{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T03:15:15Z","timestamp":1772853315893,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730042"],"award-info":[{"award-number":["81730042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901467"],"award-info":[{"award-number":["81901467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.fct.2021.112248","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T11:56:59Z","timestamp":1619783819000},"page":"112248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Bisphenol B stimulates Leydig cell proliferation but inhibits maturation in late pubertal rats"],"prefix":"10.1016","volume":"153","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoni","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yige","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3448-9823","authenticated-orcid":false,"given":"Ren-Shan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2021.112248_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0748233715603847","article-title":"The toxicological effects of bisphenol A and octylphenol on the reproductive system of prepubertal male rats","volume":"33","author":"Ahbab","year":"2017","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.fct.2021.112248_bib2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1210\/en.2003-1174","article-title":"Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells","volume":"145","author":"Akingbemi","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.fct.2021.112248_bib3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nrd4504","article-title":"The history and future of targeting cyclin-dependent kinases in cancer therapy","volume":"14","author":"Asghar","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.fct.2021.112248_bib4","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1073\/pnas.95.8.4344","article-title":"Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero","volume":"95","author":"Brandeis","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fct.2021.112248_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.talanta.2010.08.048","article-title":"Quantification of free and total bisphenol A and bisphenol B in human urine by dispersive liquid-liquid microextraction (DLLME) and heart-cutting multidimensional gas chromatography-mass spectrometry (MD-GC\/MS)","volume":"83","author":"Cunha","year":"2010","journal-title":"Talanta"},{"key":"10.1016\/j.fct.2021.112248_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1749-6632.2008.03788.x","article-title":"Role of relaxin in human osteoclastogenesis","volume":"1160","author":"Facciolli","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.fct.2021.112248_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.fct.2015.05.010","article-title":"Monitoring of bisphenols in canned tuna from Italian markets","volume":"83","author":"Fattore","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112248_bib8","series-title":"Title 21 Code of Federal Regulations (CFR) Part 175, Subpart C: Substances for Use as Components of Coatings","author":"FDA","year":"2018"},{"key":"10.1016\/j.fct.2021.112248_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s004180050004","article-title":"Sox9 protein in rat sertoli cells is age and stage dependent","volume":"113","author":"Frojdman","year":"2000","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.fct.2021.112248_bib10","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1095\/biolreprod.104.037499","article-title":"Gene expression in rat leydig cells during development from the progenitor to adult stage: a cluster Analysis","volume":"72","author":"Ge","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.fct.2021.112248_bib11","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1210\/endo.138.9.5387","article-title":"Decreased cyclin A2 and increased cyclin G1 levels coincide with loss of proliferative capacity in rat Leydig cells during pubertal development","volume":"138","author":"Ge","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.fct.2021.112248_bib12","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1083\/jcb.149.5.1019","article-title":"Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice","volume":"149","author":"Gnessi","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.fct.2021.112248_bib13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.yrtph.2015.01.002","article-title":"Endocrine activity of alternatives to BPA found in thermal paper in Switzerland","volume":"71","author":"Goldinger","year":"2015","journal-title":"Regul. Toxicol. Pharmacol. : RTP (Regul. Toxicol. Pharmacol.)"},{"key":"10.1016\/j.fct.2021.112248_bib14","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.4315\/0362-028X.JFP-13-054","article-title":"Determination of five bisphenols in commercial milk samples by liquid chromatography coupled to fluorescence detection","volume":"76","author":"Grumetto","year":"2013","journal-title":"J. Food Protect."