{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:20:06Z","timestamp":1779366006025,"version":"3.53.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministry of the Economy and Competitiveness (MINECO, Spain)","doi-asserted-by":"publisher","award":["PSI2014-55785-C2-2-R"],"award-info":[{"award-number":["PSI2014-55785-C2-2-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministry of the Economy and Competitiveness (MINECO, Spain)","doi-asserted-by":"publisher","award":["PSI2014-55785-C2-1-R"],"award-info":[{"award-number":["PSI2014-55785-C2-1-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Commission for Universities and Research of the Department of Innovation"},{"DOI":"10.13039\/501100002809","name":"Universities and Enterprise of the Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2014 FI_B00075"],"award-info":[{"award-number":["2014 FI_B00075"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.fct.2018.09.069","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T11:19:40Z","timestamp":1538219980000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner"],"prefix":"10.1016","volume":"122","author":[{"given":"Laia","family":"Guardia-Escote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Basaure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cabr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"P\u00e9rez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"S\u00e1nchez-Santed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Colomina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2018.09.069_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbr.2009.12.049","article-title":"Developmental aspects of the cholinergic system","volume":"221","author":"Abreu-Villa\u00e7a","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.fct.2018.09.069_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3940(97)00872-0","article-title":"Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype","volume":"239","author":"Allen","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.fct.2018.09.069_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.fct.2018.04.065","article-title":"Postnatal chlorpyrifos exposure and apolipoprotein E (APOE) genotype differentially affect cholinergic expression and developmental parameters in transgenic mice","volume":"118","author":"Basaure","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2018.09.069_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2016.10.014","article-title":"Two cholinesterase inhibitors trigger dissimilar effects on behavior and body weight in C57BL\/6 mice: the case of chlorpyrifos and rivastigmine","volume":"318","author":"Basaure","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.fct.2018.09.069_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/brain\/awm276","article-title":"Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology","volume":"131","author":"Berson","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.fct.2018.09.069_bib6","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jphysparis.2014.04.005","article-title":"Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms","volume":"108","author":"Blake","year":"2014","journal-title":"J. Physiol. Paris"},{"key":"10.1016\/j.fct.2018.09.069_bib69","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2010.02.027","article-title":"Impact of apolipoprotein E genotype and dietary quercetin on paraoxonase 1 status in apoE3 and apoE4 transgenic mice","volume":"211","author":"Boesch-Saadatmandi","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fct.2018.09.069_bib7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbr.2008.05.008","article-title":"Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks","volume":"193","author":"Bour","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.fct.2018.09.069_bib8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.tox.2010.11.013","article-title":"Foetal and neonatal exposure to chlorpyrifos: biochemical and metabolic alterations in the mouse liver at different developmental stages","volume":"280","author":"Buratti","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2018.09.069_bib9","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3233\/JAD-160220","article-title":"Increased expression of readthrough acetylcholinesterase variants in the brains of Alzheimer's disease patients","volume":"53","author":"Campanari","year":"2016","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.fct.2018.09.069_bib10","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.nbd.2006.07.013","article-title":"Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE \u03b54 allele, in relation to cognitive function and cerebral glucose metabolism","volume":"24","author":"Darreh-Shori","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.fct.2018.09.069_bib11","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.neurobiolaging.2009.07.015","article-title":"The apolipoprotein E \u03b54 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase","volume":"32","author":"Darreh-Shori","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.fct.2018.09.069_bib12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrn1035","article-title":"Neurobiology of butyrylcholinesterase","volume":"4","author":"Darvesh","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.fct.2018.09.069_bib13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/toxsci\/kfp017","article-title":"Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in CD-1 mice","volume":"108","author":"De Angelis","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2018.09.069_bib14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/jnc.13417","article-title":"Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice","volume":"136","author":"Dolej\u0161\u00ed","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.fct.2018.09.069_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroscience.2011.03.044","article-title":"Acetylcholinesterase inhibitor pretreatment alters stress-induced expression of acetylcholinesterase transcripts in the mouse brain","volume":"183","author":"Dori","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.fct.2018.09.069_bib16","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0022-3565(24)29217-X","article-title":"M2 muscarinic autoreceptors modulate acetylcholine release in prefrontal cortex of C57BL\/6J mouse","volume":"299","author":"Douglas","year":"2001","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.fct.2018.09.069_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408440802272158","article-title":"Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment","volume":"38","author":"Eaton","year":"2008","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.fct.2018.09.069_bib18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","article-title":"Alzheimer's disease: targeting the cholinergic system","volume":"14","author":"Ferreira-Vieira","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.fct.2018.09.069_bib19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.toxlet.2011.11.026","article-title":"The developmental neurotoxicity of organophosphorus insecticides: a direct role for the oxon metabolites","volume":"209","author":"Flaskos","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2018.09.069_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12031-015-0699-y","article-title":"mRNA levels of ACh-related enzymes in the Hippocampus of THY-tau22 mouse: a model of human