{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:26:39Z","timestamp":1790126799711,"version":"4.0.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007292","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.fct.2020.111126","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T11:26:36Z","timestamp":1579173996000},"page":"111126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["Development of TPGS\/F127\/F68 mixed polymeric micelles: Enhanced oral bioavailability and hepatoprotection of syringic acid against carbon tetrachloride-induced hepatotoxicity"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-5417","authenticated-orcid":false,"given":"Congyong","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2686-2472","authenticated-orcid":false,"given":"Huiyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-4261","authenticated-orcid":false,"given":"Michael","family":"Adu-Frimpong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangnan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-6226","authenticated-orcid":false,"given":"Ximing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.fct.2020.111126_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijpharm.2016.02.027","article-title":"In situ gelling systems based on Pluronic F127\/Pluronic F68 formulations for ocular drug delivery","volume":"502","author":"Al Khateb","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.fct.2020.111126_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.colsurfb.2018.11.077","article-title":"Rational design of polymer-lipid nanoparticles for docetaxel delivery","volume":"175","author":"Albano","year":"2019","journal-title":"Colloids Surfaces B Biointerfaces"},{"issue":"4","key":"10.1016\/j.fct.2020.111126_bib3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/mp800051m","article-title":"Factors affecting the clearance and biodistribution of polymeric nanoparticles","volume":"5","author":"Alexis","year":"2008","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.fct.2020.111126_bib4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cocis.2010.10.003","article-title":"Mixed micelles self-assembled from block copolymers for drug delivery","volume":"16","author":"Attia","year":"2011","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.fct.2020.111126_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03639045.2019.1576726","article-title":"Chrysin loaded folate conjugated PF127-F68 mixed micelles with enhanced oral bioavailabilty and anticancer activity against human breast cancer cells","volume":"45","author":"Baidya","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.fct.2020.111126_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.colsurfb.2013.07.036","article-title":"Paclitaxel-loaded PCL-TPGS nanoparticles: in vitro and in vivo performance compared with Abraxane (R)","volume":"113","author":"Bernabeu","year":"2014","journal-title":"Colloids Surfaces B Biointerfaces"},{"issue":"2","key":"10.1016\/j.fct.2020.111126_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/138920010791110836","article-title":"Nanocarriers: a general strategy for enhancement of oral bioavailability of poorly absorbed or pre-systemically metabolized drugs","volume":"11","author":"Cai","year":"2010","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.fct.2020.111126_bib8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.foodchem.2015.10.100","article-title":"Antimicrobial activity of syringic acid against Cronobacter sakazakii and its effect on cell membrane","volume":"197","author":"Chao","year":"2016","journal-title":"Food Chem."},{"issue":"29","key":"10.1016\/j.fct.2020.111126_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1088\/0957-4484\/25\/29\/295103","article-title":"In vitro and in vivo CT imaging using bismuth sulfide modified with a highly biocompatible Pluronic F127","volume":"25","author":"Chen","year":"2014","journal-title":"Nanotechnology"},{"issue":"1","key":"10.1016\/j.fct.2020.111126_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2217\/nnm.09.90","article-title":"Efavirenz-loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significantly higher oral bioavailaibility","volume":"5","author":"Chiappetta","year":"2010","journal-title":"Nanomedicine"},{"issue":"2","key":"10.1016\/j.fct.2020.111126_bib11","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.phrs.2010.01.014","article-title":"Magnetic nanoparticles and targeted drug delivering","volume":"62","author":"Chomoucka","year":"2010","journal-title":"Pharmacol. Res."},{"issue":"1\u20132","key":"10.1016\/j.fct.2020.111126_bib12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijpharm.2013.10.055","article-title":"Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability from a nanoemulsion platform","volume":"460","author":"Choudhury","year":"2014","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.fct.2020.111126_bib13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1021\/mp060121r","article-title":"Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity","volume":"4","author":"Collnot","year":"2007","journal-title":"Mol. Pharm."