{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:22:41Z","timestamp":1776928961995,"version":"3.51.2"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Santander Bank\/UCM","award":["PR26\/20326"],"award-info":[{"award-number":["PR26\/20326"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.fct.2018.09.016","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T22:29:53Z","timestamp":1536618593000},"page":"297-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Cadmium alters heat shock protein pathways in SN56 cholinergic neurons, leading to A\u03b2 and phosphorylated Tau protein generation and cell death"],"prefix":"10.1016","volume":"121","author":[{"given":"Paula","family":"Moyano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Lobo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Anad\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Sola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Pelayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimena","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Teresa","family":"Frejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-7701","authenticated-orcid":false,"given":"Javier del","family":"Pino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.fct.2018.09.016_bib1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2174\/157015911798376226","article-title":"Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics","volume":"9","author":"Abisambra","year":"2011","journal-title":"Curr. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.fct.2018.09.016_bib2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s12192-017-0768-y","article-title":"Recombinant heat shock protein 27 (HSP27\/HSPB1) protects against cadmium-induced oxidative stress and toxicity in human cervical cancer cells","volume":"22","author":"Alvarez-Olmedo","year":"2017","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.fct.2018.09.016_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0892-0362(96)00218-8","article-title":"Low-level cadmium exposure of lactating rats causes alterations in brain serotonin levels in the offspring","volume":"19","author":"Andersson","year":"1997","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.fct.2018.09.016_bib4","series-title":"Toxicological Profile for Cadmium","author":"ATSDR. Agency for toxic substances and disease registry","year":"2012"},{"key":"10.1016\/j.fct.2018.09.016_bib5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/food.19790230905","article-title":"Cadmium content of vegetable foods in the effective range of a lead smelting, plant","volume":"23","author":"Auermann","year":"1979","journal-title":"Nahrung"},{"key":"10.1016\/j.fct.2018.09.016_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fmolb.2016.00065","article-title":"Effects of a mutation in the HSPE1 gene encoding the mitochondrial co-chaperonin HSP10 and its potential association with a neurological and developmental disorder","volume":"3","author":"Bie","year":"2016","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.fct.2018.09.016_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0041-008X(03)00226-6","article-title":"Hsp27, Hsp70, and metallothionein in MDCK and LLC-PK1 renal epithelial cells: effects of prolonged exposure to cadmium","volume":"191","author":"Bonham","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5\u20136","key":"10.1016\/j.fct.2018.09.016_bib8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.etp.2006.02.012","article-title":"Lipid peroxidation and HSP72\/73 expression in rat following cadmium chloride administration: interactions of magnesium supplementation","volume":"57","author":"Boujelben","year":"2006","journal-title":"Exp. Toxicol. Pathol."},{"issue":"12","key":"10.1016\/j.fct.2018.09.016_bib9","doi-asserted-by":"crossref","first-page":"14565","DOI":"10.3390\/molecules171214565","article-title":"The protection of selenium against cadmium-induced cytotoxicity via the heat shock protein pathway in chicken splenic lymphocytes","volume":"17","author":"Chen","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2018.09.016_bib10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cbi.2014.01.007","article-title":"Interplay of calcium and cadmium in mediating cadmium toxicity","volume":"211","author":"Choong","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2018.09.016_bib11","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/jat.3285","article-title":"Inhibitory effect of cadmium on estrogen signaling in zebrafish brain and protection by zinc","volume":"36","author":"Chouchene","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.fct.2018.09.016_bib12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/15287390590925447","article-title":"Expression of stress-related genes in a cadmium-resistant A549 human cell line","volume":"68","author":"Croute","year":"2005","journal-title":"J. Toxicol. Environ. Health"},{"issue":"1","key":"10.1016\/j.fct.2018.09.016_bib13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tips.2014.10.011","article-title":"Transcription