{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:56:35Z","timestamp":1768719395778,"version":"3.49.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302938\/2020-6"],"award-info":[{"award-number":["302938\/2020-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.fct.2021.112700","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T20:25:14Z","timestamp":1637785514000},"page":"112700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Protective effect of the association of curcumin with piperine on prostatic lesions: New perspectives on BPA-induced carcinogenesis"],"prefix":"10.1016","volume":"158","author":[{"given":"Camila Helena","family":"Facina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana Gisele Pegorin","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0544-8325","authenticated-orcid":false,"given":"Thalles Fernando Rocha","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rejane Maira","family":"G\u00f3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9559-5497","authenticated-orcid":false,"given":"Patr\u00edcia Simone Leite","family":"Vilamaior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0970-4288","authenticated-orcid":false,"given":"Sebasti\u00e3o Roberto","family":"Taboga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2021.112700_bib1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nrendo.2011.56","article-title":"Endocrine disruptors in the etiology of type 2 diabetes mellitus","volume":"7","author":"Alonso-Magdalena","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.fct.2021.112700_bib2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/09603123.2018.1515896","article-title":"Association of exposure to Bisphenol A with obesity and cardiometabolic risk factors in children and adolescents","volume":"29","author":"Amin","year":"2019","journal-title":"Int. J. Environ. Health Res."},{"key":"10.1016\/j.fct.2021.112700_bib3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.coph.2009.06.002","article-title":"Anti-inflammatory drugs, antioxidants, and prostate cancer prevention","volume":"9","author":"Bardia","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.fct.2021.112700_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.mcna.2017.03.009","article-title":"Prevention of prostate cancer morbidity and mortality: primary prevention and early detection","volume":"101","author":"Barry","year":"2017","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.fct.2021.112700_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/biof.1074","article-title":"Curcumin and obesity","volume":"39","author":"Bradford","year":"2013","journal-title":"Biofactors"},{"key":"10.1016\/j.fct.2021.112700_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.fct.2018.02.060","article-title":"Effects of perinatal exposure to bisphenol A on the intraprostatic levels of aromatase and 5\u03b1-reductase isozymes in juvenile rats","volume":"115","author":"Castro","year":"2018","journal-title":"Food Chem. Toxicol. an Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.fct.2021.112700_bib7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2174\/1871520615666150116102442","article-title":"Curcumin-based anti-prostate cancer agents","volume":"15","author":"Chen","year":"2015","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.fct.2021.112700_bib8","first-page":"14","article-title":"Inherited predisposition to prostate cancer: from gene discovery to clinical impact","volume":"128","author":"Cooney","year":"2017","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"10.1016\/j.fct.2021.112700_bib9","article-title":"Global assessment of bisphenol A in the environment: review and analysis of its occurrence and bioaccumulation","volume":"13","author":"Corrales","year":"2015","journal-title":"Dose. Resp."},{"key":"10.1016\/j.fct.2021.112700_bib10","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.fct.2021.112700_bib11","first-page":"231","article-title":"Proinflammatory cytokine interleukin-6 in prostate carcinogenesis","volume":"2","author":"Culig","year":"2014","journal-title":"Am. J. Clin. Exp. Urol."},{"key":"10.1016\/j.fct.2021.112700_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s13679-017-0240-4","article-title":"Endocrine disruptors and obesity","volume":"6","author":"Darbre","year":"2017","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.fct.2021.112700_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41391-018-0081-6","article-title":"Estrogens and prostate cancer","volume":"22","author":"Dobbs","year":"2019","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.fct.2021.112700_bib14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pros.1074","article-title":"Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo","volume":"47","author":"Dorai","year":"2001","journal-title":"Prostate"},{"key":"10.1016\/j.fct.2021.112700_bib15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jnutbio.2012.05.009","article-title":"Piperine, a dietary phytochemical, inhibits angiogenesis","volume":"24","author":"Doucette","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2021.112700_bib16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/pros.23458","article-title":"Long-term oral exposure to safe dose of bisphenol A in association with high-fat diet stimulate the prostatic lesions in a rodent model for prostate cancer","volume":"78","author":"Facina","year":"2018","journal-title":"Prostate"},{"key":"10.1016\/j.fct.2021.112700_bib17","first-page":"e211","article-title":"Bisphenol A and hormone-associated cancers: current progress and perspectives","volume":"94","author":"Gao","year":"2015","journal-title":"Med. (United States)"},{"key":"10.1016\/j.fct.2021.112700_bib18","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/pros.23353","article-title":"Dual action of high estradiol doses on MNU-induced prostate neoplasms in a rodent model with high serum testosterone: protective effect and emergence of unstable epithelial microenvironment","volume":"77","author":"Gon\u00e7alves","year":"2017","journal-title":"Prostate"},{"key":"10.1016\/j.fct.2021.112700_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/sj.pcan.4500856","article-title":"The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo","volume":"9","author":"Hong","year":"2006","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.fct.2021.112700_bib20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/44517","article-title":"Exposure