},{"issue":"12","key":"10.1016\/j.fct.2020.111126_bib14","doi-asserted-by":"crossref","first-page":"21154","DOI":"10.3390\/molecules191221154","article-title":"In vitro and in vivo evaluation of the antioxidant and prooxidant activity of phenolic compounds obtained from grape (Vitis vinifera) pomace","volume":"19","author":"Cotoras","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2020.111126_bib15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.colsurfb.2015.02.007","article-title":"Novel in situ gel systems based on P123\/TPGS mixed micelles and gellan gum for ophthalmic delivery of curcumin","volume":"128","author":"Duan","year":"2015","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"10.1016\/j.fct.2020.111126_bib16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.colsurfb.2016.01.017","article-title":"Evaluation in vitro and in vivo of curcumin-loaded mPEG-PLA\/TPGS mixed micelles for oral administration","volume":"141","author":"Duan","year":"2016","journal-title":"Colloids Surfaces B Biointerfaces"},{"issue":"3","key":"10.1016\/j.fct.2020.111126_bib17","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/bmc.3566","article-title":"An efficient in vitro and in vivo HPLC method for hydnocarpin in nanomicelles formulation","volume":"30","author":"Feng","year":"2016","journal-title":"Biomed. Chromatogr."},{"issue":"1\u20132","key":"10.1016\/j.fct.2020.111126_bib18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ijpharm.2016.01.081","article-title":"Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation","volume":"501","author":"Feng","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"18","key":"10.1016\/j.fct.2020.111126_bib19","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1039\/C4AY01203H","article-title":"Comparison of different characterization methods for nanoparticle dispersions before and after aerosolization","volume":"6","author":"Fissan","year":"2014","journal-title":"Anal. Methods"},{"issue":"2\u20133","key":"10.1016\/j.fct.2020.111126_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ejps.2008.01.016","article-title":"Preparation and characterization of novel polymeric micelles for 9-nitro-20(S)-camptothecin delivery","volume":"34","author":"Gao","year":"2008","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.fct.2020.111126_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jpba.2018.10.027","article-title":"Restorative activity of aqueous extract Mangifera indica leaves against CCl4 induced hepatic damage in rats","volume":"164","author":"Gazwi","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"5","key":"10.1016\/j.fct.2020.111126_bib22","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.3109\/10717544.2015.1108374","article-title":"Liver-targeting self-assembled hyaluronic acid-glycyrrhetinic acid micelles enhance hepato-protective effect of silybin after oral administration","volume":"23","author":"Han","year":"2016","journal-title":"Drug Deliv."},{"issue":"1","key":"10.1016\/j.fct.2020.111126_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/la501789z","article-title":"Making sense of Brownian motion: colloid characterization by dynamic light scattering","volume":"31","author":"Hassan","year":"2015","journal-title":"Langmuir"},{"issue":"2","key":"10.1016\/j.fct.2020.111126_bib24","first-page":"255","article-title":"Effect of zeta potential on the properties of nano-drug delivery systems - a review (Part 1)","volume":"12","author":"Honary","year":"2013","journal-title":"Trop. J. Pharm. Res."},{"issue":"6","key":"10.1016\/j.fct.2020.111126_bib25","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2217\/nnm.16.5","article-title":"The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction","volume":"11","author":"Hoshyar","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.fct.2020.111126_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejps.2014.07.007","article-title":"The efficacy of nimodipine drug delivery using mPEG-PLA micelles and mPEG-PLA\/TPGS mixed micelles","volume":"63","author":"Huang","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.fct.2020.111126_bib27","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1248\/bpb.33.983","article-title":"Hepatoprotective effect of syringic acid and vanillic acid on CCl4-induced liver injury","volume":"33","author":"Itoh","year":"2010","journal-title":"Biol. Pharm. Bull."},{"issue":"15","key":"10.1016\/j.fct.2020.111126_bib28","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.addr.2008.09.002","article-title":"Polyoxyethylated nonionic surfactants and their applications in topical ocular drug delivery","volume":"60","author":"Jiao","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.fct.2020.111126_bib29","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1039\/C5FO01329A","article-title":"Anti-steatotic and anti-inflammatory roles of syringic acid in high-fat diet-induced obese mice","volume":"7","author":"Ju Ri","year":"2016","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.fct.2020.111126_bib30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0169-409X(02)00176-X","article-title":"Pluronic((R)) block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier","volume":"55","author":"Kabanov","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.fct.2020.111126_bib31","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.nano.2010.12.002","article-title":"A nanoemulsion formulation of dacarbazine reduces tumor size in a xenograft mouse epidermoid carcinoma model compared to dacarbazine suspension","volume":"7","author":"Kakumanu","year":"2011","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.fct.2020.111126_bib32","first-page":"165","article-title":"Comparison of radical-scavenging activities for selected phenolic acids","volume":"55","author":"Karama\u0107","year":"2005","journal-title":"Pol. J. Food Nutr. Sci."