{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:53:25Z","timestamp":1760205205063,"version":"build-2065373602"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2017 SGR n\u00b0 1531"],"award-info":[{"award-number":["2017 SGR n\u00b0 1531"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/01763"],"award-info":[{"award-number":["PI18\/01763"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008394","name":"Fundaci\u00f3 Bosch i Gimpera","doi-asserted-by":"publisher","award":["300155"],"award-info":[{"award-number":["300155"]}],"id":[{"id":"10.13039\/501100008394","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["LCF\/PR\/GN14\/10270005","LCF\/PR\/GN18\/10310003"],"award-info":[{"award-number":["LCF\/PR\/GN14\/10270005","LCF\/PR\/GN18\/10310003"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014050","name":"Armagh Observatory and Planetarium","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"Fundaci\u00f3n La Caixa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.fct.2022.113506","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T23:37:02Z","timestamp":1668037022000},"page":"113506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Application of the adverse outcome pathway to identify molecular changes in prenatal brain programming induced by IUGR: Discoveries after EGCG exposure"],"prefix":"10.1016","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-1184","authenticated-orcid":false,"given":"Britta Anna","family":"K\u00fchne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0146-876X","authenticated-orcid":false,"given":"Elisabet","family":"Teixid\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miren","family":"Ettcheto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Puig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Planas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Feliu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Pla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8128-2641","authenticated-orcid":false,"given":"Victoria","family":"Campuzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Gratac\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Fritsche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Illa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Barenys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2022.113506_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/toxsci\/kfr198","article-title":"The safety and regulation of natural products used as foods and food ingredients","volume":"123","author":"Abdel-Rahman","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2022.113506_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1176\/appi.ajp.2012.12040543","article-title":"Deviance in fetal growth and risk of autism spectrum disorder","volume":"170","author":"Abel","year":"2013","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.fct.2022.113506_bib3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3390\/ijms22020715","article-title":"Epigallocatechin gallate ameliorates the effects of prenatal alcohol exposure in a fetal alcohol spectrum disorder-like mouse model","volume":"22","author":"Almeida-Toledano","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2022.113506_bib4","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/bdr2.1189","article-title":"Building a developmental toxicity ontology","volume":"110","author":"Baker","year":"2018","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.fct.2022.113506_bib5","article-title":"Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity","author":"Bal-Price","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.fct.2022.113506_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pharmthera.2017.05.006","article-title":"Adverse outcome pathways: application to enhance mechanistic understanding of neurotoxicity","volume":"179","author":"Bal-Price","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fct.2022.113506_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00441-009-0834-6","volume":"339","author":"Barczyk","year":"2010","journal-title":"Integrins. Cell Tissue Res."},{"key":"10.1016\/j.fct.2022.113506_bib8","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-016-1709-8","article-title":"Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro","author":"Barenys","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2022.113506_bib9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/sctm.20-0223","article-title":"Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction","volume":"10","author":"Barenys","year":"2021","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.fct.2022.113506_bib10","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/1389450116666150804110049","article-title":"Is intake of flavonoid-based food supplements during pregnancy safe for the developing child? A literature review","volume":"18","author":"Barenys","year":"2016","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.fct.2022.113506_bib11","doi-asserted-by":"crossref","DOI":"10.2174\/1389450116666150804110049","article-title":"Is intake of flavonoid-based food supplements during pregnancy safe for the developing child? A literature review","author":"Barenys","year":"2016","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.fct.2022.113506_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fnana.2013.00029","article-title":"Congenital hypoplasia of the cerebellum: developmental causes and behavioral consequences","volume":"7","author":"Basson","year":"2013","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.fct.2022.113506_bib13","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.neuroimage.2012.01.059","article-title":"Altered