{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:48:17Z","timestamp":1788886097597,"version":"build-2803163510"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.fct.2020.111437","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T12:53:11Z","timestamp":1589806391000},"page":"111437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Selected food colourants with antiplatelet activity as promising compounds for the prophylaxis and treatment of thrombosis"],"prefix":"10.1016","volume":"141","author":[{"family":"Beata Olas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Urba\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Bry\u015b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2020.111437_bib1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jnutbio.2013.11.002","article-title":"One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans","volume":"25","author":"Alvarez-Suarez","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2020.111437_bib2","article-title":"Role of nutraceuticals in the prevention and treatment of hypertension and cardiovascular diseases","volume":"5","author":"Alves","year":"2019","journal-title":"J Hypertens Manag"},{"key":"10.1016\/j.fct.2020.111437_bib3","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.yrtph.2015.09.026","article-title":"Health safety issues of synthetic food colorants","volume":"73","author":"Amchova","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2020.111437_bib4","article-title":"Malagasy dye plant species: a promising source of novel natural colorants with potential applications\u2013A review","volume":"16","author":"Andriamanantena","year":"2019","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.fct.2020.111437_bib5","first-page":"204","volume":"45","author":"Austin","year":"2017","journal-title":"Haemostasis. Medicine"},{"key":"10.1016\/j.fct.2020.111437_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/08905436.2019.1673173","article-title":"Zebrafish as an animal model for food safety research: trends in the animal research","volume":"33","author":"Bailone","year":"2019","journal-title":"Food Biotechnol."},{"key":"10.1016\/j.fct.2020.111437_bib7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jat.1414","article-title":"In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection","volume":"29","author":"Chen","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.fct.2020.111437_bib8","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.3390\/molecules21101385","article-title":"New sesquiterpenoids and anti-platelet aggregation constituents from the rhizomes of Curcuma zedoaria","volume":"21","author":"Chen","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2020.111437_bib9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.foodchem.2018.07.055","article-title":"Lemon yellow# 15 a new highly stable, water soluble food colorant from the peel of Citrus limon","volume":"270","author":"Chen","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2020.111437_bib10","first-page":"233","article-title":"Azo dyes and human health: a review","volume":"34","author":"Chung","year":"2016","journal-title":"J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev."},{"key":"10.1016\/j.fct.2020.111437_bib11","first-page":"180","article-title":"Natural pigments: stabilization methods of anthocyanins for food applications","volume":"16","author":"Cortez","year":"2017","journal-title":"CRFSFS"},{"key":"10.1016\/j.fct.2020.111437_bib12","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.foodchem.2017.11.055","article-title":"Can lycopene be considered an effective protection against cardiovascular disease?","volume":"245","author":"Costa-Rodrigues","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2020.111437_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/cote.12334","article-title":"Food colorants: their past, present and future","volume":"134","author":"Coultate","year":"2018","journal-title":"Color. Technol."},{"key":"10.1016\/j.fct.2020.111437_bib14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11332-018-0477-7","article-title":"Relationship of chlorophyll supplement and platelet-related measures in endurance athletes: a randomized, double-blind, placebo-controlled study","volume":"14","author":"Cugliari","year":"2018","journal-title":"Sport Sci. Health"},{"key":"10.1016\/j.fct.2020.111437_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/cote.12393","article-title":"Encapsulation of colorants by natural polymers for food applications","volume":"135","author":"de Boer Fy","year":"2019","journal-title":"Color. Technol."