{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:44:43Z","timestamp":1785840283385,"version":"3.56.0"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.fct.2021.112074","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T19:12:40Z","timestamp":1613675560000},"page":"112074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Role of circular RNAs in visceral organ fibrosis"],"prefix":"10.1016","volume":"150","author":[{"given":"Xiaoniu","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuifen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-912X","authenticated-orcid":false,"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-3557","authenticated-orcid":false,"given":"Jie","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2021.112074_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature21715","article-title":"DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome","volume":"544","author":"Aktas","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.fct.2021.112074_bib2","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1002\/jcp.27384","article-title":"Circular RNA in cardiovascular disease","volume":"234","author":"Altesha","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.fct.2021.112074_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molcel.2014.08.019","article-title":"circRNA biogenesis competes with pre-mRNA splicing","volume":"56","author":"Ashwal-Fluss","year":"2014","journal-title":"Mol. Cell."},{"key":"10.1016\/j.fct.2021.112074_bib4","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1152\/physrev.00041.2015","article-title":"Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches","volume":"96","author":"Beermann","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.fct.2021.112074_bib5","doi-asserted-by":"crossref","first-page":"F350","DOI":"10.1152\/ajprenal.90765.2008","article-title":"Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency","volume":"297","author":"Breusegem","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.fct.2021.112074_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.addr.2017.05.017","article-title":"Therapeutic pro-fibrogenic signaling pathways in fibroblasts","volume":"121","author":"Cannito","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.fct.2021.112074_bib7","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.cell.2012.04.031","article-title":"Insights into RNA biology from an atlas of mammalian mRNA-binding proteins","volume":"149","author":"Castello","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.fct.2021.112074_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrm.2015.32","article-title":"The biogenesis and emerging roles of circular RNAs","volume":"17","author":"Chen","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fct.2021.112074_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.canlet.2018.01.011","article-title":"Circular RNA: an emerging non-coding RNA as a regulator and biomarker in cancer","volume":"418","author":"Chen","year":"2018","journal-title":"Canc. Lett."},{"key":"10.1016\/j.fct.2021.112074_bib10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/15476286.2015.1020271","article-title":"Regulation of circRNA biogenesis","volume":"12","author":"Chen","year":"2015","journal-title":"RNA Biol."},{"key":"10.1016\/j.fct.2021.112074_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/cr.2015.24","article-title":"ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner","volume":"25","author":"Chen","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.fct.2021.112074_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.gene.2017.07.078","article-title":"Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation","volume":"629","author":"Chen","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.fct.2021.112074_bib13","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.7150\/thno.42423","article-title":"Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p\/FBXW7 axis","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.fct.2021.112074_bib14","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1152\/physiolgenomics.00064.2017","article-title":"Circular RNAs in rat models of cardiovascular and renal diseases","volume":"49","author":"Cheng","year":"2017","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.fct.2021.112074_bib15","first-page":"1430350","article-title":"Pulmonary hypertension associated with idiopathic pulmonary fibrosis: current and future perspectives","author":"Collum","year":"2017","journal-title":"Can Respir J 2017"},{"key":"10.1016\/j.fct.2021.112074_bib16","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.cell.2015.02.014","article-title":"The RNA binding protein quaking regulates formation of circRNAs","volume":"160","author":"Conn","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.fct.2021.112074_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.bbrc.2020.07.066","article-title":"CircZNF609 is involved in the pathogenesis of focal segmental glomerulosclerosis by sponging miR-615-5p","volume":"531","author":"Cui","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2021.112074_bib18","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1093\/nar\/gkw027","article-title":"Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2","volume":"44","author":"Du","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fct.2021.112074_bib19","doi-asserted-by":"crossref","first-page":"14741","DOI":"10.1038\/ncomms14741","article-title":"FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons","volume":"8","author":"Errichelli","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fct.2021.112074_bib20","doi-asserted-by":"crossref","first-page":"G38","DOI":"10.1152\/ajpgi.00309.2012","article-title":"Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice","volume":"304","author":"Everitt","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.fct.2021.112074_bib21","first-page":"5135781","article-title":"Circular