{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:10:07Z","timestamp":1790784607662,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005187","name":"National and Kapodistrian University of Athens","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005187","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006470","name":"Aristotle University of Thessaloniki","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006470","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.fct.2019.02.016","type":"journal-article","created":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T23:41:49Z","timestamp":1549755709000},"page":"562-565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Serum Bisphenol A concentrations in men with idiopathic infertility"],"prefix":"10.1016","volume":"125","author":[{"given":"Christina","family":"Mantzouki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8841-929X","authenticated-orcid":false,"given":"Despoina","family":"Bliatka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paschalia K.","family":"Iliadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Margeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-3251","authenticated-orcid":false,"given":"Ioannis","family":"Papassotiriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mastorakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Kousta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios G.","family":"Goulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.fct.2019.02.016_bib2","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.fertnstert.2014.01.022","article-title":"Urinary bisphenol A, phthalates, and couple fecundity: the longitudinal investigation of fertility and the environment (LIFE) study","volume":"101","author":"Buck Louis","year":"2014","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.fct.2019.02.016_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1289\/ehp.10753","article-title":"Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.fct.2019.02.016_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuro.2011.11.002","article-title":"Neonatal Bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus","volume":"33","author":"Cao","year":"2012","journal-title":"Neurotoxicology"},{"issue":"4","key":"10.1016\/j.fct.2019.02.016_bib5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an Endocrine Society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.fct.2019.02.016_bib6","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1021\/es303640b","article-title":"Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples: considerations for epidemiological studies","volume":"47","author":"Frederiksen","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2019.02.016_bib7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2605.2005.00563.x","article-title":"Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters","volume":"29","author":"Foster","year":"2006","journal-title":"Int. J. Androl."},{"issue":"6","key":"10.1016\/j.fct.2019.02.016_bib8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.chemosphere.2009.05.024","article-title":"Assessment of human exposure to Bisphenol-A, Triclosan and Tetrabromobisphenol-A through indoor dust intake in Belgium","volume":"76","author":"Geens","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2019.02.016_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.reprotox.2004.06.014","article-title":"The toxic effects of nonylphenol on the reproductive system of male rats","volume":"19","author":"Han","year":"2004","journal-title":"Reprod. Toxicol."},{"issue":"9","key":"10.1016\/j.fct.2019.02.016_bib10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/oem.59.9.625","article-title":"Urinary bisphenol A and plasma hormone concentrations in male workers exposed to bisphenol A diglycidyl ether and mixed organic solvents","volume":"59","author":"Hanaoka","year":"2002","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.fct.2019.02.016_bib11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1289\/ehp.9360","article-title":"Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat","volume":"115","author":"Hass","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2019.02.016_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1385\/ENDO:25:2:163","article-title":"Adverse effects of environmental toxicants, octylphenol and bisphenol A, on male reproductive functions in pubertal rats","volume":"25","author":"Herath","year":"2004","journal-title":"Endocrine"},{"issue":"11","key":"10.1016\/j.fct.2019.02.016_bib13","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1093\/humrep\/17.11.2839","article-title":"Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure","volume":"17","author":"Ikezuki","year":"2002","journal-title":"Hum. Reprod."},{"issue":"Suppl. 1","key":"10.1016\/j.fct.2019.02.016_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/humrep\/13.suppl_1.33","article-title":"Epidemiology and aetiology of male infertility","volume":"13","author":"Irvine","year":"1998","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.fct.2019.02.016_bib15","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/humrep\/14.5.1250","article-title":"Regional differences in waiting time to pregnancy: pregnancy-based surveys from Denmark, France, Germany, Italy and Sweden. The European Infertility and Subfecundity Study Group","volume":"14","author":"Juul","year":"1999","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.fct.2019.02.016_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.etap.2015.06.009","article-title":"A review on endocrine disruptors and their possible impacts on human health","volume":"40","author":"Kabir","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2019.02.016_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.fertnstert.2013.09.030","article-title":"Are urinary bisphenol A levels in men related to semen quality and embryo development after medically assisted reproduction?","volume":"101","author":"Knez","year":"2014","journal-title":"Fertil. Steril."},{"issue":"13","key":"10.1016\/j.fct.2019.02.016_bib18","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1001\/jama.298.13.1499","article-title":"Expert panels weigh bisphenol-A risks","volume":"298","author":"Kuehn","year":"2007","journal-title":"Jama"},{"issue":"6","key":"10.1016\/j.fct.2019.02.016_bib19","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.chemosphere.2006.06.073","article-title":"Measurement of bisphenol A concentrations in human colostrum","volume":"66","author":"Kuruto-Niwa","year":"2007","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.fct.2019.02.016_bib20","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1289\/ehp.1307309","article-title":"Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality","volume":"122","author":"Lassen","year":"2014","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.fct.2019.02.016_bib21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.fertnstert.2010.09.026","article-title":"Urine bisphenol-A (BPA) level in relation to semen quality","volume":"95","author":"Li","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.fct.2019.02.016_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.mce.2006.04.033","article-title":"Endocrine disruptors and reproductive health: the case of bisphenol-A","volume":"254\u2013255","author":"Maffini","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"issue":"4","key":"10.1016\/j.fct.2019.02.016_bib23","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.reprotox.2010.07.005","article-title":"Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic","volume":"30","author":"Meeker","year":"2010","journal-title":"Reprod. Toxicol."