{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:57:20Z","timestamp":1764784640992,"version":"build-2065373602"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["I2059\u2013B20"],"award-info":[{"award-number":["I2059\u2013B20"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.fct.2021.112355","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T17:48:08Z","timestamp":1623952088000},"page":"112355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Micronucleus assays with the human derived liver cell line (Huh6): A promising approach to reduce the use of laboratory animals in genetic toxicology"],"prefix":"10.1016","volume":"154","author":[{"given":"Miroslav","family":"Mi\u0161\u00edk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armen","family":"Nersesyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kment","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahereh","family":"Setayesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Ferk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4077-3377","authenticated-orcid":false,"given":"Klaus","family":"Holzmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Krupitza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Knasmueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2021.112355_bib1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.fct.2018.08.003","article-title":"Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells","volume":"121","author":"Allemang","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112355_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.fct.2018.08.003","article-title":"Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells","volume":"121","author":"Allemang","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112355_bib3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/tcm.1770010306","article-title":"The mutagenicity of 45 nitrosamines in the Salmonella typhimurium","volume":"1","author":"Andrews","year":"1980","journal-title":"Teratog. Carcinog. Mutagen."},{"key":"10.1016\/j.fct.2021.112355_bib4","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1074\/jbc.M510484200","article-title":"Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione","volume":"281","author":"Bai","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2021.112355_bib5","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1093\/jnci\/91.19.1654","article-title":"Tamoxifen therapy for breast cancer and endometrial cancer risk","volume":"91","author":"Bernstein","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.fct.2021.112355_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/mutage\/geq075","article-title":"Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies","volume":"26","author":"Bonassi","year":"2011","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2021.112355_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jat.1504","article-title":"Genotoxicity of pyrrolizidine alkaloids","volume":"30","author":"Chen","year":"2010","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.fct.2021.112355_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/taap.1996.0159","article-title":"Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: implications for their carcinogenicity","volume":"139","author":"Cheung","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2021.112355_bib9","doi-asserted-by":"crossref","first-page":"31750","DOI":"10.1007\/s11356-020-09463-z","article-title":"Different working conditions shift the genetic damage levels of pesticide-exposed agriculture workers","volume":"27","author":"Cobanoglu","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fct.2021.112355_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/mutage\/gen010","article-title":"ECVAM retrospective validation of in vitro micronucleus test (MNT)","volume":"23","author":"Corvi","year":"2008","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2021.112355_bib11","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.fct.2016.08.024","article-title":"In vitro genotoxicity testing\u2013Can the performance be enhanced?","volume":"106","author":"Corvi","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112355_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.envint.2010.08.002","article-title":"Frequencies of micronuclei (MNi), nucleoplasmic bridges (NPBs), and nuclear buds (NBUDs) in farmers exposed to pesticides in Canakkale, Turkey","volume":"37","author":"Coskun","year":"2011","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2021.112355_bib13","first-page":"1","article-title":"Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma","volume":"67","author":"Doi","year":"1976","journal-title":"Gann"},{"key":"10.1016\/j.fct.2021.112355_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mrgentox.2009.06.002","article-title":"Biomarkers measured by cytokinesis-block micronucleus cytome assay for evaluating genetic damages induced by polycyclic aromatic hydrocarbons","volume":"677","author":"Duan","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib15","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1021\/tx500403t","article-title":"Pyrrolizidine alkaloids: potential role in the etiology of cancers, pulmonary hypertension, congenital anomalies, and liver disease","volume":"28","author":"Edgar","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fct.2021.112355_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1383-5718(02)00249-8","article-title":"HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures","volume":"534","author":"Fenech","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0027-5107(02)00086-6","article-title":"Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes\u2014evidence for breakage\u2013fusion-bridge cycles in the cytokinesis-block micronucleus assay","volume":"504","author":"Fenech","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib18","doi-asserted-by":"crossref","first-page":"108342","DOI":"10.1016\/j.mrrev.2020.108342","article-title":"Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humans","volume":"786","author":"Fenech","year":"2020","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mrgentox.2011.10.014","article-title":"Reduction of misleading (\"false\") positive results in mammalian cell genotoxicity assays. I. Choice of cell type","volume":"742","author":"Fowler","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/carcin\/14.2.315","article-title":"The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat","volume":"14","author":"Gary","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2021.112355_bib21","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/carcin\/19.10.1709","article-title":"Rat, but not human, sulfotransferase activates a tamoxifen metabolite to produce DNA adducts and gene mutations in bacteria and mammalian cells in