{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:12:32Z","timestamp":1790777552937,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["IRG5980006"],"award-info":[{"award-number":["IRG5980006"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["IRN60W0004"],"award-info":[{"award-number":["IRN60W0004"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.fct.2019.110915","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T11:42:14Z","timestamp":1572003734000},"page":"110915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Protective roles of trigonelline against oxalate-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells: An in vitro study"],"prefix":"10.1016","volume":"135","author":[{"given":"Paleerath","family":"Peerapen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7865-0765","authenticated-orcid":false,"given":"Visith","family":"Thongboonkerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2019.110915_bib1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrneph.2015.133","article-title":"Fibrosis: targeting EMT to reverse renal fibrosis","volume":"11","author":"Allison","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.fct.2019.110915_bib2","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/mnfr.201000147","article-title":"Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines","volume":"54","author":"Bakuradze","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2019.110915_bib3","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/ki.2009.102","article-title":"Twist: a new link from hypoxia to fibrosis","volume":"75","author":"Bechtel","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.fct.2019.110915_bib4","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1038\/sj.emboj.7601421","article-title":"Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney","volume":"25","author":"Boutet","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.fct.2019.110915_bib5","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1242\/dev.139071","article-title":"A common framework for EMT and collective cell migration","volume":"143","author":"Campbell","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.fct.2019.110915_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00441-011-1227-1","article-title":"The role of EMT in renal fibrosis","volume":"347","author":"Carew","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.fct.2019.110915_bib7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.molcel.2009.04.029","article-title":"Direct interaction between Nrf2 and p21(Cip1\/WAF1) upregulates the Nrf2-mediated antioxidant response","volume":"34","author":"Chen","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.fct.2019.110915_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18040776","article-title":"MMP-2 and 9 in chronic kidney disease","volume":"18","author":"Cheng","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2019.110915_bib9","first-page":"151","article-title":"Quantitative trait loci associated with foliar trigonelline accumulation in Glycine max L","volume":"2","author":"Cho","year":"2002","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.fct.2019.110915_bib10","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.18632\/oncotarget.1940","article-title":"ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-kB-dependent activation of Snail","volume":"5","author":"Cichon","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.fct.2019.110915_bib11","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.matbio.2017.12.013","article-title":"Renal fibrosis: recent translational aspects","volume":"68-69","author":"Francois","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.fct.2019.110915_bib12","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.intimp.2012.10.004","article-title":"Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats","volume":"14","author":"Ghule","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2019.110915_bib13","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nm.3901","article-title":"Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease","volume":"21","author":"Grande","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.fct.2019.110915_bib14","doi-asserted-by":"crossref","first-page":"232791","DOI":"10.1155\/2015\/232791","article-title":"Hypoxia-induced epithelial-mesenchymal transition is involved in Bleomycin-induced lung fibrosis","volume":"2015","author":"Guo","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.fct.2019.110915_bib15","doi-asserted-by":"crossref","first-page":"C1058","DOI":"10.1152\/ajpcell.00063.2004","article-title":"Oxalate inhibits renal proximal tubule cell proliferation via oxidative stress, p38 MAPK\/JNK, and cPLA2 signaling pathways","volume":"287","author":"Han","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.fct.2019.110915_bib16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.molmed.2015.11.009","article-title":"Epithelial plasticity versus EMT in kidney fibrosis","volume":"22","author":"Huang","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.fct.2019.110915_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1995-7645(14)60328-X","article-title":"Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells","volume":"8","author":"Ilavenil","year":"2015","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"Suppl. 14","key":"10.1016\/j.fct.2019.110915_bib18","first-page":"S446","article-title":"Oxalate-induced changes in the viability and growth of human renal epithelial cells","volume":"10","author":"Jonassen","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.fct.2019.110915_bib19","doi-asserted-by":"crossref","first-page":"462361","DOI":"10.1155\/2013\/462361","article-title":"NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys","volume":"2013","author":"Joshi","year":"2013","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.fct.2019.110915_bib20","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.fct.2019.110915_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jprot.2013.01.001","article-title":"Cellular adaptive response of distal renal tubular cells to high-oxalate environment highlights surface alpha-enolase as the enhancer of calcium oxalate monohydrate crystal adhesion","volume":"80","author":"Kanlaya","year":"2013","journal-title":"J. Proteomics"},{"key":"10.1016\/j.fct.2019.110915_bib22","doi-asserted-by":"crossref","first-page":"30233","DOI":"10.1038\/srep30233","article-title":"Protective effect of epigallocatechin-3-gallate (EGCG) via Nrf2 pathway against oxalate-induced epithelial mesenchymal transition (EMT) of renal tubular cells","volume":"6","author":"Kanlaya","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2019.110915_bib23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00425-009-1023-2","article-title":"Profiles of the biosynthesis and metabolism of pyridine nucleotides in potatoes (Solanum tuberosum L.)","volume":"231","author":"Katahira","year":"2009","journal-title":"Planta"},{"key":"10.1016\/j.fct.2019.110915_bib24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1369\/jhc.6A7157.2007","article-title":"Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney","volume":"55","author":"Kida","year":"2007","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.fct.2019.110915_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1465-9921-11-31","article-title":"Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1\/Th2 balance","volume":"11","author":"Kikuchi","year":"2010","journal-title":"Respir. Res."