{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:55:52Z","timestamp":1790740552416,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2021B012"],"award-info":[{"award-number":["LH2021B012"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.fct.2022.113563","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T12:02:59Z","timestamp":1671105779000},"page":"113563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Lambda-cyhalothrin induces lipid accumulation in mouse liver is associated with AMPK inactivation"],"prefix":"10.1016","volume":"172","author":[{"given":"Daqian","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingpei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijiao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2022.113563_bib1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s12640-012-9313-z","article-title":"Cholinergic dysfunctions and enhanced oxidative stress in the neurobehavioral toxicity of lambda-cyhalothrin in developing rats","volume":"22","author":"Ansari","year":"2012","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.fct.2022.113563_bib2","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.1007\/s11356-016-8323-4","article-title":"Pyrethroid insecticide lambda-cyhalothrin and its metabolites induce liver injury through the activation of oxidative stress and proinflammatory gene expression in rats following acute and subchronic exposure","volume":"24","author":"Aouey","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fct.2022.113563_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126075","article-title":"Cytotoxic effects on the midgut, hypopharyngeal, glands and brain of Apis mellifera honey bee workers exposed to chronic concentrations of lambda-cyhalothrin","volume":"248","author":"Arthidoro de Castro","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2022.113563_bib4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","article-title":"Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states","volume":"5","author":"Badman","year":"2007","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2022.113563_bib5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/jat\/21.5.397","article-title":"HPLC determination of flumethrin, deltamethrin, cypermethrin, and cyhalothrin residues in the milk and blood of lactating dairy cows","volume":"21","author":"Bissacot","year":"1997","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.fct.2022.113563_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/bj3410347","article-title":"Multiple-site phosphorylation of the 280 kDa isoform of acetyl-CoA carboxylase in rat cardiac myocytes: evidence that cAMP-dependent protein kinase mediates effects of beta-adrenergic stimulation","volume":"341","author":"Boone","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.fct.2022.113563_bib7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.chemosphere.2018.10.192","article-title":"Lambda-cyhalothrin affects swimming activity and physiological responses of Daphnia magna","volume":"216","author":"Bownik","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2022.113563_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117322","article-title":"Lambda-cyhalothrin and its common metabolite differentially modulate thyroid disruption effects in Chinese lizards (Eremias argus)","volume":"287","author":"Chang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2022.113563_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108533","article-title":"Maternal urinary concentrations of pyrethroid and chlorpyrifos metabolites and attention deficit hyperactivity disorder (ADHD) symptoms in 2-4-year-old children from the Odense Child Cohort","volume":"176","author":"Dalsager","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.fct.2022.113563_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tox.2017.04.014","article-title":"Prenatal exposure to lambda-cyhalothrin alters brain dopaminergic signaling in developing rats","volume":"386","author":"Dhuriya","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2022.113563_bib11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuro.2017.04.011","article-title":"Prenatal exposure to lambda-cyhalothrin impairs memory in developing rats: role of NMDA receptor induced post-synaptic signalling in hippocampus","volume":"62","author":"Dhuriya","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.fct.2022.113563_bib12","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fct.2022.113563_bib13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/0748233713475516","article-title":"Exposure to lambda-cyhalothrin, a synthetic pyrethroid, increases reactive oxygen species production and induces genotoxicity in rat peripheral blood","volume":"31","author":"Fetoui","year":"2015","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.fct.2022.113563_bib14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.celrep.2018.12.036","article-title":"Genetic liver-specific AMPK activation protects against diet-induced obesity and NAFLD","volume":"26","author":"Garcia","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.fct.2022.113563_bib15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance","volume":"66","author":"Garcia","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.fct.2022.113563_bib16","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.scitotenv.2017.11.355","article-title":"Analysis of metabolites of organophosphate and pyrethroid pesticides in human urine from urban and agricultural populations (Catalonia and Galicia)","volume":"622\u2013623","author":"Gar\u00ed","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2022.113563_bib17","doi-asserted-by":"crossref","first-page":"34268","DOI":"10.1074\/jbc.M300043200","article-title":"Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass","volume":"278","author":"Gavrilova","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2022.113563_bib18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrendo.2016.135","article-title":"PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD","volume":"13","author":"Gross","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.fct.2022.113563_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fct.2022.113563_bib20","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s00420-003-0451-8","article-title":"Biological monitoring of workers after the application of insecticidal pyrethroids","volume":"76","author":"Hardt","year":"2003","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.fct.2022.113563_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.etap.2015.11.008","article-title":"The Th1\/Th2 paradigm in lambda cyhalothrin-induced spleen toxicity: the role of thymoquinone","volume":"41","author":"Hussein","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2022.113563_bib22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cmet.2007.05.003","article-title":"Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21","volume":"5","author":"Inagaki","year":"2007","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2022.113563_bib23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.toxlet.2017.05.022","article-title":"Documenting the kinetic time course of lambda-cyhalothrin metabolites in orally exposed volunteers for the interpretation of biomonitoring data","volume":"276","author":"Khemiri","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2022.113563_bib24","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.toxlet.2018.08.008","article-title":"Kinetic time courses