{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:07:13Z","timestamp":1790017633548,"version":"4.0.1"},"reference-count":177,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"The European Union's Horizon 2020","award":["739582"],"award-info":[{"award-number":["739582"]}]},{"name":"The European Union's Horizon 2020","award":["664620"],"award-info":[{"award-number":["664620"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.fct.2018.08.071","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T18:11:11Z","timestamp":1535739071000},"page":"173-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Causes and solutions to \u201cglobesity\u201d: The new fa(s)t alarming global epidemic"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1690-1490","authenticated-orcid":false,"given":"Liliya V.","family":"Vasileva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-683X","authenticated-orcid":false,"given":"Andrey S.","family":"Marchev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5248-6135","authenticated-orcid":false,"given":"Milen I.","family":"Georgiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2018.08.071_bib1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.ecl.2008.08.005","article-title":"Brain regulation of appetite and satiety","volume":"37","author":"Ahima","year":"2008","journal-title":"Endocrinol Metab. Clin. N. Am."},{"key":"10.1016\/j.fct.2018.08.071_bib2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3803\/EnM.2015.30.3.235","article-title":"Connecting myokines and metabolism","volume":"30","author":"Ahima","year":"2015","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.fct.2018.08.071_bib3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.4014\/jmb.1612.12037","article-title":"Pinus densiflora bark extract (PineXol) decreases adiposity in mice by down-regulation of hepatic de novo lipogenesis and adipogenesis in white adipose tissue","volume":"27","author":"Ahn","year":"2017","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.fct.2018.08.071_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/nutrit\/nuv002","article-title":"Food reward system: current perspectives and future research needs","volume":"73","author":"Alonso-Alonso","year":"2015","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.fct.2018.08.071_bib5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jep.2015.09.029","article-title":"Plants used in the traditional medicine of Mesoamerica (Mexico and Central America) and the Caribbean for the treatment of obesity","volume":"175","author":"Alonso-Castro","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2018.08.071_bib6","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/oby.20309","article-title":"A randomized, phase 3 trial of naltrexone SR\/bupropion SR on weight and obesity-related risk factors (COR-II)","volume":"21","author":"Apovian","year":"2013","journal-title":"Obesity"},{"key":"10.1016\/j.fct.2018.08.071_bib7","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/dom.12690","article-title":"Effects of lorcaserin on fat and lean mass loss in obese and overweight patients without and with type 2 diabetes mellitus: the BLOSSOM and BLOOM-DM studies","volume":"18","author":"Apovian","year":"2016","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.fct.2018.08.071_bib8","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1002\/oby.20584","article-title":"Evaluation of phentermine and topiramate versus phentermine\/topiramate extended-release in obese adults","volume":"21","author":"Aronne","year":"2013","journal-title":"Obesity"},{"key":"10.1016\/j.fct.2018.08.071_bib9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ctim.2013.05.007","article-title":"Plant extracts with appetite suppressing properties for body weight control: a systematic review of double blind randomized controlled clinical trials","volume":"21","author":"Astell","year":"2013","journal-title":"Compl. Ther. Med."},{"key":"10.1016\/j.fct.2018.08.071_bib10","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1007\/s12272-017-0989-8","article-title":"Sirtuin 6, a possible therapeutic target for type 2 diabetes","volume":"40","author":"Bae","year":"2017","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.fct.2018.08.071_bib11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cmet.2012.10.003","article-title":"Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding","volume":"16","author":"Blouet","year":"2012","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2018.08.071_bib12","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.phymed.2015.10.006","article-title":"The authenticity and quality of Rhodiola rosea products","volume":"23","author":"Booker","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fct.2018.08.071_bib13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.physbeh.2014.04.025","article-title":"A functional neuroimaging review of obesity, appetitive hormones and ingestive behavior","volume":"136","author":"Burger","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.fct.2018.08.071_bib14","first-page":"81","article-title":"Screening of some medicinal plants for their pancreatic lipase inhibitory potential","volume":"4","author":"Bustanji","year":"2011","journal-title":"Jordan J. Pharm. Sci."},{"key":"10.1016\/j.fct.2018.08.071_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jep.2017.02.044","article-title":"Purple corn silk: a potential anti-obesity agent with inhibition on adipogenesis and induction on lipolysis and apoptosis in adipocytes","volume":"201","author":"Chaiittianan","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2018.08.071_bib16","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1039\/c3fo60495k","article-title":"Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans","volume":"5","author":"Chang","year":"2014","journal-title":"Food Funct"},{"key":"10.1016\/j.fct.2018.08.071_bib17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/jamasurg.2013.3654","article-title":"The effectiveness and risks of bariatric surgery: an updated systematic review and meta analysis, 2003\u20132012","volume":"149","author":"Chang","year":"2014","journal-title":"JAMA Surg"},{"key":"10.1016\/j.fct.2018.08.071_bib18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.pnpbp.2017.04.035","article-title":"Ido chronic immune activation and tryptophan metabolic pathway: a potential pathophysiological link between depression and obesity","volume":"80","author":"Chaves Filho","year":"2018","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."