{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:00:59Z","timestamp":1787504459067,"version":"build-2736575974"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.fct.2021.112119","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T05:25:00Z","timestamp":1616045100000},"page":"112119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Bioactive compounds from Octopus vulgaris ink extracts exerted anti-proliferative and anti-inflammatory effects in vitro"],"prefix":"10.1016","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-1932","authenticated-orcid":false,"given":"Mart\u00edn S.","family":"Hern\u00e1ndez-Zazueta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-3520","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Luzardo-Ocampo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S.","family":"Garc\u00eda-Romo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Noguera-Artiaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel A.","family":"Carbonell-Barrachina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Taboada-Antelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4054-1250","authenticated-orcid":false,"given":"Roc\u00edo","family":"Campos-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-0898","authenticated-orcid":false,"given":"Ema Carina","family":"Rosas-Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda G.","family":"Burboa-Zazueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josafat M.","family":"Ezquerra-Brauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Burgos-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2021.112119_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.gde.2008.01.003","article-title":"Pathways connecting inflammation and cancer","volume":"18","author":"Allavena","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.fct.2021.112119_bib2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3390\/antibiotics9110757","article-title":"Putative antimicrobial peptides of the posterior salivary glands from the cephalopod Octopus vulgaris revealed by exploring a composite protein database","volume":"9","author":"Almeida","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.fct.2021.112119_bib3","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.1038\/s41598-020-63444-3","article-title":"Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments","volume":"10","author":"Ammendola","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2021.112119_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jfca.2017.01.013","article-title":"Bioactive fatty acids in mantis shrimp, crab and caramote prawn: their content and distribution among the main lipid classes","volume":"59","author":"Balzano","year":"2017","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.fct.2021.112119_bib5","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3390\/md17080464","article-title":"Metabolites from marine microorganisms, micro, and macroalgae: immense scope for pharmacology","volume":"17","author":"Barzkar","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fct.2021.112119_bib6","first-page":"1","article-title":"Global Cancer Statistics 2018\u00a0: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","author":"Bray","year":"2018","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.fct.2021.112119_bib7","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1046\/j.1523-1755.63.s84.6.x","article-title":"Nitric oxide, oxidative stress, and apoptosis","volume":"63","author":"Br\u00fcne","year":"2003","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.fct.2021.112119_bib8","first-page":"32","article-title":"The immuno-stimulating activations of squid ink and its extracts","volume":"18","author":"Changlong","year":"1999","journal-title":"Chin. J. Mar. Drugs"},{"key":"10.1016\/j.fct.2021.112119_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1476-511X-9-117","article-title":"The activation of CD14, TLR4, and TLR2 by mmLDL induces IL-1\u03b2, IL-6, and IL-10 secretion in human monocytes and macrophages","volume":"9","author":"Ch\u00e1vez-S\u00e1nchez","year":"2010","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.fct.2021.112119_bib10","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.3389\/fphar.2019.01574","article-title":"Squid ink polysaccharides protect human fibroblast against oxidative stress by regulating NADPH oxidase and connexin43","volume":"10","author":"Chen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2021.112119_bib11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/35070009","article-title":"Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I","volume":"3","author":"Coleman","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.fct.2021.112119_bib12","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.fct.2021.112119_bib13","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.3390\/md12052700","article-title":"Cephalopod ink: production, chemistry, functions and applications","volume":"12","author":"Derby","year":"2014","journal-title":"Mar. Drugs"},{"issue":"12","key":"10.1016\/j.fct.2021.112119_bib77","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/nprot.2008.182","article-title":"Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates","volume":"3","author":"Ebada","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.fct.2021.112119_bib14","first-page":"90","article-title":"Biologically active compounds in Sepia pharaonis fish (Ehrenber, 1831) ink extract from Chennai seacoast isolated by gas chromatography","volume":"13","author":"Ebenezer","year":"2020","journal-title":"Drug Invent. Today"},{"key":"10.1016\/j.fct.2021.112119_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cyto.2009.07.003","article-title":"STAT3 in CD4+ T helper cell differentiation and inflammatory diseases","volume":"47","author":"Egwuagu","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.fct.2021.112119_bib16","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.5897\/AJPP2013.3564","article-title":"In vitro antioxidant, analgesic and cytotoxic activities