{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:52:00Z","timestamp":1759539120329,"version":"build-2065373602"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.fct.2022.112879","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T03:51:12Z","timestamp":1645588272000},"page":"112879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S1","title":["RIFM fragrance ingredient safety assessment, 5-methyl-2-hepten-4-one, CAS Registry Number 81925-81-7"],"prefix":"10.1016","volume":"161","author":[{"given":"A.M.","family":"Api","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Belsito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Botelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"G.A.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Buschmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Cancellieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Dagli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Date","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Dekant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Deodhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lapczynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lavelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.C.","family":"Liebler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Moustakas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Na","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Penning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ritacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Romine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sadekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.W.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Selechnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.G.","family":"Sipes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-0926","authenticated-orcid":false,"given":"G.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Tokura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2022.112879_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.fct.2014.11.014","article-title":"Criteria for the Research Institute for fragrance materials, Inc. (RIFM) safety evaluation process for fragrance ingredients","volume":"82","author":"Api","year":"2015","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2022.112879_bib2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yrtph.2014.11.005","article-title":"Comparison of cramer classification between toxtree, the OECD QSAR Toolbox and expert judgment","volume":"71","author":"Bhatia","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"6","key":"10.1016\/j.fct.2022.112879_bib3","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.fct.2009.02.024","article-title":"Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products","volume":"47","author":"Carthew","year":"2009","journal-title":"Food Chem. Toxicol."},{"issue":"4 Suppl. 1","key":"10.1016\/j.fct.2022.112879_bib4","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1752-153X-4-S1-S4","article-title":"CAESAR models for developmental toxicity","author":"Cassano","year":"2010","journal-title":"Chem. Cent. J."},{"issue":"3","key":"10.1016\/j.fct.2022.112879_bib5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.yrtph.2015.05.012","article-title":"Novel database for exposure to fragrance ingredients in cosmetics and personal care products","volume":"72","author":"Comiskey","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2022.112879_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.yrtph.2017.05.017","article-title":"Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model","volume":"88","author":"Comiskey","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.fct.2022.112879_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0015-6264(76)80522-6","article-title":"Estimation of toxic hazard\u2014a decision tree approach","volume":"16","author":"Cramer","year":"1978","journal-title":"Food Chem. Toxicol."},{"year":"2012","series-title":"Guidance on Information Requirements and Chemical Safety Assessment Chapter R.11: PBT Assessment, November 2012 v1.1","author":"ECHA","key":"10.1016\/j.fct.2022.112879_bib8"},{"year":"2017","series-title":"Read-across Assessment Framework (RAAF)","author":"ECHA","key":"10.1016\/j.fct.2022.112879_bib9"},{"issue":"1","key":"10.1016\/j.fct.2022.112879_bib10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jphotobiol.2009.04.005","article-title":"Can light absorption and photostability data be used to assess the photosafety risks in patients for a new drug molecule?","volume":"96","author":"Henry","year":"2009","journal-title":"J. Photochem. Photobiol. B Biol."