RNAs in cardiovascular disease: an overview","author":"Fan","year":"2017","journal-title":"Biomed Res Int 2017"},{"key":"10.1016\/j.fct.2021.112074_bib22","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1111\/jcmm.14093","article-title":"Signature of circular RNAs in peripheral blood mononuclear cells from patients with active tuberculosis","volume":"23","author":"Fu","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.fct.2021.112074_bib23","first-page":"1245","article-title":"The complexity of the translation ability of circRNAs","author":"Granados-Riveron","year":"2016","journal-title":"Biochim Biophys Acta 1859"},{"key":"10.1016\/j.fct.2021.112074_bib24","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/1873-3468.12138","article-title":"miR-152 induces human dental pulp stem cell senescence by inhibiting SIRT7 expression","volume":"590","author":"Gu","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.fct.2021.112074_bib25","first-page":"5936171","article-title":"Circular RNA profiling and bioinformatic modeling identify its regulatory role in hepatic steatosis","author":"Guo","year":"2017","journal-title":"Biomed Res Int 2017"},{"key":"10.1016\/j.fct.2021.112074_bib26","doi-asserted-by":"crossref","first-page":"3960197","DOI":"10.1155\/2017\/3960197","article-title":"circRNA_0046367 prevents hepatoxicity of lipid peroxidation: an inhibitory role against hepatic steatosis","author":"Guo","year":"2017","journal-title":"Oxid Med Cell Longev 2017"},{"key":"10.1016\/j.fct.2021.112074_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3748\/wjg.v24.i3.323","article-title":"circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling","volume":"24","author":"Guo","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2021.112074_bib28","doi-asserted-by":"crossref","first-page":"64551","DOI":"10.18632\/oncotarget.18350","article-title":"Circular RNAs: a novel type of biomarker and genetic tools in cancer","volume":"8","author":"Han","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.fct.2021.112074_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pharmthera.2018.01.010","article-title":"Circular RNA and its mechanisms in disease: from the bench to the clinic","volume":"187","author":"Han","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fct.2021.112074_bib30","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1080\/15476286.2016.1255398","article-title":"CircRNAs in the brain","volume":"14","author":"Hanan","year":"2017","journal-title":"RNA Biol."},{"key":"10.1016\/j.fct.2021.112074_bib31","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1038\/emboj.2011.359","article-title":"miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA","volume":"30","author":"Hansen","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.fct.2021.112074_bib32","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.fct.2021.112074_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2353\/ajpath.2009.081170","article-title":"Emerging concepts in the pathogenesis of lung fibrosis","volume":"175","author":"Hardie","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fct.2021.112074_bib34","first-page":"192","article-title":"Identification of differentially expressed circular RNAs during TGF-ss1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells","volume":"19","author":"Huang","year":"2018","journal-title":"Anatol. J. Cardiol."},{"key":"10.1016\/j.fct.2021.112074_bib35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.celrep.2014.12.019","article-title":"Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals","volume":"10","author":"Ivanov","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.fct.2021.112074_bib36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nbt.2890","article-title":"Detecting and characterizing circular RNAs","volume":"32","author":"Jeck","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.fct.2021.112074_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1261\/rna.035667.112","article-title":"Circular RNAs are abundant, conserved, and associated with ALU repeats","volume":"19","author":"Jeck","year":"2013","journal-title":"RNA"},{"key":"10.1016\/j.fct.2021.112074_bib38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.toxlet.2019.02.014","article-title":"The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition","volume":"307","author":"Jiang","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2021.112074_bib39","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3389\/fcell.2020.00714","article-title":"Circular RNA cMTO1 promotes PTEN expression through sponging miR-181b-5p in liver fibrosis","volume":"8","author":"Jin","year":"2020","journal-title":"Frontiers in cell and developmental biology"},{"key":"10.1016\/j.fct.2021.112074_bib40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fphar.2014.00123","article-title":"Fibroblasts in fibrosis: novel roles and mediators","volume":"5","author":"Kendall","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2021.112074_bib41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/14728222.2018.1406922","article-title":"TGFbeta as a therapeutic target in cystic fibrosis","volume":"22","author":"Kramer","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.fct.2021.112074_bib42","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1101\/gad.270421.115","article-title":"Combinatorial control of Drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteins","volume":"29","author":"Kramer","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.fct.2021.112074_bib43","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.chom.2015.01.007","article-title":"MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-kappaB pathway","volume":"17","author":"Kumar","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.fct.2021.112074_bib44","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1261\/rna.047126.114","article-title":"Circular RNAs: diversity of form and function","volume":"20","author":"Lasda","year":"2014","journal-title":"RNA"},{"key":"10.1016\/j.fct.2021.112074_bib45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.molcel.2017.02.017","article-title":"Circ-ZNF609 is a circular RNA that can Be translated and functions in myogenesis","volume":"66","author":"Legnini","year":"2017","journal-title":"Mol. Cell."