{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:21:31Z","timestamp":1770754891219,"version":"3.50.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.fct.2021.112649","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T19:25:37Z","timestamp":1635621937000},"page":"112649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Perinatal DEHP exposure modulates pituitary estrogen receptor \u03b1 and \u03b2 expression altering lactotroph and somatotroph cell growth in prepuberal and adult male rats"],"prefix":"10.1016","volume":"158","author":[{"given":"Pablo A.","family":"P\u00e9rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-5751","authenticated-orcid":false,"given":"Jonathan","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Picech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan P.","family":"Petiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-6842","authenticated-orcid":false,"given":"Jorge H.","family":"Mukdsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Diaz-Torga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia I.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L.","family":"De Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvina","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.fct.2021.112649_bib1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/aje\/kwp001","article-title":"Maternal urinary metabolites of Di-(2-Ethylhexyl) phthalate in relation to the timing of labor in a US multicenter pregnancy cohort study","volume":"169","author":"Adibi","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.fct.2021.112649_bib2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.scitotenv.2018.12.261","article-title":"The relationships between urinary phthalate metabolites, reproductive hormones and semen parameters in men attending in vitro fertilization clinic","volume":"658","author":"Al-Saleh","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"1\u20132","key":"10.1016\/j.fct.2021.112649_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4274(00)00253-8","article-title":"Structural essentials of xenoestrogen dialkyl phthalates to bind to the estrogen receptors","volume":"118","author":"Asai","year":"2000","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1210\/me.2013-1245","article-title":"Both estrogen receptor alpha and beta stimulate pituitary GH gene expression","volume":"28","author":"Avtanski","year":"2014","journal-title":"Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib5","first-page":"96","article-title":"Prenatal exposure to DEHP induces premature reproductive senescence in male mice","volume":"156","author":"Barakat","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.fct.2021.112649_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/toxics8040115","article-title":"Endocrine disruption: structural interactions of androgen receptor against di(2-ethylhexyl) phthalate and its metabolites","volume":"8","author":"Beg","year":"2020","journal-title":"Toxics"},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1385\/ENDO:18:3:303","article-title":"Combined effect of xenoestrogens and growth factors in two estrogen-responsive cell lines","volume":"18","author":"Cossette","year":"2002","journal-title":"Endocrine"},{"issue":"8","key":"10.1016\/j.fct.2021.112649_bib8","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.envres.2009.07.015","article-title":"Influence of litter size on the postnatal growth of rat pups: is there a rationale for litter-size standardization in toxicity studies?","volume":"109","author":"Chahoud","year":"2009","journal-title":"Environ. Res."},{"issue":"4","key":"10.1016\/j.fct.2021.112649_bib9","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1210\/en.2004-1111","article-title":"Bipotential effects of estrogen on growth hormone synthesis and storage in vitro","volume":"146","author":"Childs","year":"2005","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00005-017-0494-2","article-title":"The impact of di(2-ethylhexyl)phthalate on cancer progression","volume":"66","author":"Chou","year":"2018","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"Suppl. 3","key":"10.1016\/j.fct.2021.112649_bib11","doi-asserted-by":"crossref","first-page":"U95","DOI":"10.1530\/eje.0.151u095","article-title":"The regulation of GH secretion by sex steroids","volume":"151","author":"Chowen","year":"2004","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/taap.1999.8840","article-title":"High concentrations of bisphenol A induce cell growth and prolactin secretion in an estrogen-responsive pituitary tumor cell line","volume":"162","author":"Chun","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.fct.2021.112649_bib13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1262\/jrd.20147","article-title":"Estrogen receptors are involved in xenoestrogen induction of growth hormone in the rat pituitary gland","volume":"55","author":"Dang","year":"2009","journal-title":"J. Reprod. Dev."