factors HSF1 and NRF2 engage in crosstalk for cytoprotection","volume":"36","author":"Dayalan","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.fct.2018.09.016_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/19336934.2017.1291104","article-title":"secHSP70 as a tool to approach amyloid-\u03b242 and other extracellular amyloids","volume":"11","author":"De Mena","year":"2017","journal-title":"Fly"},{"key":"10.1016\/j.fct.2018.09.016_bib15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tox.2014.09.004","article-title":"Higher sensitivity to cadmium induced cell death of basal forebrain cholinergic neurons: a cholinesterase dependent mechanism","volume":"325","author":"Del Pino","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2018.09.016_bib16","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00204-015-1540-7","article-title":"Cadmium induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase of GSK-3\u03b2 enzyme, \u03b2-amyloid and Tau protein levels","volume":"90","author":"Del Pino","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"44","key":"10.1016\/j.fct.2018.09.016_bib17","doi-asserted-by":"crossref","first-page":"33182","DOI":"10.1074\/jbc.M606192200","article-title":"Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro","volume":"281","author":"Evans","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2018.09.016_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/enrs.2000.4116","article-title":"Mercury, selenium, and cadmium in human autopsy samples from Idrija residents and mercury mine workers","volume":"84","author":"Falnoga","year":"2000","journal-title":"Environ. Res."},{"key":"10.1016\/j.fct.2018.09.016_bib19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-060815-014124","article-title":"Experimental milestones in the discovery of molecular chaperones as polypeptide unfolding enzymes","volume":"85","author":"Finka","year":"2016","journal-title":"Annu. Rev. Biochem."},{"issue":"8","key":"10.1016\/j.fct.2018.09.016_bib20","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1002\/jcp.26454","article-title":"Heat shock protein (HSP) regulation by muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus","volume":"233","author":"Frinchi","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.fct.2018.09.016_bib21","first-page":"311","article-title":"The effect of cadmium on brain cells in culture","volume":"24","author":"Gerspacher","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.fct.2018.09.016_bib22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fnins.2017.00248","article-title":"The role of co-chaperones in synaptic proteostasis and neurodegenerative disease","volume":"11","author":"Gorenberg","year":"2017","journal-title":"Front. Neurosci."},{"issue":"10","key":"10.1016\/j.fct.2018.09.016_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102036","article-title":"Proteome stability as a key factor of genome integrity","volume":"18","author":"Gumeni","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2018.09.016_bib24","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0006-8993(90)90626-M","article-title":"Development and characterization of clonal cell lines derived from septal cholinergic neurons","volume":"512","author":"Hammond","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.fct.2018.09.016_bib25","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.neuro.2009.06.001","article-title":"Cadmium exposure induces mitochondria-dependent apoptosis in oligodendrocytes","volume":"30","author":"Hossain","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.fct.2018.09.016_bib26","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.1523\/JNEUROSCI.1289-09.2009","article-title":"The GAD2 promoter is a transcriptional target of estrogen receptor (ER) alpha and ER beta: a unifying hypothesis to explain diverse effects of estradiol","volume":"29","author":"Hudgens","year":"2009","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.fct.2018.09.016_bib27","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3390\/ph11010002","article-title":"Roles of heat shock proteins in apoptosis, oxidative stress, human inflammatory diseases, and cancer","volume":"11","author":"Ikwegbue","year":"2017","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.fct.2018.09.016_bib28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/19396368.2014.912363","article-title":"Protective effects of different antioxidants against cadmium induced oxidative damage in rat testis and prostate tissues","volume":"60","author":"Jahan","year":"2014","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.fct.2018.09.016_bib29","first-page":"24","article-title":"Impacts of Cd (II) on the conformation and self-aggregation of Alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain","volume":"11","author":"Jiang","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.fct.2018.09.016_bib30","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3233\/JAD-150860","article-title":"Dihydropyridine