tauopathy with No signs of motor disturbance","volume":"58","author":"Garc\u00eda-G\u00f3mez","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.fct.2018.09.069_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.fct.2016.11.028","article-title":"Sex-dependent effects of developmental exposure to different pesticides on spatial learning. The role of induced neuroinflammation in the hippocampus","volume":"99","author":"G\u00f3mez-Gim\u00e9nez","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2018.09.069_bib22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.toxlet.2013.11.019","article-title":"A systematic review of neurodevelopmental effects of prenatal and postnatal organophosphate pesticide exposure","volume":"230","author":"Gonz\u00e1lez-Alzaga","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2018.09.069_bib23","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.bcp.2007.05.023","article-title":"Heterogeneity and complexity of native brain nicotinic receptors","volume":"74","author":"Gotti","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2018.09.069_bib24","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1046\/j.1432-1327.1999.00693.x","article-title":"Structural roles of acetylcholinesterase variants in biology and pathology","volume":"264","author":"Grisaru","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.fct.2018.09.069_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2004.09.019","article-title":"Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior","volume":"159","author":"Grootendorst","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.fct.2018.09.069_bib26","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/j.1471-4159.2006.04347.x","article-title":"Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity","volume":"100","author":"Hartmann","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.fct.2018.09.069_bib27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s12031-013-0164-8","article-title":"Reassessment of the role of the central cholinergic system","volume":"53","author":"Hrabovska","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.fct.2018.09.069_bib28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neures.2017.04.016","article-title":"Prefrontal\u2013hippocampal interactions for spatial navigation","volume":"129","author":"Ito","year":"2018","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.fct.2018.09.069_bib29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0300-483X(01)00463-2","article-title":"Biotransformation of organophosphorus compounds","volume":"166","author":"Jokanovi\u0107","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2018.09.069_bib30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0169-328X(99)00047-9","article-title":"Antisense oligodeoxynucleotides against the muscarinic m2, but not m4, receptor supports its role as autoreceptors in the rat hippocampus","volume":"67","author":"Kitaichi","year":"1999","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.fct.2018.09.069_bib31","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s12031-015-0524-7","article-title":"Effect of the M1 muscarinic acetylcholine receptor on retinal neuron number studied with gene-targeted mice","volume":"56","author":"Laspas","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.fct.2018.09.069_bib32","doi-asserted-by":"crossref","first-page":"12126","DOI":"10.1073\/pnas.96.21.12126","article-title":"Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons","volume":"96","author":"L\u00e9na","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.fct.2018.09.069_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuro.2013.11.004","article-title":"Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression","volume":"40","author":"L\u00f3pez-Granero","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.fct.2018.09.069_bib34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tox.2013.03.009","article-title":"Chronic dietary exposure to chlorpyrifos causes behavioral impairments, low activity of brain membrane-bound acetylcholinesterase, and increased brain acetylcholinesterase-R mRNA","volume":"308","author":"L\u00f3pez-Granero","year":"2013","journal-title":"Toxicology"},{"issue":"240","key":"10.1016\/j.fct.2018.09.069_bib35","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"80","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.fct.2018.09.069_bib36","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","article-title":"Apolipoprotein E: far more than a lipid transport protein","volume":"1","author":"Mahley","year":"2000","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"10.1016\/j.fct.2018.09.069_bib37","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/acschemneuro.5b00096","article-title":"Gender differences in spatial learning, synaptic activity, and long-term potentiation in the Hippocampus in rats: molecular mechanisms","volume":"6","author":"Monfort","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.fct.2018.09.069_bib38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.toxlet.2012.11.012","article-title":"Long term compulsivity on the 5-choice serial reaction time task after acute Chlorpyrifos exposure","volume":"216","author":"Montes de Oca","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2018.09.069_bib39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/taap.1997.8354","article-title":"Age-and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats","volume":"149","author":"Moser","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2018.09.069_bib40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.physbeh.2015.03.006","article-title":"Chronic exposure to chlorpyrifos triggered body weight increase and memory impairment depending on human apoE polymorphisms in a targeted replacement mouse model","volume":"144","author":"Peris-Sampedro","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.fct.2018.09.069_bib41","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00204-018-2174-3","article-title":"New mechanistic insights on the metabolic-disruptor role of chlorpyrifos in apoE mice: a focus on insulin- and leptin-signalling pathways","volume":"92","author":"Peris-Sampedro","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2018.09.069_bib42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.envres.2015.06.036","article-title":"Adulthood dietary exposure to a common pesticide leads to an obese-like phenotype and a diabetic profile in apoE3 mice","volume":"142","author":"Peris-Sampedro","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.fct.2018.09.069_bib43","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.fct.2016.03.029","article-title":"Apolipoprotein E (APOE) genotype and the pesticide chlorpyrifos modulate attention, motivation and impulsivity in female mice in the 5-choice serial reaction time task","volume":"92","author":"Peris-Sampedro","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2018.09.069_bib44","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.fct.2014.07.036","article-title":"Impaired retention in A\u03b2PP Swedish mice six months after oral exposure to chlorpyrifos","volume":"72","author":"Peris-Sampedro","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2018.09.069_bib45","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1471-4159.2005.03140.x","article-title":"The readthrough variant of acetylcholinesterase remains very minor after heat shock, organophosphate inhibition and stress, in