{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:51:55Z","timestamp":1759539115190,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.fct.2021.112475","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T04:27:39Z","timestamp":1628224059000},"page":"112475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S1","title":["RIFM fragrance ingredient safety assessment, 3-(hydroxymethyl)nonan-2-one, CAS Registry Number 67801-33-6"],"prefix":"10.1016","volume":"156","author":[{"given":"A.M.","family":"Api","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Belsito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Botelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"G.A.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Buschmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Cancellieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Dagli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Date","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Dekant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Deodhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lapczynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lavelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.C.","family":"Liebler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Moustakas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Na","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Penning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ritacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Romine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sadekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.W.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Selechnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.G.","family":"Sipes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-0926","authenticated-orcid":false,"given":"G.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Tokura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2021.112475_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.fct.2014.11.014","article-title":"Criteria for the Research Institute for fragrance materials, Inc. (RIFM) safety evaluation process for fragrance ingredients","volume":"82","author":"Api","year":"2015","journal-title":"Food Chem. Toxicol."},{"volume":"vols. I and II","year":"1969","author":"Arctander","key":"10.1016\/j.fct.2021.112475_bib2"},{"issue":"1","key":"10.1016\/j.fct.2021.112475_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yrtph.2014.11.005","article-title":"Comparison of cramer classification between Toxtree, the OECD QSAR Toolbox and expert judgment","volume":"71","author":"Bhatia","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"6","key":"10.1016\/j.fct.2021.112475_bib4","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.fct.2009.02.024","article-title":"Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products","volume":"47","author":"Carthew","year":"2009","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2021.112475_bib5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.yrtph.2015.05.012","article-title":"Novel database for exposure to fragrance ingredients in cosmetics and personal care products","volume":"72","author":"Comiskey","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2021.112475_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.yrtph.2017.05.017","article-title":"Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model","volume":"88","author":"Comiskey","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.fct.2021.112475_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0015-6264(76)80522-6","article-title":"Estimation of toxic hazard\u2014a decision tree approach","volume":"16","author":"Cramer","year":"1978","journal-title":"Food Chem. Toxicol."},{"year":"2012","series-title":"Guidance on Information Requirements and Chemical Safety Assessment, November 2012 v2.1","key":"10.1016\/j.fct.2021.112475_bib8"},{"issue":"1","key":"10.1016\/j.fct.2021.112475_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jphotobiol.2009.04.005","article-title":"Can light absorption and photostability data be used to assess the photosafety risks in patients for a new drug molecule?","volume":"96","author":"Henry","year":"2009","journal-title":"J. Photochem. Photobiol. B Biol."},{"year":"2015","series-title":"Volume of Use Survey, February 2015","key":"10.1016\/j.fct.2021.112475_bib10"},{"key":"10.1016\/j.fct.2021.112475_bib11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000411610","article-title":"The freund's complete adjuvant test and the open epicutaneous test","volume":"14","author":"Klecak","year":"1985","journal-title":"Curr. Probl. Dermatol."