},{"issue":"8","key":"10.1016\/j.fct.2021.112649_bib14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.steroids.2009.03.002","article-title":"In vitro exposure to xenoestrogens induces growth hormone transcription and release via estrogen receptor-dependent pathways in rat pituitary GH3 cells","volume":"74","author":"Dang","year":"2009","journal-title":"Steroids"},{"issue":"2","key":"10.1016\/j.fct.2021.112649_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1023\/A:1026322130243","article-title":"Different behavior of lactotroph cell subpopulations in response to angiotensin II and thyrotrophin-releasing hormone","volume":"17","author":"De Paul","year":"1997","journal-title":"Cell. Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib16","doi-asserted-by":"crossref","first-page":"T61","DOI":"10.1530\/JME-13-0150","article-title":"Insight into the mechanisms of action of estrogen receptor beta in the breast, prostate, colon, and CNS","volume":"51","author":"Dey","year":"2013","journal-title":"J. Mol. Endocrinol."},{"issue":"5","key":"10.1016\/j.fct.2021.112649_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1095\/biolreprod.112.106104","article-title":"Transgenerational effects of di-(2-ethylhexyl) phthalate on testicular germ cell associations and spermatogonial stem cells in mice","volume":"88","author":"Doyle","year":"2013","journal-title":"Biol. Reprod."},{"issue":"5","key":"10.1016\/j.fct.2021.112649_bib18","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/ijc.2910580519","article-title":"Di(2-ethylhexyl)phthalate-induced changes in liver estrogen metabolism and hyperplasia","volume":"58","author":"Eagon","year":"1994","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.fct.2021.112649_bib19","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.envres.2017.07.015","article-title":"Effects of environmental pollutants on signaling pathways in rat pituitary GH3 adenoma cells","volume":"158","author":"Fortunati","year":"2017","journal-title":"Environ. Res."},{"issue":"7","key":"10.1016\/j.fct.2021.112649_bib20","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/mnfr.200600243","article-title":"Metabolism of phthalates in humans","volume":"51","author":"Frederiksen","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00204-017-2049-z","article-title":"Specific effects of prenatal DEHP exposure on neuroendocrine gene expression in the developing hypothalamus of male rats","volume":"92","author":"Gao","year":"2018","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.toxlet.2009.05.004","article-title":"Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions","volume":"189","author":"Ghisari","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2021.112649_bib23","doi-asserted-by":"crossref","first-page":"687259","DOI":"10.1155\/2009\/687259","article-title":"Prolactin and male fertility: the long and short feedback regulation","volume":"2009","author":"Gill-Sharma","year":"2009","journal-title":"Int. J. Endocrinol."},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000054361","article-title":"Cellular composition of the adult rat anterior pituitary is influenced by the neonatal sex steroid environment","volume":"68","author":"Gonzalez-Parra","year":"1998","journal-title":"Neuroendocrinology"},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib25","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.ygcen.2007.10.007","article-title":"Oestrogen receptor alpha and beta in female rat pituitary cells: an immunochemical study","volume":"155","author":"Gonzalez","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"issue":"5","key":"10.1016\/j.fct.2021.112649_bib26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.steroids.2008.01.002","article-title":"Estradiol interacts with insulin through membrane receptors to induce an antimitogenic effect on lactotroph cells","volume":"73","author":"Gutierrez","year":"2008","journal-title":"Steroids"},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mce.2012.02.008","article-title":"17beta-Estradiol stimulates the translocation of endogenous estrogen receptor alpha at the plasma membrane of normal anterior pituitary cells","volume":"355","author":"Gutierrez","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.fct.2021.112649_bib28","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbrc.2009.08.134","article-title":"Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11beta-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells","volume":"389","author":"Hong","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.fertnstert.2011.04.093","article-title":"The association between semen quality in workers and the concentration of di(2-ethylhexyl) phthalate in polyvinyl chloride pellet plant