cell culture and in vivo","volume":"94","author":"Perrier","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.fct.2018.09.069_bib46","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbr.2017.08.034","article-title":"Sex effects on spatial learning but not on spatial memory retrieval in healthy young adults","volume":"336","author":"Piber","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.fct.2018.09.069_bib47","doi-asserted-by":"crossref","first-page":"10914","DOI":"10.1073\/pnas.95.18.10914","article-title":"Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females","volume":"95","author":"Raber","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fct.2018.09.069_bib48","doi-asserted-by":"crossref","first-page":"e1845","DOI":"10.1542\/peds.2006-0338","article-title":"Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 Years of life among inner-city children","volume":"118","author":"Rauh","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.fct.2018.09.069_bib49","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.expneurol.2012.06.015","article-title":"Behavioral phenotype and BDNF differences related to apoE isoforms and sex in young transgenic mice","volume":"237","author":"Reverte","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.fct.2018.09.069_bib50","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00213-015-4113-9","article-title":"Attentional performance, impulsivity, and related neurotransmitter systems in apoE2, apoE3, and apoE4 female transgenic mice","volume":"233","author":"Reverte","year":"2016","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.fct.2018.09.069_bib51","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0041-008X(03)00229-1","article-title":"Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice","volume":"191","author":"Ricceri","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2018.09.069_bib52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/toxsci\/kfl032","article-title":"Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice","volume":"93","author":"Ricceri","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2018.09.069_bib53","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ntt.2004.12.002","article-title":"Neuropsychological effects of long-term exposure to organophosphate pesticides","volume":"27","author":"Rold\u00e1n-Tapia","year":"2005","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.fct.2018.09.069_bib54","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1749-6632.1996.tb32598.x","article-title":"Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences","volume":"802","author":"Roses","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.fct.2018.09.069_bib55","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10071-007-0096-1","article-title":"Sex differences in object location memory and spatial navigation in Long-Evans rats","volume":"11","author":"Saucier","year":"2008","journal-title":"Anim. Cognit."},{"key":"10.1016\/j.fct.2018.09.069_bib56","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.bbr.2010.11.058","article-title":"The cholinergic system in aging and neuronal degeneration","volume":"221","author":"Schliebs","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.fct.2018.09.069_bib57","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00702-006-0579-2","article-title":"The significance of the cholinergic system in the brain during aging and in Alzheimer's disease","volume":"113","author":"Schliebs","year":"2006","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.fct.2018.09.069_bib58","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1289\/ehp.8133","article-title":"Developmental exposures of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood","volume":"113","author":"Slotkin","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2018.09.069_bib59","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0006-8993(01)02387-3","article-title":"Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure","volume":"902","author":"Slotkin","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.fct.2018.09.069_bib60","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.brainresbull.2004.07.005","article-title":"\u03b17 Nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos","volume":"64","author":"Slotkin","year":"2004","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.fct.2018.09.069_bib61","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/35067589","article-title":"Acetylcholinesterase - new roles for an old actor","volume":"2","author":"Soreq","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.fct.2018.09.069_bib70","doi-asserted-by":"crossref","first-page":"17972","DOI":"10.1074\/jbc.272.29.17972","article-title":"Targeted replacement of the mouse apolipoprotein E gene with the common human","volume":"272","author":"Sullivan","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2018.09.069_bib62","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.fct.2016.08.011","article-title":"New challenges in risk assessment of chemicals when simulating real exposure scenarios; simultaneous multi-chemicals\u2019 low dose exposure","volume":"96","author":"Tsatsakis","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2018.09.069_bib63","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1177\/0960327116681652","article-title":"Simulating real-life exposures to uncover possible risks to human health: a proposed consensus for a novel methodological approach","volume":"36","author":"Tsatsakis","year":"2017","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.fct.2018.09.069_bib64","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s11682-013-9272-x","article-title":"Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction","volume":"8","author":"Ungar","year":"2014","journal-title":"Brain Imag. Behav."},{"key":"10.1016\/j.fct.2018.09.069_bib65","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ntt.2008.07.002","article-title":"Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood","volume":"30","author":"Venerosi","year":"2008","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.fct.2018.09.069_bib66","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1006\/taap.1995.1168","article-title":"Developmental neurotoxicity of chlorpyrifos: cellular mechanisms","volume":"134","author":"Whitney","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2018.09.069_bib67","first-page":"1","article-title":"Blastomere removal from cleavage-stage mouse embryos alters placental function, which is associated with placental oxidative stress and inflammation","volume":"6","author":"Yao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2018.09.069_bib68","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1523\/JNEUROSCI.22-05-01709.2002","article-title":"Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice","volume":"22","author":"Zhang","year":"2002","journal-title":"J. Neurosci."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518307130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691518307130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:43:05Z","timestamp":1759527785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691518307130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":70,"alternative-id":["S0278691518307130"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2018.09.069","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2018.09.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}