of Sepia officinalis ink and Coelatura aegyptiaca extracts","volume":"7","author":"Fahmy","year":"2013","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"10.1016\/j.fct.2021.112119_bib17","series-title":"Nitric Oxide","first-page":"213","article-title":"Electrophilic nitro-fatty acids: nitric oxide and nitrite-derived metabolic and inflammatory signaling mediators","author":"Freeman","year":"2017"},{"key":"10.1016\/j.fct.2021.112119_bib18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrrheum.2010.4","article-title":"IL-1 pathways in inflammation and human diseases","volume":"6","author":"Gabay","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.fct.2021.112119_bib19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1134\/S1607672917060114","article-title":"The effect of cisplatin on cytotoxicity of anticancer cytokine TRAIL and its receptor-selective mutant variant DR5-B1","volume":"477","author":"Gasparian","year":"2017","journal-title":"Dokl. Biochem. Biophys."},{"key":"10.1016\/j.fct.2021.112119_bib20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10545-017-0130-7","article-title":"Promises and pitfalls of untargeted metabolomics","volume":"41","author":"Gertsman","year":"2018","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.fct.2021.112119_bib21","first-page":"4","article-title":"Isolation and characterization of Lolduvin-S: a novel antimicrobial protein from the ink of indians squid Loligo duvauceli","volume":"3","author":"Girija","year":"2011","journal-title":"Int. J. Curr. Res. Rev."},{"key":"10.1016\/j.fct.2021.112119_bib22","first-page":"338","article-title":"Antibacterial effect of squid ink on ESBL producing strains of Escherichia coli and Klebsiella pneumoniae","volume":"41","author":"Girija","year":"2012","journal-title":"Indian J. Geo-Marine Sci."},{"key":"10.1016\/j.fct.2021.112119_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2017.05.033","article-title":"Jak Stat signaling and cancer: opportunities, benefits and side effects of targeted inhibition","volume":"451","author":"Groner","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.fct.2021.112119_bib24","first-page":"5889","article-title":"Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide","volume":"14","author":"Gu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.fct.2021.112119_bib25","first-page":"151","article-title":"Anticancer activity of an oligopeptide isolated from hydrolysates of Sepia Ink","volume":"9","author":"Guo-fang","year":"2011","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.fct.2021.112119_bib26","first-page":"15591","article-title":"Octopus vulgaris ink extracts exhibit antioxidant, antimutagenic, cytoprotective, antiproliferative, and proapoptotic effects in selected human cancer cell lines","volume":"1750\u20133841","author":"Hern\u00e1ndez\u2010Zazueta","year":"2021","journal-title":"J. Food Sci."},{"key":"10.1016\/j.fct.2021.112119_bib27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jff.2019.01.032","article-title":"Untargeted metabolomic evaluation of mango bagasse and mango bagasse based confection under in vitro simulated colonic fermentation","volume":"54","author":"Herrera-Cazares","year":"2019","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fct.2021.112119_bib28","article-title":"Estimated number of new cancer cases in 2018 worldwide [WWW Document]","author":"IARC","year":"2018","journal-title":"Canc. Today"},{"key":"10.1016\/j.fct.2021.112119_bib29","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2021.112119_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/md17090491","article-title":"Marine natural products: a source of novel anticancer drugs","author":"Khalifa","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fct.2021.112119_bib31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/ijc.22682","article-title":"Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese","volume":"121","author":"Kuriki","year":"2007","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.fct.2021.112119_bib32","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-12-253","article-title":"Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems","volume":"12","author":"L\u00ea Cao","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.fct.2021.112119_bib33","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1002\/ptr.4905","article-title":"Houttuynia cordata Thunb. volatile oil exhibited anti-inflammatory effects in vivo and inhibited nitric oxide and Tumor Necrosis Factor-\u03b1 production in LPS-stimulated mouse peritoneal macrophages in vitro","volume":"27","author":"Li","year":"2013","journal-title":"Phyther. Res."},{"key":"10.1016\/j.fct.2021.112119_bib34","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3390\/cells9030618","article-title":"Immunotherapy, inflammation and colorectal cancer","volume":"9","author":"Lichtenstern","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.fct.2021.112119_bib35","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.foodchem.2008.02.026","article-title":"Structural characterisation and antimutagenic activity of a novel polysaccharide isolated from Sepiella maindroni ink","volume":"110","author":"Liu","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2021.112119_bib36","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1021\/acs.jafc.6b01854","article-title":"Preventive effects of a novel polysaccharide from Sepia esculenta ink on ovarian failure and its action mechanisms in cyclophosphamide-treated mice","volume":"64","author":"Liu","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2021.112119_bib37","first-page":"1292","article-title":"Polysaccharide from Sepia esculenta ink and cisplatin inhibit synergistically proliferation and metastasis of triple-negative breast cancer MDA-MB-231 cells. Iran","volume":"19","author":"Liu","year":"2016","journal-title":"J. Basic Med. Sci."