{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:33:16Z","timestamp":1790710396699,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TURSP-2020\/288"],"award-info":[{"award-number":["TURSP-2020\/288"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.fct.2021.112348","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T05:43:01Z","timestamp":1623822181000},"page":"112348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["A comprehensive phytochemical, biological, toxicological and molecular docking evaluation of Suaeda fruticosa (L.) Forssk.: An edible halophyte medicinal plant"],"prefix":"10.1016","volume":"154","author":[{"given":"Hammad","family":"Saleem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umair","family":"Khurshid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0516-4966","authenticated-orcid":false,"given":"Muhammad","family":"Sarfraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5777-6112","authenticated-orcid":false,"given":"Muhammad Imran","family":"Tousif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulwahab","family":"Alamri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0926-2790","authenticated-orcid":false,"given":"Sirajudheen","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-0434","authenticated-orcid":false,"given":"Abdulhakeem","family":"Alamri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irshad","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan H.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzi M.","family":"Mahomoodally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5164-1970","authenticated-orcid":false,"given":"Nafees","family":"Ahemad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2021.112348_bib1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fshw.2014.02.001","article-title":"In vitro antioxidant, anti-diabetic, cholinesterase and tyrosinase inhibitory potential of fresh juice from Citrus hystrix and C. maxima fruits","volume":"3","author":"Abirami","year":"2014","journal-title":"Food Science and Human Wellness"},{"key":"10.1016\/j.fct.2021.112348_bib2","series-title":"Prospects for Saline Agriculture","author":"Ahmad","year":"2013"},{"key":"10.1016\/j.fct.2021.112348_bib3","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(99)99004-3","article-title":"Total antioxidant activity measured by chemiluminescence methods","author":"Alho","year":"1999"},{"key":"10.1016\/j.fct.2021.112348_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.9755\/ejfa.2015-04-060","article-title":"Estimation of bioenergy potential for local biomass in the United Arab Emirates","author":"Ashraf","year":"2016","journal-title":"Emir. J. Food Agric."},{"key":"10.1016\/j.fct.2021.112348_bib5","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jhazmat.2010.11.022","article-title":"Metal accumulation potential of wild plants in tannery effluent contaminated soil of Kasur, Pakistan: field trials for toxic metal cleanup using Suaeda fruticosa","volume":"186","author":"Bareen","year":"2011","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2021.112348_bib7","first-page":"725","article-title":"Effect of Suaeda fruticosa aqueous extract in the hypercholesterolaemic and insulin-resistant sand rat","volume":"54","author":"Bennani-Kabchi","year":"1999","journal-title":"Therapie"},{"key":"10.1016\/j.fct.2021.112348_bib8","first-page":"273","article-title":"Antidiabetic and hyperlipaemic effects of Citrus Maxima Linn fruits on alloxan-induced diabetic rats","volume":"2","author":"Bhandurge","year":"2010","journal-title":"Int. J. Drug Dev. Res."},{"key":"10.1016\/j.fct.2021.112348_bib11","series-title":"Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet","author":"Crozier","year":"2008"},{"key":"10.1016\/j.fct.2021.112348_bib12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11746-998-0248-8","article-title":"Antioxidant activity of burdock (Arctium lappa Linne): its scavenging effect on free-radical and active oxygen","volume":"75","author":"Duh","year":"1998","journal-title":"J. Am. Oil Chem. Soc."},{"key":"10.1016\/j.fct.2021.112348_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2011.00022","article-title":"Revisiting the role of acetylcholinesterase in Alzheimer's disease: cross-talk with P-tau and \u03b2-amyloid","volume":"4","author":"Garc\u00eda-Ayll\u00f3n","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.fct.2021.112348_bib14","series-title":"Arid Land Ecosystems: Volume 2, Structure, Functioning and Management","author":"Goodall","year":"2009"},{"key":"10.1016\/j.fct.2021.112348_bib15","doi-asserted-by":"crossref","first-page":"5660","DOI":"10.1016\/j.chroma.2009.05.069","article-title":"Metabolite profiling of plant extracts by ultra-high-pressure liquid chromatography at elevated temperature coupled to time-of-flight mass spectrometry","volume":"1216","author":"Grata","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.fct.2021.112348_bib16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.phytol.2017.03.005","article-title":"In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiaca","volume":"20","author":"Grochowski","year":"2017","journal-title":"Phytochemistry Letters"},{"key":"10.1016\/j.fct.2021.112348_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10715769009148569","article-title":"How to characterize a biological antioxidant","volume":"9","author":"Halliwell","year":"1990","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.fct.2021.112348_bib18","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0006-2952(95)00088-H","article-title":"Antioxidant characterization: methodology and mechanism","volume":"49","author":"Halliwell","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2021.112348_bib19","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1007\/s11738-012-1035-6","article-title":"Salt tolerance of a cash crop halophyte Suaeda fruticosa: biochemical responses to salt and exogenous chemical treatments","volume":"34","author":"Hameed","year":"2012","journal-title":"Acta Physiol. Plant."