air","volume":"96","author":"Huang","year":"2011","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.fct.2021.112649_bib30","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1530\/REP-13-0448","article-title":"Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters","volume":"147","author":"Isling","year":"2014","journal-title":"Reproduction"},{"issue":"10","key":"10.1016\/j.fct.2021.112649_bib31","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1289\/ehp.1205113","article-title":"Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men","volume":"120","author":"Joensen","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00204-006-0132-y","article-title":"Di-(2-ethylhexyl) phthalate suppresses tamoxifen-induced apoptosis in GH3 pituitary cells","volume":"81","author":"Kim","year":"2007","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib33","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2605.2005.00607.x","article-title":"Di(2-ethylhexyl)phthalate (DEHP): human metabolism and internal exposure-- an update and latest results","volume":"29","author":"Koch","year":"2006","journal-title":"Int. J. Androl."},{"issue":"14","key":"10.1016\/j.fct.2021.112649_bib34","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1289\/ehp.6202","article-title":"In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy","volume":"111","author":"Latini","year":"2003","journal-title":"Environ. Health Perspect."},{"issue":"9","key":"10.1016\/j.fct.2021.112649_bib35","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1210\/endo.142.9.8395","article-title":"ER beta inhibits proliferation and invasion of breast cancer cells","volume":"142","author":"Lazennec","year":"2001","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.fct.2021.112649_bib36","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/er.2003-0035","article-title":"Estrogen regulation of growth hormone action","volume":"25","author":"Leung","year":"2004","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib37","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/taap.2000.8972","article-title":"A single dose of Di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces sertoli cell proliferation, and decreases cyclin D2 expression","volume":"166","author":"Li","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib38","first-page":"31","article-title":"An association of elevated serum prolactin with phthalate exposure in adult men","volume":"24","author":"Li","year":"2011","journal-title":"Biomed. Environ. Sci."},{"issue":"8","key":"10.1016\/j.fct.2021.112649_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.350","article-title":"Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.fct.2021.112649_bib40","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.1210\/en.2009-0847","article-title":"In utero exposure to di-(2-ethylhexyl) phthalate decreases mineralocorticoid receptor expression in the adult testis","volume":"150","author":"Martinez-Arguelles","year":"2009","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib41","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.maturitas.2010.03.001","article-title":"Exposure to environmental endocrine disrupting compounds and men's health","volume":"66","author":"Meeker","year":"2010","journal-title":"Maturitas"},{"issue":"9","key":"10.1016\/j.fct.2021.112649_bib42","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1210\/endo.139.9.6181","article-title":"Cellular distribution and gene regulation of estrogen receptors alpha and beta in the rat pituitary gland","volume":"139","author":"Mitchner","year":"1998","journal-title":"Endocrinology"},{"issue":"13","key":"10.1016\/j.fct.2021.112649_bib43","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1128\/MCB.02039-06","article-title":"The pituitary function of androgen receptor constitutes a glucocorticoid production circuit","volume":"27","author":"Miyamoto","year":"2007","journal-title":"Mol. Cell Biol."},{"issue":"Suppl. 3","key":"10.1016\/j.fct.2021.112649_bib44","first-page":"S489","article-title":"A mixture of diethylhexyl, diisononyl and dibutyl phthalate decreased anogenital distance, postnatal testosterone levels, and changed social behavior in Wistar rats","volume":"69","author":"Morova","year":"2020","journal-title":"Physiol. Res."},{"issue":"4","key":"10.1016\/j.fct.2021.112649_bib45","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1074\/mcp.M113.030403","article-title":"Post-transcriptional regulation of human breast cancer cell proteome by unliganded estrogen receptor beta via microRNAs","volume":"13","author":"Nassa","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"issue":"2","key":"10.1016\/j.fct.2021.112649_bib46","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1210\/endo.141.2.7330","article-title":"Ontogenetic changes in the expression of estrogen receptor alpha and beta in rat pituitary gland detected by immunohistochemistry","volume":"141","author":"Nishihara","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.fct.2021.112649_bib47","series-title":"Puberty in the Rat Knobil and Neill's Physiology of Reproduction","first-page":"2061","author":"Ojeda","year":"2006"},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib48","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.taap.2008.04.001","article-title":"Correlation