{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:38:55Z","timestamp":1791689935665,"version":"4.3.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["838991"],"award-info":[{"award-number":["838991"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["PID2019-103914RB-I00"],"award-info":[{"award-number":["PID2019-103914RB-I00"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.fct.2022.113254","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T21:17:27Z","timestamp":1655932647000},"page":"113254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Physiologically relevant curcuminoids inhibit angiogenesis via VEGFR2 in human aortic endothelial cells"],"prefix":"10.1016","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-8764","authenticated-orcid":false,"given":"Juan Antonio","family":"Gim\u00e9nez-Bastida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"\u00c1vila-G\u00e1lvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Carmena-Bargue\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"P\u00e9rez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Esp\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-0678","authenticated-orcid":false,"given":"Antonio","family":"Gonz\u00e1lez-Sarr\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2022.113254_bib1","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1002\/ptr.6403","article-title":"A review of molecular mechanisms involved in anticancer and antiangiogenic effects of natural polyphenolic compounds","volume":"33","author":"Abbaszadeh","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.fct.2022.113254_bib2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12079-016-0352-8","article-title":"VEGF-A\/VEGFR2 signaling network in endothelial cells relevant to angiogenesis","volume":"10","author":"Abhinand","year":"2016","journal-title":"J. Cell Commun. Signal"},{"key":"10.1016\/j.fct.2022.113254_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1160\/TH14-05-0454","article-title":"Tumour growth inhibition and antiangiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition","volume":"113","author":"Abusnina","year":"2015","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.fct.2022.113254_bib4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/BF03401744","article-title":"Curcumin is an in vivo inhibitor of angiogenesis","volume":"4","author":"Arbiser","year":"1998","journal-title":"Mol. Med."},{"key":"10.1016\/j.fct.2022.113254_bib5","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nprot.2010.6","article-title":"In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract","volume":"5","author":"Arnaoutova","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.fct.2022.113254_bib6","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1016\/S0024-3205(00)00868-7","article-title":"Occurrence of orally administered curcuminoid as glucuronide and glucuronide\/sulfate conjugates in rat plasma","volume":"67","author":"Asai","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2022.113254_bib7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.fbio.2019.04.005","article-title":"Curcumin inhibits angiogenesis in endothelial cells using downregulation of the PI3K\/Akt signaling pathway","volume":"29","author":"Astinfeshan","year":"2019","journal-title":"Food Biosci."},{"key":"10.1016\/j.fct.2022.113254_bib8","doi-asserted-by":"crossref","first-page":"E5718","DOI":"10.3390\/ijms21165718","article-title":"Dietary phenolics against breast cancer. A critical evidence-based review and future perspectives","volume":"21","author":"\u00c1vila-G\u00e1lvez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2022.113254_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202100163","article-title":"Disposition of dietary polyphenols in breast cancer patients' tumors, and their associated anticancer activity: the particular case of curcumin","volume":"65","author":"\u00c1vila-G\u00e1lvez","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2022.113254_bib10","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1136\/gut.2008.152496","article-title":"Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition","volume":"57","author":"Binion","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.fct.2022.113254_bib11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.fct.2022.113254_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67289-8","article-title":"Angiogenesis analyzer for ImageJ - a comparative morphometric analysis of \u201cendothelial tube formation assay\u201d and \u201cFibrin Bead assay.\u201d","volume":"10","author":"Carpentier","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2022.113254_bib13","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1002\/mnfr.201500407","article-title":"Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2 activity","volume":"59","author":"Cerezo","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2022.113254_bib14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc2868","article-title":"Targeting the tumour vasculature: insights from physiological angiogenesis","volume":"10","author":"Chung","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.fct.2022.113254_bib15","doi-asserted-by":"crossref","DOI":"10.3791\/51312-v","article-title":"Endothelial cell tube formation assay for the in vitro study of angiogenesis","author":"DeCicco-Skinner","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.fct.2022.113254_bib16","doi-asserted-by":"crossref","first-page":"6154","DOI":"10.1021\/acs.jafc.0c02607","article-title":"Mechanistic differences in the inhibition of NF-\u03baB by turmeric and its curcuminoid constituents","volume":"68","author":"Edwards","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2022.113254_bib17","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3945\/jn.108.100966","article-title":"Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57\/BL mice","volume":"139","author":"Ejaz","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.fct.2022.113254_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1081\/RRS-120025567","article-title":"Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF","volume":"23","author":"Endo","year":"2003","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.fct.2022.113254_bib19","article-title":"Endothelial cells deconjugate resveratrol metabolites to free resveratrol: a possible role in tissue factor modulation","volume":"63","author":"Fern\u00e1ndez-Castillejo","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2022.113254_bib20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature04483","article-title":"Angiogenesis as a therapeutic