{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:22:28Z","timestamp":1789046548721,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.fct.2022.113576","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T20:22:11Z","timestamp":1671654131000},"page":"113576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Exposure to acrylamide inhibits testosterone production in mice testes and Leydig cells by activating ERK1\/2 phosphorylation"],"prefix":"10.1016","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1435-6601","authenticated-orcid":false,"given":"Junqiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-9593","authenticated-orcid":false,"given":"Xiaoqian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunshan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2022.113576_bib1","doi-asserted-by":"crossref","first-page":"53249","DOI":"10.1007\/s11356-021-14532-y","article-title":"Eruca sativa seed extract modulates oxidative stress and apoptosis and up-regulates the expression of Bcl-2 and Bax genes in acrylamide-induced testicular dysfunction in rats","volume":"28","author":"Abd-Elsalam","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fct.2022.113576_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11033-019-05125-7","article-title":"Targeting ERK\/COX-2 signaling pathway in permethrin-induced testicular toxicity: a possible modulating effect of matrine","volume":"47","author":"Atef","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.fct.2022.113576_bib3","doi-asserted-by":"crossref","first-page":"26664","DOI":"10.1007\/s11356-019-05915-3","article-title":"The effects of naringin on different cyclophosphamide-induced organ toxicities in rats: investigation of changes in some metabolic enzyme activities","volume":"26","author":"Caglayan","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fct.2022.113576_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.toxlet.2012.03.007","article-title":"Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats","volume":"211","author":"Camacho","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2022.113576_bib5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.fct.2013.08.018","article-title":"Acrylamide exposure among Turkish toddlers from selected cereal-based baby food samples","volume":"60","author":"Cengiz","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib6","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.fct.2012.10.025","article-title":"Acrylamide-induced mitochondria collapse and apoptosis in human astrocytoma cells","volume":"51","author":"Chen","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib7","first-page":"532","article-title":"Testosterone and voluntary exercise, alone or together increase cardiac activation of AKT and ERK1\/2 in diabetic rats","volume":"107","author":"Chodari","year":"2016","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.fct.2022.113576_bib8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/03602530701519151","article-title":"The steroidogenic acute regulatory protein as a target of endocrine disruption in male reproduction","volume":"39","author":"Clark","year":"2007","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.fct.2022.113576_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.acthis.2015.11.004","article-title":"The role of CAPE in PI3K\/AKT\/mTOR activation and oxidative stress on testis torsion","volume":"118","author":"Dilber","year":"2016","journal-title":"Acta Histochem."},{"key":"10.1016\/j.fct.2022.113576_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2021.101964","article-title":"Analysis of silymarin-modulating effects against acrylamide-induced cerebellar damage in male rats: biochemical and pathological markers","volume":"115","author":"Elsawy","year":"2021","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.fct.2022.113576_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27134100","article-title":"Protective effect of lycium ruthenicum polyphenols on oxidative stress against acrylamide induced liver injury in rats","volume":"27","author":"Gao","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2022.113576_bib12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.toxlet.2022.01.014","article-title":"Pubertal exposure to acrylamide disrupts spermatogenesis by interfering with meiotic progression in male mice","volume":"358","author":"Gao","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2022.113576_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1095\/biolreprod.109.078915","article-title":"Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity","volume":"82","author":"Ghanayem","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.fct.2022.113576_bib14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/01616412.2019.1576319","article-title":"Neuroprotective effects of Ellagic acid against acrylamide-induced neurotoxicity in rats","volume":"41","author":"Goudarzi","year":"2019","journal-title":"Neurol. Res."},{"key":"10.1016\/j.fct.2022.113576_bib15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5271\/sjweh.608","article-title":"Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose","volume":"27","author":"Hagmar","year":"2001","journal-title":"Scand. J. Work. Environ. Health"},{"key":"10.1016\/j.fct.2022.113576_bib16","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4103\/1008-682X.160260","article-title":"Annexin A5 regulates Leydig cell testosterone production via ERK1\/2 pathway","volume":"18","author":"He","year":"2016","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.fct.2022.113576_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112156","article-title":"Rosmarinic acid attenuates acrylamide induced apoptosis of BRL-3A cells by inhibiting oxidative stress and endoplasmic reticulum stress","volume":"151","author":"Hong","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111190","article-title":"Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: a multi-biomarker approach","volume":"138","author":"Kandemir","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","article-title":"Pathological roles of MAPK signaling pathways in human diseases","author":"Kim","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fct.2022.113576_bib20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.talanta.2014.07.042","article-title":"Determination of acrylamide and glycidamide in various biological matrices by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study","volume":"131","author":"Kim","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.fct.2022.113576_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118301","article-title":"Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-\u03baB, Bax\/Bcl-2 and PI3K\/Akt\/mTOR signaling pathways","volume":"261","author":"Kucukler","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2022.113576_bib22","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00204-005-0656-6","article-title":"Chemoprevention of acrylamide toxicity by antioxidative agents in rats--effective suppression of testicular toxicity by phenylethyl isothiocyanate","volume":"79","author":"Lee","year":"2005","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib23","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.fct.2016.09.035","article-title":"Glycidamide