small-world topology of structural brain networks in infants with intrauterine growth restriction and its association with later neurodevelopmental outcome","volume":"60","author":"Batalle","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.fct.2022.113506_bib14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuroimage.2014.05.065","article-title":"Long-term reorganization of structural brain networks in a rabbit model of intrauterine growth restriction","volume":"100","author":"Batalle","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.fct.2022.113506_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/0471140856.tx1221s59","article-title":"Comparative human and rat \u201cneurosphere assay\u201d for developmental neurotoxicity testing","volume":"59","author":"Baumann","year":"2014","journal-title":"Curr. Protoc. Toxicol."},{"key":"10.1016\/j.fct.2022.113506_bib16","doi-asserted-by":"crossref","first-page":"13854","DOI":"10.1523\/JNEUROSCI.4494-07.2007","article-title":"\u03b21 integrins in radial glia but not in migrating neurons are essential for the Formation of cell layers in the cerebral cortex","volume":"27","author":"Belvindrah","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.fct.2022.113506_bib17","series-title":"Studies in Classification, Data Analysis, and Knowledge Organization (GfKL 2007)","article-title":"{KNIME}: the {K}onstanz {I}nformation {M}iner","author":"Berthold","year":"2007"},{"key":"10.1016\/j.fct.2022.113506_bib18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13041-016-0258-7","article-title":"Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome","volume":"9","author":"Borralleras","year":"2016","journal-title":"Mol. Brain"},{"key":"10.1016\/j.fct.2022.113506_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2019.03.010","article-title":"Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)\/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe\/PS1dE9 Alzheimer's disease mice model","volume":"301","author":"Cano","year":"2019","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.fct.2022.113506_bib20","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0103-16.2016","article-title":"Combined treatment with environmental enrichment and (-)-Epigallocatechin-3-Gallate ameliorates learning deficits and hippocampal alterations in a mouse model of down syndrome","volume":"3","author":"Catuara-Solarz","year":"2016","journal-title":"eNeuro"},{"key":"10.1016\/j.fct.2022.113506_bib21","doi-asserted-by":"crossref","DOI":"10.1021\/jf034634b","article-title":"Capillary electrophoretic determination of theanine, caffeine, and catechins in fresh tea leaves and oolong tea and their effects on rat neurosphere adhesion and migration","author":"Chen","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2022.113506_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.tiv.2019.04.005","article-title":"A mode-of-action ontology model for safety evaluation of chemicals: outcome of a series of workshops on repeated dose toxicity","volume":"59","author":"Desprez","year":"2019","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2022.113506_bib23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.expneurol.2014.06.021","article-title":"Functional correlates of central white matter maturation in perinatal period in rabbits","volume":"261","author":"Drobyshevsky","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.fct.2022.113506_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031497","article-title":"Neonatal neurobehavior and diffusion MRI changes in brain reorganization due to intrauterine growth restriction in a rabbit model","volume":"7","author":"Eixarch","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2022.113506_bib25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000264063","article-title":"An experimental model of fetal growth restriction based on selective ligature of uteroplacental vessels in the pregnant rabbit","volume":"26","author":"Eixarch","year":"2009","journal-title":"Fetal Diagn. Ther."},{"key":"10.1016\/j.fct.2022.113506_bib26","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1016\/j.sjbs.2021.04.084","article-title":"Effect of prenatal exposure of green tea extract on the developing central nervous system of rat fetuses; histological, immune-histochemical and ultrastructural studies","volume":"28","author":"El-Borm","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.fct.2022.113506_bib67","first-page":"5239","article-title":"Scientific Opinion on the safety of green tea catechins","volume":"16","year":"2018","journal-title":"EFSA J."},{"key":"10.1016\/j.fct.2022.113506_bib27","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/glia.22314","article-title":"Proper cerebellar development requires expression of \u03b21-integrin in Bergmann glia, but not in granule neurons","volume":"60","author":"Frick","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.fct.2022.113506_bib28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0896-6273(01)00374-9","article-title":"\u03b21-Class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex","volume":"31","author":"Graus-Porta","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.fct.2022.113506_bib29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brainres.2018.07.012","article-title":"Chronic mild hypoxia increases expression of laminins 111 and 411 and the laminin receptor \u03b16\u03b21 integrin at the blood-brain