},{"key":"10.1016\/j.fct.2020.111437_bib16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfx197","article-title":"The need for, and the role of the toxicological chemist in the design of safer chemicals","volume":"161","author":"DeVito","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2020.111437_bib17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.foodcont.2017.03.047","article-title":"Analysis of foreign bodies present in European food using data from Rapid Alert System for Food and Feed (RASFF)","volume":"79","author":"Djekic","year":"2017","journal-title":"Food Contr."},{"issue":"3","key":"10.1016\/j.fct.2020.111437_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2903\/j.efsa.2004.1","article-title":"Scientific opinion on the re-evaluation of caramel colours (E 150 a,b,c, as food additives","volume":"9","author":"European Food Safety Authority (Efsa)","year":"2011","journal-title":"EFSA J"},{"key":"10.1016\/j.fct.2020.111437_bib19","series-title":"Official Journal of the European Union. Commission Regulation (EU) No 231\/2012 of 9 March 2012 Laying Down Specifications for Food Additives Listed in Annexes II an III to Regulation (EC) No 1333\/2008 of the European Parliament and of the Council","author":"European Union","year":"2012"},{"key":"10.1016\/j.fct.2020.111437_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejphar.2017.04.009","article-title":"Flavonoids and platelet aggregation: a brief review","volume":"807","author":"Faggio","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2020.111437_bib21","first-page":"97","article-title":"Are anthocyanins and flavonoids responsible for the blood pressure lowering effect and antiplatelet activity of Morus nigra","volume":"2","author":"Fakhree","year":"2012","journal-title":"Biomed Int"},{"key":"10.1016\/j.fct.2020.111437_bib22","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.2174\/1381612825666190925163827","article-title":"A brief review of cardiovascular diseases, associated risk factors and current treatment regimes","volume":"5","author":"Flora","year":"2019","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.fct.2020.111437_bib23","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1039\/C8TX00034D","article-title":"Is tartrazine really safe? In silico and ex vivo toxicological studies in human leukocytes: a question of dose","volume":"20","author":"Floriano","year":"2018","journal-title":"Toxicol Res"},{"key":"10.1016\/j.fct.2020.111437_bib24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrcardio.2016.179","article-title":"Peripheral artery disease: epidemiology and global perspectives","volume":"14","author":"Fowkes","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.fct.2020.111437_bib25","first-page":"12","article-title":"Assessment of in vitro effects of anthocyanins on platelet function","volume":"26","author":"Gaiz","year":"2019","journal-title":"Alternative Ther. Health Med."},{"key":"10.1016\/j.fct.2020.111437_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.nut.2011.08.009","article-title":"The strawberry: composition, nutritional quality, and impact on human health","volume":"28","author":"Giampieri","year":"2012","journal-title":"Nutrition"},{"key":"10.1016\/j.fct.2020.111437_bib27","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1161\/ATVBAHA.118.311804","article-title":"Genetically determined platelet count and risk of cardiovascular disease: mendelian randomization study","volume":"38","author":"Gill","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.fct.2020.111437_bib28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12199-019-0825-5","article-title":"Public health risks related to food safety issues in the food market: a systematic literature review","volume":"24","author":"Gizaw","year":"2019","journal-title":"Environ. Health Prev. Med."},{"key":"10.1016\/j.fct.2020.111437_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/ijdvl.IJDVL_1143_16","article-title":"Turmeric: a condiment, cosmetic and cure","volume":"84","author":"Gopinath","year":"2018","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"10.1016\/j.fct.2020.111437_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1089\/jmf.2018.4268","article-title":"Recent progress in the discovery of bioactive components from edible natural sources with antithrombotic activity","volume":"22","author":"Hahn","year":"2019","journal-title":"J. Med. Food"},{"key":"10.1016\/j.fct.2020.111437_bib31","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/00365513.2013.821710","article-title":"Fibrinogen and FXIII dose response effects on albumin-induced coagulopathy","volume":"73","author":"Hanna","year":"2013","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.fct.2020.111437_bib32","first-page":"35","article-title":"Repeated dose toxicity study of caramel I by 28-day oral administration in rates","volume":"7","author":"Harigae","year":"2000","journal-title":"Jpn J Food Chem"},{"key":"10.1016\/j.fct.2020.111437_bib33","doi-asserted-by":"crossref","first-page":"104267","DOI":"10.1016\/j.yexmp.2019.104267","article-title":"Evaluation