{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:33:31Z","timestamp":1789720411960,"version":"4.0.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1600402"],"award-info":[{"award-number":["2017YFC1600402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.fct.2021.112583","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T11:10:42Z","timestamp":1632395442000},"page":"112583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["2-Amino-3-methylimidazo[4,5-f]quinoline induced oxidative stress and inflammation via TLR4\/MAPK and TLR4\/NF-\u03baB signaling pathway in zebrafish (Danio rerio) livers"],"prefix":"10.1016","volume":"157","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyi","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fct.2021.112583_bib1","first-page":"10","article-title":"Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates induction of tumors in three macaques","volume":"81","author":"Adamson","year":"1990","journal-title":"Jpn. J. Canc. Res."},{"issue":"2","key":"10.1016\/j.fct.2021.112583_bib2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1289\/ehp.94102190","article-title":"Induction of hepatocellular carcinoma in nonhuman primates by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline","volume":"102","author":"Adamson","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2021.112583_bib3","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.foodchem.2018.12.058","article-title":"Heterocyclic aromatic amines in cooked food: a review on formation, health risk-toxicology and their analytical techniques","volume":"280","author":"Barzegar","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2021.112583_bib4","series-title":"Some Naturally Occurring Substances : Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins","author":"Cancer","year":"1993"},{"issue":"12","key":"10.1016\/j.fct.2021.112583_bib5","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.3390\/ijms20122957","article-title":"Quercetin inhibits the production of IL-1beta-induced inflammatory cytokines and chemokines in ARPE-19 cells via the MAPK and NF-kappaB signaling pathways","volume":"20","author":"Cheng","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2021.112583_bib6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neuro.2018.01.009","article-title":"Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons","volume":"65","author":"Cruz-Hernandez","year":"2018","journal-title":"Neurotoxicology"},{"issue":"45","key":"10.1016\/j.fct.2021.112583_bib7","doi-asserted-by":"crossref","first-page":"12348","DOI":"10.1021\/acs.jafc.9b03674","article-title":"Bioaccumulation and metabolism of carbosulfan in zebrafish (Danio rerio) and the toxic effects of its metabolites","volume":"67","author":"Cui","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2021.112583_bib8","doi-asserted-by":"crossref","first-page":"126609","DOI":"10.1016\/j.chemosphere.2020.126609","article-title":"Genotoxicity and oxidative damage in zebrafish (Danio rerio) after exposure to effluent from ethyl alcohol industry","volume":"251","author":"Derikvandy","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2021.112583_bib9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.biopha.2017.05.103","article-title":"Lutein mitigates cyclophosphamide induced lung and liver injury via NF-kappaB\/MAPK dependent mechanism","volume":"92","author":"El-Kholy","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.fct.2021.112583_bib10","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1021\/jf504895h","article-title":"Oxidative stress and DNA damage induced by imidacloprid in zebrafish (Danio rerio)","volume":"63","author":"Ge","year":"2015","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.fct.2021.112583_bib11","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1053\/j.gastro.2015.08.034","article-title":"Zebrafish: an important tool for liver disease research","volume":"149","author":"Goessling","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2021.112583_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.aquatox.2017.04.014","article-title":"Immunosuppressive effects and associated compensatory responses in zebrafish after full life-cycle exposure to environmentally relevant concentrations of cadmium","volume":"188","author":"Guo","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fct.2021.112583_bib13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.envres.2018.05.012","article-title":"DNA damage protection by bulk and nano forms of quercetin in lymphocytes of patients with chronic obstructive pulmonary disease exposed to the food mutagen 2-amino-3-methylimidazo [4,5-f]quinolone (IQ)","volume":"166","author":"Habas","year":"2018","journal-title":"Environ. Res."},{"issue":"21","key":"10.1016\/j.fct.2021.112583_bib14","doi-asserted-by":"crossref","first-page":"9702","DOI":"10.7150\/thno.44297","article-title":"Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder","volume":"10","author":"Hu","year":"2020","journal-title":"Theranostics"},{"issue":"10","key":"10.1016\/j.fct.2021.112583_bib15","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1039\/D0FO01570A","article-title":"Lactoferrin attenuates lipopolysaccharide-stimulated inflammatory responses and barrier impairment through the modulation of NF-kappaB\/MAPK\/Nrf2 pathways in IPEC-J2 cells","volume":"11","author":"Hu","year":"2020","journal-title":"Food Funct"},{"key":"10.1016\/j.fct.2021.112583_bib16","doi-asserted-by":"crossref","first-page":"109354","DOI":"10.1016\/j.biopha.2019.109354","article-title":"Hepatoprotective effect of different combinations of 18alpha-and 18beta-Glycyrrhizic acid against CCl4-induced liver injury in rats","volume":"122","author":"Huo","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.fct.2021.112583_bib17","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.placenta.2010.05.002","article-title":"Toxicokinetics of the food-toxin IQ in human placental perfusion is not affected by ABCG2 or xenobiotic metabolism","volume":"31","author":"Immonen","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.fct.2021.112583_bib18","doi-asserted-by":"crossref","first-page":"125788","DOI":"10.1016\/j.jhazmat.2021.125788","article-title":"Embryonic exposure to low concentrations of aflatoxin