culture","volume":"19","author":"Glatt","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2021.112355_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/138920008783331086","article-title":"Cell lines: a tool for in vitro drug metabolism studies","volume":"9","author":"Gomez-Lechon","year":"2008","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.fct.2021.112355_bib23","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1124\/dmd.110.035873","article-title":"Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes","volume":"39","author":"Guo","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.fct.2021.112355_bib67","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1080\/15287394.2020.1822972","article-title":"Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment","volume":"83","author":"Guo","year":"2020","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.fct.2021.112355_bib24","doi-asserted-by":"crossref","first-page":"503305","DOI":"10.1016\/j.mrgentox.2020.503305","article-title":"Genotoxicity of selected pyrrolizidine alkaloids in human hepatoma cell lines HepG2 and Huh6","volume":"861\u2013862","author":"Hadi","year":"2021","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib25","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1038\/s41598-017-03754-1","article-title":"Genotoxicity and cytotoxicity of the plasma jet-treated medium on lymphoblastoid WIL2-NS cell line using the cytokinesis block micronucleus cytome assay","volume":"7","author":"Hong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2021.112355_bib26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.mrgentox.2008.01.002","article-title":"Possible involvement of oxidative stress in trichloroethylene-induced genotoxicity in human HepG2 cells","volume":"652","author":"Hu","year":"2008","journal-title":"Mutat. Res."},{"year":"1976","series-title":"Some Naturaly Occurring Substances","key":"10.1016\/j.fct.2021.112355_bib27"},{"year":"1999","series-title":"Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide","key":"10.1016\/j.fct.2021.112355_bib28"},{"year":"2008","series-title":"Pharmaceuticals (Tamoxifen)","key":"10.1016\/j.fct.2021.112355_bib29"},{"year":"2009","series-title":"Cadmium and Cadmium Compounds","key":"10.1016\/j.fct.2021.112355_bib30"},{"year":"2012","series-title":"Personal Habits and Indoor Combustions","key":"10.1016\/j.fct.2021.112355_bib31"},{"year":"2019","series-title":"Styrene, Styrene-7,8-Oxide, and Quinoline","key":"10.1016\/j.fct.2021.112355_bib32"},{"year":"2011","series-title":"Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use","key":"10.1016\/j.fct.2021.112355_bib33"},{"key":"10.1016\/j.fct.2021.112355_bib34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1383-5718(98)00191-0","article-title":"Chemically induced micronucleus formation in V79 cells--comparison of three different test approaches","volume":"439","author":"Kalweit","year":"1999","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib35","first-page":"339","article-title":"Biomonitoring findings for occupational lead exposure in battery and ceramic tile workers using biochemical markers, alkaline comet assay, and micronucleus test coupled with fluorescence in situ hybridisation","volume":"71","author":"Kasuba","year":"2020","journal-title":"Arh. Hig. Rada. Toksikol."},{"key":"10.1016\/j.fct.2021.112355_bib36","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1016\/j.fct.2010.06.030","article-title":"Evaluation of the genotoxicity of 10 selected dietary\/environmental compounds with the in vitro micronucleus cytokinesis-block assay in an interlaboratory comparison","volume":"48","author":"Katic","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112355_bib37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mrgentox.2015.10.006","article-title":"Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests","volume":"795","author":"Kirkland","year":"2016","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib70","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.mrgentox.2008.03.008","article-title":"Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: a follow-up to an ECVAM workshop","volume":"653","author":"Kirkland","year":"2008","journal-title":"Mutat Res"},{"key":"10.1016\/j.fct.2021.112355_bib38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mrgentox.2006.11.008","article-title":"How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: report of an ECVAM Workshop","volume":"628","author":"Kirkland","year":"2007","journal-title":"Mutat. Res."},{"year":"2019","series-title":"The Micronucleus Assay in Toxicology","author":"Knasm\u00fcller","key":"10.1016\/j.fct.2021.112355_bib39"},{"key":"10.1016\/j.fct.2021.112355_bib40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.tox.2004.02.008","article-title":"Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge","volume":"198","author":"Knasmuller","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2021.112355_bib41","first-page":"1227","article-title":"Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase","volume":"21","author":"Kushida","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2021.112355_bib69","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/mutage\/geq039","article-title":"Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays","volume":"25","author":"Le Hegarat","year":"2010","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2021.112355_bib42","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/toxsci\/kfu004","article-title":"Performance of comet and micronucleus assays in metabolic competent HepaRG cells to predict in vivo genotoxicity","volume":"138","author":"Le Hegarat","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2021.112355_bib43","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","article-title":"Reactive oxygen species in cancer","volume":"44","author":"Liou","year":"2010","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.fct.2021.112355_bib44","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0027-5107(71)90054-6","article-title":"Dimethylnitrosamine: formation of mutagenic compounds by interaction with mouse liver microsomes","volume":"13","author":"Malling","year":"1971","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib68","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tox.2004.02.009","article-title":"Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents","volume":"198","author":"Mersch-Sundermann","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2021.112355_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mrgentox.2015.06.016","article-title":"The micronucleus assay in mammalian cells in vitro to assess health benefits of various phytochemicals","volume":"793","author":"Meschini","year":"2015","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib46","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/em.22254","article-title":"Cytome