},{"year":"2015","series-title":"Volume of Use Survey","key":"10.1016\/j.fct.2022.112879_bib11"},{"issue":"12","key":"10.1016\/j.fct.2022.112879_bib12","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.fct.2007.06.021","article-title":"Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients","volume":"45","author":"Kroes","year":"2007","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2022.112879_bib13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yrtph.2011.09.004","article-title":"Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern","volume":"62","author":"Laufersweiler","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"year":"2020","series-title":"Fragrance Skin Sensitization Evaluation and Human Testing, Dermatitis","author":"Na","key":"10.1016\/j.fct.2022.112879_bib14"},{"year":"2015","series-title":"Guidance Document On the Reporting Of Integrated Approaches To Testing And Assessment (IATA). ENV\/JM\/HA(2015)7","author":"OECD","key":"10.1016\/j.fct.2022.112879_bib15"},{"year":"2018","series-title":"The OECD QSAR Toolbox, v3.2\u20134.2","author":"OECD","key":"10.1016\/j.fct.2022.112879_bib16"},{"year":"1985","series-title":"5-Methyl-2-hepten-4-one (Filbertone): Mangnusson and Kligman Maximization Study in the guinea Pig","key":"10.1016\/j.fct.2022.112879_bib17"},{"year":"1986","series-title":"Klecak Open Epicutaneous Test: Determination of the Contact Sensitization Potential of 5-Methyl-2-Hepten-4-One (Filbertone) in the guinea Pig","key":"10.1016\/j.fct.2022.112879_bib18"},{"year":"1987","series-title":"Salmonella Mutation Test (Ames Test) with 5-Methyl-2-Hepten-4-One (Filbertone)","key":"10.1016\/j.fct.2022.112879_bib19"},{"year":"1989","series-title":"Test for Delayed Contact Hypersensitivity with 5-Methyl-2-Hepten-4-One in the Albino guinea Pig","key":"10.1016\/j.fct.2022.112879_bib20"},{"year":"1995","series-title":"5-Methyl-2-hepten-4-one: Local Lymph Node Assay","key":"10.1016\/j.fct.2022.112879_bib21"},{"year":"1996","series-title":"5-Methyl-2-hepten-4-one (Filbertone): Local Lymph Node Assay","key":"10.1016\/j.fct.2022.112879_bib22"},{"year":"1998","series-title":"5-Methyl-2-hepten-4-one (Filbertone): Repetitive Cutaneous Test (Patch Test)","key":"10.1016\/j.fct.2022.112879_bib23"},{"year":"2004","series-title":"5,6,7-Trimethylocta-2,5-dien-4-one (Pomarose): Local Lymph Node Assay (LLNA) in Mice","key":"10.1016\/j.fct.2022.112879_bib24"},{"year":"2005","series-title":"5-Methyl-2-hepten-4-one (Filbertone): Repeat Insult Patch Test","key":"10.1016\/j.fct.2022.112879_bib25"},{"year":"2006","series-title":"Repeated Insult Patch Test with 5,6,7-Trimethylocta-2,5-Dien-4-One (Pomarose)","key":"10.1016\/j.fct.2022.112879_bib26"},{"year":"2009","series-title":"(E)-7-Methyl-3-octen-2-one (7-Methyl-3-Octen-2-One): Induction of Micronuclei in Cultured Human Peripheral Blood Lymphocytes","key":"10.1016\/j.fct.2022.112879_bib27"},{"year":"2010","series-title":"(E)-7-Methyl-3-octen-2-one (7-Methyl-3-Octen-2-One): Induction of Micronuclei in Cultured Human Peripheral Blood Lymphocytes","key":"10.1016\/j.fct.2022.112879_bib28"},{"year":"2012","series-title":"(E)-7-Methyl-3-octen-2-one (7-Methyl-3-Octen-2-One): Induction of Micronuclei in the Bone Marrow of Treated Rats","key":"10.1016\/j.fct.2022.112879_bib29"},{"year":"2013","series-title":"5-Methyl-2-hepten-4-one (Filbertone G): Ready Biodegradability CO2 in Sealed Vessels (Headspace Test). Unpublished Report from Symrise. RIFM Report Number 67931","key":"10.1016\/j.fct.2022.112879_bib30"},{"year":"2015","series-title":"Induction of Antioxidant-Response Element Dependent Gene Activity Cytotoxicity (Using MTT) in the Keratinocyte ARE- Reporter Cell Line Keratinosens. RIFM Report Number 69647","key":"10.1016\/j.fct.2022.112879_bib31"},{"year":"2015","series-title":"Direct Peptide Reactivity Assay (DPRA) of Alpha-Amylcinnamyl Alcohol, Benzyl Cinnamate, Butyl Acrylate, P-Tert-Butyldihydrocinnamaldehyde, Carvone and 1-cyclohexylethyl 2-butenoate. RIFM Report Number 69649","key":"10.1016\/j.fct.2022.112879_bib32"},{"year":"2016","series-title":"2-Hepten-4-one, 5-methyl-, (2E)- and 2-Hepten-4-One, 5-methyl-, (2E)- (Filbertone): Salmonella typhimurium and Escherichia coli Reverse Mutation Assay","key":"10.1016\/j.fct.2022.112879_bib33"},{"year":"2016","series-title":"2-Hepten-4-one, 5-methyl-, (2E)- and 2-Hepten-4-One, 5-methyl-, (2E)- (Filbertone): Determination of Water Solubility","key":"10.1016\/j.fct.2022.112879_bib34"},{"year":"2016","series-title":"2-Hepten-4-one, 5-methyl-, (2E)- and 2-Hepten-4-One, 5-methyl-, (2E)- (Filbertone): Partition Coefficient (N-octanol\/water)","key":"10.1016\/j.fct.2022.112879_bib35"},{"year":"2016","series-title":"Effect of 2-Hepten-4-One, 5-methyl-, (2E)- and 2-Hepten-4-One, 5-methyl-, (2E)- (Filbertone) to Pseudokirchneriella Subcapitata in a 72-hour Algal Growth Inhibition Test","key":"10.1016\/j.fct.2022.112879_bib36"},{"year":"2016","series-title":"Effect of 2-Hepten-4-One, 5-methyl-, (2E)- and 