barrier","volume":"1700","author":"Halder","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.fct.2022.113506_bib30","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.reprotox.2020.09.002","article-title":"An ontology for developmental processes and toxicities of neural tube closure","volume":"99","author":"Heusinkveld","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.fct.2022.113506_bib31","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1242\/jcs.03098","article-title":"Integrin ligands at a glance","volume":"119","author":"Humphries","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.fct.2022.113506_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076453","article-title":"Long-Term functional outcomes and correlation with regional brain connectivity by MRI diffusion tractography metrics in a near-term rabbit model of intrauterine growth restriction","volume":"8","author":"Illa","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2022.113506_bib33","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bpobgyn.2004.02.009","article-title":"Perinatal mortality and fetal growth restriction","volume":"18","author":"Kady","year":"2004","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.fct.2022.113506_bib34","article-title":"Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro","author":"Klose","year":"2022","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.fct.2022.113506_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2018.10.055","article-title":"Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres","volume":"123","author":"K\u00fchne","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113506_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10051205","article-title":"Docosahexaenoic acid and melatonin prevent impaired oligodendrogenesis induced by intrauterine growth restriction (IUGR)","volume":"10","author":"K\u00fchne","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.fct.2022.113506_bib37","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1177\/0883073807302605","article-title":"Neurodevelopmental outcome of children with intrauterine growth retardation: a longitudinal, 10-Year prospective study","volume":"22","author":"Leitner","year":"2007","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.fct.2022.113506_bib38","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/glia.20995","article-title":"In the hypoxic central nervous system, endothelial cell proliferation is followed by astrocyte activation, proliferation, and increased expression of the alpha 6 beta 4 integrin and dystroglycan","volume":"58","author":"Li","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.fct.2022.113506_bib39","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s11373-007-9170-6","article-title":"Tea polyphenols inhibit rat vascular smooth muscle cell adhesion and migration on collagen and laminin via interference with cell\u2013ECM interaction","volume":"14","author":"Lo","year":"2007","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.fct.2022.113506_bib40","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1111\/j.1530-0277.2010.01282.x","article-title":"The preventive effect of oral EGCG in a fetal alcohol spectrum disorder mouse model","volume":"34","author":"Long","year":"2010","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.fct.2022.113506_bib41","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.mcn.2006.04.005","article-title":"Dendritic arbors of developing retinal ganglion cells are stabilized by \u03b21-integrins","volume":"32","author":"Marrs","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.fct.2022.113506_bib42","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1111\/j.1476-5381.2009.00452.x","article-title":"Epigallocatechin gallate reduces human monocyte mobility and adhesion in vitro","volume":"158","author":"Melgarejo","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fct.2022.113506_bib43","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1289\/ehp.0800207","article-title":"Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing","volume":"117","author":"Moors","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2022.113506_bib44","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.1523\/JNEUROSCI.1432-05.2005","article-title":"Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases","volume":"25","author":"Moresco","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.fct.2022.113506_bib45","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0140-6736(11)61577-8","article-title":"Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review","volume":"379","author":"Mwaniki","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.fct.2022.113506_bib46","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/dneu.20931","article-title":"Regulation of axonal outgrowth and pathfinding by integrin-ecm interactions","volume":"71","author":"Myers","year":"2011","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.fct.2022.113506_bib47","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/brv.12398","article-title":"Integrins promote axonal regeneration after injury of the nervous system","volume":"93","author":"Nieuwenhuis","year":"2018","journal-title":"Biol. Rev."