{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:16:55Z","timestamp":1791919015834,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Fujian Provincial Science and Technology Department and Chinese Academy of Sciences","award":["2019T3033"],"award-info":[{"award-number":["2019T3033"]}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2018JJ2464"],"award-info":[{"award-number":["2018JJ2464"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangxi Zhuang Autonomous Region Science and Technology Department","award":["2018AC01007"],"award-info":[{"award-number":["2018AC01007"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31960666"],"award-info":[{"award-number":["31960666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.fct.2020.111326","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T20:04:17Z","timestamp":1586549057000},"page":"111326","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"special_numbering":"C","title":["Baicalin alleviates deoxynivalenol-induced intestinal inflammation and oxidative stress damage by inhibiting NF-\u03baB and increasing mTOR signaling pathways in piglets"],"prefix":"10.1016","volume":"140","author":[{"given":"Peng","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfa","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daixiu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2020.111326_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/nu9121343","article-title":"The food contaminants nivalenol and deoxynivalenol induce inflammation in intestinal epithelial cells by regulating reactive oxygen species release","volume":"9","author":"Adesso","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2020.111326_bib2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1152\/physrev.1998.78.2.547","article-title":"The free radical theory of aging matures","volume":"78","author":"Beckman","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.fct.2020.111326_bib3","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.tiv.2015.06.020","article-title":"Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol","volume":"29","author":"Cano-Sancho","year":"2015","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2020.111326_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.fct.2015.11.019","article-title":"The mycotoxins deoxynivalenol and nivalenol show in vivo synergism on jejunum enterocytes apoptosis","volume":"87","author":"Cheat","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111326_bib5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3389\/fphar.2017.00547","article-title":"Baicalin alleviates lipopolysaccharide-induced liver inflammation in chicken by suppressing TLR4-mediated NF-\u03baB pathway","volume":"8","author":"Cheng","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2020.111326_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11010018","article-title":"Phytic acid decreases oxidative stress and intestinal lesions induced by fumonisin B1 and deoxynivalenol in intestinal explants of pigs","volume":"11","author":"da Silva","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.fct.2020.111326_bib7","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.phrs.2015.08.021","article-title":"The effects of baicalein and baicalin on mitochondrial function and dynamics: a review","volume":"100","author":"de Oliveira","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.fct.2020.111326_bib8","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.phrs.2015.08.021","article-title":"The effects of baicalein and baicalin on mitochondrial function and dynamics: a review","volume":"100","author":"de Oliveira","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.fct.2020.111326_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.toxlet.2010.10.006","article-title":"Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2","volume":"200","author":"Diesing","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2020.111326_bib10","first-page":"1","article-title":"Worldwide contamination of food-crops with mycotoxins: validity of the widely cited 'FAO estimate' of 25","author":"Eskola","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fct.2020.111326_bib11","doi-asserted-by":"crossref","first-page":"e80997","DOI":"10.1371\/journal.pone.0080997","article-title":"Inhibitory effect of baicalin on iNOS and NO expression in intestinal mucosa of rats with acute endotoxemia","volume":"8","author":"Feng","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.fct.2020.111326_bib12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ccr.2006.08.007","article-title":"Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival","volume":"10","author":"Ghosh","year":"2006","journal-title":"Canc. Cell"},{"key":"10.1016\/j.fct.2020.111326_bib13","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/molehr\/gaz036","article-title":"Baicalin improves the in vitro developmental capacity of pig embryos by inhibiting apoptosis, regulating mitochondrial activity and activating sonic hedgehog signaling","volume":"25","author":"Guo","year":"2019","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.fct.2020.111326_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.taap.2016.03.006","article-title":"Deoxynivalenol exposure induces autophagy\/apoptosis and epigenetic modification changes during porcine oocyte maturation","volume":"300","author":"Han","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2020.111326_bib15","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.fsi.2018.10.039","article-title":"Deoxynivalenol decreased intestinal immune function related to NF-\u03baB and TOR signalling in juvenile grass carp (Ctenopharyngodon idella)","volume":"84","author":"Huang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fct.2020.111326_bib16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1017\/S0007114519000928","article-title":"The involvement of NF-\u03baB\/P38 pathways in extracts attenuating of K88-induced acute intestinal injury in weaned piglets","volume":"122","author":"Huang","year":"2019","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fct.2020.111326_bib17","doi-asserted-by":"crossref","first-page":"850","DOI":"10.14336\/AD.2017.0829","article-title":"The effects of baicalin and baicalein on cerebral ischemia: a review","volume":"8","author":"Liang","year":"2017","journal-title":"Aging Dis."