},{"key":"10.1016\/j.fct.2021.112074_bib46","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2017.05.023","article-title":"Coordinated circRNA biogenesis and function with NF90\/NF110 in viral infection","volume":"67","author":"Li","year":"2017","journal-title":"Mol. Cell."},{"key":"10.1016\/j.fct.2021.112074_bib47","first-page":"3256","article-title":"Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis","volume":"42","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.fct.2021.112074_bib48","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41419-020-02747-9","article-title":"CircRNA TADA2A relieves idiopathic pulmonary fibrosis by inhibiting proliferation and activation of fibroblasts","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2021.112074_bib49","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12943-017-0630-y","article-title":"Circles reshaping the RNA world: from waste to treasure","volume":"16","author":"Liu","year":"2017","journal-title":"Mol. Canc."},{"key":"10.1016\/j.fct.2021.112074_bib50","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.omtn.2017.12.006","article-title":"circHLA-C plays an important role in lupus nephritis by sponging miR-150. Molecular therapy","volume":"10","author":"Luan","year":"2018","journal-title":"Nucleic acids"},{"key":"10.1016\/j.fct.2021.112074_bib51","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI60331","article-title":"The acute respiratory distress syndrome","volume":"122","author":"Matthay","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fct.2021.112074_bib52","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.fct.2021.112074_bib53","first-page":"547","article-title":"Circular RNA: an emerging key player in RNA world","volume":"18","author":"Meng","year":"2017","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.fct.2021.112074_bib54","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/bioinformatics\/btx446","article-title":"CircPro: an integrated tool for the identification of circRNAs with protein-coding potential","volume":"33","author":"Meng","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fct.2021.112074_bib55","article-title":"Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension","volume":"96","author":"Miao","year":"2017","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.fct.2021.112074_bib56","first-page":"8529796","article-title":"Microarray analysis and detection of MicroRNAs associated with chronic thromboembolic pulmonary hypertension","author":"Miao","year":"2017","journal-title":"Biomed Res Int 2017"},{"key":"10.1016\/j.fct.2021.112074_bib57","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/dmrr.2568","article-title":"Research progress in signalling pathway in diabetic nephropathy","volume":"31","author":"Ni","year":"2015","journal-title":"Diabetes\/metabolism research and reviews"},{"key":"10.1016\/j.fct.2021.112074_bib58","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijcard.2019.04.006","article-title":"Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p","volume":"292","author":"Ni","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.fct.2021.112074_bib59","doi-asserted-by":"crossref","first-page":"16076","DOI":"10.1038\/nrdp.2016.76","volume":"2","author":"Pai","year":"2016","journal-title":"Tuberculosis. Nature reviews. Disease primers"},{"key":"10.1016\/j.fct.2021.112074_bib60","doi-asserted-by":"crossref","DOI":"10.2337\/db200203","article-title":"circRNA_010383 acts as a sponge for miR-135a and its downregulated expression contributes to renal fibrosis in diabetic nephropathy","author":"Peng","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.fct.2021.112074_bib61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ebiom.2017.12.007","article-title":"Potential diagnostic power of blood circular RNA expression in active","volume":"27","author":"Qian","year":"2018","journal-title":"Pulmonary Tuberculosis. EBioMedicine"},{"key":"10.1016\/j.fct.2021.112074_bib62","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.molcel.2015.03.027","article-title":"Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed","volume":"58","author":"Rybak-Wolf","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.fct.2021.112074_bib63","first-page":"33","article-title":"The circular RNA MICRA for risk stratification after myocardial infarction","volume":"17","author":"Salgado-Somoza","year":"2017","journal-title":"Int J Cardiol Heart Vasc"},{"key":"10.1016\/j.fct.2021.112074_bib64","first-page":"4066","article-title":"Downregulation of microRNA-637 increases risk of hypoxia-induced pulmonary hypertension by modulating expression of cyclin dependent kinase 6 (CDK6) in pulmonary smooth muscle cells","volume":"22","author":"Sang","year":"2016","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res. : international medical journal of experimental and clinical research"},{"key":"10.1016\/j.fct.2021.112074_bib65","first-page":"91","article-title":"Silicosis and lung cancer: current perspectives","volume":"9","author":"Sato","year":"2018","journal-title":"Lung Canc."