of phthalate exposures with semen quality","volume":"231","author":"Pant","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2021.112649_bib49","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.envpol.2019.02.069","article-title":"The effects of bisphenol A, benzyl butyl phthalate, and di(2-ethylhexyl) phthalate on estrogen receptor alpha in estrogen receptor-positive cells under hypoxia","volume":"248","author":"Park","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2021.112649_bib50","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.reprotox.2019.01.005","article-title":"Sanitary pads and diapers contain higher phthalate contents than those in common commercial plastic products","volume":"84","author":"Park","year":"2019","journal-title":"Reprod. Toxicol."},{"issue":"6","key":"10.1016\/j.fct.2021.112649_bib51","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1210\/endo.140.6.6752","article-title":"Stage- and region-specific expression of estrogen receptor alpha isoforms during ontogeny of the pituitary gland","volume":"140","author":"Pasqualini","year":"1999","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.reprotox.2010.12.055","article-title":"Prenatal environmental exposures, epigenetics, and disease","volume":"31","author":"Perera","year":"2011","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.fct.2021.112649_bib53","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/jcp.26025","article-title":"Estrogen receptor beta regulates the tumoral suppressor PTEN to modulate pituitary cell growth","volume":"233","author":"Perez","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.fct.2021.112649_bib54","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.mce.2015.08.009","article-title":"Inhibitory role of ERbeta on anterior pituitary cell proliferation by controlling the expression of proteins related to cell cycle progression","volume":"415","author":"Perez","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.fct.2021.112649_bib55","doi-asserted-by":"crossref","first-page":"127304","DOI":"10.1016\/j.chemosphere.2020.127304","article-title":"The phthalate DEHP modulates the estrogen receptors alpha and beta increasing lactotroph cell population in female pituitary glands","volume":"258","author":"Perez","year":"2020","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.fct.2021.112649_bib56","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1210\/en.2011-1450","article-title":"Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring","volume":"153","author":"Pocar","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.fct.2021.112649_bib57","doi-asserted-by":"crossref","first-page":"104580","DOI":"10.1016\/j.envint.2019.02.003","article-title":"Phthalate exposure and female reproductive and developmental outcomes: a systematic review of the human epidemiological evidence","volume":"130","author":"Radke","year":"2019","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib58","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"Faseb. J."},{"issue":"2","key":"10.1016\/j.fct.2021.112649_bib59","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-3148.2010.01056.x","article-title":"DEHP-plasticised PVC: relevance to blood services","volume":"21","author":"Sampson","year":"2011","journal-title":"Transfus. Med."},{"key":"10.1016\/j.fct.2021.112649_bib60","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.envres.2016.07.043","article-title":"First trimester phthalate exposure and male newborn genital anomalies","volume":"151","author":"Sathyanarayana","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.fct.2021.112649_bib61","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1248\/jhs.47.495","article-title":"Several environmental pollutants have binding affinities for both androgen receptor and estrogen receptor","volume":"47","author":"Satoh","year":"2001","journal-title":"J. Health Sci."},{"issue":"1","key":"10.1016\/j.fct.2021.112649_bib62","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2605.2005.00567.x","article-title":"Human exposure to phthalates via consumer products","volume":"29","author":"Schettler","year":"2006","journal-title":"Int. J. Androl."},{"issue":"6","key":"10.1016\/j.fct.2021.112649_bib63","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1177\/0960327114555926","article-title":"Lactational exposure of phthalate causes long-term disruption in testicular architecture by altering tight junctional and apoptotic protein expression in Sertoli cells of first filial generation pubertal Wistar rats","volume":"34","author":"Sekaran","year":"2015","journal-title":"Hum. Exp. Toxicol."