},{"key":"10.1016\/j.fct.2020.111326_bib18","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1039\/C7TX00202E","article-title":"Effect of deoxynivalenol on apoptosis, barrier function, and expression levels of genes involved in nutrient transport, mitochondrial biogenesis and function in IPEC-J2 cells","volume":"6","author":"Liao","year":"2017","journal-title":"Toxicol. Res. (Camb)."},{"key":"10.1016\/j.fct.2020.111326_bib19","first-page":"1222","article-title":"Polymorphisms in the oxidative stress genes, superoxide dismutase, glutathione peroxidase and catalase and risk of non-Hodgkin's lymphoma","volume":"91","author":"Lightfoot","year":"2006","journal-title":"Haematologica"},{"key":"10.1016\/j.fct.2020.111326_bib20","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1021\/acs.chemrestox.6b00001","article-title":"Protective capacity of resveratrol, a natural polyphenolic compound, against deoxynivalenol-induced intestinal barrier dysfunction and bacterial translocation","volume":"29","author":"Ling","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fct.2020.111326_bib21","doi-asserted-by":"crossref","first-page":"110658","DOI":"10.1016\/j.fct.2019.110658","article-title":"The response of glandular gastric transcriptome to T-2 toxin in chicks","volume":"132","author":"Luo","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111326_bib22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.fct.2020.111326_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10030113","article-title":"Individual and combined occurrence of mycotoxins in feed ingredients and complete feeds in China","volume":"10","author":"Ma","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.fct.2020.111326_bib24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.fct.2014.06.027","article-title":"Role of oxidative stress in deoxynivalenol induced toxicity","volume":"72","author":"Mishra","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111326_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10110464","article-title":"Deoxynivalenol affects cell metabolism and increases protein biosynthesis in intestinal porcine epithelial cells (IPEC-J2): DON increases protein biosynthesis","volume":"10","author":"Nossol","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.fct.2020.111326_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/toxsci\/kft145","article-title":"Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stress","volume":"135","author":"Pan","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2020.111326_bib27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2013.01.007","article-title":"Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage","volume":"268","author":"Pan","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2020.111326_bib28","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3390\/toxins2061300","article-title":"Deoxynivalenol-induced proinflammatory gene expression: mechanisms and pathological sequelae","volume":"2","author":"Pestka","year":"2010","journal-title":"Toxins"},{"key":"10.1016\/j.fct.2020.111326_bib29","doi-asserted-by":"crossref","first-page":"12814","DOI":"10.3748\/wjg.v21.i45.12814","article-title":"Chemosensitization of HepG2 cells by suppression of NF-\u03baB\/p65 gene transcription with specific-siRNA","volume":"21","author":"Shi","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2020.111326_bib30","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.bbrc.2005.06.202","article-title":"Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway","volume":"334","author":"Silswal","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2020.111326_bib31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12550-013-0170-2","article-title":"Protective effects of antioxidants on deoxynivalenol-induced damage in murine lymphoma cells","volume":"29","author":"Strasser","year":"2013","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.fct.2020.111326_bib32","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.freeradbiomed.2015.09.012","article-title":"Autophagy protects intestinal epithelial cells against deoxynivalenol toxicity by alleviating oxidative stress via IKK signaling pathway","volume":"89","author":"Tang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fct.2020.111326_bib33","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-kappaB transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fct.2020.111326_bib34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.etap.2016.09.003","article-title":"Protective role of selenium in the activities of antioxidant enzymes in piglet splenic lymphocytes exposed to deoxynivalenol","volume":"47","author":"Wang","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2020.111326_bib35","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s00204-014-1354-z","article-title":"Deoxynivalenol: signaling pathways and human exposure risk assessment--an update","volume":"88","author":"Wang","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2020.111326_bib36","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.immuni.2008.08.012","article-title":"The