to bisphenol A advances puberty","volume":"401","author":"Howdeshell","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.fct.2021.112700_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.toxlet.2011.02.013","article-title":"Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKC\u03b1\/ERK1\/2-dependent matrix metalloproteinase-9 expression","volume":"203","author":"Hwang","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2021.112700_bib22","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/pros.21147","article-title":"Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen","volume":"70","author":"Ide","year":"2010","journal-title":"Prostate"},{"key":"10.1016\/j.fct.2021.112700_bib23","first-page":"9384","article-title":"Therapeutic applications of curcumin for patients with pancreatic cancer","volume":"20","author":"Kanai","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2021.112700_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/ayu.AYU_63_17","article-title":"Evaluation of anti-inflammatory effects of systemically administered curcumin, lycopene and piperine as an adjunct to scaling and root planing: a clinical study","volume":"38","author":"Kaur","year":"2017","journal-title":"Ayu"},{"key":"10.1016\/j.fct.2021.112700_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7762\/cnr.2017.6.4.229","article-title":"Index-based dietary patterns and the risk of prostate cancer","volume":"6","author":"Kim","year":"2017","journal-title":"Clin. Nutr. Res."},{"key":"10.1016\/j.fct.2021.112700_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fonc.2017.00077","article-title":"Inflammation in prostatic hyperplasia and carcinoma-basic scientific approach","volume":"7","author":"Kru\u0161lin","year":"2017","journal-title":"Front. Oncol."},{"key":"10.1016\/j.fct.2021.112700_bib27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/aps.2011.209","article-title":"Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model","volume":"33","author":"Lai","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.fct.2021.112700_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yrtph.2014.02.002","article-title":"Critical comments on the WHO-UNEP state of the science of endocrine disrupting chemicals - 2012","volume":"69","author":"Lamb","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2021.112700_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cbf.3265","article-title":"Bisphenol A triggers proliferation and migration of laryngeal squamous cell carcinoma via GPER mediated upregulation of IL-6","volume":"35","author":"Li","year":"2017","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.fct.2021.112700_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/nu12113498","article-title":"Low-dose bisphenol-A promotes epigenetic changes at ppar\u03b3 promoter in adipose precursor cells","volume":"12","author":"Longo","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2021.112700_bib32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.mce.2006.04.033","article-title":"Endocrine disruptors and reproductive health: the case of bisphenol-A","volume":"254\u2013255","author":"Maffini","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.fct.2021.112700_bib33","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.2174\/0929867324666170523120656","article-title":"Piperine as a potential anti-cancer agent: a review on preclinical studies","volume":"25","author":"Manayi","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.fct.2021.112700_bib34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.canlet.2015.07.009","article-title":"The paradoxical role of IL-10 in immunity and cancer","volume":"367","author":"Mannino","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2021.112700_bib35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12986-018-0250-6","article-title":"Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1\u03b2","volume":"15","author":"Miyazawa","year":"2018","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.fct.2021.112700_bib36","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.biotechadv.2017.12.002","article-title":"Bisphenol A (BPA) and cell signaling pathways","volume":"36","author":"Murata","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.fct.2021.112700_bib37","doi-asserted-by":"crossref","first-page":"1939S","DOI":"10.3945\/ajcn.110.001057","article-title":"Developmental exposure to endocrine-disrupting chemicals programs for reproductive tract alterations and obesity later in life","volume":"94","author":"Newbold","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.fct.2021.112700_bib38","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.fct.2013.08.007","article-title":"Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy","volume":"60","author":"Ouyang","year":"2013","journal-title":"Food Chem. Toxicol. an Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.fct.2021.112700_bib39","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.clnu.2014.12.019","article-title":"Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: a randomized controlled trial and an updated meta-analysis","volume":"34","author":"Panahi","year":"2015","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.fct.2021.112700_bib40","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/07315724.2018.1557572","article-title":"Effect of curcumin and \u03b1-lipoic acid in attenuating weight gain and adiposity","volume":"38","author":"Panzhinskiy","year":"2019","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.fct.2021.112700_bib41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/13685538.2017.1379491","article-title":"The influence of nutritional factors on prostate cancer incidence and aggressiveness. aging male off","volume":"21","author":"Pascual-Geler","year":"2018","journal-title":"J. Int. Soc. Study Aging Male"},{"key":"10.1016\/j.fct.2021.112700_bib42","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1080\/10408398.2015.1126547","article-title":"Risks and benefits related to alimentary exposure to xenoestrogens","volume":"57","author":"Paterni","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fct.2021.112700_bib43","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.etap.2015.07.012","article-title":"Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats","volume":"40","author":"Patial","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2021.112700_bib44","series-title":"Topics in Integrative, Alternative, and Complementary Therapies (PDQ\u00ae): Patient Version","year":"2002"},{"key":"10.1016\/j.fct.2021.112700_bib45","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0378-4274(83)90198-4","article-title":"Acute and subacute toxicity of piperine in mice, rats and hamsters","volume":"16","author":"Piyachaturawat","year":"1983","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2021.112700_bib46","first-page":"461","article-title":"Dietary prevention of hormone refractory prostate cancer in Lobund-Wistar rats: a review of studies in a relevant animal model","volume":"56","author":"Pollard","year":"2006","journal-title":"Comp. Med."