{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:54:43Z","timestamp":1787316883474,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.fct.2020.111127","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T19:24:12Z","timestamp":1578943452000},"page":"111127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["A physiologically based pharmacokinetic model of doxycycline for predicting tissue residues and withdrawal intervals in grass carp (Ctenopharyngodon idella)"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-5216","authenticated-orcid":false,"given":"Ning","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chun","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-8366","authenticated-orcid":false,"given":"Zhoumeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2020.111127_bib1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0378-4347(00)00261-9","article-title":"Simple and reliable method of doxycycline determination in human plasma and biological tissues","volume":"744","author":"Axisa","year":"2000","journal-title":"J. Chromatogr. B Biomed. Appl."},{"key":"10.1016\/j.fct.2020.111127_bib2","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1095-8649.1987.tb05276.x","article-title":"Temperature\u2010dependence of cardiac output and regional blood flow in rainbow trout, Salmo gairdneri Richardson","volume":"31","author":"Barron","year":"1987","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.fct.2020.111127_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.fct.2015.12.020","article-title":"Health concerns and management of select veterinary drug residues","volume":"88","author":"Baynes","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111127_bib4","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1128\/AAC.01355-05","article-title":"Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine","volume":"50","author":"Buur","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.fct.2020.111127_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.yrtph.2018.09.008","article-title":"Structural and functional pharmacokinetic analogs for physiologically based pharmacokinetic (PBPK) model evaluation","volume":"99","author":"Ellison","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2020.111127_bib6","author":"EMA"},{"key":"10.1016\/j.fct.2020.111127_bib7","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1007\/s00204-019-02591-7","article-title":"Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project","volume":"93","author":"Escher","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2020.111127_bib8","article-title":"Commission regulation (EU) 2015\/151 of 30 january 2015 amending the annex to regulation (EU) No 37\/2010 as regards the substance 'doxycycline'","author":"EU","year":"2015","journal-title":"Off. J. Eur. Union"},{"key":"10.1016\/j.fct.2020.111127_bib9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00204-018-2372-z","article-title":"In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds","volume":"93","author":"Fabian","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2020.111127_bib10","series-title":"The State of World Fisheries and Aquaculture - Meeting the Sustainable Development Goals","author":"FAO","year":"2018"},{"key":"10.1016\/j.fct.2020.111127_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0300-9629(87)90119-8","article-title":"Estimates of plasma, packed cell and total blood volume in tissues of the rainbow trout (Salmo gairdneri)","volume":"87","author":"Gingerich","year":"1987","journal-title":"Comp. Biochem. Physiol. A Physiol."},{"key":"10.1016\/j.fct.2020.111127_bib12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1086\/physzool.62.1.30159997","article-title":"The effect of temperature acclimation and adrenaline on the performance of a perfused trout heart","volume":"62","author":"Graham","year":"1989","journal-title":"Physiol. Zool."},{"key":"10.1016\/j.fct.2020.111127_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scitotenv.2016.10.146","article-title":"Toxicokinetic models and related tools in environmental risk assessment of chemicals","volume":"578","author":"Grech","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2020.111127_bib14","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.scitotenv.2018.09.163","article-title":"Generic physiologically-based toxicokinetic modelling for fish: integration of environmental factors and species variability","volume":"651","author":"Grech","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2020.111127_bib15","first-page":"557","article-title":"A comparative study: effects of the coated slow-release multi-trace elements and trace elements on growth performance, digestion and absorption capacities and growth development in the intestine of young grass carp (Ctenopharyngodon idella)","volume":"37","author":"Hu","year":"2019","journal-title":"J. Sichuan Agric. Univ."},{"key":"10.1016\/j.fct.2020.111127_bib16","first-page":"2002","article-title":"Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modelling","volume":"32","author":"Huang","year":"2015","journal-title":"Food Addit. Contam. A"},{"key":"10.1016\/j.fct.2020.111127_bib17","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1021\/acs.jafc.5b02780","article-title":"Metabolic disposition and elimination of cyadox in pigs, chickens, carp, and rats","volume":"63","author":"Huang","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2020.111127_bib18","author":"JFCRF"},{"key":"10.1016\/j.fct.2020.111127_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0034-5687(81)90023-2","article-title":"Gill O2 consumption in a teleost fish, Gadus morhua","volume":"44","author":"Johansen","year":"1981","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.fct.2020.111127_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cej.2012.12.079","article-title":"Degradation of veterinary antibiotics by dielectric barrier discharge plasma","volume":"219","author":"Kim","year":"2013","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.fct.2020.111127_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tiv.2019.05.002","article-title":"Physiologically based kinetic models for farm animals: critical review of published models and future perspectives for their use in chemical risk assessment","volume":"60","author":"Lautz","year":"2019","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.fct.2020.111127_bib22","series-title":"Xenobiotics in Fish","article-title":"A physiologically based pharmacokinetic model for predicting the withdrawal period of oxytetracycline in cultured