{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:32:16Z","timestamp":1790811136040,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 106-2320-B-037-018"],"award-info":[{"award-number":["MOST 106-2320-B-037-018"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 106-2314-B-037-072"],"award-info":[{"award-number":["MOST 106-2314-B-037-072"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"E-Da hospital","award":["EDAHP105023"],"award-info":[{"award-number":["EDAHP105023"]}]},{"name":"E-Da hospital","award":["EDAHP106013"],"award-info":[{"award-number":["EDAHP106013"]}]},{"name":"E-Da hospital","award":["EDAHI107005"],"award-info":[{"award-number":["EDAHI107005"]}]},{"name":"E-Da hospital","award":["NCKUEDA10508"],"award-info":[{"award-number":["NCKUEDA10508"]}]},{"name":"\u201cKMU Research Center for Environmental Medicine\u201d"},{"name":"\u201cTMU Research Center of Cancer Translational Medicine\u201d","award":["DP2-107-20000"],"award-info":[{"award-number":["DP2-107-20000"]}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education (MOE) in Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.fct.2019.110700","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T01:58:58Z","timestamp":1564106338000},"page":"110700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-1209","authenticated-orcid":false,"given":"Yung-Ning","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7589-8527","authenticated-orcid":false,"given":"Yu-Chen S.H.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-1299","authenticated-orcid":false,"given":"I-Hsuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2824-6419","authenticated-orcid":false,"given":"Hung-Yun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tsun","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Jong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-Nan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5146-8354","authenticated-orcid":false,"given":"Jau-Ling","family":"Suen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2019.110700_bib1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.immuni.2014.05.012","article-title":"Mining the human gut microbiota for effector strains that shape the immune system","volume":"40","author":"Ahern","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.fct.2019.110700_bib2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.envres.2018.02.039","article-title":"Plasticizer, di(2-ethylhexyl)phthalate (DEHP) enhances cockroach allergen extract-driven airway inflammation by enhancing pulmonary Th2 as well as Th17 immune responses in mice","volume":"164","author":"Alfardan","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.fct.2019.110700_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-food-041715-033151","article-title":"Bosom buddies: the symbiotic relationship between infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and probiotic features","volume":"7","author":"Arboleya","year":"2016","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"10.1016\/j.fct.2019.110700_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aab2271","article-title":"Early infancy microbial and metabolic alterations affect risk of childhood asthma","volume":"7","author":"Arrieta","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.fct.2019.110700_bib5","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.4049\/jimmunol.181.3.1728","article-title":"An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways","volume":"181","author":"Bissonnette","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.fct.2019.110700_bib6","doi-asserted-by":"crossref","first-page":"e429","DOI":"10.1542\/peds.113.5.e429","article-title":"Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit","volume":"113","author":"Calafat","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.fct.2019.110700_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00060-18","article-title":"Gut microbiome analysis identifies potential etiological factors in acute gastroenteritis","volume":"86","author":"Castano-Rodriguez","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fct.2019.110700_bib8","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00253-013-5405-9","article-title":"Bifidobacteria: their impact on gut microbiota composition and their applications as probiotics in infants","volume":"98","author":"Di Gioia","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.fct.2019.110700_bib9","doi-asserted-by":"crossref","first-page":"11971","DOI":"10.1073\/pnas.1002601107","article-title":"Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns","volume":"107","author":"Dominguez-Bello","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fct.2019.110700_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.anaerobe.2011.09.006","article-title":"The impact of perinatal probiotic intervention on gut microbiota: double-blind placebo-controlled trials in Finland and Germany","volume":"18","author":"Grzeskowiak","year":"2012","journal-title":"Anaerobe"},{"key":"10.1016\/j.fct.2019.110700_bib11","article-title":"Pulmonary toxicity and adjuvant effect of di-(2-exylhexyl) phthalate in ovalbumin-immunized BALB\/c mice","volume":"7","author":"Guo","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2019.110700_bib12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tox.2014.07.011","article-title":"Di-(2-ethylhexyl) phthalate adjuvantly induces imbalanced humoral immunity in ovalbumin-sensitized BALB\/c mice ascribing to T follicular helper cells hyperfunction","volume":"324","author":"Han","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2019.110700_bib13","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/oem.2004.017590","article-title":"Phthalates and human health","volume":"62","author":"Hauser","year":"2005","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.fct.2019.110700_bib14","article-title":"Fetal and childhood exposure to phthalate diesters and cognitive function in children up to 12 Years of age: Taiwanese maternal and infant cohort study","volume":"10","author":"Huang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2019.110700_bib15","article-title":"Age and gender differences in urinary levels of eleven phthalate metabolites in general Taiwanese population after a DEHP episode","volume":"10","author":"Huang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2019.110700_bib16","doi-asserted-by":"crossref","first-page":"e362","DOI":"10.1542\/peds.2013-3937","article-title":"Stool microbiota and vaccine responses of infants","volume":"134","author":"Huda","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.fct.2019.110700_bib17","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1159\/000111102","article-title":"Mode of delivery - effects on gut microbiota and humoral immunity","volume":"93","author":"Huurre","year":"2008","journal-title":"Neonatology"},{"key":"10.1016\/j.fct.2019.110700_bib18","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jaci.2017.03.017","article-title":"Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications","volume":"141","author":"Jahreis","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fct.2019.110700_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jhazmat.2014.06.055","article-title":"A comprehensive assessment of human exposure to phthalates from environmental media and food in Tianjin, China","volume":"279","author":"Ji","year":"2014","journal-title":"J. Hazard Mater."