of complete blood count parameters in cardiovascular diseases: an early indicator of prognosis?","volume":"110","author":"Haybar","year":"2019","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.fct.2020.111437_bib34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.amjcard.2018.10.016","article-title":"Relation of platelet parameters with incident cardiovascular disease (the dongfeng-tongji cohort study)","volume":"123","author":"He","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.fct.2020.111437_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.7555\/JBR.29.20150121","article-title":"Platelets in hemostasis and thrombosis: novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis","volume":"29","author":"Hou","year":"2015","journal-title":"J Biomed Res"},{"key":"10.1016\/j.fct.2020.111437_bib36","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.lab.2005.03.018","article-title":"Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation","volume":"146","author":"Hsiao","year":"2005","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.fct.2020.111437_bib37","first-page":"447","article-title":"4-methylimidizole, IARC mongraphs on the evaluation of carcinogenic risks to humans, some chemical resent in industrial and consumer products","volume":"101","author":"International Agency for Research on Cancer (IARC)","year":"2013","journal-title":"Foods Drink.-water 101"},{"key":"10.1016\/j.fct.2020.111437_bib38","doi-asserted-by":"crossref","first-page":"509","DOI":"10.21608\/jbaar.2016.108745","article-title":"Molecular and cytochemical comparative assessment between the two food additives; sunset yellow and curcumin-induce testicular toxicity in mice","volume":"2","author":"Ismail","year":"2016","journal-title":"J Biosci Applied Res"},{"key":"10.1016\/j.fct.2020.111437_bib39","series-title":"Food and Agriculture Organization of the United Nations. Caramel Colours. Combined Compendium of Food Additive Specification","author":"Joint FAO\/WHO Expert Committee on Food Additives (JECFA)","year":"2011"},{"key":"10.1016\/j.fct.2020.111437_bib40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/2213346104666170908161908","article-title":"Food additives: mercy or ban","volume":"4","author":"Juhasz","year":"2017","journal-title":"Curr Green Chem"},{"key":"10.1016\/j.fct.2020.111437_bib41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11515-017-1449-z","article-title":"Analysis of curcumin interaction with human serum albumin using spectroscopic studies with molecular simulation","volume":"12","author":"Kar","year":"2017","journal-title":"Front. Biol."},{"key":"10.1016\/j.fct.2020.111437_bib42","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1108\/PRT-02-2019-0009","article-title":"Bioactive composition and promising health benefits of natural food flavors and colorants: potential beyond their basic functions","volume":"49","author":"Kaur","year":"2019","journal-title":"Pigment Resin Technol."},{"key":"10.1016\/j.fct.2020.111437_bib43","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1002\/jcp.26249","article-title":"Curcumin, hemostasis, thrombosis, and coagulation","volume":"233","author":"Keihanian","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.fct.2020.111437_bib44","doi-asserted-by":"crossref","first-page":"1361779","DOI":"10.1080\/16546628.2017.1361779","article-title":"Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits","volume":"61","author":"Khoo","year":"2017","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.fct.2020.111437_bib45","first-page":"1","article-title":"Inhibition of platelet activation using vitamins","author":"Kobzar","year":"2019","journal-title":"Platelets"},{"key":"10.1016\/j.fct.2020.111437_bib46","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCRESAHA.117.310795","article-title":"Circulating platelets as mediators of immunity, inflammation, and thrombosis","volume":"122","author":"Koupenova","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.fct.2020.111437_bib47","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.freeradbiomed.2018.06.027","article-title":"Anthocyanins and their gut metabolites attenuate monocyte adhesion and transendothelial migration through nutrigenomic mechanisms regulating endothelial cell permeability","volume":"124","author":"Krga","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fct.2020.111437_bib48","first-page":"1159","article-title":"Natural food colors","volume":"8","author":"Kriti","year":"2018","journal-title":"Plant Archiv"},{"key":"10.1016\/j.fct.2020.111437_bib49","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s12272-016-0708-x","article-title":"Antithrombotic and antiplatelet activities of pelargonidin in vivo and in