{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:28:48Z","timestamp":1773300528836,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.fct.2020.111329","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T11:17:05Z","timestamp":1586517425000},"page":"111329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Impaired ferritinophagy flux induced by high fat diet mediates hepatic insulin resistance via endoplasmic reticulum stress"],"prefix":"10.1016","volume":"140","author":[{"given":"Chunjie","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guibin","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.fct.2020.111329_bib1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.nutres.2012.11.012","article-title":"Dietary fat level affects tissue iron levels but not the iron regulatory gene HAMP in rats","volume":"33","author":"Ahmed","year":"2013","journal-title":"Nutr. Res."},{"issue":"9","key":"10.1016\/j.fct.2020.111329_bib2","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.3390\/nu6093587","article-title":"Obesity as an emerging risk factor for iron deficiency","volume":"6","author":"Aigner","year":"2014","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.fct.2020.111329_bib3","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/ajcn\/87.5.1374","article-title":"Pathways underlying iron accumulation in human nonalcoholic fatty liver disease","volume":"87","author":"Aigner","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"issue":"7","key":"10.1016\/j.fct.2020.111329_bib4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.bbagen.2008.09.004","article-title":"Ferritins: a family of molecules for iron storage, antioxidation and more","volume":"1790","author":"Arosio","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.fct.2020.111329_bib5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molcel.2014.04.031","article-title":"NCOA4 transcriptional coactivator inhibits activation of DNA replication origins","volume":"55","author":"Bellelli","year":"2014","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.fct.2020.111329_bib6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.celrep.2015.12.065","article-title":"NCOA4 deficiency impairs systemic iron homeostasis","volume":"14","author":"Bellelli","year":"2016","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.fct.2020.111329_bib7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1467-789X.2011.00938.x","article-title":"The relationship between obesity and hypoferraemia in adults: a systematic review","volume":"13","author":"Cheng","year":"2012","journal-title":"Obes. Rev."},{"issue":"12","key":"10.1016\/j.fct.2020.111329_bib8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.nutres.2011.09.014","article-title":"Diet-induced obesity leads to decreased hepatic iron storage in mice","volume":"31","author":"Chung","year":"2011","journal-title":"Nutr. Res."},{"issue":"1","key":"10.1016\/j.fct.2020.111329_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3390\/nu7010335","article-title":"Obesity promotes alterations in iron recycling","volume":"7","author":"Citelli","year":"2015","journal-title":"Nutrients"},{"issue":"20","key":"10.1016\/j.fct.2020.111329_bib10","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1182\/blood-2009-05-224188","article-title":"Specific iron chelators determine the route of ferritin degradation","volume":"114","author":"Domenico","year":"2009","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.fct.2020.111329_bib26","first-page":"46","article-title":"Iron metabolism in genetically obese (obob) Mice.pdf","volume":"118","author":"Failla","year":"1988","journal-title":"American Institute of Nutrition"},{"issue":"12","key":"10.1016\/j.fct.2020.111329_bib11","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1210\/jc.2009-1361","article-title":"Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency","volume":"94","author":"Giudice","year":"2009","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"1","key":"10.1016\/j.fct.2020.111329_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17010130","article-title":"Iron homeostasis in health and disease","volume":"17","author":"Gozzelino","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.fct.2020.111329_bib20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.diabres.2007.02.004","article-title":"Study of iron metabolism disturbances in an animal model of insulin resistance","volume":"77","author":"Guenno","year":"2007","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.fct.2020.111329_bib13","doi-asserted-by":"crossref","first-page":"4928703","DOI":"10.1155\/2018\/4928703","article-title":"Growth inhibition of a novel iron chelator, DpdtC, against hepatoma carcinoma cell lines partly attributed to ferritinophagy-mediated lysosomal ROS generation","author":"Huang","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.fct.2020.111329_bib14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mce.2015.03.007","article-title":"Involvement of iron depletion in palmitate-induced lipotoxicity of beta cells","volume":"407","author":"Jung","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.fct.2020.111329_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1152\/physiolgenomics.00150.2009","article-title":"Dietary iron-deficient anemia induces a variety of metabolic changes and even apoptosis in rat liver: a DNA microarray study","volume":"42","author":"Kamei","year":"2010","journal-title":"Physiol. Genom."},{"issue":"7","key":"10.1016\/j.fct.2020.111329_bib16","doi-asserted-by":"crossref","first-page":"9709","DOI":"10.1007\/s13277-016-4878-4","article-title":"Iron chelator-induced apoptosis via the ER stress pathway in gastric cancer cells","volume":"37","author":"Kim","year":"2016","journal-title":"Tumour Biol"},{"issue":"4","key":"10.1016\/j.fct.2020.111329_bib17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000440905","article-title":"Mechanism of ER stress and inflammation for hepatic insulin resistance in obesity","volume":"67","author":"Kim","year":"2015","journal-title":"Ann. Nutr. Metab."},{"issue":"6","key":"10.1016\/j.fct.2020.111329_bib18","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1182\/blood.V94.6.2128","article-title":"The cellular labile iron pool and intracellular ferritin in K562 cells","volume":"94","author":"Konijn","year":"1999","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.fct.2020.111329_bib19","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.bbamcr.2014.04.004","article-title":"Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells","volume":"1843","author":"Kwon","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"1","key":"10.1016\/j.fct.2020.111329_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4093\/dmj.2017.41.1.10","article-title":"Nuclear receptors resolve endoplasmic reticulum stress to improve hepatic insulin resistance","volume":"41","author":"Lee","year":"2017","journal-title":"Diabetes Metab. J"},{"issue":"16","key":"10.1016\/j.fct.2020.111329_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800164","article-title":"Frataxin-mediated PINK1-parkin-dependent mitophagy in hepatic steatosis: the protective effects of quercetin","volume":"62","author":"Liu","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"issue":"4","key":"10.1016\/j.fct.2020.111329_bib23","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1172\/JCI115997","article-title":"Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study","volume":"90","author":"Magnusson","year":"1992","journal-title":"J. Clin. Invest."