},{"key":"10.1016\/j.fct.2020.111126_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0168-3659(93)90172-2","article-title":"Block copolymer micelles as vehicles for drug delivery","volume":"24","author":"Kataoka","year":"1993","journal-title":"J. Control. Release"},{"issue":"1\u20132","key":"10.1016\/j.fct.2020.111126_bib34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijpharm.2016.12.047","article-title":"Optimization and evaluation of Oridonin-loaded Soluplus (R)-Pluronic P105 mixed micelles for oral administration","volume":"518","author":"Ke","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.fct.2020.111126_bib35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.colsurfb.2010.06.017","article-title":"Effect of porous silica on sustained release behaviors of pH sensitive Pluronic F127\/poly(acrylic acid) hydrogels containing tulobuterol","volume":"80","author":"Kim","year":"2010","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"10.1016\/j.fct.2020.111126_bib36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cis.2015.04.006","article-title":"Nanocarriers for the delivery of active ingredients and fractions extracted from natural products used in traditional Chinese medicine (TCM)","volume":"221","author":"Liu","year":"2015","journal-title":"Adv. Colloid Interface Sci."},{"issue":"29","key":"10.1016\/j.fct.2020.111126_bib37","doi-asserted-by":"crossref","first-page":"9138","DOI":"10.1021\/la401556k","article-title":"Surface and size effects on cell interaction of gold nanoparticles with both phagocytic and nonphagocytic cells","volume":"29","author":"Liu","year":"2013","journal-title":"Langmuir"},{"issue":"3","key":"10.1016\/j.fct.2020.111126_bib38","doi-asserted-by":"crossref","DOI":"10.1208\/s12249-019-1290-6","article-title":"Preparation and characterization of syringic acid-loaded TPGS liposome with enhanced oral bioavailability and in vivo antioxidant efficiency","volume":"20","author":"Liu","year":"2019","journal-title":"AAPS PharmSciTech"},{"issue":"7","key":"10.1016\/j.fct.2020.111126_bib39","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1021\/mp400175n","article-title":"Mediation of in vitro cytochrome P450 activity by common pharmaceutical excipients","volume":"10","author":"Martin","year":"2013","journal-title":"Mol. Pharm."},{"issue":"8","key":"10.1016\/j.fct.2020.111126_bib40","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/lt.24784","article-title":"Mesenchymal stem cells attenuate acute liver injury by altering ratio between interleukin 17 producing and regulatory natural killer T cells","volume":"23","author":"Milosavljevic","year":"2017","journal-title":"Liver Transplant."},{"issue":"2","key":"10.1016\/j.fct.2020.111126_bib41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jct.2006.06.014","article-title":"Temperature and salt addition effects on the solubility behaviour of some phenolic compounds in water","volume":"39","author":"Noubigh","year":"2007","journal-title":"J. Chem. Thermodyn."},{"issue":"1\u20132","key":"10.1016\/j.fct.2020.111126_bib42","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijpharm.2005.10.044","article-title":"On the use of the Weibull function for the discernment of drug release mechanisms","volume":"309","author":"Papadopoulou","year":"2006","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.fct.2020.111126_bib43","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.colsurfb.2011.04.015","article-title":"Interaction and solubilization of some phenolic antioxidants in Pluronic (R) micelles","volume":"86","author":"Parmar","year":"2011","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"10.1016\/j.fct.2020.111126_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108691","article-title":"Galangin loaded galactosylated pluronic F68 polymeric micelles for liver targeting","volume":"112","author":"Patil","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"32","key":"10.1016\/j.fct.2020.111126_bib45","doi-asserted-by":"crossref","first-page":"1801074","DOI":"10.1002\/adfm.201801074","article-title":"Gd43+[AlPCS4]34\u2212 nanoagent generating 1O2 for photodynamic therapy","volume":"28","author":"Po\u00df","year":"2018","journal-title":"Adv. Funct. Mater."},{"issue":"4","key":"10.1016\/j.fct.2020.111126_bib46","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S1360-1385(97)01018-2","article-title":"Antioxidant properties of phenolic compounds","volume":"2","author":"Rice-Evans","year":"1997","journal-title":"Trends Plant Sci."},{"issue":"4","key":"10.1016\/j.fct.2020.111126_bib47","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3109\/0886022X.2016.1149868","article-title":"Protective effect of syringic acid on kidney ischemia-reperfusion injury","volume":"38","author":"Sancak","year":"2016","journal-title":"Ren. Fail."},{"key":"10.1016\/j.fct.2020.111126_bib48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2019.01.056","article-title":"Syringic acid protects from isoproterenol induced cardiotoxicity in rats","volume":"849","author":"Shahzad","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.fct.2020.111126_bib49","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ijpharm.2015.10.009","article-title":"Co-delivery of docetaxel and chloroquine via PEO-PPO-PCL\/TPGS micelles for overcoming multidrug resistance","volume":"495","author":"Shi","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.fct.2020.111126_bib50","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1248\/cpb.56.468","article-title":"Experimental and theoretical studies on the inclusion complexation of syringic acid with alpha-, beta-, gamma- and heptakis(2,6-di-O-methyl)-beta-cyclodextrin","volume":"56","author":"Song","year":"2008","journal-title":"Chem. Pharmaceut. Bull."