},{"key":"10.1016\/j.fct.2021.112248_bib15","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1530\/REP-12-0465","article-title":"Comparison of cell types in the rat Leydig cell lineage after ethane dimethanesulfonate treatment","volume":"145","author":"Guo","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.fct.2021.112248_bib16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tem.2010.09.003","article-title":"Akt isoforms and glucose homeostasis - the leptin connection","volume":"22","author":"Hay","year":"2011","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.fct.2021.112248_bib17","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1210\/en.2003-0365","article-title":"A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia","volume":"144","author":"Hirakawa","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.fct.2021.112248_bib18","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1101\/gad.8.19.2302","article-title":"The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis","volume":"8","author":"Ingraham","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.fct.2021.112248_bib19","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3389\/fendo.2019.00777","article-title":"Growth hormone and insulin-like growth factor Action in reproductive tissues","volume":"10","author":"Ipsa","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.fct.2021.112248_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/excr.1997.3590","article-title":"Cytoplasmic localization of cyclin D3 in seminiferous tubules during testicular development","volume":"234","author":"Kang","year":"1997","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.fct.2021.112248_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/toxsci\/kfi074","article-title":"Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds","volume":"84","author":"Kitamura","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2021.112248_bib22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1210\/mend.15.1.0586","article-title":"Targeted disruption of luteinizing hormone\/human chorionic gonadotropin receptor gene","volume":"15","author":"Lei","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.fct.2021.112248_bib23","doi-asserted-by":"crossref","first-page":"136100","DOI":"10.1016\/j.scitotenv.2019.136100","article-title":"Serum concentration of bisphenol analogues in pregnant women in China","volume":"707","author":"Li","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2021.112248_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chemosphere.2017.09.116","article-title":"Perfluorooctane sulfonate impairs rat Leydig cell development during puberty","volume":"190","author":"Li","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2021.112248_bib25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fendo.2020.00447","article-title":"Bisphenols and leydig cell development and function","volume":"11","author":"Li","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.fct.2021.112248_bib26","doi-asserted-by":"crossref","first-page":"152633","DOI":"10.1016\/j.tox.2020.152633","article-title":"Perfluoroheptanoic acid induces Leydig cell hyperplasia but inhibits spermatogenesis in rats after pubertal exposure","volume":"448","author":"Li","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2021.112248_bib27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/19440049.2013.868611","article-title":"A survey of bisphenol A and other bisphenol analogues in foodstuffs from nine cities in China","volume":"31","author":"Liao","year":"2013","journal-title":"Food Addit. Contam. Part A, Chemistry, analysis, control, exposure & risk assessment"},{"key":"10.1016\/j.fct.2021.112248_bib28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.envpol.2018.12.006","article-title":"In utero exposure to bisphenol A disrupts fetal testis development in rats","volume":"246","author":"Lv","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2021.112248_bib29","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/gb4184","article-title":"Cyclin-dependent kinases","volume":"15","author":"Malumbres","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.fct.2021.112248_bib30","doi-asserted-by":"crossref","first-page":"9954","DOI":"10.1038\/s41598-019-46272-y","article-title":"Discovery of novel oestrogen receptor alpha agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors","volume":"9","author":"Masuya","year":"2019","journal-title":"Sci. Rep."},{"issue":"135","key":"10.1016\/j.fct.2021.112248_bib31","article-title":"The industrial chemical bisphenol A (BPA) interferes with proliferative activity and development of steroidogenic capacity in rat Leydig cells","volume":"86","author":"Nanjappa","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.fct.2021.112248_bib32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1538\/expanim.53.391","article-title":"Comparative study on toxicokinetics of bisphenol A in F344 rats, monkeys (Macaca fascicularis), and chimpanzees (Pan troglodytes)","volume":"53","author":"Negishi","year":"2004","journal-title":"Exp. Anim."},{"key":"10.1016\/j.fct.2021.112248_bib33","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.4049\/jimmunol.1601503","article-title":"AKT2 regulates pulmonary inflammation and fibrosis via modulating macrophage activation","volume":"198","author":"Nie","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.fct.2021.112248_bib34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1095\/biolreprod.114.117473","article-title":"Regulation of the proliferation and differentiation of leydig stem cells in the adult testis","volume":"90","author":"Odeh","year":"2014","journal-title":"Biol. Reprod."