B1 triggers global transcriptomic changes, defective yolk lipid mobilization, abnormal gastrointestinal tract development and inflammation in zebrafish","volume":"416","author":"Ivanovics","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2021.112583_bib19","doi-asserted-by":"crossref","first-page":"153082","DOI":"10.1016\/j.phymed.2019.153082","article-title":"Hepatoprotective and anti-inflammatory effects of total flavonoids of Qu Zhi Ke (peel of Citrus changshan-huyou) on non-alcoholic fatty liver disease in rats via modulation of NF-kappaB and MAPKs","volume":"64","author":"Jiang","year":"2019","journal-title":"Phytomedicine"},{"issue":"21","key":"10.1016\/j.fct.2021.112583_bib20","doi-asserted-by":"crossref","first-page":"7894","DOI":"10.3390\/ijms21217894","article-title":"Polydeoxyribonucleotide exerts protective effect against CCl4-induced acute liver injury through inactivation of NF-kappaB\/MAPK signaling pathway in mice","volume":"21","author":"Ko","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.fct.2021.112583_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/carcin\/16.1.39","article-title":"Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research","volume":"16","author":"Layton","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2021.112583_bib22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.fct.2012.12.054","article-title":"Effects of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) on histopathology, oxidative stress, and expression of c-fos, c-jun and p16 in rat stomachs","volume":"55","author":"Li","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112583_bib23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.fct.2017.11.054","article-title":"Hepatorenal protective effects of medicinal herbs in An-Gong-Niu-Huang Wan (AGNH) against cinnabar- and realgar-induced oxidative stress and inflammatory damage in mice","volume":"119","author":"Li","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112583_bib24","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3389\/fphar.2018.01438","article-title":"Bicyclol attenuates liver inflammation induced by infection of hepatitis C virus via repressing ROS-mediated activation of MAPK\/NF-kappaB signaling pathway","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2021.112583_bib25","doi-asserted-by":"crossref","first-page":"125129","DOI":"10.1016\/j.chemosphere.2019.125129","article-title":"Tebuconazole induced oxidative stress related hepatotoxicity in adult and larval zebrafish (Danio rerio)","volume":"241","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2021.112583_bib26","doi-asserted-by":"crossref","first-page":"111725","DOI":"10.1016\/j.ecoenv.2020.111725","article-title":"Curcumin protects against Aflatoxin B1-induced liver injury in broilers via the modulation of long non-coding RNA expression","volume":"208","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2021.112583_bib27","doi-asserted-by":"crossref","first-page":"125230","DOI":"10.1016\/j.jhazmat.2021.125230","article-title":"Long-term exposure to 2-amino-3-methylimidazo[4,5-f]quinoline can trigger a potential risk of Parkinson's disease","volume":"412","author":"Li","year":"2021","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.fct.2021.112583_bib28","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1021\/jf5039184","article-title":"Protective effects of Selenium-enriched probiotics on carbon tetrachloride-induced liver fibrosis in rats","volume":"63","author":"Liu","year":"2015","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.fct.2021.112583_bib29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41419-019-1543-z","article-title":"Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide\/d-galactosamine-induced acute liver injury by licochalcone A","volume":"10","author":"Lv","year":"2019","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.fct.2021.112583_bib30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0304-3835(99)00139-1","article-title":"Free radical generation from heterocyclic amines by cytochrome b5 reductase in the presence of NADH","volume":"143","author":"Maedaa","year":"1999","journal-title":"Canc. Lett."},{"issue":"3","key":"10.1016\/j.fct.2021.112583_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0269-7491(93)90049-T","article-title":"Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine, in airborne particles and diesel-exhaust particles","volume":"80","author":"Manabe","year":"1993","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.fct.2021.112583_bib32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","article-title":"Mitochondrial dysfunction and signaling in chronic liver diseases","volume":"155","author":"Mansouri","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2021.112583_bib33","doi-asserted-by":"crossref","first-page":"111251","DOI":"10.1016\/j.fct.2020.111251","article-title":"Geraniol protects against cyclophosphamide-induced hepatotoxicity in rats: possible role of MAPK and PPAR-gamma signaling pathways","volume":"139","author":"Mohammed","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.fct.2021.112583_bib34","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/mc.10089","article-title":"Generation of free radicals and induction of DNA adducts by activation of heterocyclic aromatic amines via different metabolic pathways in vitro","volume":"35","author":"Moonen","year":"2002","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.fct.2021.112583_bib35","doi-asserted-by":"crossref","first-page":"111937","DOI":"10.1016\/j.fct.2020.111937","article-title":"Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver","volume":"148","author":"Nan","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2021.112583_bib36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1289\/ehp.8667129","article-title":"Carcinogenicity in mice and rats of heterocyclic amines in cooked foods","volume":"67","author":"Ohgaki","year":"1986","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.fct.2021.112583_bib37","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1021\/jf980644e","article-title":"formation of mutagenic\/carcinogenic heterocyclic amines in dry-heated model systems, meats, and meat drippings","volume":"47","author":"Pais","year":"1999","journal-title":"J. Agric. Food Chem."