},{"issue":"12","key":"10.1016\/j.fct.2021.112475_bib12","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.fct.2007.06.021","article-title":"Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients","volume":"45","author":"Kroes","year":"2007","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2021.112475_bib13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yrtph.2011.09.004","article-title":"Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern","volume":"62","author":"Laufersweiler","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"year":"2020","series-title":"Fragrance Skin Sensitization Evaluation and Human Testing, Dermatitis: November 16, 2020. Volume Publish Ahead of Print Issue","author":"Na","key":"10.1016\/j.fct.2021.112475_bib14"},{"year":"1964","series-title":"Repeated Insult Patch Test with Methyl Lavender Ketone. Unpublished Report from International Flavors and Fragrances. RIFM Report Number 53574","key":"10.1016\/j.fct.2021.112475_bib16"},{"year":"1964","series-title":"Repeated Insult Patch Test with Methyl Lavender Ketone. Unpublished Report from International Flavors and Fragrances. RIFM Report Number 53575","key":"10.1016\/j.fct.2021.112475_bib17"},{"year":"1966","series-title":"Repeated Insult Patch Test with Methyl Lavender Ketone. Unpublished Report from International Flavors and Fragrances. RIFM Report Number 53576","key":"10.1016\/j.fct.2021.112475_bib18"},{"year":"1973","series-title":"Repeated Insult Patch Test with Methyl Lavender Ketone. Unpublished Report from International Flavors and Fragrances. RIFM Report Number 53577","key":"10.1016\/j.fct.2021.112475_bib19"},{"year":"1978","series-title":"Report on Human Maximization Studies. Report to RIFM. RIFM Report Number 1698","key":"10.1016\/j.fct.2021.112475_bib20"},{"year":"1979","series-title":"Report on Human Maximization Studies. Report to RIFM. RIFM Report Number 1697","key":"10.1016\/j.fct.2021.112475_bib21"},{"year":"1981","series-title":"Report on Human Maximization Studies. Report to RIFM. RIFM Report Number 1792","key":"10.1016\/j.fct.2021.112475_bib22"},{"year":"2013","series-title":"Report on the Testing of 3-(hydroxymethyl)nonan-2-One in the BlueScreen HC Assay (-\/+ S9 Metabolic Activation). RIFM Report Number 65132","key":"10.1016\/j.fct.2021.112475_bib23"},{"year":"2013","series-title":"Repeated Insult Patch Test with Methyl Lavender Ketone. Unpublished Report from International Flavors and Fragrances. RIFM Report Number 66210","key":"10.1016\/j.fct.2021.112475_bib24"},{"year":"2013","series-title":"3-(Hydroxymethyl)nonan-2-one (Methyl Lavender Ketone): Bacterial Reverse Mutation Assay. RIFM Report Number 70055","key":"10.1016\/j.fct.2021.112475_bib25"},{"year":"2014","series-title":"3-(Hydroxymethyl)nonan-2-one, Methyl Lavender Ketone and 2-nonanone: in Vitro Mammalian Cell Micronucleus Assay in Human Peripheral Blood Lymphocytes (HPBL). RIFM Report Number 68493","key":"10.1016\/j.fct.2021.112475_bib26"},{"year":"2017","series-title":"Exposure Survey 14, January 2017","key":"10.1016\/j.fct.2021.112475_bib27"},{"year":"2017","series-title":"Exposure Survey 15, March 2017","key":"10.1016\/j.fct.2021.112475_bib28"},{"year":"2020","series-title":"Updating Exposure Assessment for Skin Sensitization Quantitative Risk Assessment for Fragrance Materials. RIFM Report Number 76775","key":"10.1016\/j.fct.2021.112475_bib29"},{"key":"10.1016\/j.fct.2021.112475_bib30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.yrtph.2015.05.017","article-title":"Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products","volume":"72","author":"Safford","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2021.112475_bib31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yrtph.2017.02.021","article-title":"Application of the expanded Creme RIFM consumer exposure model to fragrance ingredients in cosmetic, personal care and air care products","volume":"86","author":"Safford","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"6","key":"10.1016\/j.fct.2021.112475_bib32","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/etc.5620210627","article-title":"A Framework for prioritizing fragrance materials for aquatic risk assessment","volume":"21","author":"Salvito","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"year":"2012","series-title":"Estimation Programs Interface Suite for Microsoft Windows, v4.0\u2013v4.11","key":"10.1016\/j.fct.2021.112475_bib33"},{"year":"2012","series-title":"The ECOSAR (ECOlogical Structure Activity Relationship) Class Program for Microsoft Windows, v2.0","key":"10.1016\/j.fct.2021.112475_bib34"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521005081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521005081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:11:31Z","timestamp":1759529491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691521005081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":33,"alternative-id":["S0278691521005081"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2021.112475","relation":{},"ISSN":["0278-6915"],"issn-type":[{"type":"print","value":"0278-6915"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RIFM fragrance ingredient safety assessment, 3-(hydroxymethyl)nonan-2-one, CAS Registry Number 67801-33-6","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2021.112475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112475"}}