},{"key":"10.1016\/j.fct.2021.112074_bib66","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.21037\/jtd.2017.10.111","article-title":"Idiopathic pulmonary fibrosis: a holistic approach to disease management in the antifibrotic age","volume":"9","author":"Shaw","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.fct.2021.112074_bib67","first-page":"1786","article-title":"Circular RNA, a novel marker for cancer determination (Review)","volume":"42","author":"Su","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.fct.2021.112074_bib68","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3389\/fphys.2019.00279","article-title":"Regulatory non-coding RNAs network in non-alcoholic fatty liver disease","volume":"10","author":"Sulaiman","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.fct.2021.112074_bib69","doi-asserted-by":"crossref","first-page":"40342","DOI":"10.1038\/srep40342","article-title":"CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts","volume":"7","author":"Tang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2021.112074_bib70","doi-asserted-by":"crossref","first-page":"8779","DOI":"10.1111\/jcmm.15513","article-title":"Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p\/E-cadherin signals","volume":"24","author":"Tang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.fct.2021.112074_bib71","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.7150\/thno.15007","article-title":"Crucial role of miR-433 in regulating cardiac fibrosis","volume":"6","author":"Tao","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.fct.2021.112074_bib72","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.fct.2021.112074_bib73","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"TGF-beta activation and function in immunity","volume":"32","author":"Travis","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fct.2021.112074_bib74","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fnmol.2016.00074","article-title":"Circular RNAs: novel regulators of neuronal development","volume":"9","author":"van Rossum","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.fct.2021.112074_bib75","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.bbrc.2017.08.131","article-title":"The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: a microarray study","volume":"493","author":"Wan","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2021.112074_bib76","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1261\/rna.048272.114","article-title":"Efficient backsplicing produces translatable circular mRNAs","volume":"21","author":"Wang","year":"2015","journal-title":"RNA"},{"key":"10.1016\/j.fct.2021.112074_bib77","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1093\/eurheartj\/ehv713","article-title":"A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223","volume":"37","author":"Wang","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.fct.2021.112074_bib78","first-page":"1353","article-title":"Characteristics of circular RNA expression in lung tissues from mice with hypoxiainduced pulmonary hypertension","volume":"42","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.fct.2021.112074_bib79","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.1111\/jcmm.14432","article-title":"CircMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7","volume":"23","author":"Wang","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.fct.2021.112074_bib80","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2018.06.003","article-title":"Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications","volume":"65","author":"Weiskirchen","year":"2019","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.fct.2021.112074_bib81","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1248\/bpb.b19-00901","article-title":"circACTR2: a novel mechanism regulating high glucose-induced fibrosis in renal tubular cells via pyroptosis","volume":"43","author":"Wen","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.fct.2021.112074_bib82","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yjmcc.2016.07.007","article-title":"Characterization of circular RNAs in human, mouse and rat hearts","volume":"98","author":"Werfel","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.fct.2021.112074_bib83","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.febslet.2014.04.037","article-title":"MiR-152 reduces human umbilical vein endothelial cell proliferation and migration by targeting ADAM17","volume":"588","author":"Wu","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.fct.2021.112074_bib84","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.fct.2021.112074_bib85","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.18632\/oncotarget.22846","article-title":"Circular RNAs: clinical relevance in cancer","volume":"9","author":"Xu","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.fct.2021.112074_bib86","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1096\/fj.201701118R","article-title":"Silica-induced initiation of circular ZC3H4 RNA\/ZC3H4 pathway promotes the pulmonary macrophage activation","volume":"32","author":"Yang","year":"2018","journal-title":"Faseb. J."},{"key":"10.1016\/j.fct.2021.112074_bib87","article-title":"Investigation of circular RNAs and related genes in pulmonary fibrosis based on bioinformatics analysis","author":"Yang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.fct.2021.112074_bib88","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.omtn.2019.06.026","article-title":"A novel circular RNA mediates pyroptosis of diabetic cardiomyopathy by functioning as a competing endogenous RNA. Molecular therapy","volume":"17","author":"Yang","year":"2019","journal-title":"Nucleic acids"},{"key":"10.1016\/j.fct.2021.112074_bib89","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-981-13-1426-1_21","article-title":"Circular RNAs in organ fibrosis","volume":"1087","author":"Yao","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.fct.2021.112074_bib90","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/toxsci\/kfy221","article-title":"The CDR1as\/miR-7\/TGFBR2 Axis modulates EMT in silica-induced pulmonary fibrosis","volume":"166","author":"Yao","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2021.112074_bib91","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1111\/jcmm.13684","article-title":"Dysregulated circRNAs in plasma from active tuberculosis patients","volume":"22","author":"Yi","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.fct.2021.112074_bib92","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.molcel.2013.08.017","article-title":"Circular intronic long noncoding RNAs","volume":"51","author":"Zhang","year":"2013","journal-title":"Mol. Cell."