},{"key":"10.1016\/j.fct.2018.08.071_bib19","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nri3071","article-title":"Macrophage-mediated inflammation in metabolic disease","volume":"11","author":"Chawla","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fct.2018.08.071_bib20","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.clnu.2015.05.003","article-title":"Therapeutic effect of high-dose green tea extract on weight reduction: a randomized, double-blind, placebo-controlled clinical trial","volume":"35","author":"Chen","year":"2016","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.fct.2018.08.071_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2017.10.004","article-title":"Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond","volume":"54","author":"Cheng","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2018.08.071_bib22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/2042098613489721","article-title":"Safety of antiobesity drugs","volume":"4","author":"Cheung","year":"2013","journal-title":"Ther. Adv. drug Saf."},{"key":"10.1016\/j.fct.2018.08.071_bib23","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1074\/jbc.M112.432344","article-title":"C\/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver","volume":"288","author":"Chikka","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2018.08.071_bib24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/B978-0-12-407766-9.00017-1","article-title":"Protein tyrosine phosphatase 1B (PTP1B) and obesity","volume":"91","author":"Cho","year":"2013","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.fct.2018.08.071_bib25","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.nutres.2016.03.001","article-title":"Aster spathulifolius Maxim extract reduces body weight and fat mass in obese humans","volume":"36","author":"Cho","year":"2016","journal-title":"Nutr. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1089\/jmf.2017.3965","article-title":"Standardized Cirsium setidens Nakai ethanolic extract suppresses adipogenesis and regulates lipid metabolisms in 3T3-L1 adipocytes and C57BL\/6J mice fed high-fat diets","volume":"20","author":"Cho","year":"2017","journal-title":"J. Med. Food"},{"key":"10.1016\/j.fct.2018.08.071_bib27","first-page":"1","article-title":"Effect of a herbal extract powder (YY-312) from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode on body fat mass in overweight adults: a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical tria","volume":"17","author":"Cho","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.fct.2018.08.071_bib28","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrendo.2016.222","article-title":"The cellular and molecular bases of leptin and ghrelin resistance in obesity","volume":"13","author":"Cui","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.fct.2018.08.071_bib29","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/ptr.5898","article-title":"The beneficial effect of anthocyanidin-rich Vitis vinifera L. Grape skin extract on metabolic changes induced by high-fat diet in mice involves antiinflammatory and antioxidant actions","volume":"31","author":"da Costa","year":"2017","journal-title":"Phyther. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib30","first-page":"2050","article-title":"Medicinal plants for the treatment of obesity: ethnopharmacological approach and chemical and biological studies","volume":"9","author":"de Freitas Junior","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib31","doi-asserted-by":"crossref","DOI":"10.1080\/10942912.2017.1357041","article-title":"Metabolic diversity and in vitro pancreatic lipase inhibition activity of some varieties of Mangifera indica L. fruits","volume":"20","author":"De Pradhan","year":"2017","journal-title":"Int. J. Food Prop."},{"key":"10.1016\/j.fct.2018.08.071_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules22060972","article-title":"Baccharis trimera (Less.) DC exhibits an anti-adipogenic effect by inhibiting the expression of proteins involved in adipocyte differentiation","volume":"22","author":"de Souza Marinho do Nascimento","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2018.08.071_bib33","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.apjtb.2015.09.012","article-title":"Screening for anti-pancreatic lipase properties of 28 traditional Thai medicinal herbs","volume":"5","author":"Dechakhamphu","year":"2015","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.fct.2018.08.071_bib34","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3945\/jn.115.219238","article-title":"Long-term supplementation of green tea extract does not modify adiposity or bone mineral density in a randomized trial of overweight and obese postmenopausal women","volume":"146","author":"Dostal","year":"2016","journal-title":"J. Nutr."},{"key":"10.1016\/j.fct.2018.08.071_bib35","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3945\/jn.115.222414","article-title":"Green tea extract and catechol-O-methyltransferase genotype modify fasting serum insulin and plasma adiponectin concentrations in a randomized controlled trial of overweight and obese postmenopausal women","volume":"146","author":"Dostal","year":"2016","journal-title":"J. Nutr."},{"key":"10.1016\/j.fct.2018.08.071_bib36","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1177\/193229680800200623","article-title":"Body composition methods: comparisons and interpretation","volume":"2","author":"Duren","year":"2008","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.fct.2018.08.071_bib37","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/ptr.5343","article-title":"Effect of Zingiber officinale supplementation on obesity management with respect to the uncoupling protein 1-3826A>G and \u03b23-adrenergic receptor Trp64Arg polymorphism","volume":"29","author":"Ebrahimzadeh Attari","year":"2015","journal-title":"Phyther. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib38","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.mce.2012.08.018","article-title":"Genome-wide association studies of obesity and metabolic syndrome","volume":"382","author":"Fall","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.fct.2018.08.071_bib39","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1586\/eem.11.50","article-title":"Pharmacotherapy for obesity: a field in crisis?","volume":"6","author":"Fenske","year":"2011","journal-title":"Expet Rev. Endocrinol. Metabol."