},{"issue":"4","key":"10.1016\/j.fct.2020.111126_bib51","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bionut.2014.07.010","article-title":"Antihyperglycemic effect of syringic acid on attenuating the key enzymes of carbohydrate metabolism in experimental diabetic rats","volume":"4","author":"Srinivasan","year":"2014","journal-title":"Biomed. Prev. Nutr."},{"key":"10.1016\/j.fct.2020.111126_bib52","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bcp.2018.06.007","article-title":"Syringic acid prevents skin carcinogenesis via regulation of NoX and EGFR signaling","volume":"154","author":"Su Jeong","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.fct.2020.111126_bib53","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/jphp.12134","article-title":"Size- dependent internalisation of folate- decorated nanoparticles via the pathways of clathrin and caveolae- mediated endocytosis in ARPE-19 cells","volume":"66","author":"Suen","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2020.111126_bib54","first-page":"41","article-title":"An efficient HPLC method for determination of syringic acid liposome in rats plasma and mice tissue: pharmacokinetic and biodistribution application","volume":"14","author":"Sun","year":"2018","journal-title":"Curr. Pharmaceut. Anal."},{"key":"10.1016\/j.fct.2020.111126_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.05.039","article-title":"In vitro\/in vivo hepatoprotective properties of 1-O-(4-hydroxymethylphenyl)-\u03b1-L-rhamnopyranoside from Moringa oleifera seeds against carbon tetrachloride-induced hepatic injury","volume":"131","author":"Sun","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"11","key":"10.1016\/j.fct.2020.111126_bib56","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0142-9612(93)90004-L","article-title":"Surface modification of nanoparticles by PEO\/PPO block copolymers to minimize interactions with blood components and prolong blood circulation in rats","volume":"14","author":"Tan","year":"1993","journal-title":"Biomaterials"},{"key":"10.1016\/j.fct.2020.111126_bib57","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molliq.2018.10.089","article-title":"Pluronic F127\/Pluronic P123\/vitamin E TPGS mixed micelles for oral delivery of mangiferin and quercetin: mixture-design optimization, micellization, and solubilization behavior","volume":"274","author":"Thanitwatthanasak","year":"2019","journal-title":"J. Mol. Liq."},{"issue":"8","key":"10.1016\/j.fct.2020.111126_bib58","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1021\/acs.cgd.6b00750","article-title":"Syringic acid: structural elucidation and Co-crystallization","volume":"16","author":"Thipparaboina","year":"2016","journal-title":"Cryst. Growth Des."},{"issue":"5","key":"10.1016\/j.fct.2020.111126_bib59","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s10753-015-0177-2","article-title":"The neuroprotective effect of syringic acid on spinal cord ischemia\/reperfusion injury in rats","volume":"38","author":"Tokmak","year":"2015","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.fct.2020.111126_bib60","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/pharmaceutics11030132","article-title":"Overview of the manufacturing methods of solid dispersion Technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs","volume":"11","author":"Tran","year":"2019","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.fct.2020.111126_bib61","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.jconrel.2013.08.006","article-title":"Stability of nanosuspensions in drug delivery","volume":"172","author":"Wang","year":"2013","journal-title":"J. Control. Release"},{"issue":"1\u20132","key":"10.1016\/j.fct.2020.111126_bib62","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijpharm.2013.02.004","article-title":"Controlled preparation and antitumor efficacy of vitamin E TPGS-functionalized PLGA nanoparticles for delivery of paclitaxel","volume":"446","author":"Wang","year":"2013","journal-title":"Int. J. Pharm."},{"issue":"12","key":"10.1016\/j.fct.2020.111126_bib63","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1166\/jbn.2017.2442","article-title":"Curcumin-loaded TPGS\/F127\/P123 mixed polymeric micelles for cervical cancer therapy: formulation, characterization, and in vitro and in vivo evaluation","volume":"13","author":"Wang","year":"2017","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.fct.2020.111126_bib64","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jddst.2018.04.002","article-title":"Pharmacokinetics, biodistribution, and bioavailability of gossypol-loaded Pluronic (R) F127 nanoparticles","volume":"45","author":"Wang","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.fct.2020.111126_bib65","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ijpharm.2019.01.049","article-title":"Pluronic F127-based micelles for tumor-targeted bufalin delivery","volume":"559","author":"Wang","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.fct.2020.111126_bib66","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.addr.2011.02.001","article-title":"Physical and chemical stability of drug