},{"issue":"7498","key":"10.1016\/j.fct.2020.111329_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.fct.2020.111329_bib25","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/jhn.12025","article-title":"The double burden of obesity and iron deficiency on children and adolescents in Greece: the Healthy Growth Study","volume":"26","author":"Manios","year":"2013","journal-title":"J. Hum. Nutr. Diet."},{"issue":"2","key":"10.1016\/j.fct.2020.111329_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1753-4887.2008.00145.x","article-title":"Iron deficiency and obesity: the contribution of inflammation and diminished iron absorption","volume":"67","author":"McClung","year":"2009","journal-title":"Nutr. Rev."},{"issue":"47","key":"10.1016\/j.fct.2020.111329_bib28","doi-asserted-by":"crossref","first-page":"23724","DOI":"10.1073\/pnas.1906643116","article-title":"Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina","volume":"116","author":"Notomi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.fct.2020.111329_bib29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2337\/db13-0213","article-title":"Obesity alters adipose tissue macrophage iron content and tissue iron distribution","volume":"63","author":"Orr","year":"2014","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.fct.2020.111329_bib30","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tips.2017.04.004","article-title":"Roles of diacylglycerols and ceramides in hepatic insulin resistance","volume":"38","author":"Petersen","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"issue":"238","key":"10.1016\/j.fct.2020.111329_bib31","first-page":"238","article-title":"NCOA4-Mediated ferritinophagy: a potential link to neurodegeneration","volume":"13","author":"Rey","year":"2019","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.fct.2020.111329_bib32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI77812","article-title":"The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux","volume":"126","author":"Samuel","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fct.2020.111329_bib33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuro.2013.06.002","article-title":"Iron depletion increases manganese uptake and potentiates apoptosis through ER stress","volume":"38","author":"Seo","year":"2013","journal-title":"Neurotoxicology"},{"issue":"3","key":"10.1016\/j.fct.2020.111329_bib34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cmet.2013.02.007","article-title":"Iron and diabetes risk","volume":"17","author":"Simcox","year":"2013","journal-title":"Cell Metabol."},{"issue":"12","key":"10.1016\/j.fct.2020.111329_bib35","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.jnutbio.2011.10.013","article-title":"High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption","volume":"23","author":"Sonnweber","year":"2012","journal-title":"J. Nutr. Biochem."},{"issue":"18","key":"10.1016\/j.fct.2020.111329_bib36","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1046\/j.1432-1033.2003.03759.x","article-title":"Transient increase of the labile iron pool in HepG2 cells by intravenous iron preparations","volume":"270","author":"Sturm","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.fct.2020.111329_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.fct.2014.02.022","article-title":"Quercetin attenuates chronic ethanol hepatotoxicity: implication of \"free\" iron uptake and release","volume":"67","author":"Tang","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.fct.2020.111329_bib38","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1002\/jcp.27603","article-title":"Insulin resistance: review of the underlying molecular mechanisms","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"41","key":"10.1016\/j.fct.2020.111329_bib39","doi-asserted-by":"crossref","first-page":"10729","DOI":"10.1021\/acs.jafc.8b03906","article-title":"Flaxseed oil attenuates hepatic steatosis and insulin resistance in mice by rescuing the adaption to ER stress","volume":"66","author":"Yu","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2020.111329_bib40","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.diabres.2018.06.017","article-title":"Epigallocatechin gallate improves insulin resistance in HepG2 cells through alleviating inflammation and lipotoxicity","volume":"142","author":"Zhang","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"4","key":"10.1016\/j.fct.2020.111329_bib41","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1101\/gad.201731.112","article-title":"ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation","volume":"27","author":"Zhang","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.fct.2020.111329_bib42","first-page":"61","article-title":"Exenatide improves glucocorticoid-induced glucose intolerance in mice","volume":"4","author":"Zhao","year":"2011","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"2","key":"10.1016\/j.fct.2020.111329_bib43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbrc.2019.01.022","article-title":"Iron regulatory protein 2 deficiency may correlate with insulin resistance","volume":"510","author":"Zhou","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2020.111329_bib44","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fct.2018.02.019","article-title":"Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a\/XBP1s pathway","volume":"114","author":"Zhu","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111329_bib45","doi-asserted-by":"crossref","first-page":"110990","DOI":"10.1016\/j.fct.2019.110990","article-title":"Baicalein attenuates impairment of hepatic lysosomal acidification induced by high fat diet via maintaining V-ATPase assembly","volume":"136","author":"Zhu","year":"2020","journal-title":"Food Chem. Toxicol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691520302179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691520302179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:59:50Z","timestamp":1759528790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691520302179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":45,"alternative-id":["S0278691520302179"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2020.111329","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired ferritinophagy flux induced by high fat diet mediates hepatic insulin resistance via endoplasmic reticulum stress","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2020.111329","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111329"}}