},{"key":"10.1016\/j.fct.2021.112119_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.25815","article-title":"Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates","author":"Lonkar","year":"2011","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.fct.2021.112119_bib39","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/chem.201804901","article-title":"\u03b2-Ketoiminato Iridium(III) organometallic complexes: selective cytotoxicity towards colorectal cancer cells HCT116 p53 -\/-","volume":"25","author":"Lord","year":"2019","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.fct.2021.112119_bib40","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jff.2015.11.017","article-title":"High throughput sequencing analysis reveals amelioration of intestinal dysbiosis by squid ink polysaccharide","volume":"20","author":"Lu","year":"2016","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fct.2021.112119_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mnfr.201700362","article-title":"Anthocyanins from purple corn ameliorated Tumor Necrosis Factor-\u03b1-induced inflammation and insulin resistance in 3T3-L1 adipocytes via activation of insulin signaling and enhanced GLUT4 translocation","volume":"61","author":"Luna-Vital","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2021.112119_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.foodchem.2018.03.096","article-title":"Fermented non-digestible fraction from combined nixtamalized corn (Zea mays L.)\/cooked common bean (Phaseolus vulgaris L.) chips modulate anti-inflammatory markers on RAW 264.7 macrophages","volume":"259","author":"Luzardo-Ocampo","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2021.112119_bib43","doi-asserted-by":"crossref","first-page":"109097","DOI":"10.1016\/j.foodres.2020.109097","article-title":"Consumption of a baked corn and bean snack reduced chronic colitis inflammation in CD-1 mice via downregulation of IL-1 receptor, TLR, and TNF-\u03b1 associated pathways","volume":"132","author":"Luzardo-Ocampo","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.fct.2021.112119_bib44","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1182\/blood-2011-11-392985","article-title":"Functional STAT3 deficiency compromises the generation of human T follicular helper cells","volume":"119","author":"Ma","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.fct.2021.112119_bib45","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s10886-010-9869-0","article-title":"The effect of sampling methods on the apparent constituents of ink from the squid Sepioteuthis australis","volume":"36","author":"Madaras","year":"2010","journal-title":"J. Chem. Ecol."},{"key":"10.1016\/j.fct.2021.112119_bib46","doi-asserted-by":"crossref","DOI":"10.4103\/0975-7406.171700","article-title":"Exploring the ocean for new drug developments: marine pharmacology","author":"Malve","year":"2016","journal-title":"J. Pharm. BioAllied Sci."},{"key":"10.1016\/j.fct.2021.112119_bib47","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3390\/md18080380","article-title":"OctoPartenopin: identification and preliminary characterization of a novel antimicrobial peptide from the suckers of Octopus vulgaris","volume":"18","author":"Maselli","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fct.2021.112119_bib48","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.e10-04-0335","article-title":"The proliferation rate paradox in antimitotic chemotherapy","author":"Mitchison","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.fct.2021.112119_bib49","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s12029-016-9845-1","article-title":"A review on dietary and non-dietary risk factors associated with gastrointestinal cancer","volume":"47","author":"Mysuru Shivanna","year":"2016","journal-title":"J. Gastrointest. Canc."},{"key":"10.1016\/j.fct.2021.112119_bib50","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3136\/fstr.6.171","article-title":"Tyrosinase activity in antitumor compounds of squid ink","volume":"6","author":"Naraoka","year":"2000","journal-title":"Food Sci. Technol. Res."},{"key":"10.1016\/j.fct.2021.112119_bib51","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1002\/jsfa.9951","article-title":"Functional and sensory properties of pistachio nuts as affected by cultivar","volume":"99","author":"Noguera\u2010Artiaga","year":"2019","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.fct.2021.112119_bib52","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neulet.2010.03.026","article-title":"Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-\u03baB activation in BV2 murine microglial cells","volume":"474","author":"Oh","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.fct.2021.112119_bib53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cyto.2016.06.017","article-title":"JAK-STAT signaling in cancer: from cytokines to non-coding genome","volume":"87","author":"Pencik","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.fct.2021.112119_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011765","article-title":"Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation","volume":"5","author":"Rajam\u00e4ki","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.fct.2021.112119_bib55","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11306-017-1253-4","article-title":"Polycystic ovary syndrome in Indian women: a mass spectrometry based serum metabolomics approach","volume":"13","author":"RoyChoudhury","year":"2017","journal-title":"Metabolomics"},{"key":"10.1016\/j.fct.2021.112119_bib56","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0006-291X(03)01379-2","article-title":"Toxicity of melanin-free ink of Sepia officinalis to transformed cell lines: identification of the active factor as tyrosinase","volume":"308","author":"Russo","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2021.112119_bib57","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.nutres.2013.07.002","article-title":"Systematic review of saturated fatty acids on inflammation and circulating levels of adipokines","volume":"33","author":"Santos","year":"2013","journal-title":"Nutr. Res."