nanoparticles","volume":"63","author":"Wu","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.fct.2020.111126_bib67","first-page":"1","article-title":"Preparation and evaluation of Isoliquiritigenin-loaded F127\/P123 polymeric micelles","author":"Xie","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.fct.2020.111126_bib68","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.ijbiomac.2017.05.136","article-title":"Enhanced effect of folated pluronic F87-PLA\/TPGS mixed micelles on targeted delivery of paclitaxel","volume":"103","author":"Xiong","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fct.2020.111126_bib69","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijbiomac.2018.05.168","article-title":"Antioxidant and hepatoprotective effects of purified Rhodiola rosea polysaccharides","volume":"117","author":"Xu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fct.2020.111126_bib70","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.fct.2016.10.025","article-title":"Reversal of ethanol-induced hepatotoxicity by cinnamic and syringic acids in mice","volume":"98","author":"Yan","year":"2016","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2020.111126_bib71","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijpharm.2013.03.020","article-title":"Cytotoxic effect of novel Flammulina velutipes sterols and its oral bioavailability via mixed micellar nanoformulation","volume":"448","author":"Yi","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.fct.2020.111126_bib72","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.2147\/IJN.S170692","article-title":"Bufalin-loaded vitamin E succinate-grafted-chitosan oligosaccharide\/RGD conjugated TPGS mixed micelles demonstrated improved antitumor activity against drug-resistant colon cancer","volume":"13","author":"Yuan","year":"2018","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"10.1016\/j.fct.2020.111126_bib73","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1208\/s12248-010-9185-1","article-title":"DDSolver: an add-in Program for modeling and comparison of drug dissolution profiles","volume":"12","author":"Zhang","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.fct.2020.111126_bib74","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ijpharm.2018.11.049","article-title":"Glutathione-sensitive PEGylated curcumin prodrug nanomicelles: preparation, characterization, cellular uptake and bioavailability evaluation","volume":"555","author":"Zhang","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.fct.2020.111126_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11030107","article-title":"Enhanced oral bioavailability, anti-tumor activity and hepatoprotective effect of 6-shogaol loaded in a type of novel micelles of polyethylene glycol and linoleic acid conjugate","volume":"11","author":"Zhang","year":"2019","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.fct.2020.111126_bib76","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1002\/hep.30563","article-title":"Tissue repair in the mouse liver following acute carbon tetrachloride depends on injury-induced Wnt\/\u03b2-catenin signaling","volume":"69","author":"Zhao","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2020.111126_bib77","first-page":"1","article-title":"Preparation and in vitro\/in vivo evaluation of 6-Gingerol TPGS\/PEG-PCL polymeric micelles","author":"Zhen","year":"2018","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.fct.2020.111126_bib78","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jff.2014.04.001","article-title":"Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: preparation, in vitro and in vivo evaluation","volume":"8","author":"Zhu","year":"2014","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fct.2020.111126_bib79","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.actbio.2015.11.031","article-title":"Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system fore the treatment of liver cancer","volume":"30","author":"Zhu","year":"2016","journal-title":"Acta Biomater."},{"issue":"1\u20132","key":"10.1016\/j.fct.2020.111126_bib80","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijpharm.2017.07.011","article-title":"Glycyrrhetinic acid-modified TPGS polymeric micelles for hepatocellular carcinoma-targeted therapy","volume":"529","author":"Zhu","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.fct.2020.111126_bib81","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1208\/s12249-019-1361-8","article-title":"Self-microemulsifying drug delivery system for improved oral delivery of limonene: preparation, characterization, in vitro and in vivo evaluation","volume":"20","author":"Zhu","year":"2019","journal-title":"AAPS PharmSciTech"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691520300132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691520300132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:57:18Z","timestamp":1759528638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691520300132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":81,"alternative-id":["S0278691520300132"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2020.111126","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of TPGS\/F127\/F68 mixed polymeric micelles: Enhanced oral bioavailability and hepatoprotection of syringic acid against carbon tetrachloride-induced hepatotoxicity","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2020.111126","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111126"}}