TSC-mTOR signaling pathway regulates the innate inflammatory response","volume":"29","author":"Weichhart","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.fct.2020.111326_bib37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s40104-016-0122-8","article-title":"Aflatoxin B1, zearalenone and deoxynivalenol in feed ingredients and complete feed from different Province in China","volume":"7","author":"Wu","year":"2016","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.fct.2020.111326_bib38","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3390\/toxins7041341","article-title":"Dietary L-arginine supplementation protects weanling pigs from deoxynivalenol-induced toxicity","volume":"7","author":"Wu","year":"2015","journal-title":"Toxins"},{"key":"10.1016\/j.fct.2020.111326_bib39","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12917-015-0449-y","article-title":"Growth performance, serum biochemical profile, jejunal morphology, and the expression of nutrients transporter genes in deoxynivalenol (DON)-challenged growing pigs","volume":"11","author":"Wu","year":"2015","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.fct.2020.111326_bib40","doi-asserted-by":"crossref","first-page":"e113687","DOI":"10.1371\/journal.pone.0113687","article-title":"An NMR-based metabolomic approach to investigate the effects of supplementation with glutamic acid in piglets challenged with deoxynivalenol","volume":"9","author":"Wu","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.fct.2020.111326_bib41","doi-asserted-by":"crossref","first-page":"e100591","DOI":"10.1371\/journal.pone.0100591","article-title":"Therapeutic effects of glutamic acid in piglets challenged with deoxynivalenol","volume":"9","author":"Wu","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.fct.2020.111326_bib42","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00204-014-1280-0","article-title":"Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update","volume":"88","author":"Wu","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2020.111326_bib43","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.biopha.2017.12.024","article-title":"Baicalin alleviates atherosclerosis by relieving oxidative stress and inflammatory responses via inactivating the NF-\u03baB and p38 MAPK signaling pathways","volume":"97","author":"Wu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2020.111326_bib44","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.2527\/jas.2013-6427","article-title":"Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: II. Intestinal morphology and function","volume":"91","author":"Xiao","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.fct.2020.111326_bib45","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.2527\/jas.2013-6427","article-title":"Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: II. Intestinal morphology and function","volume":"91","author":"Xiao","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.fct.2020.111326_bib46","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.2527\/jas.2013-6426","article-title":"Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: I. Growth performance, immune function, and antioxidation capacity","volume":"91","author":"Xiao","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.fct.2020.111326_bib47","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1021\/acs.jafc.8b03662","article-title":"Protection of porcine intestinal-wpithelial cells from deoxynivalenol-induced damage by resveratrol via the Nrf2 signaling pathway","volume":"67","author":"Yang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2020.111326_bib48","doi-asserted-by":"crossref","first-page":"e99633","DOI":"10.1371\/journal.pone.0099633","article-title":"Nuclear NF-\u03baB p65 in peripheral blood mononuclear cells correlates with urinary MCP-1, RANTES and the severity of type 2 diabetic nephropathy","volume":"9","author":"Yi","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.fct.2020.111326_bib49","doi-asserted-by":"crossref","first-page":"8140962","DOI":"10.1155\/2017\/8140962","article-title":"The evaluation of antioxidant and anti-inflammatory effects of Eucommia ulmoides flavones using diquat-challenged piglet models","author":"Yuan","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.fct.2020.111326_bib50","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/mnfr.201200536","article-title":"Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells","volume":"57","author":"Zhai","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2020.111326_bib51","doi-asserted-by":"crossref","first-page":"e0179421","DOI":"10.1371\/journal.pone.0179421","article-title":"Molecular cloning, characterization and expression analysis of Frizzled 6 in the small intestine of pigs (Sus scrofa)","volume":"12","author":"Zou","year":"2017","journal-title":"PloS One"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691520302143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691520302143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:59:29Z","timestamp":1759528769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691520302143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":51,"alternative-id":["S0278691520302143"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2020.111326","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalin alleviates deoxynivalenol-induced intestinal inflammation and oxidative stress damage by inhibiting NF-\u03baB and increasing mTOR signaling pathways in piglets","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2020.111326","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111326"}}