},{"issue":"7","key":"10.1016\/j.fct.2021.112649_bib64","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/jcb.25108","article-title":"In utero exposure to phthalate downregulates critical genes in Leydig cells of F1 male progeny","volume":"116","author":"Sekaran","year":"2015","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.fct.2021.112649_bib65","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1007\/s00128-004-0374-4","article-title":"Detection of phthalate metabolites in human amniotic fluid","volume":"72","author":"Silva","year":"2004","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"1\u20133","key":"10.1016\/j.fct.2021.112649_bib66","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tox.2005.10.018","article-title":"Urinary oxidative metabolites of di(2-ethylhexyl) phthalate in humans","volume":"219","author":"Silva","year":"2006","journal-title":"Toxicology"},{"issue":"10","key":"10.1016\/j.fct.2021.112649_bib67","doi-asserted-by":"crossref","first-page":"E1189","DOI":"10.1152\/ajpendo.00408.2011","article-title":"17beta-Estradiol modulates the prolactin secretion induced by TRH through membrane estrogen receptors via PI3K\/Akt in female rat anterior pituitary cell culture","volume":"302","author":"Sosa","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.fct.2021.112649_bib68","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1210\/endo.138.5.5132","article-title":"The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo","volume":"138","author":"Steinmetz","year":"1997","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.fct.2021.112649_bib69","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1289\/ehp.8100","article-title":"Decrease in anogenital distance among male infants with prenatal phthalate exposure","volume":"113","author":"Swan","year":"2005","journal-title":"Environ. Health Perspect."},{"issue":"2\u20133","key":"10.1016\/j.fct.2021.112649_bib70","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.tox.2005.02.002","article-title":"Differential effects of phthalate esters on transcriptional activities via human estrogen receptors alpha and beta, and androgen receptor","volume":"210","author":"Takeuchi","year":"2005","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib71","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11102-016-0777-3","article-title":"Benzene and 2-ethyl-phthalate induce proliferation in normal rat pituitary cells","volume":"20","author":"Tapella","year":"2017","journal-title":"Pituitary"},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib72","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1095\/biolreprod.103.021378","article-title":"Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in female rat pituitary","volume":"70","author":"Tena-Sempere","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.fct.2021.112649_bib73","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.taap.2016.08.001","article-title":"DEHP exposure in utero disturbs sex determination and is potentially linked with precocious puberty in female mice","volume":"307","author":"Wang","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.fct.2021.112649_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/toxics7020021","article-title":"A review of biomonitoring of phthalate exposures","volume":"7","author":"Wang","year":"2019","journal-title":"Toxics"},{"issue":"5","key":"10.1016\/j.fct.2021.112649_bib75","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00204-012-0805-7","article-title":"The inhibition by di(2-ethylhexyl)-phthalate of erg-mediated K(+) current in pituitary tumor (GH(3)) cells","volume":"86","author":"Wu","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2021.112649_bib76","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.chemosphere.2014.10.056","article-title":"Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice","volume":"124","author":"Xu","year":"2015","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.fct.2021.112649_bib77","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000321683","article-title":"Estrogen receptors and signaling pathways in lactotropes and somatotropes","volume":"92","author":"Zarate","year":"2010","journal-title":"Neuroendocrinology"},{"issue":"3","key":"10.1016\/j.fct.2021.112649_bib78","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1289\/ehp.1306681","article-title":"Temporal trends in phthalate exposures: findings from the national health and nutrition examination survey, 2001-2010","volume":"122","author":"Zota","year":"2014","journal-title":"Environ. Health Perspect."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521006827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691521006827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:15:17Z","timestamp":1759529717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691521006827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":78,"alternative-id":["S0278691521006827"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2021.112649","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perinatal DEHP exposure modulates pituitary estrogen receptor \u03b1 and \u03b2 expression altering lactotroph and somatotroph cell growth in prepuberal and adult male rats","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2021.112649","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112649"}}