Derivatives modulate heat shock responses and have a neuroprotective effect in a transgenic mouse model of Alzheimer's disease","volume":"53","author":"Kasza","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"10.1016\/j.fct.2018.09.016_bib31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.fsi.2015.01.004","article-title":"Identification, tissue distribution and characterization of two heat shock factors (HSFs) in goldfish (Carassius auratus)","volume":"43","author":"Kim","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"2\u20133","key":"10.1016\/j.fct.2018.09.016_bib32","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbadis.2004.10.011","article-title":"Phosphorylated tau and the neurodegenerative foldopathies","volume":"1739","author":"Kosik","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fct.2018.09.016_bib33","doi-asserted-by":"crossref","first-page":"E2122","DOI":"10.3390\/ijms17122122","article-title":"Effect of estradiol on neurotrophin receptors in basal forebrain cholinergic neurons: relevance for Alzheimer's disease","volume":"17","author":"Kwakowsky","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2018.09.016_bib34","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00702-017-1785-9","article-title":"The anticancer estrogen receptor antagonist tamoxifen impairs consolidation of inhibitory avoidance memory through estrogen receptor alpha","volume":"124","author":"Lichtenfels","year":"2017","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.fct.2018.09.016_bib35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta DeltaC(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"12","key":"10.1016\/j.fct.2018.09.016_bib36","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1253\/circj.CJ-16-0712","article-title":"M3 Muscarinic receptor signaling stabilizes a novel mutant human ether-a-go-go-related gene channel protein via phosphorylation of heat shock factor 1 in transfected cells","volume":"80","author":"Mahati","year":"2016","journal-title":"Circ. J."},{"key":"10.1016\/j.fct.2018.09.016_bib37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.chemosphere.2016.11.067","article-title":"Cadmium alters the expression of small heat shock protein genes in the aquatic midge chironomus riparius","volume":"169","author":"Mart\u00edn-Folgar","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2018.09.016_bib38","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.etap.2006.11.009","article-title":"Cadmium neurotoxicity","volume":"23","author":"Mendez-Armenta","year":"2007","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2018.09.016_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2478\/10004-1254-65-2014-2405","article-title":"Protective effects of oestradiol against cadmium-induced changes in blood parameters and oxidative damage in rats","volume":"65","author":"Mladenovi\u0107","year":"2014","journal-title":"Arh. Hig. Rada. Toksikol."},{"key":"10.1016\/j.fct.2018.09.016_bib40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tox.2018.04.003","article-title":"SN56 neuronal cell death after 24\u202fh and 14\u202fdays chlorpyrifos exposure through glutamate transmission dysfunction, increase of GSK-3\u03b2 enzyme, \u03b2-amyloid and tau protein levels","volume":"402\u2013403","author":"Moyano","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2018.09.016_bib41","doi-asserted-by":"crossref","first-page":"796869","DOI":"10.1155\/2014\/796869","article-title":"Heat shock protein 90 in Alzheimer's disease","volume":"2014","author":"Ou","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.fct.2018.09.016_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-510X(01)00672-4","article-title":"Determination of cadmium and zinc in Alzheimer's brain tissue using inductively coupled plasma mass spectrometry","volume":"195","author":"Panayi","year":"2002","journal-title":"J. Neurol. Sci."},{"issue":"3","key":"10.1016\/j.fct.2018.09.016_bib43","first-page":"193","article-title":"Heat shock protein 90 inhibitor regulates necroptotic cell death via down-regulation of receptor interacting proteins","volume":"70","author":"Park","year":"2015","journal-title":"Pharmazie"},{"issue":"6","key":"10.1016\/j.fct.2018.09.016_bib44","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/jnc.12080","article-title":"Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease","volume":"124","author":"Pierce","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.fct.2018.09.016_bib45","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbrc.2004.06.108","article-title":"Cadmium induces the expression of specific stress proteins in sea urchin embryos","volume":"321","author":"Roccheri","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.fct.2018.09.016_bib46","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nrm3658","article-title":"Chaperone machines for protein folding, unfolding and disaggregation","volume":"14","author":"Saibil","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fct.2018.09.016_bib47","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/0960327116646840","article-title":"Functional