micronucleus assays with a metabolically competent human derived liver cell line (Huh6): a promising approach for routine testing of chemicals?","volume":"60","author":"Misik","year":"2019","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.fct.2021.112355_bib47","doi-asserted-by":"crossref","first-page":"402995","DOI":"10.1016\/j.mrgentox.2018.12.003","article-title":"Use of human derived liver cells for the detection of genotoxins in comet assays","volume":"845","author":"Misik","year":"2019","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib48","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1021\/tx00042a026","article-title":"Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450","volume":"7","author":"Nakajima","year":"1994","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fct.2021.112355_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2016.05.003","article-title":"Use of the lymphocyte cytokinesis-block micronucleus assay in occupational biomonitoring of genome damage caused by in vivo exposure to chemical genotoxins: past, present and future","volume":"770","author":"Nersesyan","year":"2016","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mrrev.2016.04.002","article-title":"Results of micronucleus assays with individuals who are occupationally and environmentally exposed to mercury, lead and cadmium","volume":"770","author":"Nersesyan","year":"2016","journal-title":"Mutat. Res."},{"article-title":"Test No. 487","year":"2016","series-title":"Vitro Mammalian Cell Micronucleus Test","key":"10.1016\/j.fct.2021.112355_bib51"},{"key":"10.1016\/j.fct.2021.112355_bib52","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S1471-4914(02)02282-7","article-title":"Selective estrogen receptor modulators (SERMS) and their roles in breast cancer prevention","volume":"8","author":"Park","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.fct.2021.112355_bib53","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mrgentox.2011.03.013","article-title":"In vitro genotoxicity test approaches with better predictivity: summary of an IWGT workshop","volume":"723","author":"Pfuhler","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib54","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/carcin\/22.6.839","article-title":"Understanding the genotoxicity of tamoxifen?","volume":"22","author":"Phillips","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2021.112355_bib55","doi-asserted-by":"crossref","first-page":"110285","DOI":"10.1016\/j.biopha.2020.110285","article-title":"Genotoxic effect of non-lethal concentrations of minocycline in human glial cell culture","volume":"128","author":"Puty","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2021.112355_bib56","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/rpd\/ncw292","article-title":"A cytogenetic biomonitoring of industrial radiographers occupationally exposed to low levels of ionizing radiation by using cbmn assay","volume":"175","author":"Shakeri","year":"2017","journal-title":"Radiat. Protect. Dosim."},{"key":"10.1016\/j.fct.2021.112355_bib57","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.fct.2017.04.033","article-title":"Evaluation of cytotoxic, apoptotic, mutagenic, and chemopreventive activities of semi-synthetic esters of gallic acid","volume":"105","author":"Silva","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112355_bib58","series-title":"Development of the new hepatic cell lines for genotoxicity and carcinogenicity studies","first-page":"107","author":"Tomc","year":"2019"},{"key":"10.1016\/j.fct.2021.112355_bib59","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/mutage\/ges030","article-title":"Performance of in vitro gammaH2AX assay in HepG2 cells to predict in vivo genotoxicity","volume":"27","author":"Tsamou","year":"2012","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2021.112355_bib60","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1383-5718(03)00031-7","article-title":"Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays","volume":"536","author":"Valentin-Severin","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib66","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1158\/1535-7163.MCT-10-0917","article-title":"A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression","volume":"10","author":"van Zijl","year":"2011","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.fct.2021.112355_bib61","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00204-017-2109-4","article-title":"Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?","volume":"92","author":"Waldherr","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2021.112355_bib62","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1477-3163-5-14","article-title":"Reactive oxygen species: role in the development of cancer and various chronic conditions","volume":"5","author":"Waris","year":"2006","journal-title":"J. Carcinog."},{"key":"10.1016\/j.fct.2021.112355_bib63","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mrgentox.2011.05.007","article-title":"Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells","volume":"724","author":"Westerink","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib64","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mrgentox.2009.12.007","article-title":"The development of RAD51C, Cystatin A, p53 and Nrf2 luciferase-reporter assays in metabolically competent HepG2 cells for the assessment of mechanism-based genotoxicity and of oxidative stress in the early research phase of drug development","volume":"696","author":"Westerink","year":"2010","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2021.112355_bib65","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.3748\/wjg.v9.i12.2732","article-title":"Heterologous expression of human cytochrome P450 2E1 in HepG2 cell line","volume":"9","author":"Zhuge","year":"2003","journal-title":"World J. Gastroenterol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521003884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521003884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:13:42Z","timestamp":1759529622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691521003884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":70,"alternative-id":["S0278691521003884"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2021.112355","relation":{},"ISSN":["0278-6915"],"issn-type":[{"type":"print","value":"0278-6915"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Micronucleus assays with the human derived liver cell line (Huh6): A promising approach to reduce the use of laboratory animals in genetic toxicology","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2021.112355","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112355"}}