vitro","volume":"39","author":"Ku","year":"2016","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.fct.2020.111437_bib50","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.fct.2009.04.026","article-title":"Effect of the carthamins yellow from Carthamus tinctorius L. on hemorheological disorders of blood stasis in rats","volume":"47","author":"Li","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111437_bib51","doi-asserted-by":"crossref","first-page":"9723","DOI":"10.1007\/s00253-019-10214-5","article-title":"The gut microbiota: a new perspective on the toxicity of malachite green (MG)","volume":"103","author":"Li","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.fct.2020.111437_bib52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.thromres.2019.04.033","article-title":"A review of global coagulation assays\u2014is there a role in thrombosis risk prediction?","volume":"179","author":"Lim","year":"2019","journal-title":"Thromb. Res."},{"key":"10.1016\/j.fct.2020.111437_bib53","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3390\/molecules24020366","article-title":"Roles of phenolic compounds in the reduction of risk factors of cardiovascular diseases","volume":"24","author":"Lutz","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2020.111437_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tifs.2016.03.009","article-title":"Food colorants: challenges, opportunities and current desires of agro-industries to ensure consumer expectations and regulatory practices","volume":"52","author":"Martins","year":"2016","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.fct.2020.111437_bib55","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.compbiolchem.2015.04.006","article-title":"Study on the interaction of artificial and natural food colorants with human serum albumin: a computational point of view","volume":"56","author":"Masone","year":"2015","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.fct.2020.111437_bib56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1504\/IJRAM.2017.082556","article-title":"Future platforms for toxicity testing","volume":"20","author":"McBride","year":"2017","journal-title":"Int. J. Risk Assess. Manag."},{"key":"10.1016\/j.fct.2020.111437_bib57","first-page":"49","article-title":"Effects of sub-chronic exposure of the food dye tartrazine on the haematology of swiss albino mice (Mus musculus)","volume":"21","author":"Meena","year":"2017","journal-title":"Indian J. Environ. Sci."},{"key":"10.1016\/j.fct.2020.111437_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12986-019-0421-0","article-title":"Functional properties of beetroot (Beta vulgaris) in management of cardio-metabolic diseases","volume":"17","author":"Mirmiran","year":"2020","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.fct.2020.111437_bib59","first-page":"1","article-title":"Azoreductase: a key player of xenobiotic metabolism","volume":"5","author":"Misal","year":"2018","journal-title":"BIOB"},{"key":"10.1016\/j.fct.2020.111437_bib60","first-page":"e55525","article-title":"Turbidimetry on human washed platelets: the effect of the pannexin1-inhibitor Brilliant Blue FCF on collagen-induced aggregation","author":"Molica","year":"2017","journal-title":"JoVE"},{"key":"10.1016\/j.fct.2020.111437_bib61","first-page":"95","article-title":"Oral dose effects of reactive dye Orange ME2R2 on blood profiles and organs of rabbit","volume":"9","author":"Morshed","year":"2018","journal-title":"JoE"},{"key":"10.1016\/j.fct.2020.111437_bib62","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3389\/fphar.2018.00521","article-title":"Lycopene and vascular health","volume":"23","author":"Mozos","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2020.111437_bib63","first-page":"1","article-title":"Polyphenols: modulators of platelet function and platelet micropraticle generation?","volume":"21","author":"Nignpense","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2020.111437_bib64","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1080\/14779072.2016.1176528","article-title":"Epidemiology of cardiovascular disease: recent novel outlooks on risk factors and clinical approaches","volume":"14","author":"Niiranen","year":"2016","journal-title":"Expert Rev. Cardiovasc Ther."},{"key":"10.1016\/j.fct.2020.111437_bib65","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/foods9010058","article-title":"Analytical and sample preparation techniques for the determination of food colorants in food matrices","volume":"9","author":"Ntrallou","year":"2020","journal-title":"Foods"},{"key":"10.1016\/j.fct.2020.111437_bib66","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1253\/circj.CJ-19-0239","article-title":"Triglycerides as residual risk for atherosclerotic cardiovascular disease","volume":"83","author":"Ohmura","year":"2019","journal-title":"Circ. J."