},{"issue":"38","key":"10.1016\/j.fct.2021.112583_bib38","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.1021\/acs.jafc.6b02763","article-title":"Diet supplementation with Allicin protects against alcoholic fatty liver disease in mice by improving anti-inflammation and Antioxidative functions","volume":"64","author":"Panyod","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"Pt B","key":"10.1016\/j.fct.2021.112583_bib39","doi-asserted-by":"crossref","first-page":"114535","DOI":"10.1016\/j.envpol.2020.114535","article-title":"Long-term bisphenol S exposure aggravates non-alcoholic fatty liver by regulating lipid metabolism and inducing endoplasmic reticulum stress response with activation of unfolded protein response in male zebrafish","volume":"263","author":"Qin","year":"2020","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.fct.2021.112583_bib40","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.fct.2010.01.026","article-title":"Hepatotoxicity of tubers of Indian Kudzu (Pueraria tuberosa) in rats","volume":"48","author":"Santosh","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"11","key":"10.1016\/j.fct.2021.112583_bib41","first-page":"1204","article-title":"Evidence of direct generation of oxygen free radicals from heterocyclic amines by NADPH\/cytochrome P-450 reductase in vitro","volume":"83","author":"Sato","year":"1992","journal-title":"Jpn. J. Canc. Res."},{"issue":"3","key":"10.1016\/j.fct.2021.112583_bib42","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/carcin\/20.3.353","article-title":"DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis","volume":"20","author":"Schut","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2021.112583_bib43","doi-asserted-by":"crossref","first-page":"110899","DOI":"10.1016\/j.ecoenv.2020.110899","article-title":"Diet containing grape seed meal by-product counteracts AFB1 toxicity in liver of pig after weaning","volume":"203","author":"Taranu","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.fct.2021.112583_bib44","doi-asserted-by":"crossref","first-page":"16005","DOI":"10.1038\/s41598-018-34351-5","article-title":"Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model","volume":"8","author":"Van der Helm","year":"2018","journal-title":"Sci. Rep."},{"issue":"29","key":"10.1016\/j.fct.2021.112583_bib45","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1021\/acs.jafc.8b02293","article-title":"Protective effect and mechanism of Theanine on lipopolysaccharide-induced inflammation and acute liver injury in mice","volume":"66","author":"Wang","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"29","key":"10.1016\/j.fct.2021.112583_bib46","doi-asserted-by":"crossref","first-page":"7758","DOI":"10.1021\/acs.jafc.8b02627","article-title":"Protective effects of sesquiterpenoids from the root of panax ginseng on fulminant liver injury induced by lipopolysaccharide\/d-galactosamine","volume":"66","author":"Wang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2021.112583_bib47","doi-asserted-by":"crossref","first-page":"133540","DOI":"10.1016\/j.scitotenv.2019.07.346","article-title":"Co-exposure with titanium dioxide nanoparticles exacerbates MCLR-induced brain injury in zebrafish","volume":"693","author":"Wu","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"20","key":"10.1016\/j.fct.2021.112583_bib48","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1021\/acs.jafc.9b08313","article-title":"High l-carnitine ingestion impairs liver function by disordering gut bacteria composition in mice","volume":"68","author":"Wu","year":"2020","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.fct.2021.112583_bib49","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.3390\/cancers12061608","article-title":"Low molecular weight fucoidan prevents radiation-induced fibrosis and secondary tumors in a zebrafish model","volume":"12","author":"Wu","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.fct.2021.112583_bib50","doi-asserted-by":"crossref","first-page":"124705","DOI":"10.1016\/j.chemosphere.2019.124705","article-title":"Tamoxifen-induced hepatotoxicity via lipid accumulation and inflammation in zebrafish","volume":"239","author":"Yu","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2021.112583_bib51","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.biopha.2017.10.103","article-title":"Histone deacetylase 6 inhibitor ACY-1215 protects against experimental acute liver failure by regulating the TLR4-MAPK\/NF-kappaB pathway","volume":"97","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2021.112583_bib52","doi-asserted-by":"crossref","first-page":"112122","DOI":"10.1016\/j.jep.2019.112122","article-title":"The protection of indolealkylamines from LPS-induced inflammation in zebrafish","volume":"243","author":"Zhang","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.fct.2021.112583_bib53","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1021\/acs.jafc.0c06588","article-title":"2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induced colon injury by disrupting the intestinal bacterial composition and lipid metabolic pathways in rats","volume":"69","author":"Zhao","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.fct.2021.112583_bib54","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/01635580802710741","article-title":"Well-done meat intake, heterocyclic amine exposure, and cancer risk","volume":"61","author":"Zheng","year":"2009","journal-title":"Nutr. Canc."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521006165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521006165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:11:57Z","timestamp":1759529517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691521006165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":54,"alternative-id":["S0278691521006165"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2021.112583","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"2-Amino-3-methylimidazo[4,5-f]quinoline induced oxidative stress and inflammation via TLR4\/MAPK and TLR4\/NF-\u03baB signaling pathway in zebrafish (Danio rerio) livers","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2021.112583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"112583"}}