involvement of L-type calcium channels and cyclic nucleotide-dependent pathways in cadmium-induced myometrial relaxation in rats","volume":"36","author":"Saroj","year":"2017","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.fct.2018.09.016_bib48","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1523\/JNEUROSCI.5507-05.2006","article-title":"Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses","volume":"26","author":"Scheiderer","year":"2006","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.fct.2018.09.016_bib49","doi-asserted-by":"crossref","first-page":"58","DOI":"10.6026\/97320630008058","article-title":"The protection role of heat shock protein 70 (HSP-70) in the testes of cadmium-exposed rats","volume":"8","author":"Selim","year":"2012","journal-title":"Bioinformation"},{"issue":"2","key":"10.1016\/j.fct.2018.09.016_bib50","first-page":"412","article-title":"Cadmium-mediated activation of the HSP90\/HSF1 pathway regulated by reactive persulfides\/polysulfides","volume":"156","author":"Shinkai","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"6","key":"10.1016\/j.fct.2018.09.016_bib51","first-page":"5267","article-title":"Suppression of Alzheimer's disease-related phenotypes by the heat shock protein 70 inducer, geranylgeranylacetone, in APP\/PS1 transgenic mice via the ERK\/p38 MAPK signaling pathway","volume":"14","author":"Sun","year":"2017","journal-title":"Exp Ther Med"},{"issue":"1","key":"10.1016\/j.fct.2018.09.016_bib52","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00294-017-0748-x","article-title":"Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo","volume":"64","author":"Tam\u00e1s","year":"2018","journal-title":"Curr. Genet."},{"key":"10.1016\/j.fct.2018.09.016_bib53","doi-asserted-by":"crossref","first-page":"898034","DOI":"10.1155\/2013\/898034","article-title":"Cadmium and its neurotoxic effects","volume":"2013","author":"Wang","year":"2013","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"10.1016\/j.fct.2018.09.016_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22011","article-title":"Alleviation of cadmium-induced oxidative stress by trehalose via inhibiting the Nrf2-Keap1 signaling pathway in primary rat proximal tubular cells","volume":"32","author":"Wang","year":"2018","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.fct.2018.09.016_bib55","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.CIR.103.3.435","article-title":"Endothelial dysfunction and oxidative stress during estrogen deficiency in spontaneously hypertensive rats","volume":"103","author":"Wassmann","year":"2001","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.fct.2018.09.016_bib56","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2990.2006.00689.x","article-title":"Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains","volume":"32","author":"Wilhelmus","year":"2006","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"17","key":"10.1016\/j.fct.2018.09.016_bib57","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1161\/CIRCULATIONAHA.110.942250","article-title":"Hold me tight: role of the heat shock protein family of chaperones in cardiac disease","volume":"122","author":"Willis","year":"2010","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.fct.2018.09.016_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17101703","article-title":"Sulforaphane prevents testicular damage in kunming mice exposed to cadmium via activation of NRF2\/ARE signaling pathways","volume":"17","author":"Yang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2018.09.016_bib59","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.aquatox.2017.06.022","article-title":"Preheating mitigates cadmium toxicity in zebrafish livers: evidence from promoter demethylation, gene transcription to biochemical levels","volume":"190","author":"Zheng","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fct.2018.09.016_bib60","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000431032","article-title":"Calcium homeostasis disruption - a bridge connecting cadmium-induced apoptosis, autophagy and tumorigenesis","volume":"38","author":"Zhou","year":"2015","journal-title":"Oncol Res Treat"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518306604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518306604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:45:48Z","timestamp":1759527948000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691518306604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":60,"alternative-id":["S0278691518306604"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2018.09.016","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium alters heat shock protein pathways in SN56 cholinergic neurons, leading to A\u03b2 and phosphorylated Tau protein generation and cell death","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2018.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}