},{"key":"10.1016\/j.fct.2021.112700_bib47","doi-asserted-by":"crossref","DOI":"10.1177\/1756287218820804","article-title":"Abiraterone acetate in combination with prednisone in the treatment of metastatic hormone-sensitive prostate cancer: clinical evidence and experience","volume":"11","author":"Purshouse","year":"2019","journal-title":"Ther. Adv. Urol."},{"key":"10.1016\/j.fct.2021.112700_bib48","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.envres.2017.08.045","article-title":"Environmental chemicals and breast cancer: an updated review of epidemiological literature informed by biological mechanisms","volume":"160","author":"Rodgers","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.fct.2021.112700_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065889","article-title":"Piperine, a bioactive component of pepper spice exerts therapeutic effects on androgen dependent and androgen independent prostate cancer cells","volume":"8","author":"Samykutty","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2021.112700_bib50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrurol.2017.167","article-title":"The inflammatory microenvironment and microbiome in prostate cancer development","volume":"15","author":"Sfanos","year":"2018","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.fct.2021.112700_bib51","article-title":"Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes","volume":"7","author":"Shao","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2021.112700_bib52","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1158\/0008-5472.CAN-03-0946","article-title":"Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the bar harbor meeting of the mouse models of human cancer consortium prostate pathology committee","volume":"64","author":"Shappell","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2021.112700_bib53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2006-957450","article-title":"Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers","volume":"64","author":"Shoba","year":"1998","journal-title":"Planta Med."},{"key":"10.1016\/j.fct.2021.112700_bib54","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.fct.2021.112700_bib55","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/01635581.2012.630551","article-title":"Cancer cell signaling pathways targeted by spice-derived nutraceuticals","volume":"64","author":"Sung","year":"2012","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.fct.2021.112700_bib56","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.fct.2007.02.002","article-title":"Studies on the in vitro absorption of spice principles--curcumin, capsaicin and piperine in rat intestines","volume":"45","author":"Suresh","year":"2007","journal-title":"Food Chem. Toxicol. an Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.fct.2021.112700_bib57","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/00087114.2003.10589340","article-title":"Nuclear phenotypes and morphometry of human secretory prostate cells: a comparative study of benign and malignant lesions in Brazilian patients","volume":"56","author":"Taboga","year":"2003","journal-title":"Caryologia"},{"key":"10.1016\/j.fct.2021.112700_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/biom10111536","article-title":"Curcumin against prostate cancer: current evidence","volume":"10","author":"Termini","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.fct.2021.112700_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199194","article-title":"Testosterone treatment and the risk of aggressive prostate cancer in men with low testosterone levels","volume":"13","author":"Walsh","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2021.112700_bib60","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1158\/0008-5472.54.65.1","article-title":"Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor status","volume":"65","author":"Wetherill","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2021.112700_bib61","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s10571-016-0443-3","article-title":"Low dose of bisphenol A activates NF-\u03baB\/IL-6 signals to increase malignancy of neuroblastoma cells","volume":"37","author":"Xiong","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.fct.2021.112700_bib62","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/apm.12650","article-title":"Curcumin inhibits the survival and metastasis of prostate cancer cells via the Notch-1 signaling pathway","volume":"125","author":"Yang","year":"2017","journal-title":"APMIS"},{"key":"10.1016\/j.fct.2021.112700_bib63","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.3892\/ol.2016.4536","article-title":"Pyridine analogues of curcumin exhibit high activity for inhibiting CWR-22Rv1 human prostate cancer cell growth and androgen receptor activation","volume":"11","author":"Zhou","year":"2016","journal-title":"Oncol. Lett."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152100733X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152100733X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:17:55Z","timestamp":1759529875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869152100733X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":62,"alternative-id":["S027869152100733X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2021.112700","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of the association of curcumin with piperine on prostatic lesions: New perspectives on BPA-induced carcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2021.112700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"112700"}}