},{"issue":"Suppl. 1","key":"10.1016\/j.fct.2019.110700_bib20","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1073\/pnas.1000081107","article-title":"Succession of microbial consortia in the developing infant gut microbiome","volume":"108","author":"Koenig","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fct.2019.110700_bib21","doi-asserted-by":"crossref","first-page":"A440","DOI":"10.1289\/ehp.108-a440b","article-title":"Human exposure estimates for phthalates","volume":"108","author":"Kohn","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2019.110700_bib22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1289\/ehp.10498","article-title":"The association between phthalates in dust and allergic diseases among Bulgarian children","volume":"116","author":"Kolarik","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2019.110700_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.tox.2007.03.010","article-title":"Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB\/c mice","volume":"235","author":"Larsen","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2019.110700_bib24","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.envpol.2017.10.030","article-title":"Di-(2-ethylhexyl) phthalate enhances melanoma tumor growth via differential effect on M1-and M2-polarized macrophages in mouse model","volume":"233","author":"Lee","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2019.110700_bib25","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.chemosphere.2010.10.073","article-title":"Phthalate exposure in pregnant women and their children in central Taiwan","volume":"82","author":"Lin","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2019.110700_bib26","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1053\/jpsu.2000.19249","article-title":"Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers","volume":"35","author":"Loff","year":"2000","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.fct.2019.110700_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10937400903094091","article-title":"Reproductive and developmental toxicity of phthalates","volume":"12","author":"Lyche","year":"2009","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.fct.2019.110700_bib28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/sj.jes.7500614","article-title":"Creatinine corrections for estimating children's and adult's pesticide intake doses in equilibrium with urinary pesticide and creatinine concentrations","volume":"18","author":"Mage","year":"2008","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.fct.2019.110700_bib29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2180-9-123","article-title":"The Firmicutes\/Bacteroidetes ratio of the human microbiota changes with age","volume":"9","author":"Mariat","year":"2009","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.fct.2019.110700_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tim.2012.12.001","article-title":"Development of intestinal microbiota in infants and its impact on health","volume":"21","author":"Matamoros","year":"2013","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.fct.2019.110700_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.aller.2015.01.013","article-title":"Intestinal microbiota and allergic diseases: a systematic review","volume":"44","author":"Melli","year":"2016","journal-title":"Allergol. Immunopathol."},{"key":"10.1016\/j.fct.2019.110700_bib32","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1001\/jamapediatrics.2017.0378","article-title":"Association between breast milk bacterial communities and establishment and development of the infant gut microbiome","volume":"171","author":"Pannaraj","year":"2017","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.fct.2019.110700_bib33","author":"SCENIHR"},{"key":"10.1016\/j.fct.2019.110700_bib34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1203\/PDR.0b013e3181e5c1f7","article-title":"Inflammatory effects of phthalates in neonatal neutrophils","volume":"68","author":"Vetrano","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.fct.2019.110700_bib35","article-title":"Transplacentally acquired maternal antibody against hepatitis B surface antigen in infants and its influence on the response to hepatitis B vaccine","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2019.110700_bib36","doi-asserted-by":"crossref","first-page":"13754","DOI":"10.1021\/es403141u","article-title":"Temporal changes of urinary oxidative metabolites of di(2-ethylhexyl)phthalate after the 2011 phthalate incident in Taiwanese children: findings of a six month follow-up","volume":"47","author":"Wu","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2019.110700_bib37","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1016\/j.vaccine.2018.04.066","article-title":"The influence of the intestinal microbiome on vaccine responses","volume":"36","author":"Zimmermann","year":"2018","journal-title":"Vaccine"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691519304909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691519304909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:55:45Z","timestamp":1759528545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691519304909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":37,"alternative-id":["S0278691519304909"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2019.110700","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2019.110700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110700"}}