of lambda-cyhalothrin metabolites after dermal application of Matador EC 120 in volunteers","volume":"296","author":"Khemiri","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2022.113563_bib25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jbt.21580","article-title":"Permethrin alters adipogenesis in 3T3-L1 adipocytes and causes insulin resistance in C2C12 myotubes","volume":"28","author":"Kim","year":"2014","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.fct.2022.113563_bib26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pestbp.2016.01.005","article-title":"4,4'-Dichlorodiphenyltrichloroethane (DDT) and 4,4'-dichlorodiphenyldichloroethylene (DDE) promote adipogenesis in 3T3-L1 adipocyte cell culture","volume":"131","author":"Kim","year":"2016","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fct.2022.113563_bib27","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1073\/pnas.95.8.4333","article-title":"ADD1\/SREBP1 activates PPARgamma through the production of endogenous ligand","volume":"95","author":"Kim","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fct.2022.113563_bib29","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cmet.2011.03.009","article-title":"AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice","volume":"13","author":"Li","year":"2011","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2022.113563_bib30","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.scitotenv.2015.10.148","article-title":"Pesticides in persimmons, jujubes and soil from China: residue levels, risk assessment and relationship between fruits and soils","volume":"542","author":"Liu","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2022.113563_bib31","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.scitotenv.2018.03.030","article-title":"Pyrethroid insecticide lambda-cyhalothrin induces hepatic cytochrome P450 enzymes, oxidative stress and apoptosis in rats","volume":"631\u2013632","author":"Mart\u00ednez","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2022.113563_bib32","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.fct.2022.113563_bib33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1021\/jf3039814","article-title":"Imidacloprid, a neonicotinoid insecticide, potentiates adipogenesis in 3T3-L1 adipocytes","volume":"61","author":"Park","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2022.113563_bib34","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1136\/gutjnl-2016-311408","article-title":"Hepatic-specific PPAR\u03b1-FGF21 action in NAFLD","volume":"65","author":"Piccinin","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.fct.2022.113563_bib35","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.semcdb.2012.01.003","article-title":"PPARs: fatty acid sensors controlling metabolism","volume":"23","author":"Poulsen","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.fct.2022.113563_bib36","first-page":"265","article-title":"Lambda cyhalothrin induced alterations in Clarias batrachus","volume":"30","author":"Saravanan","year":"2009","journal-title":"J. Environ. Biol."},{"key":"10.1016\/j.fct.2022.113563_bib37","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3390\/nu14030710","article-title":"Effects of thiamin restriction on exercise-associated glycogen metabolism and AMPK activation level in skeletal muscle","volume":"14","author":"Sato","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2022.113563_bib38","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.fct.2008.12.010","article-title":"Residues of lambda-cyhalothrin in tea","volume":"47","author":"Seenivasan","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113563_bib39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.fct.2017.01.015","article-title":"Deltamethrin increases the fat accumulation in 3T3-L1 adipocytes and Caenorhabditis elegans","volume":"101","author":"Shen","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113563_bib40","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1172\/JCI134165","article-title":"Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease","volume":"130","author":"Smith","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fct.2022.113563_bib41","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.3390\/molecules23112950","article-title":"Flubendiamide enhances adipogenesis and inhibits AMPK\u03b1 in 3T3-L1 adipocytes","volume":"23","author":"Sun","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2022.113563_bib42","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.chemosphere.2017.10.115","article-title":"Pyrethroid pesticide residues in the global environment: an overview","volume":"191","author":"Tang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2022.113563_bib43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1748-1716.2009.01970.x","article-title":"AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives","volume":"196","author":"Viollet","year":"2009","journal-title":"Acta Physiol."},{"key":"10.1016\/j.fct.2022.113563_bib44","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.fct.2010.02.002","article-title":"Vitamin E modulates reproductive toxicity of pyrethroid lambda-cyhalothrin in male rabbits","volume":"48","author":"Yousef","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113563_bib45","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/nu10020187","article-title":"Aged oolong tea reduces high-fat diet-induced fat accumulation and dyslipidemia by regulating the AMPK\/ACC signaling pathway","volume":"10","author":"Yuan","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2022.113563_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110791","article-title":"Deltamethrin promotes adipogenesis via AMPK\u03b1 and ER stress-mediated pathway in 3T3- L1 adipocytes and Caenorhabditis elegans","volume":"134","author":"Yuan","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113563_bib47","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cmet.2009.03.012","article-title":"AMPK: an emerging drug target for diabetes and the metabolic syndrome","volume":"9","author":"Zhang","year":"2009","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2022.113563_bib48","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.chemosphere.2017.07.091","article-title":"Environmentally relevant levels of \u03bb-cyhalothrin, fenvalerate, and permethrin cause developmental toxicity and disrupt endocrine system in zebrafish (Danio rerio) embryo","volume":"185","author":"Zhang","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2022.113563_bib49","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1016\/j.foodchem.2013.05.121","article-title":"Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K\/AKT signaling pathways","volume":"141","author":"Zhang","year":"2013","journal-title":"Food Chem."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152200761X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152200761X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:21:47Z","timestamp":1759530107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869152200761X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":48,"alternative-id":["S027869152200761X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2022.113563","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lambda-cyhalothrin induces lipid accumulation in mouse liver is associated with AMPK inactivation","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2022.113563","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113563"}}