},{"key":"10.1016\/j.fct.2018.08.071_bib40","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.amepre.2011.10.026","article-title":"Obesity and severe obesity forecasts through 2030","volume":"42","author":"Finkelstein","year":"2012","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.fct.2018.08.071_bib41","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0140-6736(10)62037-5","article-title":"National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9\u00b71 million participants","volume":"377","author":"Finucane","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.fct.2018.08.071_bib42","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/dom.12502","article-title":"Current and emerging medications for overweight or obesity in people with comorbidities","volume":"17","author":"Fujioka","year":"2015","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.fct.2018.08.071_bib43","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0140-6736(11)60205-5","article-title":"Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial","volume":"377","author":"Gadde","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.fct.2018.08.071_bib44","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/BJ20140143","article-title":"Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity","volume":"461","author":"Galic","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.fct.2018.08.071_bib45","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.neuro.30.051606.094324","article-title":"Neurobiology of feeding and energy expenditure","volume":"30","author":"Gao","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.fct.2018.08.071_bib501","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jep.2016.06.059","article-title":"The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes","volume":"191","author":"Gao","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2018.08.071_bib46","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11240-015-0840-1","article-title":"Metabolic alterations of Verbascum nigrum L. plants and SAArT transformed roots as revealed by NMR-based metabolomics","volume":"123","author":"Georgiev","year":"2015","journal-title":"Plant Cell Tissue Organ Cult."},{"key":"10.1016\/j.fct.2018.08.071_bib47","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nrg.2017.72","article-title":"Convergence between biological, behavioural and genetic determinants of obesity","volume":"18","author":"Ghosh","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.fct.2018.08.071_bib48","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12906-016-1214-x","article-title":"Effects of Greenselect Phytosome\u00ae on weight maintenance after weight loss in obese women: a randomized placebo-controlled study","volume":"16","author":"Gilardini","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.fct.2018.08.071_bib49","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.bbadis.2013.05.004","article-title":"Neural melanocortin receptors in obesity and related metabolic disorders","volume":"1842","author":"Girardet","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.fct.2018.08.071_bib50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Global Burden of Disease","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.fct.2018.08.071_bib51","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2174\/1568008013341163","article-title":"Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance","volume":"1","author":"Goldstein","year":"2001","journal-title":"Curr. Drug Targets - Immune, Endocr. Metab. Disord."},{"key":"10.1016\/j.fct.2018.08.071_bib52","doi-asserted-by":"crossref","first-page":"17034","DOI":"10.1038\/nrdp.2017.34","volume":"3","author":"Gonz\u00e1lez-Muniesa","year":"2017","journal-title":"Obesity. Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.fct.2018.08.071_bib53","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/cob.12159","article-title":"Safety and tolerability review of lorcaserin in clinical trials","volume":"6","author":"Greenway","year":"2016","journal-title":"Clin. Obes."},{"key":"10.1016\/j.fct.2018.08.071_bib54","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fct.2018.08.071_bib55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrendo.2016.135","article-title":"PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD","volume":"13","author":"Gross","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.fct.2018.08.071_bib56","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1089\/jmf.2016.3811","article-title":"Germacrone attenuates hyperlipidemia and improves lipid metabolism in high-fat diet-induced obese C57BL\/6J mice","volume":"20","author":"Guo","year":"2017","journal-title":"J. Med. Food"},{"key":"10.1016\/j.fct.2018.08.071_bib57","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cub.2014.09.003","article-title":"Adipocytes","volume":"24","author":"Gupta","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.fct.2018.08.071_bib58","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3945\/ajcn.112.036350","article-title":"Energy balance and its components: implications for body weight regulation","volume":"95","author":"Hall","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.fct.2018.08.071_bib59","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.2105\/AJPH.2014.301931","article-title":"Dynamic interplay among homeostatic, hedonic, and cognitive feedback circuits regulating body weight","volume":"104","author":"Hall","year":"2014","journal-title":"Am. J. Publ. Health"},{"key":"10.1016\/j.fct.2018.08.071_bib60","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1039\/C6FO01170E","article-title":"Anti-obesity effects of arctii fructus (Arctium lappa) in white\/brown adipocytes and high-fat diet-induced obese mice","volume":"7","author":"Han","year":"2016","journal-title":"Food Funct"},{"key":"10.1016\/j.fct.2018.08.071_bib61","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2017.0774","article-title":"Keeping the home fires burning: AMP-activated protein kinase","volume":"15","author":"Hardie","year":"2018","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.fct.2018.08.071_bib62","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.3748\/wjg.15.3073","article-title":"A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity","volume":"15","author":"Hasani-Ranjbar","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2018.08.071_bib63","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/ijcp.12771","article-title":"Weight management in obesity - past and present","volume":"70","author":"Haslam","year":"2016","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.fct.2018.08.071_bib64","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","article-title":"The Nrf2 regulatory network provides an interface between redox and intermediary metabolism","volume":"39","author":"Hayes","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.fct.2018.08.071_bib65","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1515\/reveh-2017-0038","article-title":"The role of nutrition in influencing mechanisms involved in environmentally mediated diseases","volume":"33","author":"Hennig","year":"2018","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.fct.2018.08.071_bib66","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ctcp.2015.12.003","article-title":"Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: a randomized controlled clinical trial","volume":"22","author":"Hosseini","year":"2016","journal-title":"Compl. Ther. Clin. Pract."