},{"key":"10.1016\/j.fct.2021.112119_bib58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.canlet.2005.04.009","article-title":"Molecular mechanisms of aging-associated inflammation","volume":"236","author":"Sarkar","year":"2006","journal-title":"Canc. Lett."},{"key":"10.1016\/j.fct.2021.112119_bib59","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12943-017-0721-9","article-title":"Tumor-related interleukins: old validated targets for new anti-cancer drug development","volume":"16","author":"Setrerrahmane","year":"2017","journal-title":"Mol. Canc."},{"key":"10.1016\/j.fct.2021.112119_bib60","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.2147\/IJN.S164518","article-title":"Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends","volume":"Volume 13","author":"Sohail","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.fct.2021.112119_bib61","first-page":"125","article-title":"Antitumoral activity in inks of Sepia officinalis and Octopus vulgaris (Cephalopoda) from the northern tunisian coast (central Mediterranean sea)","volume":"27","author":"Soufi-Kechaou","year":"2017","journal-title":"Ann. Ser. Hist. Nat."},{"key":"10.1016\/j.fct.2021.112119_bib62","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1038\/s41598-020-58674-4","article-title":"Clinical efficacy and safety of anti-PD-1\/PD-L1 inhibitors for the treatment of advanced or metastatic cancer: a systematic review and meta-analysis","volume":"10","author":"Sun","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2021.112119_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218125","article-title":"A multi-targeting natural compound with growth inhibitory and anti-angiogenic properties re-sensitizes chemotherapy resistant cancer","volume":"14","author":"Taylor","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.fct.2021.112119_bib64","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1080\/00222933.2013.826830","article-title":"Morphofunctional characterization and antibacterial activity of haemocytes from Octopus vulgaris","volume":"49","author":"Troncone","year":"2015","journal-title":"J. Nat. Hist."},{"key":"10.1016\/j.fct.2021.112119_bib65","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.fct.2021.112119_bib66","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.3748\/wjg.v25.i31.4383","article-title":"Systemic inflammation in colorectal cancer: underlying factors, effects, and prognostic significance","volume":"25","author":"Tuomisto","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2021.112119_bib67","article-title":"Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization","volume":"19","author":"Van Vuuren","year":"2019","journal-title":"Canc. Cell Int."},{"key":"10.1016\/j.fct.2021.112119_bib68","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/nar\/gkl825","article-title":"STRING 7 - recent developments in the integration and prediction of protein interactions","volume":"35","author":"von Mering","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fct.2021.112119_bib69","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S0007114509231758","article-title":"In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation","volume":"102","author":"Wang","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fct.2021.112119_bib70","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40495-019-00167-8","article-title":"The link of marine products with autophagy-associated cell death in cancer cell","volume":"5","author":"Wargasetia","year":"2019","journal-title":"Curr. Pharmacol. Reports"},{"key":"10.1016\/j.fct.2021.112119_bib71","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.3892\/mmr.2017.6964","article-title":"Role of quercetin in protecting ARPE-19 cells against H2O2-induced injury via nuclear factor erythroid 2 like 2 pathway activation and endoplasmic reticulum stress inhibition","volume":"16","author":"Weng","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.fct.2021.112119_bib72","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1016\/j.yexcr.2007.08.009","article-title":"Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells","volume":"313","author":"Yuan","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.fct.2021.112119_bib73","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1093\/bioinformatics\/btr331","article-title":"Identification of cavities on protein surface using multiple computational approaches for drug binding site prediction","volume":"27","author":"Zhang","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fct.2021.112119_bib74","doi-asserted-by":"crossref","first-page":"23202","DOI":"10.18632\/oncotarget.15539","article-title":"Sepia ink oligopeptide induces apoptosis and growth inhibition in human lung cancer cells","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.fct.2021.112119_bib75","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/md7010009","article-title":"Protective effects of squid ink extract towards hemopoietic injuries induced by cyclophosphamine","volume":"7","author":"Zhong","year":"2009","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fct.2021.112119_bib76","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1039\/C4FO00569D","article-title":"Dietary squid ink polysaccharide could enhance SIgA secretion in chemotherapeutic mice","volume":"5","author":"Zuo","year":"2014","journal-title":"Food Funct"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521001526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521001526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:07:01Z","timestamp":1759529221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691521001526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":77,"alternative-id":["S0278691521001526"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2021.112119","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioactive compounds from Octopus vulgaris ink extracts exerted anti-proliferative and anti-inflammatory effects in vitro","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2021.112119","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112119"}}