{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:52:38Z","timestamp":1759539158734,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.fct.2022.113241","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T21:51:25Z","timestamp":1655502685000},"page":"113241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S1","title":["RIFM fragrance ingredient safety assessment, dihydrocarveol (isomer unspecified), CAS Registry Number 619-01-2"],"prefix":"10.1016","volume":"167","author":[{"given":"A.M.","family":"Api","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Belsito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Botelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"G.A.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Cancellieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Chon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Dagli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Date","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Dekant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Deodhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lapczynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lavelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.C.","family":"Liebler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Moustakas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Na","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Penning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ritacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Romine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sadekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.W.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Selechnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.G.","family":"Sipes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-0926","authenticated-orcid":false,"given":"G.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Tokura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2022.113241_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.fct.2014.11.014","article-title":"Criteria for the Research Institute for fragrance materials, Inc. (RIFM) safety evaluation process for fragrance ingredients","volume":"82","author":"Api","year":"2015","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.fct.2022.113241_bib2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.fct.2009.02.024","article-title":"Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products","volume":"47","author":"Carthew","year":"2009","journal-title":"Food Chem. Toxicol."},{"issue":"4 Suppl. 1","key":"10.1016\/j.fct.2022.113241_bib3","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1752-153X-4-S1-S4","article-title":"CAESAR models for developmental toxicity","author":"Cassano","year":"2010","journal-title":"Chem. Cent. J."},{"issue":"3","key":"10.1016\/j.fct.2022.113241_bib4","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.yrtph.2015.05.012","article-title":"Novel database for exposure to fragrance ingredients in cosmetics and personal care products","volume":"72","author":"Comiskey","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2022.113241_bib5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.yrtph.2017.05.017","article-title":"Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model","volume":"88","author":"Comiskey","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"year":"2012","series-title":"Guidance on Information Requirements and Chemical Safety Assessment","key":"10.1016\/j.fct.2022.113241_bib6"},{"year":"2017","series-title":"Read-across Assessment Framework (RAAF)","key":"10.1016\/j.fct.2022.113241_bib7"},{"issue":"3","key":"10.1016\/j.fct.2022.113241_bib8","first-page":"4727","article-title":"Scientific opinion on flavouring group evaluation 57, revision 1 (FGE.57Rev1): consideration of isopulegone and three flavouring substances evaluated by JECFA (55th meeting)","volume":"15","year":"2017","journal-title":"EFSA J."},{"issue":"1","key":"10.1016\/j.fct.2022.113241_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jphotobiol.2009.04.005","article-title":"Can light absorption and photostability data be used to assess the photosafety risks in patients for a new drug molecule?","volume":"96","author":"Henry","year":"2009","journal-title":"J. Photochem. Photobiol. B Biol."},{"year":"2015","series-title":"Volume of Use Survey","key":"10.1016\/j.fct.2022.113241_bib10"},{"issue":"12","key":"10.1016\/j.fct.2022.113241_bib11","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.fct.2007.06.021","article-title":"Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients","volume":"45","author":"Kroes","year":"2007","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2022.113241_bib12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yrtph.2011.09.004","article-title":"Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern","volume":"62","author":"Laufersweiler","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.fct.2022.113241_bib13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0041-008X(92)90296-5","article-title":"a-2u-globulin is the only member of the lipocalin protein superfamily that binds to hyaline droplet inducing agents","volume":"116","author":"Lehman-McKeeman","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.fct.2022.113241_bib14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0041-008X(90)90326-P","article-title":"Lysosomal degradation of alpha2u-globulin and alpha2u-globulin-xenobiotic conjugates","volume":"103","author":"Lehman-McKeeman","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.fct.2022.113241_bib15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/DER.0000000000000684","article-title":"Fragrance skin sensitization evaluation and human testing: 30-year