},{"key":"10.1016\/j.fct.2022.113506_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194476","article-title":"Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse model","volume":"13","author":"Ortiz-Romero","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2022.113506_bib49","first-page":"585","article-title":"(-)-Epigallocatechin-3-gallate inhibits invasion and migration of salivary gland adenocarcinoma cells","volume":"23","author":"Park","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.fct.2022.113506_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules23061297","article-title":"Beneficial effects of green tea catechins on neurodegenerative diseases","volume":"23","author":"Pervin","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2022.113506_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/srep42220","article-title":"Green tea polyphenol tailors cell adhesivity of RGD displaying surfaces: multicomponent models monitored optically","volume":"7","author":"Peter","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2022.113506_bib52","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000512948","article-title":"Structural brain changes during the neonatal period in a rabbit model of intrauterine growth restriction","volume":"42","author":"Pla","year":"2020","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.fct.2022.113506_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2022.918520","article-title":"Protocols for the evaluation of neurodevelopmental alterations in rabbit models in vitro and in vivo","author":"Pla","year":"2022","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.fct.2022.113506_bib54","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/NEN.0b013e31825cfa81","article-title":"Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4","volume":"71","author":"Reid","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"year":"2016","series-title":"Transcriptomic Regulations in Oligodendroglial and Microglial Cells Related to Brain Damage Following Fetal Growth Restriction","author":"Rideau Batista Novais","key":"10.1016\/j.fct.2022.113506_bib55"},{"key":"10.1016\/j.fct.2022.113506_bib56","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/glia.20876","article-title":"Conditional deletion of \u03b21-integrin in astroglia causes partial reactive gliosis","volume":"57","author":"Robel","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.fct.2022.113506_bib57","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1038\/s41598-019-40328-9","article-title":"Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models","volume":"9","author":"Souchet","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2022.113506_bib58","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuroscience.2016.07.031","article-title":"Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome","volume":"333","author":"Stagni","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.fct.2022.113506_bib59","series-title":"Factors Affecting Neurodevelopment","first-page":"619","article-title":"Chapter 53 - epigallocatechin-3-gallate: linking the neurogenesis, hippocampus, and down syndrome","author":"Stagni","year":"2021"},{"key":"10.1016\/j.fct.2022.113506_bib60","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0304-3835(01)00685-1","article-title":"Inhibitory effect of epigallocatechin gallate on adhesion of murine melanoma cells to laminin","volume":"173","author":"Suzuki","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2022.113506_bib61","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1017\/S146114571000060X","article-title":"Epigallocatechin-3-gallate ameliorates alcohol-induced cognitive dysfunctions and apoptotic neurodegeneration in the developing rat brain","volume":"13","author":"Tiwari","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.fct.2022.113506_bib62","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.expneurol.2011.08.002","article-title":"Intrauterine growth restriction affects the maturation of myelin","volume":"232","author":"Tolcos","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.fct.2022.113506_bib66","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1177\/147323000303100205","article-title":"A Single Ascending Dose Study of Epigallocatechin Gallate in Healthy Volunteers","volume":"31","author":"Ullmann","year":"2003","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.fct.2022.113506_bib63","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1523\/JNEUROSCI.3942-11.2012","article-title":"Integrin \u03b21 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior","volume":"32","author":"Warren","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.fct.2022.113506_bib64","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1523\/JNEUROSCI.5746-12.2013","article-title":"Modeling transformations of neurodevelopmental sequences across mammalian species","volume":"33","author":"Workman","year":"2013","journal-title":"J. Neurosci."},{"year":"2022","series-title":"Database of Privately and Publicly Funded Clinical Studies Conducted Around the World","author":"WWW clinicaltrialsgiov","key":"10.1016\/j.fct.2022.113506_bib65"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691522007049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691522007049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:23:43Z","timestamp":1759530223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691522007049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":67,"alternative-id":["S0278691522007049"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2022.113506","relation":{},"ISSN":["0278-6915"],"issn-type":[{"type":"print","value":"0278-6915"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Application of the adverse outcome pathway to identify molecular changes in prenatal brain programming induced by IUGR: Discoveries after EGCG exposure","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2022.113506","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"113506"}}