},{"key":"10.1016\/j.fct.2018.08.071_bib67","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jtcme.2017.04.006","article-title":"Traditional Persian Medicine and management of metabolic dysfunction in polycystic ovary syndrome","volume":"8","author":"Hosseinkhani","year":"2018","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.fct.2018.08.071_bib68","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1021\/jf062912b","article-title":"Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells","volume":"55","author":"Hsu","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2018.08.071_bib69","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.nutres.2016.07.004","article-title":"Defatted safflower seed extract inhibits adipogenesis in 3T3-L1 preadipocytes and improves lipid profiles in C57BL\/6J ob\/ob mice fed a high-fat diet","volume":"36","author":"Hwang","year":"2016","journal-title":"Nutr. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib70","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1080\/13880209.2017.1357736","article-title":"Bioactivity-guided isolation and identification of anti-adipogenic compounds from Sanguisorba officinalis","volume":"55","author":"Im","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.fct.2018.08.071_bib71","doi-asserted-by":"crossref","DOI":"10.1080\/16546628.2017.1338919","article-title":"Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet","volume":"61","author":"Jambocus","year":"2017","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib72","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s12272-001-1210-9","article-title":"A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta","volume":"31","author":"Jang","year":"2008","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.fct.2018.08.071_bib73","first-page":"1","article-title":"Agrimonia pilosa Ledeb. aqueous extract improves impaired glucose tolerance in high-fat diet-fed rats by decreasing the inflammatory response","volume":"17","author":"Jang","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.fct.2018.08.071_bib74","first-page":"89","article-title":"Anti-lipase potential of the organic and aqueous extracts of ten traditional edible and medicinal plants in Palestine; a comparison study with orlistat","volume":"4","author":"Jaradat","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.fct.2018.08.071_bib75","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2337\/diacare.27.1.155","article-title":"XENical in the prevention of diabetes in obese subjects (XENDOS) study","volume":"27","author":"Jarl","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.fct.2018.08.071_bib76","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.12388","article-title":"Effects of (-)-epigallocatechin 3- O -(3- O -methyl) gallate (EGCG3\u2033Me)- phospholipids complex on pancreatic \u03b1-amylase and lipase activities","volume":"41","author":"Jiang","year":"2017","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.fct.2018.08.071_bib77","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1089\/jmf.2016.3704","article-title":"Sanguisorba officinalis L. extracts exert antiobesity effects in 3T3-L1 adipocytes and C57BL\/6J mice fed high-fat diets","volume":"19","author":"Jung","year":"2016","journal-title":"J. Med. Food"},{"key":"10.1016\/j.fct.2018.08.071_bib78","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bbacli.2016.03.002","article-title":"Implication of hepatokines in metabolic disorders and cardiovascular diseases","volume":"5","author":"Jung","year":"2016","journal-title":"BBA Clin"},{"key":"10.1016\/j.fct.2018.08.071_bib79","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/ijo.2017.176","article-title":"Effects of peripheral administration of a Neuromedin U receptor 2-selective agonist on food intake and body weight in obese mice","volume":"41","author":"Kaisho","year":"2017","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.fct.2018.08.071_bib80","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.cmet.2015.09.007","article-title":"Brown and beige fat: physiological roles beyond heat generation","volume":"22","author":"Kajimura","year":"2015","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2018.08.071_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2016.10.013","article-title":"Physiological effects of epigallocatechin-3-gallate (EGCG) on energy expenditure for prospective fat oxidation in humans: a systematic review and meta-analysis","volume":"43","author":"Kapoor","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2018.08.071_bib82","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2217\/14750708.4.5.641","article-title":"Secondary causes of obesity","volume":"4","author":"Karam","year":"2007","journal-title":"Therapy"},{"key":"10.1016\/j.fct.2018.08.071_bib83","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.neuron.2011.02.016","article-title":"Reward mechanisms in obesity: new insights and future directions","volume":"69","author":"Kenny","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.fct.2018.08.071_bib84","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/ptr.3672","article-title":"Betulinic acid has an inhibitory effect on pancreatic lipase and induces adipocyte lipolysis","volume":"26","author":"Kim","year":"2012","journal-title":"Phyther. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0188583","article-title":"Inhibitory activity of chokeberry, bilberry, raspberry and cranberry polyphenol-rich extract towards adipogenesis and oxidative stress in differentiated 3T3-L1 adipose cells","volume":"12","author":"Kowalska","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2018.08.071_bib86","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbadis.2013.05.017","article-title":"Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance","volume":"1842","author":"Lee","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.fct.2018.08.071_bib87","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1124\/pr.113.007757","article-title":"Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system","volume":"66","author":"Lee","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.fct.2018.08.071_bib88","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cytogfr.2016.10.003","article-title":"Myokines and adipokines: involvement in the crosstalk between skeletal muscle and adipose tissue","volume":"33","author":"Li","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.fct.2018.08.071_bib89","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.beem.2013.08.003","article-title":"Adiponectin action in skeletal muscle","volume":"28","author":"Liu","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.fct.2018.08.071_bib90","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/obr.12456","article-title":"Waist-to-height ratio, body mass index and waist circumference for screening paediatric cardio-metabolic risk factors: a meta-analysis","volume":"17","author":"Lo","year":"2016","journal-title":"Obes. Rev."},{"key":"10.1016\/j.fct.2018.08.071_bib91","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature14177","article-title":"Genetic Studies of Body Mass index Yield New Insights for Obesity Biology","volume":"518","author":"Locke","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.fct.2018.08.071_bib92","doi-asserted-by":"crossref","first-page":"9508","DOI":"10.3390\/nu7115483","article-title":"Coleus forskohlii extract supplementation in conjunction with a hypocaloric diet reduces the risk factors of metabolic syndrome in overweight and obese subjects: a randomized controlled trial","volume":"7","author":"Loftus","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2018.08.071_bib93","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1476-069X-5-25","article-title":"Obesity, physical activity, and the urban environment: public health research needs","volume":"5","author":"Lopez","year":"2006","journal-title":"Environ. Health"},{"key":"10.1016\/j.fct.2018.08.071_bib94","first-page":"89","article-title":"The role of SOCS-3 protein in leptin resistance and obesity","volume":"40","author":"Lubis","year":"2008","journal-title":"Acta Med. Indones."},{"key":"10.1016\/j.fct.2018.08.071_bib95","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1017\/S1368980014002559","article-title":"How calorie-focused thinking about obesity and related diseases may mislead and harm public health. An alternative","volume":"18","author":"Lucan","year":"2015","journal-title":"Publ. Health Nutr."},{"key":"10.1016\/j.fct.2018.08.071_bib96","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cmet.2015.03.001","article-title":"Regulation of obesity-related insulin resistance with gut anti-inflammatory agents","volume":"21","author":"Luck","year":"2015","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2018.08.071_bib97","first-page":"897","article-title":"Inhibitors of pancreatic lipase: state of the art and clinical perspectives","volume":"13","author":"Lunagariya","year":"2014","journal-title":"EXCLI J"},{"key":"10.1016\/j.fct.2018.08.071_bib98","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/2040622314522848","article-title":"Pharmacotherapy for obesity: novel agents and paradigms","volume":"5","author":"Manning","year":"2014","journal-title":"Ther. Adv. Chronic Dis."},{"key":"10.1016\/j.fct.2018.08.071_bib99","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.phytol.2016.12.030","article-title":"Phytochemical variations of Rhodiola rosea L. wild-grown in Bulgaria","volume":"20","author":"Marchev","year":"2017","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.fct.2018.08.071_bib100","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/nyas.13407","article-title":"Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?","volume":"1401","author":"Marchev","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.fct.2018.08.071_bib101","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nrendo.2016.142","article-title":"Anti-obesogenic and antidiabetic effects of plants and mushrooms","volume":"13","author":"Martel","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.fct.2018.08.071_bib102","doi-asserted-by":"crossref","first-page":"519","DOI":"10.17113\/ftb.55.04.17.5138","article-title":"In vitro inhibition of pancreatic lipase by polyphenols: a kinetic, Fluorescence spectroscopy and molecular docking study","volume":"55","author":"Martinez-Gonzalez","year":"2017","journal-title":"Food Technol. Biotechnol."},{"key":"10.1016\/j.fct.2018.08.071_bib103","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.cmet.2013.05.008","article-title":"Immunological goings-on in visceral adipose tissue","volume":"17","author":"Mathis","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2018.08.071_bib104","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1016\/j.biotechadv.2017.12.015","article-title":"Activation of Nrf2 signaling by natural products-can it alleviate diabetes?","volume":"36","author":"Matzinger","year":"2017","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.fct.2018.08.071_bib105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/osp4.84","article-title":"Liraglutide for weight management: a critical review of the evidence","volume":"3","author":"Mehta","year":"2017","journal-title":"Obes. Sci. Pract."},{"key":"10.1016\/j.fct.2018.08.071_bib106","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbadis.2008.12.004","article-title":"Leptin signaling in brain: a link between nutrition and cognition?","volume":"1792","author":"Morrison","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.fct.2018.08.071_bib107","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.bbadis.2008.09.005","article-title":"Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesity","volume":"1792","author":"Morrison","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.fct.2018.08.071_bib108","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/clc.22437","article-title":"Conicity index and waist-to-hip ratio are superior obesity indices in predicting 10-year cardiovascular risk among men and women","volume":"38","author":"Motamed","year":"2015","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.fct.2018.08.071_bib109","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.bbadis.2013.05.031","article-title":"Understanding the variegation of fat: novel regulators of adipocyte differentiation and fat tissue biology","volume":"1842","author":"Mueller","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.fct.2018.08.071_bib110","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1021\/jf047814+","article-title":"Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro","volume":"53","author":"Nakai","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2018.08.071_bib111","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3136\/fstr.21.77","article-title":"Hypolipidemic property of a new fermented tea made with third crop green tea (Camellia sinensis) leaves and unripe satsuma Mandarin (Citrus unshiu) fruits","volume":"21","author":"Nakayama","year":"2015","journal-title":"Food Sci. Technol. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib112","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1016\/S0140-6736(17)32129-3","article-title":"Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128\u00b79 million children, adolescents, and adults","volume":"390","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.fct.2018.08.071_bib113","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bcp.2017.11.007","article-title":"Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice","volume":"147","author":"Neelakantan","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2018.08.071_bib114","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22101795","article-title":"Pharmabiotics as an emerging medication for metabolic syndrome and its related diseases","volume":"22","author":"Nguyen","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2018.08.071_bib115","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.bmcl.2004.01.091","article-title":"Carnosic acid, a new class of lipid absorption inhibitor from sage","volume":"14","author":"Ninomiya","year":"2004","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.fct.2018.08.071_bib116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules22040671","article-title":"Effects of flavonoids and triterpene analogues from leaves of Eleutherococcus sieboldianus (Makino) Koidz. \u201cHimeukogi\u201d in 3T3-L1 preadipocytes","volume":"22","author":"Nishina","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2018.08.071_bib117","first-page":"1","article-title":"Metabolic adaptation in obesity and type ii diabetes: myokines, adipokines and hepatokines","volume":"18","author":"Oh","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2018.08.071_bib118","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jff.2017.11.044","article-title":"Polyphenol-rich ethyl acetate fraction of Molineria latifolia rhizome restores oxidant-antioxidant balance by possible engagement of KEAP1-NRF2 and PKC\/NF-\u03baB signalling pathways","volume":"42","author":"Ooi","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fct.2018.08.071_bib119","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.170917","article-title":"Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor \u03b3 signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes","volume":"4","author":"Pan","year":"2017","journal-title":"R. Soc. open Sci."},{"key":"10.1016\/j.fct.2018.08.071_bib120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/oby.20539","article-title":"Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial","volume":"22","author":"Park","year":"2014","journal-title":"Obesity"},{"key":"10.1016\/j.fct.2018.08.071_bib121","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.indcrop.2016.12.038","article-title":"Stephalagine, an alkaloid with pancreatic lipase inhibitory activity isolated from the fruit peel of Annona crassiflora Mart","volume":"97","author":"Pereira","year":"2017","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.fct.2018.08.071_bib122","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature08532","article-title":"Human genetics illuminates the paths to metabolic disease","volume":"462","author":"O'Rahilly","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.fct.2018.08.071_bib123","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.npep.2015.09.008","article-title":"Neuropeptide Y: a stressful review","volume":"55","author":"Reichmann","year":"2016","journal-title":"Neuropeptides"},{"key":"10.1016\/j.fct.2018.08.071_bib124","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1152\/ajpendo.00297.2015","article-title":"Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism","volume":"309","author":"Rodr\u00edguez","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.fct.2018.08.071_bib125","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3945\/ajcn.116.137075","article-title":"Effects of green tea catechin extract on serum lipids in postmenopausal women\u202f: a randomized, placebo-controlled","volume":"104","author":"Samavat","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.fct.2018.08.071_bib126","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.biopha.2016.10.105","article-title":"Beneficial effects of Plantago albicans on high-fat diet-induced obesity in rats","volume":"84","author":"Samout","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2018.08.071_bib127","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1467-789X.2004.00149.x","article-title":"Psychiatric medication-induced obesity\u202f: a review","author":"Schwartz","year":"2004","journal-title":"Obes. Rev."},{"key":"10.1016\/j.fct.2018.08.071_bib128","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jep.2018.01.014","article-title":"In vitro anti-diabetic effect of flavonoids and pheophytins from Allophylus cominia Sw. on the glucose uptake assays by HepG2, L6, 3T3-L1 and fat accumulation in 3T3-L1 adipocytes","volume":"216","author":"Semaan","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2018.08.071_bib129","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/184598","article-title":"The role of NRF2: adipocyte differentiation, obesity, and insulin resistance","volume":"2013","author":"Seo","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.fct.2018.08.071_bib130","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3858\/emm.2011.43.4.025","article-title":"Anti-obesity effects of Lysimachia foenum-graecum characterized by decreased adipogenesis and regulated lipid metabolism","volume":"43","author":"Seo","year":"2011","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.fct.2018.08.071_bib131","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.bbrc.2011.12.039","article-title":"Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet","volume":"417","author":"Seo","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2018.08.071_bib132","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1017\/S0007114516004621","article-title":"Fermented green tea extract exhibits hypolipidaemic effects through the inhibition of pancreatic lipase and promotion of energy expenditure","volume":"117","author":"Seo","year":"2017","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fct.2018.08.071_bib133","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/973143","article-title":"Medicinal