},{"key":"10.1016\/j.fct.2021.112074_bib93","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1002\/stem.1795","article-title":"MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway","volume":"32","author":"Zhang","year":"2014","journal-title":"Stem Cell."},{"key":"10.1016\/j.fct.2021.112074_bib94","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.celrep.2016.03.058","article-title":"The biogenesis of nascent circular RNAs","volume":"15","author":"Zhang","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.fct.2021.112074_bib95","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1101\/gr.202895.115","article-title":"Diverse alternative back-splicing and alternative splicing landscape of circular RNAs","volume":"26","author":"Zhang","year":"2016","journal-title":"Genome Res."},{"key":"10.1016\/j.fct.2021.112074_bib96","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13046-017-0624-z","article-title":"Circular RNAs: emerging cancer biomarkers and targets","volume":"36","author":"Zhang","year":"2017","journal-title":"J. Exp. Clin. Canc. Res."},{"key":"10.1016\/j.fct.2021.112074_bib97","doi-asserted-by":"crossref","first-page":"113571","DOI":"10.18632\/oncotarget.22710","article-title":"Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.fct.2021.112074_bib98","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41419-019-1430-7","article-title":"circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2021.112074_bib99","doi-asserted-by":"crossref","first-page":"105660","DOI":"10.1016\/j.biocel.2019.105660","article-title":"Lung myofibroblast transition and fibrosis is regulated by circ0044226","volume":"118","author":"Zhang","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.fct.2021.112074_bib100","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1038\/ncomms11215","article-title":"Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs","volume":"7","author":"Zheng","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fct.2021.112074_bib101","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.bbrc.2017.04.044","article-title":"A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-beta1","volume":"487","author":"Zhou","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2021.112074_bib102","article-title":"MicroRNA-7 inhibits tumor metastasis and reverses epithelial-mesenchymal transition through AKT\/ERK1\/2 inactivation by targeting EGFR in epithelial ovarian cancer","volume":"9","author":"Zhou","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.fct.2021.112074_bib103","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3233\/CBM-181296","article-title":"Circular RNAs as novel rising stars with huge potentials in development and disease","volume":"22","author":"Zhou","year":"2018","journal-title":"Canc. Biomarkers"},{"key":"10.1016\/j.fct.2021.112074_bib104","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.gene.2018.08.052","article-title":"Preliminary screening and functional analysis of circular RNAs associated with hepatic stellate cell activation","volume":"677","author":"Zhou","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.fct.2021.112074_bib105","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/hepr.13284","article-title":"Differential expression of circular RNAs in hepatic tissue in a model of liver fibrosis and functional analysis of their target genes","volume":"49","author":"Zhou","year":"2019","journal-title":"Hepatol. Res. : the official journal of the Japan Society of Hepatology"},{"key":"10.1016\/j.fct.2021.112074_bib106","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1159\/000495556","article-title":"Thymosin-beta4 mediates hepatic stellate cell activation by interfering with CircRNA-0067835\/miR-155\/FoxO3 signaling pathway","volume":"51","author":"Zhu","year":"2018","journal-title":"Cell. Physiol. Biochem. : international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"key":"10.1016\/j.fct.2021.112074_bib107","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3389\/fgene.2019.00564","article-title":"Upregulation of circular RNA CircNFIB attenuates cardiac fibrosis by sponging miR-433","volume":"10","author":"Zhu","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.fct.2021.112074_bib108","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.molimm.2017.08.008","article-title":"The circular RNA of peripheral blood mononuclear cells: hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis","volume":"90","author":"Zhuang","year":"2017","journal-title":"Mol. Immunol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521001071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521001071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:07:32Z","timestamp":1759529252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691521001071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":108,"alternative-id":["S0278691521001071"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2021.112074","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of circular RNAs in visceral organ fibrosis","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2021.112074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112074"}}