chinook salmon (Oncorhynchus tshawytscha)","author":"Law","year":"1999"},{"key":"10.1016\/j.fct.2020.111127_bib23","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0041-008X(91)90041-C","article-title":"A biologically based toxicokinetic model for pyrene in rainbow trout","volume":"110","author":"Law","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2020.111127_bib24","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1080\/19440049.2014.938363","article-title":"Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus)","volume":"31","author":"Leavens","year":"2014","journal-title":"Food Addit. Contam. A"},{"key":"10.1016\/j.fct.2020.111127_bib25","author":"Li","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2020.111127_bib26","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.fct.2017.06.023","article-title":"Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment","volume":"107","author":"Li","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111127_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/toxsci\/kfy067","article-title":"Probabilistic physiologically based pharmacokinetic model for penicillin G in milk from dairy cows following intramammary or intramuscular administrations","volume":"164","author":"Li","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2020.111127_bib28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/jvp.12311","article-title":"Mathematical modeling and simulation in animal health \u2013 Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment","volume":"39","author":"Lin","year":"2016","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2020.111127_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/toxsci\/kfx070","article-title":"Performance assessment and translation of physiologically based pharmacokinetic models from acslX to Berkeley Madonna, MATLAB, and R Language: oxytetracycline and gold nanoparticles as case examples","volume":"158","author":"Lin","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2020.111127_bib30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jps.24244","article-title":"Development and application of a multiroute physiologically based pharmacokinetic model for oxytetracycline in dogs and humans","volume":"104","author":"Lin","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.fct.2020.111127_bib31","first-page":"162","article-title":"A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice","volume":"10","author":"Lin","year":"2016","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.fct.2020.111127_bib32","article-title":"Cardiac output in fish: measurement techniques and applications","author":"Linton","year":"2004","journal-title":"Fish. Oceans"},{"key":"10.1016\/j.fct.2020.111127_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ecoenv.2004.09.002","article-title":"Physiological effects of thermomechanical newsprint mill effluent on Atlantic salmon (Salmo salar L.)","volume":"62","author":"Linton","year":"2005","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2020.111127_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.aquaculture.2018.09.051","article-title":"First report of Vibrio vulnificus infection in grass carp Ctenopharyngodon idellus in China","volume":"499","author":"Liu","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.fct.2020.111127_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.envpol.2017.01.003","article-title":"Usage, residue, and human health risk of antibiotics in Chinese aquaculture: a review","volume":"223","author":"Liu","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2020.111127_bib36","article-title":"Antibiotic use in aquaculture, policies and regulation, health and environmental risks: a review of the top 15 major producers","author":"Lulijwa","year":"2019","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.fct.2020.111127_bib37","series-title":"National Food Safety Standard(approval Draft)- Maximum Residue Limits for Veterinary Drugs in Animal Derived Food","author":"MAA","year":"2017"},{"key":"10.1016\/j.fct.2020.111127_bib38","series-title":"Berkeley Madonna User's Guide","author":"Macey","year":"2009"},{"key":"10.1016\/j.fct.2020.111127_bib39","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1111\/bcp.13721","article-title":"Target site pharmacokinetics of doxycycline for rosacea in healthy volunteers is independent of the food effect","volume":"84","author":"Pal","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.fct.2020.111127_bib40","series-title":"Veterinary Pharmacology and Therapeutics","first-page":"858","article-title":"Tetracycline antibiotics","author":"Papich","year":"2018"},{"key":"10.1016\/j.fct.2020.111127_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2018.12.081","article-title":"Temperature-dependent pharmacokinetics of florfenicol in Nile tilapia (Oreochromis niloticus) following single oral and intravenous administration","author":"Rairat","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.fct.2020.111127_bib42","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1046\/j.1365-2109.2002.00783.x","article-title":"Temperature\u2010dependent pharmacokinetics and tissue distribution of oxolinic acid in sea bass, Dicentrarchus labrax L., after a single intravascular injection","volume":"33","author":"Rigos","year":"2002","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.fct.2020.111127_bib43","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0044-8486(03)00213-8","article-title":"Tissue distribution and residue depletion of oxolinic acid in gilthead sea bream (Sparus aurata) and sharpsnout sea bream (Diplodus puntazzo) following multiple in-feed dosing","volume":"224","author":"Rigos","year":"2003","journal-title":"Aquaculture"},{"key":"10.1016\/j.fct.2020.111127_bib44","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1096-4959(01)00379-7","article-title":"Liver gangliosides of various animals ranging from fish to mammalian species","volume":"129","author":"Saito","year":"2001","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.fct.2020.111127_bib45","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1439-0426.2006.00703.x","article-title":"Absorption, tissue distribution, metabolism and excretion of ormetoprim and sulphadimethoxine in cod (Gadus morhua) after oral administration of Romet(30)","volume":"22","author":"Samuelsen","year":"2006","journal-title":"J. Appl. Ichthyol."