},{"key":"10.1016\/j.fct.2020.111437_bib67","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fct.2016.09.008","article-title":"Sea buckthorn as a source of important bioactive compounds in cardiovascular diseases","volume":"97","author":"Olas","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111437_bib68","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/advances\/nmx014","article-title":"Dietary supplements with antiplatelet activity: a Solution for everyone?","volume":"9","author":"Olas","year":"2018","journal-title":"Adv Nutr"},{"key":"10.1016\/j.fct.2020.111437_bib69","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1080\/10408398.2014.889652","article-title":"Food colors: existing and emerging food safety concerns","volume":"57","author":"Oplatowska-Stachowiak","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fct.2020.111437_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182997","article-title":"Anticoagulant action of low, physiologic, and high albumin levels in whole blood","volume":"12","author":"Paar","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.fct.2020.111437_bib71","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/nu11020456","article-title":"Chemical characterization and antiplatelet potential of bioactive extract from tomato pomace (Byproduct of Tomato Paste)","volume":"11","author":"Palomo","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2020.111437_bib72","doi-asserted-by":"crossref","first-page":"174","DOI":"10.2174\/1381612822666151112152143","article-title":"Cardioprotective effects of Aronia melanocarpa anthocynanins. From laboratory experiments to clinical practice","volume":"22","author":"Parzonko","year":"2016","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.fct.2020.111437_bib73","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/0310057X1504300207","article-title":"The effects of haemodilution with albumin on coagulation in vitro as assessed by rotational thromboelastometry","volume":"43","author":"Pathirana","year":"2015","journal-title":"Anaesth. Intensive Care"},{"key":"10.1016\/j.fct.2020.111437_bib74","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1208\/s12249-017-0866-2","article-title":"Stability of organoleptic agents in pharmaceuticals and cosmetics","volume":"19","author":"Patil","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.fct.2020.111437_bib75","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.2174\/0929867324666170714102619","article-title":"Chemistry in the bioactivity of chlorophylls: an overview","volume":"24","author":"Perez-Galvez","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.fct.2020.111437_bib76","first-page":"1","article-title":"Food additive safety: a review of toxicologic and regulatory issues","volume":"1","author":"Pressman","year":"2017","journal-title":"Toxicol Res Appl"},{"key":"10.1016\/j.fct.2020.111437_bib77","doi-asserted-by":"crossref","first-page":"8286","DOI":"10.1039\/C9FO02020A","article-title":"Effects of betalains on atherogenic risk factors in patients with atherosclerotic cardiovascular disease","volume":"10","author":"Rahimi","year":"2019","journal-title":"Food Funct"},{"key":"10.1016\/j.fct.2020.111437_bib78","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.fbio.2015.12.009","article-title":"An overview of encapsulation of active compounds used in food products by drying technology","volume":"13","author":"Ray","year":"2016","journal-title":"Food Biosci"},{"key":"10.1016\/j.fct.2020.111437_bib79","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.thromres.2005.01.002","article-title":"Anthocyanins and colonic metabolites of dietary polyphenols inhibit platelet function","volume":"116","author":"Rechner","year":"2005","journal-title":"Thromb. Res."},{"key":"10.1016\/j.fct.2020.111437_bib80","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/fsn3.906","article-title":"Study of a common azo food dye in mice model: toxicity reports and its relation to carcinogenicity","volume":"7","author":"Reza","year":"2019","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.fct.2020.111437_bib81","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cofs.2015.08.004","article-title":"Natural food pigments and colorants","volume":"7","author":"Rodriguez-Amaya","year":"2016","journal-title":"Curr Opin Food Sci"},{"key":"10.1016\/j.fct.2020.111437_bib82","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.foodres.2018.05.028","article-title":"Update on natural food pigments-A mini-review on carotenoids, anthocyanins, and betalains","volume":"124","author":"Rodriguez-Amaya","year":"2019","journal-title":"Food Res. Int."