target","volume":"438","author":"Ferrara","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.fct.2022.113254_bib21","doi-asserted-by":"crossref","first-page":"19469","DOI":"10.18632\/oncotarget.3625","article-title":"Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway","volume":"6","author":"Fu","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.fct.2022.113254_bib22","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1039\/C5FO00771B","article-title":"Hesperetin and its sulfate and glucuronide metabolites inhibit TNF-\u03b1 induced human aortic endothelial cell migration and decrease plasminogen activator inhibitor-1 (PAI-1) levels","volume":"7","author":"Gim\u00e9nez-Bastida","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.fct.2022.113254_bib23","doi-asserted-by":"crossref","first-page":"8866","DOI":"10.1021\/jf300290f","article-title":"Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts","volume":"60","author":"Gim\u00e9nez-Bastida","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2022.113254_bib24","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/mnfr.201100741","article-title":"Multitargeting by turmeric, the golden spice: from kitchen to clinic","volume":"57","author":"Gupta","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2022.113254_bib25","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0006-291X(02)02306-9","article-title":"Molecular mechanisms of antiangiogenic effect of curcumin","volume":"297","author":"Gururaj","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2022.113254_bib26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41538-021-00119-x","article-title":"Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin","volume":"6","author":"Harada","year":"2022","journal-title":"NPJ Sci. Food"},{"key":"10.1016\/j.fct.2022.113254_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.gene.2018.11.062","article-title":"Curcumin modulates the angiogenic potential of human endothelial cells via FAK\/P-38 MAPK signaling pathway","volume":"688","author":"Hosseini","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.fct.2022.113254_bib28","first-page":"324","article-title":"[Study on anti-angiogenesis effect of three curcumin pigments and expression of their relevant factors]","volume":"40","author":"Huang","year":"2015","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.fct.2022.113254_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fcell.2019.00045","article-title":"The use of live cell imaging and automated image analysis to assist with determining optimal parameters for angiogenic assay in vitro","volume":"7","author":"Huuskes","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.fct.2022.113254_bib30","first-page":"1058","article-title":"Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production","volume":"61","author":"Ireson","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2022.113254_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/mto.2016.18","article-title":"Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K\/Akt\/mTOR signaling pathways in lung cancer","volume":"3","author":"Jiao","year":"2016","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.fct.2022.113254_bib32","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.2174\/1389557521666210122153823","article-title":"Curcumin: an insight into molecular pathways involved in anticancer activity","volume":"21","author":"Joshi","year":"2021","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.fct.2022.113254_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.7412","article-title":"Effect of turmeric supplementation on the pharmacokinetics of paclitaxel in breast cancer patients: a study with population pharmacokinetics approach","author":"Kalluru","year":"2022","journal-title":"Phytother Res."},{"key":"10.1016\/j.fct.2022.113254_bib34","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1002\/tox.23332","article-title":"Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K\/Akt pathway","volume":"36","author":"Kao","year":"2021","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.fct.2022.113254_bib35","doi-asserted-by":"crossref","first-page":"8797","DOI":"10.1021\/acs.jmedchem.8b00938","article-title":"Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors","volume":"61","author":"Kettle","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.fct.2022.113254_bib36","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/j.1349-7006.2002.tb01247.x","article-title":"Microarray-based analysis of antiangiogenic activity of demethoxycurcumin on human umbilical vein endothelial cells: crucial involvement of the down-regulation of matrix metalloproteinase","volume":"93","author":"Kim","year":"2002","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.fct.2022.113254_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/srep14205","article-title":"Introduction of methyl groups at C2 and C6 positions enhances the antiangiogenesis activity of curcumin","volume":"5","author":"Koo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2022.113254_bib38","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jnutbio.2018.09.021","article-title":"Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGF\u03b2-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues","volume":"63","author":"Kunihiro","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2022.113254_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800267","article-title":"Detection of plasma curcuminoids from dietary intake of turmeric-containing food in human volunteers","volume":"62","author":"Mahale","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2022.113254_bib40","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1002\/mnfr.201100378","article-title":"Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed?","volume":"55","author":"Menendez","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2022.113254_bib41","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.fct.2022.113254_bib42","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/mnfr.201400866","article-title":"Dietary phenolics against colorectal cancer--From promising preclinical results to poor translation into clinical trials: pitfalls and future needs","volume":"59","author":"N\u00fa\u00f1ez-S\u00e1nchez","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2022.113254_bib43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/mnfr.201400515","article-title":"Breast cancer chemoprevention by dietary natural phenolic compounds: specific epigenetic related molecular