},{"key":"10.1016\/j.fct.2021.112348_bib20","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1021\/ci3001277","article-title":"ZINC: a free tool to discover chemistry for biology","volume":"52","author":"Irwin","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.fct.2021.112348_bib21","series-title":"Atlas Florae Europaeae: Volume 3: Distribution of Vascular Plants in Europe","author":"Jalas","year":"1988"},{"key":"10.1016\/j.fct.2021.112348_bib22","first-page":"297","article-title":"Antioxidant, anti-inflammatory and anticancer activities of the medicinal halophyte Reaumuria vermiculata","volume":"15","author":"Karker","year":"2016","journal-title":"EXCLI journal"},{"key":"10.1016\/j.fct.2021.112348_bib23","series-title":"Biomolecular Screening for Inhibitors of Butyrylcholinesterase: Identification and Characterization Using in Vitro and in Silico Tools","author":"Karlsson","year":"2013"},{"key":"10.1016\/j.fct.2021.112348_bib25","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1016\/j.fct.2009.05.040","article-title":"Antioxidant and antimicrobial activities of the edible medicinal halophyte Tamarix gallica L. and related polyphenolic constituents","volume":"47","author":"Ksouri","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112348_bib27","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1080\/07391102.2018.1439403","article-title":"Combinatorial peptide library screening for discovery of diverse \u03b1-glucosidase inhibitors using molecular dynamics simulations and binary QSAR models","volume":"37","author":"Mollica","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.fct.2021.112348_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jff.2017.05.001","article-title":"Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: in vivo and in vitro evaluation of its nutraceutical potential","volume":"35","author":"Mollica","year":"2017","journal-title":"Journal of Functional Foods"},{"key":"10.1016\/j.fct.2021.112348_bib29","article-title":"The antioxidant and free-radical scavenging activities of Tamarix boveana and Suaeda fruticosa fractions and related active compound","volume":"10","author":"Naija","year":"2014","journal-title":"European Scientific Journal, ESJ"},{"key":"10.1016\/j.fct.2021.112348_bib30","article-title":"In vitro assessment of cytotoxicity, antioxidant, and anti-inflammatory activities of Ricinus communis (Euphorbiaceae) leaf extracts","volume":"2014","author":"Nemudzivhadi","year":"2014","journal-title":"Evid. base Compl. Alternative Med."},{"key":"10.1016\/j.fct.2021.112348_bib31","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jocn.2003.12.007","article-title":"Alzheimer's disease pathogenesis and therapeutic interventions","volume":"11","author":"Parihar","year":"2004","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.fct.2021.112348_bib32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/ptr.1954","article-title":"Survey and mechanism of skin depigmenting and lightning agents","volume":"20","author":"Parvez","year":"2006","journal-title":"Phytother Res.: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives"},{"key":"10.1016\/j.fct.2021.112348_bib33","series-title":"Halophytes as Medicinal Plants","author":"Qasim","year":"2011"},{"key":"10.1016\/j.fct.2021.112348_bib34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Mechanisms of disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.fct.2021.112348_bib35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2125.2012.04217.x","article-title":"Drugs for Alzheimer's disease","volume":"73","author":"Ritter","year":"2012","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.fct.2021.112348_bib36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.indcrop.2018.12.062","article-title":"In vitro biological propensities and chemical profiling of Euphorbia milii Des Moul (Euphorbiaceae): a novel source for bioactive agents","volume":"130","author":"Saleem","year":"2019","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.fct.2021.112348_bib37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0378-8741(01)00197-0","article-title":"Purification and identification of active antibacterial components in Carpobrotus edulis L","volume":"76","author":"van der Watt","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2021.112348_bib38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jaridenv.2006.05.010","article-title":"Potential of halophytes as source of edible oil","volume":"68","author":"Weber","year":"2007","journal-title":"J. Arid Environ."},{"key":"10.1016\/j.fct.2021.112348_bib39","series-title":"Plants for Arid Lands: Proceedings of the Kew International Conference on Economic Plants for Arid Lands Held in the Jodrell Laboratory, Royal Botanic Gardens, Kew, England, 23\u201327 July 1984","author":"Wickens","year":"2012"},{"key":"10.1016\/j.fct.2021.112348_bib40","article-title":"Phytochemical analysis of some medicinal plants","author":"Yadav","year":"2011","journal-title":"J. Phytol."},{"key":"10.1016\/j.fct.2021.112348_bib41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.indcrop.2018.11.027","article-title":"Phenolic profiling and in vitro biological properties of two Lamiaceae species (Salvia modesta and Thymus argaeus): a comprehensive evaluation","volume":"128","author":"Zengin","year":"2019","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.fct.2021.112348_bib42","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.eujim.2015.12.004","article-title":"Screening of in vitro antioxidant and enzyme inhibitory activities of different extracts from two uninvestigated wild plants: Centranthus longiflorus subsp. longiflorus and Cerinthe minor subsp. auriculata","volume":"8","author":"Zengin","year":"2016","journal-title":"European Journal of Integrative Medicine"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521003811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521003811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:14:02Z","timestamp":1759529642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691521003811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":37,"alternative-id":["S0278691521003811"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2021.112348","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive phytochemical, biological, toxicological and molecular docking evaluation of Suaeda fruticosa (L.) Forssk.: An edible halophyte medicinal plant","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2021.112348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112348"}}