},{"key":"10.1016\/j.fct.2020.111437_bib83","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.scitotenv.2018.06.388","article-title":"Crystal violet and toxicity removal by adsorption and simultaneous photocatalysis in a continuous flow micro-reactor","volume":"644","author":"Sacco","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2020.111437_bib84","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2478\/s11535-012-0057-9","article-title":"Anthocyanins from red cabbage extract\u2014evidence of protective effects on blood platelets","volume":"7","author":"Saluk","year":"2012","journal-title":"Open Life Sci."},{"key":"10.1016\/j.fct.2020.111437_bib85","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.ijbiomac.2015.07.039","article-title":"Red cabbage anthocyanins as inhibitors of lipopolysaccharide-induced oxidative stress in blood platelets","volume":"80","author":"Saluk","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fct.2020.111437_bib86","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.fct.2018.01.022","article-title":"Dietary polyphenols: structures, bioavailability and protective effects against atherosclerosis","volume":"113","author":"Santhakumar","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111437_bib87","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/0253-7613.174428","article-title":"Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study","volume":"48","author":"Sawardekar","year":"2016","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.fct.2020.111437_bib88","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1055\/s-0038-1675144","article-title":"Platelet signaling in primary haemostasis and arterial thrombus formation: part 1","volume":"38","author":"Scharf","year":"2018","journal-title":"H\u00e4mostaseologie"},{"key":"10.1016\/j.fct.2020.111437_bib89","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2019.00007","article-title":"Microbial pigments in the food industry\u2014challenges and the way forward","volume":"6","author":"Sen","year":"2019","journal-title":"Front Nutr"},{"key":"10.1016\/j.fct.2020.111437_bib90","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1007\/s13197-012-0633-z","article-title":"Food caramels: a review","volume":"51","author":"Sengar","year":"2014","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.fct.2020.111437_bib91","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.5958\/0974-360X.2019.00421.9","article-title":"A review on food coloring agents-safe or unsafe?","volume":"12","author":"Shanmugasundaram","year":"2019","journal-title":"Res. J. Pharm. Technol."},{"key":"10.1016\/j.fct.2020.111437_bib92","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-food-030216-025923","article-title":"Natural colorants: food colorants from natural sources","volume":"8","author":"Sigurdson","year":"2017","journal-title":"Annu Rev Food Sci Technol"},{"key":"10.1016\/j.fct.2020.111437_bib93","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1111\/1750-3841.13927","article-title":"Establishing standards on colors from natural sources","volume":"82","author":"Simon","year":"2017","journal-title":"J. Food Sci."},{"key":"10.1016\/j.fct.2020.111437_bib94","article-title":"Azo dye toxicity: a measure of toxic effect metabolized azo dyes have on the body","volume":"2","author":"Smith","year":"2016","journal-title":"LSFRS"},{"key":"10.1016\/j.fct.2020.111437_bib95","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1160\/th13-12-1002","article-title":"Plant food anthocyanins inhibit platelet granule secretion in hypercholesterolaemia: involving the signalling pathway of PI3K\u2013Akt","volume":"112","author":"Song","year":"2014","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.fct.2020.111437_bib96","doi-asserted-by":"crossref","first-page":"103491","DOI":"10.1016\/j.jff.2019.103491","article-title":"Betanin-enriched red beet extract attenuated platelet activation and aggregation by suppressing Akt and P38 Mitogen-activated protein kinases phosphorylation","volume":"61","author":"Song","year":"2019","journal-title":"J Funct Foods"},{"key":"10.1016\/j.fct.2020.111437_bib97","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5923\/j.fph.20190902.02","article-title":"Specific energy: a new approach to ultrasound-assisted extraction of natural colorants","volume":"9","author":"Strieder","year":"2019","journal-title":"Food Publ. Health"},{"key":"10.1016\/j.fct.2020.111437_bib98","doi-asserted-by":"crossref","first-page":"8713","DOI":"10.1002\/jcb.27192","article-title":"The regulatory role of curcumin on platelet functions","volume":"119","author":"Tabeshpour","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.fct.2020.111437_bib99","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.alit.2018.02.012","article-title":"Cochineal dye-induced immediate allergy: review of Japanese cases and proposed new diagnostic chart","volume":"67","author":"Takeo","year":"2018","journal-title":"Allergol. Int."