experience","volume":"32","author":"Na","year":"2021","journal-title":"Dermatitis"},{"first-page":"7","year":"2015","series-title":"Guidance Document on the Reporting of Integrated Approaches to Testing and Assessment (IATA). ENV\/JM\/HA","key":"10.1016\/j.fct.2022.113241_bib16"},{"year":"2018","series-title":"The OECD QSAR Toolbox, v3.2\u20134.2","key":"10.1016\/j.fct.2022.113241_bib17"},{"year":"1977","series-title":"Report on Human Maximization Studies. Report to RIFM. RIFM Report Number 1691","key":"10.1016\/j.fct.2022.113241_bib18"},{"year":"2014","series-title":"Report on the Testing of Dihydrocarveol (Isomer Unspecified) in the BlueScreen HC Assay (-\/+ S9 Metabolic Activation). RIFM Report Number 67383","key":"10.1016\/j.fct.2022.113241_bib19"},{"year":"2016","series-title":"Dihydrocarveol (Isomer Unspecified): Reverse Mutation Assay 'Ames Test' Using Salmonella typhimurium and Escherichia coli. RIFM Report Number 70259","key":"10.1016\/j.fct.2022.113241_bib20"},{"year":"2016","series-title":"Dihydrocarveol (Isomer Unspecified): Micronucleus Test in Human Lymphocytes in Vitro. RIFM Report Number 70828","key":"10.1016\/j.fct.2022.113241_bib21"},{"volume":"22","journal-title":"Exposure Survey","year":"2018","key":"10.1016\/j.fct.2022.113241_bib22"},{"year":"2020","series-title":"Clustering a Chemical Inventory for Safety Assessment of Fragrance Ingredients: Identifying Read-Across Analogs to Address Data Gaps. RIFM Report Number 76272","key":"10.1016\/j.fct.2022.113241_bib23"},{"issue":"3","key":"10.1016\/j.fct.2022.113241_bib24","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.yrtph.2015.03.001","article-title":"Principles for identification of high potency category chemicals for which the dermal sensitization threshold (DST) approach should not be applied","volume":"72","author":"Roberts","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"7","key":"10.1016\/j.fct.2022.113241_bib25","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/tx700024w","article-title":"Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization","volume":"20","author":"Roberts","year":"2007","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.fct.2022.113241_bib26","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1021\/ci100050t","article-title":"Extended-connectivity fingerprints","volume":"50","author":"Rogers","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.fct.2022.113241_bib27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.yrtph.2015.05.017","article-title":"Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products","volume":"72","author":"Safford","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2022.113241_bib28","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yrtph.2017.02.021","article-title":"Application of the expanded Creme RIFM consumer exposure model to fragrance ingredients in cosmetic, personal care and air care products","volume":"86","author":"Safford","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.fct.2022.113241_bib29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.yrtph.2008.02.010","article-title":"The dermal sensitisation threshold--A TTC approach for allergic contact dermatitis","volume":"51","author":"Safford","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.fct.2022.113241_bib30","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.yrtph.2015.04.020","article-title":"Extension of the dermal sensitization threshold (DST) approach to incorporate chemicals classified as reactive","volume":"72","author":"Safford","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.fct.2022.113241_bib31","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.yrtph.2011.03.009","article-title":"Refinement of the dermal sensitisation threshold (DST) approach using a larger dataset and incorporating mechanistic chemistry domains","volume":"60","author":"Safford","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"6","key":"10.1016\/j.fct.2022.113241_bib32","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/etc.5620210627","article-title":"A Framework for prioritizing fragrance materials for aquatic risk assessment","volume":"21","author":"Salvito","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"issue":"3","key":"10.1016\/j.fct.2022.113241_bib33","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.yrtph.2015.05.016","article-title":"A strategy for structuring and reporting a read-across prediction of toxicity","volume":"72","author":"Schultz","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2022.113241_bib34","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.fct.2014.09.015","article-title":"An in silico skin absorption model for fragrance materials","volume":"74","author":"Shen","year":"2014","journal-title":"Food Chem. Toxicol."},{"year":"2012","series-title":"Estimation Programs Interface Suite for Microsoft Windows, v4.0\u2013v4.11","key":"10.1016\/j.fct.2022.113241_bib35"},{"year":"2012","series-title":"The ECOSAR (ECOlogical Structure Activity Relationship) Class Program for Microsoft Windows, v2.0","key":"10.1016\/j.fct.2022.113241_bib36"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691522004392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691522004392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:19:51Z","timestamp":1759529991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691522004392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":36,"alternative-id":["S0278691522004392"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2022.113241","relation":{},"ISSN":["0278-6915"],"issn-type":[{"type":"print","value":"0278-6915"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RIFM fragrance ingredient safety assessment, dihydrocarveol (isomer unspecified), CAS Registry Number 619-01-2","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2022.113241","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113241"}}