2-Hepten-4-One, 5-methyl-, (2E)- (Filbertone) to Daphnia Magna in a 48-hour Immobilization Test","key":"10.1016\/j.fct.2022.112879_bib37"},{"year":"2016","series-title":"5-Methyl-2-hepten-4-one and 2-Hepten-4-One, 5-methyl-, (2E)- (Filbertone): Determination of Physico-Chemical Properties Melting Point and Boiling Point","key":"10.1016\/j.fct.2022.112879_bib38"},{"year":"2016","series-title":"5-Methyl-2-hepten-4-one and 2-Hepten-4-One, 5-methyl-, (2E)- (Filbertone): Determination of Physico-Chemical Properties Vapour Pressure","key":"10.1016\/j.fct.2022.112879_bib39"},{"year":"2016","series-title":"Direct Peptide Reactivity Assay (DPRA) in Fragrance Materials. RIFM Report Number 72225","key":"10.1016\/j.fct.2022.112879_bib40"},{"year":"2016","series-title":"Induction of Antioxidant-Response-Element Dependent Gene Activity and Cytotoxicity (Using MTT) in the Keratinocyte ARE-Reporter Cell Line KeratinoSens for Fragrance Materials. RIFM Report Number 72232","key":"10.1016\/j.fct.2022.112879_bib41"},{"volume":"14","journal-title":"Exposure Survey","year":"2017","key":"10.1016\/j.fct.2022.112879_bib42"},{"year":"2017","series-title":"Evaluation of the Sensitization Potential Using the SENS-IS Test of Multiple Materials","key":"10.1016\/j.fct.2022.112879_bib43"},{"year":"2017","series-title":"5,6,7-Trimethylocta-2,5-dien-4-one: in Vitro Sensitization: Dendritic Cell Line Activation Assay Human Cell Line Activation Test (H-CLAT). RIFM Report Number 72775","key":"10.1016\/j.fct.2022.112879_bib44"},{"year":"2020","series-title":"Updating Exposure Assessment for Skin Sensitization Quantitative Risk Assessment for Fragrance Materials","key":"10.1016\/j.fct.2022.112879_bib45"},{"issue":"7","key":"10.1016\/j.fct.2022.112879_bib46","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/tx700024w","article-title":"Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization","volume":"20","author":"Roberts","year":"2007","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.fct.2022.112879_bib47","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1021\/ci100050t","article-title":"Extended-connectivity fingerprints","volume":"50","author":"Rogers","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.fct.2022.112879_bib48","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.yrtph.2015.05.017","article-title":"Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products","volume":"72","author":"Safford","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2022.112879_bib49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yrtph.2017.02.021","article-title":"Application of the expanded Creme RIFM consumer exposure model to fragrance ingredients in cosmetic, personal care and air care products","volume":"86","author":"Safford","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"6","key":"10.1016\/j.fct.2022.112879_bib50","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/etc.5620210627","article-title":"A Framework for prioritizing fragrance materials for aquatic risk assessment","volume":"21","author":"Salvito","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"issue":"3","key":"10.1016\/j.fct.2022.112879_bib51","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.yrtph.2015.05.016","article-title":"A strategy for structuring and reporting a read-across prediction of toxicity","volume":"72","author":"Schultz","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2022.112879_bib52","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.fct.2014.09.015","article-title":"An in silico skin absorption model for fragrance materials","volume":"74","author":"Shen","year":"2014","journal-title":"Food Chem. Toxicol."},{"year":"2012","series-title":"Estimation Programs Interface Suite for Microsoft Windows, v4.0\u2013v4.11","author":"US EPA","key":"10.1016\/j.fct.2022.112879_bib53"},{"year":"2012","series-title":"The ECOSAR (ECOlogical Structure Activity Relationship) Class Program for Microsoft Windows, v1.11","author":"US EPA","key":"10.1016\/j.fct.2022.112879_bib54"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152200076X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152200076X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:17:53Z","timestamp":1759529873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869152200076X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":54,"alternative-id":["S027869152200076X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2022.112879","relation":{},"ISSN":["0278-6915"],"issn-type":[{"type":"print","value":"0278-6915"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RIFM fragrance ingredient safety assessment, 5-methyl-2-hepten-4-one, CAS Registry Number 81925-81-7","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2022.112879","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112879"}}