},{"key":"10.1016\/j.fct.2019.110915_bib26","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.7314\/APJCP.2013.14.6.3625","article-title":"Hydrogen peroxide promotes epithelial to mesenchymal transition and stemness in human malignant mesothelioma cells","volume":"14","author":"Kim","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.fct.2019.110915_bib27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fct.2019.110915_bib28","doi-asserted-by":"crossref","first-page":"29884","DOI":"10.3402\/fnr.v59.29884","article-title":"Raf\/ERK\/Nrf2 signaling pathway and MMP-7 expression involvement in the trigonelline-mediated inhibition of hepatocarcinoma cell migration","volume":"59","author":"Liao","year":"2015","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.fct.2019.110915_bib29","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000481668","article-title":"High uric acid-induced epithelial-mesenchymal transition of renal tubular epithelial cells via the TLR4\/NF-kB signaling pathway","volume":"46","author":"Liu","year":"2017","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.fct.2019.110915_bib30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/emmm.200900043","article-title":"Inflammation and EMT: an alliance towards organ fibrosis and cancer progression","volume":"1","author":"Lopez-Novoa","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.fct.2019.110915_bib31","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis","volume":"21","author":"Lovisa","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.fct.2019.110915_bib32","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.tem.2016.06.004","article-title":"Partial epithelial-to-mesenchymal transition and other new mechanisms of kidney fibrosis","volume":"27","author":"Lovisa","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.fct.2019.110915_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-017-3000-6","article-title":"CLDN-1 promoted the epithelial to migration and mesenchymal transition (EMT) in human bronchial epithelial cells via Notch pathway","volume":"432","author":"Lv","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.fct.2019.110915_bib34","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/jcp.24922","article-title":"Chronic oxidative stress leads to malignant transformation along with acquisition of stem cell characteristics, and epithelial to mesenchymal transition in human renal epithelial cells","volume":"230","author":"Mahalingaiah","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.fct.2019.110915_bib35","doi-asserted-by":"crossref","first-page":"28808","DOI":"10.1038\/srep28808","article-title":"Alpha-tubulin enhanced renal tubular cell proliferation and tissue repair but reduced cell death and cell-crystal adhesion","volume":"6","author":"Manissorn","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2019.110915_bib36","doi-asserted-by":"crossref","first-page":"F785","DOI":"10.1152\/ajprenal.00488.2015","article-title":"Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL\/6 mice","volume":"310","author":"Mulay","year":"2016","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.fct.2019.110915_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800008","article-title":"Protein network analysis and functional studies of calcium oxalate crystal-induced cytotoxicity in renal tubular epithelial cells","volume":"18","author":"Peerapen","year":"2018","journal-title":"Proteomics"},{"key":"10.1016\/j.fct.2019.110915_bib38","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.taap.2007.09.016","article-title":"Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid","volume":"226","author":"Pi","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2019.110915_bib39","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1096\/fj.201600426R","article-title":"Lamin A\/C in renal tubular cells is important for tissue repair, cell proliferation, and calcium oxalate crystal adhesion, and is associated with potential crystal receptors","volume":"30","author":"Pongsakul","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.fct.2019.110915_bib40","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1681\/ASN.2004050425","article-title":"Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells","volume":"16","author":"Rhyu","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.fct.2019.110915_bib41","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1021\/acs.jafc.5b00530","article-title":"Influence of coffee genotype on bioactive compounds and the in vitro capacity to scavenge reactive oxygen and nitrogen species","volume":"63","author":"Rodrigues","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2019.110915_bib42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/2229-4708.90354","article-title":"A validated RP-HPLC method for quantitation of trigonelline from herbal formulations containing Trigonella foenum-graecum (L.) seeds","volume":"2","author":"Shailajan","year":"2011","journal-title":"Pharm. Methods"},{"key":"10.1016\/j.fct.2019.110915_bib43","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.3892\/mmr.2016.5744","article-title":"Molecular mechanisms of melatonin in the reversal of LPS-induced EMT in peritoneal mesothelial cells","volume":"14","author":"Shi","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.fct.2019.110915_bib44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jprot.2018.06.015","article-title":"Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix","volume":"185","author":"Singhto","year":"2018","journal-title":"J. Proteomics"},{"key":"10.1016\/j.fct.2019.110915_bib45","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fimmu.2018.00316","article-title":"Roles of macrophage exosomes in immune response