},{"issue":"9","key":"10.1016\/j.fct.2019.02.016_bib24","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1289\/ehp.1002037","article-title":"Are environmental levels of bisphenol a associated with reproductive function in fertile men?","volume":"118","author":"Mendiola","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.fct.2019.02.016_bib25","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1021\/acs.est.5b03736","article-title":"Exposure of preschool-age Greek children (RHEA cohort) to bisphenol A, parabens, phthalates, and organophosphates","volume":"50","author":"Myridakis","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2019.02.016_bib26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.reprotox.2007.06.004","article-title":"In vivo effects of bisphenol A in laboratory rodent studies","volume":"24","author":"Richter","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.fct.2019.02.016_bib27","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2605.2009.01049.x","article-title":"Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity","volume":"33","author":"Rider","year":"2010","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.fct.2019.02.016_bib28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tox.2009.09.012","article-title":"Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis","volume":"265","author":"Salian","year":"2009","journal-title":"Toxicology"},{"issue":"11","key":"10.1016\/j.fct.2019.02.016_bib29","doi-asserted-by":"crossref","first-page":"A703","DOI":"10.1289\/ehp.021100703","article-title":"Parent bisphenol A accumulation in the human maternal-fetal-placental unit","volume":"110","author":"Schonfelder","year":"2002","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.fct.2019.02.016_bib30","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0015-0282(02)03105-9","article-title":"Best practice policies for male infertility","volume":"77","author":"Sharlip","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.fct.2019.02.016_bib31","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1289\/ehp.110-1241268","article-title":"Chemical mixtures research: significance and future perspectives","volume":"110","author":"Suk","year":"2002","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.fct.2019.02.016_bib32","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/bmc.345","article-title":"Determination of bisphenol A in human breast milk by HPLC with column-switching and fluorescence detection","volume":"18","author":"Sun","year":"2004","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.fct.2019.02.016_bib33","first-page":"94","article-title":"The effects of low and high doses of bisphenol A on the reproductive system of female and male rat offspring","volume":"40","author":"Talsness","year":"2000","journal-title":"Congenital. Anom."},{"key":"10.1016\/j.fct.2019.02.016_bib34","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1177\/153537020122600309","article-title":"Bisphenol A inhibits testicular functions and increases luteinizing hormone secretion in adult male rats","volume":"226","author":"Tohei","year":"2001","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.fct.2019.02.016_bib35","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.chemosphere.2014.10.044","article-title":"Biomonitoring of bisphenol A in hair of Greek population","volume":"118","author":"Tzatzarakis","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2019.02.016_bib36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to bisphenol a (bpa)","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.fct.2019.02.016_bib37","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.envint.2016.01.021","article-title":"Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic","volume":"89\u201390","author":"Vitku","year":"2016","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.fct.2019.02.016_bib38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.reprotox.2007.07.005","article-title":"Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure","volume":"24","author":"vom Saal","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.fct.2019.02.016_bib39","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.reprotox.2007.05.010","article-title":"In vitro molecular mechanisms of bisphenol a action","volume":"24","author":"Wetherill","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.fct.2019.02.016_bib40","unstructured":"WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland."},{"key":"10.1016\/j.fct.2019.02.016_bib41","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/humupd\/7.3.236","article-title":"Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: evidence for importance of the androgen-oestrogen balance and assessment of the relevance to man","volume":"7","author":"Williams","year":"2001","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.fct.2019.02.016_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2015.01.002","article-title":"Adult exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of the hypothalamic-pituitary-testicular axis","volume":"329","author":"Wisniewski","year":"2015","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.fct.2019.02.016_bib43","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tips.2011.01.001","article-title":"Impacts of environmental toxicants on male reproductive dysfunction","volume":"32","author":"Wong","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.fct.2019.02.016_bib44","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jchromb.2005.11.050","article-title":"Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry","volume":"831","author":"Ye","year":"2006","journal-title":"J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691519300663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691519300663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:50:57Z","timestamp":1759528257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691519300663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":43,"alternative-id":["S0278691519300663"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2019.02.016","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum Bisphenol A concentrations in men with idiopathic infertility","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2019.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}