plants and their inhibitory activities against pancreatic lipase: a review","volume":"2015","author":"Seyedan","year":"2015","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.fct.2018.08.071_bib134","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/s41598-018-20078-w","article-title":"New role of phenothiazine derivatives as peripherally acting CB1 receptor antagonizing anti-obesity agents","volume":"8","author":"Sharma","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2018.08.071_bib135","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.bbadis.2017.05.007","article-title":"Melanocortin neurons: multiple routes to regulation of metabolism","volume":"1863","author":"Shen","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fct.2018.08.071_bib136","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1089\/met.2012.0060","article-title":"Harmonizing the diagnosis of metabolic syndrome-focusing on abdominal obesity","volume":"11","author":"Silva","year":"2013","journal-title":"Metab. Syndrome Relat. Disord."},{"key":"10.1016\/j.fct.2018.08.071_bib137","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.fct.2016.06.018","article-title":"Adulteration of herbal sexual enhancers and slimmers: the wish for better sexual well-being and perfect body can be risky","volume":"108","author":"Skalicka-Wo\u017aniak","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2018.08.071_bib138","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.imr.2014.09.007","article-title":"Exercise-induced myokines in health and metabolic diseases","volume":"3","author":"So","year":"2014","journal-title":"Integr. Med. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib139","first-page":"1","article-title":"The inhibitory activity of herbal medicines on the keys enzymes and steps related to carbohydrate and lipid digestion","volume":"16","author":"Sompong","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.fct.2018.08.071_bib140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1142\/S0192415X17500549","article-title":"Cinnamomum cassia prevents high-fat diet-induced obesity in mice through the increase of muscle energy","volume":"45","author":"Song","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.fct.2018.08.071_bib141","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.70","article-title":"Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules","volume":"49","author":"Song","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.fct.2018.08.071_bib142","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(01)00240-9","article-title":"Obesity and the regulation of energy balance","volume":"104","author":"Spiegelman","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.fct.2018.08.071_bib143","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.phytochem.2017.07.006","article-title":"Evaluation of Asteraceae herbal extracts in the management of diabetes and obesity. Contribution of caffeoylquinic acids on the inhibition of digestive enzymes activity and formation of advanced glycation end-products (in vitro)","volume":"143","author":"Sp\u00ednola","year":"2017","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fct.2018.08.071_bib144","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1007\/s00044-017-1836-7","article-title":"Bis-indole alkaloids from Tabernaemontana divaricata as potent pancreatic lipase inhibitors: molecular modelling studies and experimental validation","volume":"26","author":"Sridhar","year":"2017","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib145","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/nrendo.2017.122","article-title":"Current pharmacotherapy for obesity","volume":"14","author":"Srivastava","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.fct.2018.08.071_bib146","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/ptr.5583","article-title":"A review of natural stimulant and non-stimulant thermogenic agents","volume":"30","author":"Stohs","year":"2016","journal-title":"Phytother Res."},{"key":"10.1016\/j.fct.2018.08.071_bib147","article-title":"Beiging of white adipose tissue as a therapeutic strategy for weight loss in humans","volume":"31","author":"Thyagarajan","year":"2017","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"key":"10.1016\/j.fct.2018.08.071_bib148","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s13679-014-0129-4","article-title":"Alcohol consumption and obesity: an update","volume":"4","author":"Traversy","year":"2015","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.fct.2018.08.071_bib149","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jfda.2016.10.018","article-title":"Cellular models for the evaluation of the antiobesity effect of selected phytochemicals from food and herbs","volume":"25","author":"Tung","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.fct.2018.08.071_bib150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178769","article-title":"Alamandine reduces leptin expression through the c-Src\/p38 MAP kinase pathway in adipose tissue","volume":"12","author":"Uchiyama","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2018.08.071_bib151","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1001\/jamasurg.2017.2348","article-title":"Factors associated with achieving a body mass index of less than 30 after bariatric surgery","volume":"152","author":"Varban","year":"2017","journal-title":"JAMA Surg"},{"key":"10.1016\/j.fct.2018.08.071_bib152","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s40618-017-0719-6","article-title":"Drug-induced obesity and its metabolic consequences: a review with a focus on mechanisms and possible therapeutic options","volume":"40","author":"Verhaegen","year":"2017","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.fct.2018.08.071_bib153","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbr.2014.08.065","article-title":"Serotonin controlling feeding and satiety","volume":"277","author":"Voigt","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.fct.2018.08.071_bib154","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bcp.2014.07.018","article-title":"Natural product agonists of peroxisome proliferator-activated receptor gamma (PPAR\u03b3): a review","volume":"92","author":"Wang","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2018.08.071_bib155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2013.09.001","article-title":"Novel insights of dietary polyphenols and