to calcium oxalate monohydrate crystals","volume":"9","author":"Singhto","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fct.2019.110915_bib46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2147\/JIR.S128292","article-title":"Oxidant-induced autophagy and ferritin degradation contribute to epithelial-mesenchymal transition through lysosomal iron","volume":"10","author":"Sioutas","year":"2017","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.fct.2019.110915_bib47","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201802720RR","article-title":"ARID1A knockdown triggers epithelial-mesenchymal transition and carcinogenesis features of renal cells: role in renal cell carcinoma","author":"Somsuan","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.fct.2019.110915_bib48","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00441-016-2464-0","article-title":"Epithelial-mesenchymal transition in tissue repair and fibrosis","volume":"365","author":"Stone","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.fct.2019.110915_bib49","first-page":"1194","article-title":"Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C","volume":"16","author":"Tanaka","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.fct.2019.110915_bib50","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11010-014-2152-x","article-title":"Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARgamma activity in type 2 diabetic rats","volume":"396","author":"Tharaheswari","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.fct.2019.110915_bib51","first-page":"163","article-title":"Assessment of gelatinases (MMP-2 and MMP-9 by gelatin zymography","volume":"57","author":"Toth","year":"2001","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.fct.2019.110915_bib52","doi-asserted-by":"crossref","first-page":"24389","DOI":"10.1038\/srep24389","article-title":"Epithelial cell migration requires the interaction between the vimentin and keratin intermediate filaments","volume":"6","author":"Velez-delValle","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2019.110915_bib53","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00018-017-2699-2","article-title":"Characterizations of PMCA2-interacting complex and its role as a calcium oxalate crystal-binding protein","volume":"75","author":"Vinaiphat","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.fct.2019.110915_bib54","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1383-5718(97)00065-X","article-title":"Trigonelline, a naturally occurring constituent of green coffee beans behind the mutagenic activity of roasted coffee?","volume":"391","author":"Wu","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2019.110915_bib55","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.fct.2019.110915_bib56","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1038\/sj.onc.1209712","article-title":"Transforming growth factor-beta1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism","volume":"25","author":"Yang","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.fct.2019.110915_bib57","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/antiox2040230","article-title":"Antioxidant and antiradical activity of coffee","volume":"2","author":"Yashin","year":"2013","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2019.110915_bib58","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1271\/bbb.80805","article-title":"Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats","volume":"73","author":"Yoshinari","year":"2009","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.fct.2019.110915_bib59","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbrc.2007.07.146","article-title":"Snail1 is involved in the renal epithelial-mesenchymal transition","volume":"362","author":"Yoshino","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2019.110915_bib60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41419-017-0198-x","article-title":"Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2019.110915_bib61","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12860-016-0101-0","article-title":"Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells","volume":"17","author":"Zhao","year":"2016","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.fct.2019.110915_bib62","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/ndt\/gfw308","article-title":"Matrix metalloproteinase 9-dependent Notch signaling contributes to kidney fibrosis through peritubular endothelial-mesenchymal transition","volume":"32","author":"Zhao","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.fct.2019.110915_bib63","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrneph.2015.215","article-title":"Renal fibrosis in 2015: understanding the mechanisms of kidney fibrosis","volume":"12","author":"Zhou","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.fct.2019.110915_bib64","first-page":"164219","article-title":"Protection of trigonelline on experimental diabetic peripheral neuropathy","volume":"2012","author":"Zhou","year":"2012","journal-title":"Evid. Based Compl. Altern. Med."},{"key":"10.1016\/j.fct.2019.110915_bib65","doi-asserted-by":"crossref","first-page":"38646","DOI":"10.1038\/srep38646","article-title":"Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2019.110915_bib66","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000479088","article-title":"Trigonelline inhibits inflammation and protects beta cells to prevent fetal growth restriction during pregnancy in a mouse model of diabetes","volume":"100","author":"Zhou","year":"2017","journal-title":"Pharmacology"},{"key":"10.1016\/j.fct.2019.110915_bib67","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s11302-017-9571-6","article-title":"Modulation of the TGF-beta1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells","volume":"13","author":"Zuccarini","year":"2017","journal-title":"Purinergic Signal."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691519307057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691519307057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:46:21Z","timestamp":1777545981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691519307057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":67,"alternative-id":["S0278691519307057"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2019.110915","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective roles of trigonelline against oxalate-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells: An in vitro study","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2019.110915","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110915"}}