},{"issue":"6","key":"10.1016\/j.fct.2021.112248_bib35","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/JLB.2MIR0817-349R","article-title":"The PI3K\/AKT signaling pathway in regulatory T-cell development, stability, and function","volume":"103","author":"Pompura","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.fct.2021.112248_bib36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1677\/jme.1.01963","article-title":"Induction of steroidogenesis in immature rat Leydig cells by interleukin-1alpha is dependent on extracellular signal-regulated kinases","volume":"36","author":"Renlund","year":"2006","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.fct.2021.112248_bib37","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1095\/biolreprod.103.021550","article-title":"Mullerian-inhibiting substance inhibits rat Leydig cell regeneration after ethylene dimethanesulphonate ablation","volume":"70","author":"Salva","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.fct.2021.112248_bib38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/(SICI)1097-4636(19990605)45:3<192::AID-JBM5>3.0.CO;2-A","article-title":"Estrogenicity of bisphenol A and bisphenol A dimethacrylate in vitro","volume":"45","author":"Schafer","year":"1999","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.fct.2021.112248_bib39","doi-asserted-by":"crossref","first-page":"106001","DOI":"10.1289\/EHP5200","article-title":"Evidence for bisphenol B endocrine properties: scientific and regulatory perspectives","volume":"127","author":"Serra","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2021.112248_bib40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cell.2013.08.062","article-title":"The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit","volume":"155","author":"Spencer","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.fct.2021.112248_bib41","article-title":"Endocrine disruptors and Leydig cell function","volume":"684504","author":"Svechnikov","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.fct.2021.112248_bib42","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/0748233719831528","article-title":"Bisphenol A analogues bisphenol B, bisphenol F, and bisphenol S induce oxidative stress, disrupt daily sperm production, and damage DNA in rat spermatozoa: a comparative in vitro and in vivo study","volume":"35","author":"Ullah","year":"2019","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.fct.2021.112248_bib43","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.chemosphere.2018.06.089","article-title":"Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: comparative in vitro and in vivo studies on the sperms and testicular tissues of rats","volume":"209","author":"Ullah","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2021.112248_bib44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.fct.2018.08.024","article-title":"Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: a focus on the possible hormonal mode of action","volume":"121","author":"Ullah","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112248_bib45","doi-asserted-by":"crossref","first-page":"111299","DOI":"10.1016\/j.ecoenv.2020.111299","article-title":"Bisphenol A(BPA), BPS and BPB-induced oxidative stress and apoptosis mediated by mitochondria in human neuroblastoma cell lines","volume":"207","author":"Wang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2021.112248_bib46","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tips.2011.01.001","article-title":"Impacts of environmental toxicants on male reproductive dysfunction","volume":"32","author":"Wong","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.fct.2021.112248_bib47","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1210\/en.2004-0646","article-title":"Pubertal and adult Leydig cell function in Mullerian inhibiting substance-deficient mice","volume":"146","author":"Wu","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.fct.2021.112248_bib48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.stemcr.2016.11.010","article-title":"Direct reprogramming of mouse fibroblasts toward leydig-like cells by defined factors","volume":"8","author":"Yang","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.fct.2021.112248_bib49","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fphys.2017.00430","article-title":"Insights into the development of the adult Leydig cell lineage from stem Leydig cells","volume":"8","author":"Ye","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.fct.2021.112248_bib50","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1210\/mend.15.1.0582","article-title":"Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LHRKO) mice","volume":"15","author":"Zhang","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.fct.2021.112248_bib51","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.reprotox.2013.07.025","article-title":"Oxidative stress and phthalate-induced down-regulation of steroidogenesis in MA-10 Leydig cells","volume":"42","author":"Zhou","year":"2013","journal-title":"Reprod. Toxicol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521002817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521002817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:07:33Z","timestamp":1759529253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691521002817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":51,"alternative-id":["S0278691521002817"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2021.112248","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bisphenol B stimulates Leydig cell proliferation but inhibits maturation in late pubertal rats","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2021.112248","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112248"}}