},{"key":"10.1016\/j.fct.2020.111437_bib100","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1017\/S0007114517002124","article-title":"The effect of anthocyanin supplementation in modulating platelet function in sedentary population: a randomised, double-blind, placebo-controlled, cross-over trial","volume":"118","author":"Thompson","year":"2017","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fct.2020.111437_bib101","first-page":"9","article-title":"Anthocyanins: naturally occurring fruit pigments with functional properties","volume":"39","author":"Turturic\u0103","year":"2015","journal-title":"Ann Univ Dunarea Galati Fascicle VI Food Technol"},{"key":"10.1016\/j.fct.2020.111437_bib102","doi-asserted-by":"crossref","DOI":"10.3390\/foods8050178","article-title":"Consumer distrust about e-numbers: a qualitative study among food experts","volume":"8","author":"van Gunst","year":"2019","journal-title":"Foods"},{"key":"10.1016\/j.fct.2020.111437_bib103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10787-019-00612-6","article-title":"Role of flavonoids in thrombotic, cardiovascular, and inflammatory diseases","volume":"27","author":"Vazhappilly","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.fct.2020.111437_bib104","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.fct.2017.12.004","article-title":"Caramel color safety\u2013an update","volume":"111","author":"Vollmuth","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2020.111437_bib105","first-page":"19","article-title":"Current status of health food regulation and standards in the United States","volume":"10","author":"Wang","year":"2019","journal-title":"J Food Saf Qualit"},{"key":"10.1016\/j.fct.2020.111437_bib106","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12959-016-0100-6","article-title":"Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies","volume":"14","author":"Xu","year":"2016","journal-title":"Thromb. J."},{"key":"10.1016\/j.fct.2020.111437_bib107","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1055\/s-0038-1656551","article-title":"Cyanidin-3-o-\u03b2-glucoside induces megakaryocyte apoptosis via PI3K\/Akt-and MAPKs-mediated inhibition of NF-\u03baB signalling","volume":"118","author":"Ya","year":"2018","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.fct.2020.111437_bib108","article-title":"Plant food delphinidin-3-glucoside significantly inhibits platelet activation and thrombosis: novel protective roles against cardiovascular diseases","volume":"7","author":"Yang","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.fct.2020.111437_bib109","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.3945\/jn.116.245944","article-title":"Plant-based food cyanidin-3-glucoside modulates human platelet glycoprotein VI signaling and inhibits platelet activation and thrombus formation","volume":"147","author":"Yao","year":"2017","journal-title":"J. Nutr."},{"key":"10.1016\/j.fct.2020.111437_bib110","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s13659-017-0119-9","article-title":"Natural colorants: historical, processing and sustainable prospects","volume":"7","author":"Yusuf","year":"2017","journal-title":"Nat Prod Bioprospect"},{"key":"10.1016\/j.fct.2020.111437_bib111","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1039\/C4FO00670D","article-title":"Atheroprotective effects of (poly) phenols: a focus on cell cholesterol metabolism","volume":"6","author":"Zanotti","year":"2015","journal-title":"Food Funct"},{"key":"10.1016\/j.fct.2020.111437_bib112","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1142\/S0192415X16500130","article-title":"Phytochemistry and pharmacology of Carthamus tinctorius L","volume":"44","author":"Zhang","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.fct.2020.111437_bib113","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3177\/jnsv.63.237","article-title":"Anthocyanin cyanidin-3-glucoside attenuates platelet granule release in mice fed high-fat diets","volume":"63","author":"Zhou","year":"2017","journal-title":"J. Nutr. Sci. Vitaminol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691520303276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691520303276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:04:40Z","timestamp":1759529080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691520303276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":113,"alternative-id":["S0278691520303276"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2020.111437","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selected food colourants with antiplatelet activity as promising compounds for the prophylaxis and treatment of thrombosis","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2020.111437","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111437"}}