year":"2009","journal-title":"Canc. Lett."},{"key":"10.1016\/j.fct.2018.07.036_bib67","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1038\/sj.onc.1207641","article-title":"Lupeol modulates NF-\u03baB and PI3K\/Akt pathways and inhibits skin cancer in CD-1 mice","volume":"23","author":"Saleem","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.fct.2018.07.036_bib68","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3923\/ajava.2015.724.739","article-title":"Prebiotics: an emerging nutritional approach for improving gut health of livestock and poultry","volume":"10","author":"Samal","year":"2015","journal-title":"Asian J. Anim. Vet. Adv."},{"key":"10.1016\/j.fct.2018.07.036_bib69","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2012.05.006","article-title":"Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action","volume":"199","author":"Sandoval-Acu\u00f1a","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2018.07.036_bib70","unstructured":"Saraf, A., Sankhala, S., Simultaneous Determination of Rutin and Quercetin in Different Parts of Tecomella Undulata (Seem): an Endangered Medicinal Plant."},{"key":"10.1016\/j.fct.2018.07.036_bib71","first-page":"68","article-title":"Anti-diabetic activity of compound","volume":"8","author":"Sarker","year":"2017","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.fct.2018.07.036_bib72","doi-asserted-by":"crossref","first-page":"S741","DOI":"10.1016\/S2221-1691(12)60307-4","article-title":"In vitro antioxidant and anticancer potential of bark of costus pictus D. Don","volume":"2","author":"Sathuvan","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.fct.2018.07.036_bib73","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1124\/jpet.113.208991","article-title":"Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats","volume":"348","author":"Satoh","year":"2014","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.fct.2018.07.036_bib74","first-page":"1200","article-title":"Anti diabetic and antioxidant activity of Methanolic leaf extracts of Costus pictus D. Don in alloxan induced diabetic rats","volume":"1","author":"Sethumathi","year":"2009","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.fct.2018.07.036_bib75","first-page":"97","article-title":"Phytochemical investigation of the insulin plant \u201cCostus pictus\u201d D. Don","volume":"4","author":"Shiny","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.fct.2018.07.036_bib76","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.trsl.2016.03.014","article-title":"Clinical importance of nonsteroidal anti-inflammatory drug enteropathy: the relevance of tumor necrosis factor as a promising target","volume":"175","author":"Singh","year":"2016","journal-title":"Transl. Res."},{"key":"10.1016\/j.fct.2018.07.036_bib78","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.vascn.2015.11.008","article-title":"A novel model for NSAID induced gastroenteropathy in rats","volume":"78","author":"Singh","year":"2016","journal-title":"J. Pharmacol. Toxicol. Meth."},{"key":"10.1016\/j.fct.2018.07.036_bib79","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.vascn.2015.11.008","article-title":"A novel model for NSAID induced gastroenteropathy in rats","volume":"78","author":"Singh","year":"2016","journal-title":"J. Pharmacol. Toxicol. Meth."},{"key":"10.1016\/j.fct.2018.07.036_bib80","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.etp.2016.10.004","article-title":"Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: evidence from a preclinical study in rats","volume":"69","author":"Singh","year":"2017","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.fct.2018.07.036_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2017.04.006","article-title":"Overcoming the exacerbating effects of ranitidine on NSAID-induced small intestinal toxicity with quercetin: providing a complete GI solution","author":"Singh","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2018.07.036_bib82","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.fct.2017.07.034","article-title":"Curcumin, a component of turmeric, efficiently prevents diclofenac sodium-induced gastroenteropathic damage in rats: a step towards translational medicine","volume":"108","author":"Singh","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2018.07.036_bib83","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00204-007-0263-9","article-title":"Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction","volume":"82","author":"Sivalingam","year":"2008","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2018.07.036_bib84","doi-asserted-by":"crossref","first-page":"287","DOI":"10.22159\/ajpcr.2016.v9s3.14920","article-title":"Docking studies on antidiabetic molecular targets of phytochemical compounds of syzygium cumini (l.) Skeels","volume":"9","author":"Smruthi","year":"2016","journal-title":"Asian J. Pharmaceut. Clin. Res."},{"key":"10.1016\/j.fct.2018.07.036_bib85","series-title":"Lupeol, a Triterpene, Prevents Free Radical Mediated Macromolecular Damage and Alleviates Benzoyl Peroxide Induced Biochemical Alterations in Murine Skin","author":"Sultana","year":"2003"},{"key":"10.1016\/j.fct.2018.07.036_bib86","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1600-0838.2009.01026.x","article-title":"Dietary supplements and medications in elite sport\u2013polypharmacy or real need?","volume":"21","author":"Suzic Lazic","year":"2011","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"10.1016\/j.fct.2018.07.036_bib87","series-title":"Ayurveda Based Novel Integrative Approach And\/or Technique to Predict Chemical Constituents from Any Substance And\/or Sample","author":"Swapnil P Borse","year":"2016"},{"key":"10.1016\/j.fct.2018.07.036_bib88","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2337\/diacare.29.04.06.dc05-1748","article-title":"Diabetes and 30-day mortality from peptic ulcer bleeding and perforation","volume":"29","author":"Thomsen","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fct.2018.07.036_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3164\/jcbn.2007001","article-title":"Recent advances in indian herbal drug ResearchGuest editor: Thomas Paul Asir DevasagayamCurrent status of herbal drugs in India: an overview","volume":"41","author":"Vaidya","year":"2007","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.fct.2018.07.036_bib90","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3109\/15563650.2013.860985","article-title":"Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy","volume":"52","author":"Vecchio","year":"2014","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.fct.2018.07.036_bib91","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1053\/j.gastro.2011.06.075","article-title":"Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis","volume":"141","author":"Wallace","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2018.07.036_bib92","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1124\/mol.104.010082","article-title":"Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase\/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts","volume":"68","author":"Yen","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.fct.2018.07.036_bib93","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/ismej.2014.165","article-title":"Host adaptive immunity alters gut microbiota","volume":"9","author":"Zhang","year":"2015","journal-title":"ISME J."},{"key":"10.1016\/j.fct.2018.07.036_bib94","article-title":"The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model","volume":"2008","author":"Zhang","year":"2009","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.fct.2018.07.036_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162354","article-title":"Type 2 diabetes mellitus is associated with more serious small intestinal mucosal injuries","volume":"11","author":"Zhong","year":"2016","journal-title":"PLoS One"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518304812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518304812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:47:21Z","timestamp":1759528041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691518304812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":94,"alternative-id":["S0278691518304812"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2018.07.036","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential synergistic effects of quercetin with other phytoconstituents of Costus pictus (insulin plant) extract in the control of hyperglycemia and prevention of NSAID-induced gastroenteropathy in diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2018.07.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}