obesity","volume":"25","author":"Wang","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2018.08.071_bib156","doi-asserted-by":"crossref","DOI":"10.1080\/16546628.2017.1379861","article-title":"Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet\u2013induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles","volume":"61","author":"Wang","year":"2017","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.fct.2018.08.071_bib157","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1002\/jsfa.8387","article-title":"High-theabrownins instant dark tea product by Aspergillus Niger via submerged fermentation: \u03b1 -glucosidase and pancreatic lipase inhibition and antioxidant activity","volume":"97","author":"Wang","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.fct.2018.08.071_bib158","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/adc.2005.085522","article-title":"Measuring body composition","volume":"91","author":"Wells","year":"2006","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.fct.2018.08.071_bib159","series-title":"Obesity and overweight","author":"WHO","year":"2017"},{"key":"10.1016\/j.fct.2018.08.071_bib160","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1017\/S0029665100000434","article-title":"The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box","volume":"59","author":"Williams","year":"2000","journal-title":"Proc. Nutr. Soc. CAB Int. Nutr. Soc. Nutr. Soc."},{"key":"10.1016\/j.fct.2018.08.071_bib161","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cmet.2016.01.003","article-title":"The intestinal immune system in obesity and insulin resistance","volume":"23","author":"Winer","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2018.08.071_bib162","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jep.2015.12.015","article-title":"The anti-angiogenic herbal extract from Melissa officinalis inhibits adipogenesis in 3T3-L1 adipocytes and suppresses adipocyte hypertrophy in high fat diet-induced obese C57BL\/6J mice","volume":"178","author":"Woo","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2018.08.071_bib163","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1467-789X.2008.00547.x","article-title":"Long-term effectiveness of diet-plus-exercise interventions vs. diet-only interventions for weight loss: a meta-analysis","volume":"10","author":"Wu","year":"2009","journal-title":"Obes. Rev."},{"key":"10.1016\/j.fct.2018.08.071_bib164","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","article-title":"Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human","volume":"150","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.fct.2018.08.071_bib165","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s13679-015-0169-4","article-title":"Overweight and obesity: prevalence, consequences, and causes of a growing public health problem","volume":"4","author":"Wyatt","year":"2015","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.fct.2018.08.071_bib166","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.beem.2013.09.003","article-title":"Adiponectin receptors: a review of their structure, function and how they work","volume":"28","author":"Yamauchi","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.fct.2018.08.071_bib167","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bbadis.2016.05.008","article-title":"Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors","volume":"1862","author":"Yang","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.fct.2018.08.071_bib168","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1080\/13880209.2016.1278454","article-title":"Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL\/6 mice","volume":"55","author":"Yang","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.fct.2018.08.071_bib169","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/cbdv.200800153","article-title":"Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of Chinese tea plant (Camellia sinensis)","volume":"6","author":"Yoshikawa","year":"2009","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.fct.2018.08.071_bib170","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/nu10020187","article-title":"Aged oolong tea reduces high-fat diet-induced fat accumulation and dyslipidemia by regulating the AMPK\/ACC signaling pathway","volume":"10","author":"Yuan","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2018.08.071_bib171","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/j.1476-5381.2011.01363.x","article-title":"NPY receptors as potential targets for anti-obesity drug development","volume":"163","author":"Yulyaningsih","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fct.2018.08.071_bib172","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.phytochem.2010.07.011","article-title":"Possible anti-obesity therapeutics from nature \u2013 a review","volume":"71","author":"Yun","year":"2010","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fct.2018.08.071_bib173","article-title":"Preventive effects of Salvia officinalis leaf extract on insulin resistance and inflammation in a model of high fat diet- induced obesity in mice that responds to rosiglitazone","volume":"6","author":"Zaibi","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.fct.2018.08.071_bib174","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.foodchem.2014.09.144","article-title":"Phenolic profiles of 20 Canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on \u03b1-glucosidase and pancreatic lipase","volume":"172","author":"Zhang","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2018.08.071_bib175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2016.11.010","article-title":"Ginseng and obesity: observations and understanding in cultured cells, animals and humans","volume":"44","author":"Zhang","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2018.08.071_bib176","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.ejmech.2017.07.046","article-title":"A novel glucagon-like peptide-1\/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects","volume":"138","author":"Zhou","year":"2017","journal-title":"Eur. J. Med. Chem."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518306276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518306276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:44:24Z","timestamp":1759527864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691518306276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":177,"alternative-id":["S0278691518306276"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2018.08.071","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Causes and solutions to \u201cglobesity\u201d: The new fa(s)t alarming global epidemic","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2018.08.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}