targets","volume":"59","author":"Pan","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2022.113254_bib44","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.fct.2022.113254_bib45","doi-asserted-by":"crossref","first-page":"E34","DOI":"10.3390\/biomedicines5020034","article-title":"The role of angiogenesis in cancer treatment","volume":"5","author":"Rajabi","year":"2017","journal-title":"Biomedicines"},{"key":"10.1016\/j.fct.2022.113254_bib46","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/jcp.25795","article-title":"Promising antitumor properties of bisdemethoxycurcumin: a naturally occurring curcumin analogue","volume":"233","author":"Ramezani","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.fct.2022.113254_bib67","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1021\/acs.jctc.8b01026","article-title":"OPLS3e: Extending force field coverage for drug-like small molecules","volume":"15","author":"Roos","year":"2019","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.fct.2022.113254_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/srep28832","article-title":"Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system","volume":"6","author":"Seo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2022.113254_bib48","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2174\/1570161116666180209113014","article-title":"Antiangiogenic activity of curcumin in cancer therapy: a narrative review","volume":"17","author":"Shakeri","year":"2019","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.fct.2022.113254_bib49","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1750-2187-2-10","article-title":"Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis","volume":"2","author":"Shankar","year":"2007","journal-title":"J. Mol. Signal."},{"key":"10.1016\/j.fct.2022.113254_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.01021","article-title":"Turmeric and its major compound curcumin on health: bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications","volume":"11","author":"Sharifi-Rad","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2022.113254_bib51","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/mnfr.201200462","article-title":"Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: an in vitro and in vivo study","volume":"57","author":"Sheu","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2022.113254_bib52","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.molmed.2017.01.002","article-title":"Direct effects of anti-angiogenic therapies on tumor cells: VEGF signaling","volume":"23","author":"Simon","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.fct.2022.113254_bib53","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.2174\/1389557520666200414161316","article-title":"Traditional uses, therapeutic effects and recent advances of curcumin: a mini-review","volume":"20","author":"Slika","year":"2020","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.fct.2022.113254_bib54","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1021\/ci800166p","article-title":"Lead finder: an approach to improve accuracy of protein-ligand docking, binding energy estimation, and virtual screening","volume":"48","author":"Stroganov","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.fct.2022.113254_bib55","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.atherosclerosis.2003.12.011","article-title":"Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells","volume":"173","author":"Tan","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.fct.2022.113254_bib56","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41589-019-0278-6","article-title":"MCC950 closes the active conformation of NLRP3 to an inactive state","volume":"15","author":"Tapia-Abell\u00e1n","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.fct.2022.113254_bib57","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.fct.2022.113254_bib58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.crbiot.2021.05.001","article-title":"Differences between common endothelial cell models (primary human aortic endothelial cells and EA.hy926 cells) revealed through transcriptomics, bioinformatics, and functional analysis","volume":"3","author":"Wang","year":"2021","journal-title":"Curr. Res. Biotechnol."},{"key":"10.1016\/j.fct.2022.113254_bib59","article-title":"Effects of curcumin on vessel formation insight into the pro- and antiangiogenesis of curcumin","author":"Wang","year":"2019","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.fct.2022.113254_bib60","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1002\/mnfr.201500399","article-title":"Curcumin inhibits lymphangiogenesis in vitro and in vivo","volume":"59","author":"Wang","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2022.113254_bib61","article-title":"Molecular bases of VEGFR-2-mediated physiological function and pathological role","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.fct.2022.113254_bib62","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4161\/cbt.11.2.14405","article-title":"Curcumin: a component of the golden spice, targets multiple angiogenic pathways","volume":"11","author":"Yadav","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.fct.2022.113254_bib63","doi-asserted-by":"crossref","first-page":"e1112","DOI":"10.1038\/cddis.2014.85","article-title":"Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin","volume":"5","author":"Yoon","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2022.113254_bib64","first-page":"109","article-title":"Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice","volume":"34","author":"Yoysungnoen","year":"2006","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"10.1016\/j.fct.2022.113254_bib65","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/817972","article-title":"Antitumor and antiangiogenic activities of curcumin in cervical cancer xenografts in nude mice","author":"Yoysungnoen-Chintana","year":"2014","journal-title":"BioMed Res. Int."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691522004525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691522004525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:20:25Z","timestamp":1759530025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691522004525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":66,"alternative-id":["S0278691522004525"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2022.113254","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiologically relevant curcuminoids inhibit angiogenesis via VEGFR2 in human aortic endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2022.113254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"113254"}}