},{"key":"10.1016\/j.fct.2020.111127_bib46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0044-8486(96)01508-6","article-title":"Multiple-dose pharmacokinetic study of Romet30 in Atlantic salmon (Salmo salar) and in vitro antibacterial activity against Aeromonas salmonicida","volume":"152","author":"Samuelsen","year":"1997","journal-title":"Aquaculture"},{"key":"10.1016\/j.fct.2020.111127_bib47","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1095-8649.1999.tb02054.x","article-title":"Blood flow distribution and tissue allometry in channel catfish","volume":"54","author":"Schultz","year":"1999","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.fct.2020.111127_bib48","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1577\/1548-8659(1976)38[116:IATOCD]2.0.CO;2","article-title":"Incidence and treatment of columnaris disease in grass carp brood stock","volume":"38","author":"Shireman","year":"1976","journal-title":"Prog. Fish-Cult."},{"key":"10.1016\/j.fct.2020.111127_bib49","first-page":"3","article-title":"Digestion in teleost fishes. Lectures presented at the FAO\/UNDP Training course in fish feeding technology","author":"Smith","year":"1980","journal-title":"ACDP\/REP\/80\/11"},{"key":"10.1016\/j.fct.2020.111127_bib50","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0010-406X(68)90372-1","article-title":"The effect of exercise on the distribution of blood to various organs in rainbow trout","volume":"25","author":"Stevens","year":"1968","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.fct.2020.111127_bib51","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2331\/fishsci.63.349","article-title":"Comparison of digestive and absorptive functions between tiger puffer and red sea bream","volume":"63","author":"Takii","year":"1997","journal-title":"Fish. Sci."},{"key":"10.1016\/j.fct.2020.111127_bib52","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0044-8486(83)90267-3","article-title":"Effects of soybean processing methods on the growth of carp (Cyprinus carpio)","volume":"32","author":"Viola","year":"1983","journal-title":"Aquaculture"},{"key":"10.1016\/j.fct.2020.111127_bib53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000220836","article-title":"The disposition of doxycycline by the rat","volume":"17","author":"Von Wittenau","year":"1972","journal-title":"Chemotherapy"},{"key":"10.1016\/j.fct.2020.111127_bib54","series-title":"Characterization and Application of Physiologically Based Pharmacokinetic Models in Risk Assessment. I.P.o.C.S.W.I","author":"WHO","year":"2010"},{"key":"10.1016\/j.fct.2020.111127_bib55","doi-asserted-by":"crossref","first-page":"110592","DOI":"10.1016\/j.fct.2019.110592","article-title":"Tissue residue depletion kinetics and withdrawal time estimation of doxycycline in grass carp, Ctenopharyngodon idella, following multiple oral administrations","volume":"131","author":"Xu","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111127_bib56","doi-asserted-by":"crossref","first-page":"734204","DOI":"10.1016\/j.aquaculture.2019.734204","article-title":"Effect of temperature on plasma and tissue kinetics of doxycycline in grass carp (Ctenopharyngodon idella) after oral administration","volume":"511","author":"Xu","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.fct.2020.111127_bib57","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.fct.2019.02.029","article-title":"Development and application of a population physiologically based pharmacokinetic model for florfenicol and its metabolite florfenicol amine in cattle","volume":"126","author":"Yang","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111127_bib58","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1365-2885.2012.01419.x","article-title":"A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolation","volume":"36","author":"Yang","year":"2013","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2020.111127_bib59","doi-asserted-by":"crossref","first-page":"734542","DOI":"10.1016\/j.aquaculture.2019.734542","article-title":"Effects of water temperature on tissue depletion of florfenicol and its metabolite florfenicol amine in crucian carp (Carassius auratus gibelio) following multiple oral doses","volume":"515","author":"Yang","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.fct.2020.111127_bib60","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/jvp.12143","article-title":"A physiologically based pharmacokinetic model for quinoxaline-2-carboxylic acid in rats, extrapolation to pigs","volume":"38","author":"Yang","year":"2015","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2020.111127_bib61","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1023\/A:1023279604975","article-title":"The evaluation of secondary stress response of grass carp (Ctenopharyngodon idella, Val. 1844) after exposing to the saline water","volume":"25","author":"Yavuzcan-Y\u0131ld\u0131z","year":"2001","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.fct.2020.111127_bib62","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1021\/acs.jafc.7b01740","article-title":"Pharmacokinetics of mequindox and its marker residue 1,4-bisdesoxymequindox in swine following multiple oral gavage and intramuscular administration: an experimental study coupled with population physiologically based pharmacokinetic modeling","volume":"65","author":"Zeng","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2020.111127_bib63","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1021\/acs.jafc.8b07133","article-title":"Assessing global human exposure to T-2 toxin via poultry meat consumption using a lifetime physiologically based pharmacokinetic model","volume":"67","author":"Zeng","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2020.111127_bib64","first-page":"192","article-title":"Physiologically based pharmacokinetic model for quinocetone in pigs and extrapolation to mequindox","volume":"34","author":"Zhu","year":"2017","journal-title":"Food Addit. Contam. A"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691520300144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691520300144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:56:30Z","timestamp":1759528590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691520300144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":64,"alternative-id":["S0278691520300144"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2020.111127","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A physiologically based pharmacokinetic model of doxycycline for predicting tissue residues and withdrawal intervals in grass carp (Ctenopharyngodon idella)","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2020.111127","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111127"}}