inhibits progesterone production through reactive oxygen species-induced apoptosis in R2C Rat Leydig Cells","volume":"108","author":"Li","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tox.2005.08.018","article-title":"Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system","volume":"217","author":"Li","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2022.113576_bib25","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.fct.2011.03.003","article-title":"Acrylamide up-regulates cyclooxygenase-2 expression through the MEK\/ERK signaling pathway in mouse epidermal cells","volume":"49","author":"Lim","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/821615","article-title":"The role of specific mitogen-activated protein kinase signaling cascades in the regulation of steroidogenesis","author":"Manna","year":"2011","journal-title":"J. Signal Transduction"},{"key":"10.1016\/j.fct.2022.113576_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxlet.2018.02.002","article-title":"Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: involvement of the crosstalk between Nrf2 and NF-\u03baB pathways regulated by MAPKs","volume":"288","author":"Pan","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2022.113576_bib28","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1007\/s12035-016-0021-1","article-title":"Mitochondrion-mediated apoptosis induced by acrylamide is regulated by a balance between Nrf2 antioxidant and MAPK signaling pathways in PC12 cells","volume":"54","author":"Pan","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.fct.2022.113576_bib29","doi-asserted-by":"crossref","first-page":"e1443","DOI":"10.1371\/journal.pone.0001443","article-title":"A mitochondrial kinase complex is essential to mediate an ERK1\/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesis","volume":"3","author":"Poderoso","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2022.113576_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.canlet.2012.01.007","article-title":"DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis","volume":"332","author":"Roos","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2022.113576_bib31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40360-019-0317-7","article-title":"Single and simultaneous effects of acrylamide and ethanol on bone microstructure of mice after one remodeling cycle","volume":"20","author":"Sarocka","year":"2019","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.02.012","article-title":"The regulation of spermatogenesis by androgens","volume":"30","author":"Smith","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.fct.2022.113576_bib33","doi-asserted-by":"crossref","first-page":"19731","DOI":"10.1016\/S0021-9258(18)55053-5","article-title":"The 30-kDa mitochondrial proteins induced by hormone stimulation in MA-10 mouse Leydig tumor cells are processed from larger precursors","volume":"266","author":"Stocco","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2022.113576_bib34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00204-006-0145-6","article-title":"Apoptosis induced by acrylamide in SH-SY5Y cells","volume":"81","author":"Sumizawa","year":"2007","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.foodchem.2014.01.017","article-title":"1,3-Dichloro-2-propanol inhibits progesterone production through the expression of steroidogenic enzymes and cAMP concentration in Leydig cells","volume":"154","author":"Sun","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2022.113576_bib36","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s11064-019-02741-4","article-title":"Neuroprotective effects of thymoquinone in acrylamide-induced peripheral nervous system toxicity through MAPKinase and apoptosis pathways in rat","volume":"44","author":"Tabeshpour","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.fct.2022.113576_bib37","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00204-010-0638-1","article-title":"Life stage-related differences in susceptibility to acrylamide-induced neural and testicular toxicity","volume":"85","author":"Takahashi","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/13813455.2017.1374978","article-title":"Protective effect of rutin against brain injury induced by acrylamide or gamma radiation: role of PI3K\/AKT\/GSK-3\u03b2\/NRF-2 signalling pathway","volume":"124","author":"Thabet","year":"2018","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.fct.2022.113576_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/toxics9070155","article-title":"A review of dietary intake of acrylamide in humans","volume":"9","author":"Timmermann","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.fct.2022.113576_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105105","article-title":"Acrylamide and its metabolite induce neurotoxicity via modulation of protein kinase C and AMP-activated protein kinase pathways","volume":"72","author":"Triningsih","year":"2021","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2022.113576_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0890-6238(02)00078-3","article-title":"Effects of acrylamide on rodent reproductive performance","volume":"17","author":"Tyl","year":"2003","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.reprotox.2009.11.002","article-title":"Reproductive toxicity of acrylamide-treated male rats","volume":"29","author":"Wang","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.etap.2017.05.013","article-title":"Role of PI3K\/AKT\/mTOR signaling pathway in DBP-induced apoptosis of testicular sertoli cells in vitro","volume":"53","author":"Wang","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2022.113576_bib44","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1530\/REP-17-0064","article-title":"Steroidogenesis in Leydig cells: effects of aging and environmental factors","volume":"154","author":"Wang","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.fct.2022.113576_bib45","first-page":"409","article-title":"TDRG1 functions in testicular seminoma are dependent on the PI3K\/Akt\/mTOR signaling pathway","volume":"9","author":"Wang","year":"2016","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.fct.2022.113576_bib46","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1210\/me.2011-0059","article-title":"The Leydig cell MEK\/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility","volume":"25","author":"Yamashita","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.fct.2022.113576_bib47","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4142\/jvs.2005.6.2.103","article-title":"Genotoxicity and toxicological effects of acrylamide on reproductive system in male rats","volume":"6","author":"Yang","year":"2005","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.fct.2022.113576_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112766","article-title":"Gestational exposure to acrylamide suppresses luteal endocrine function through dysregulation of ovarian angiogenesis, oxidative stress and apoptosis in mice","volume":"159","author":"Yu","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2022.113576_bib49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy059","article-title":"Leydig cells: formation, function, and regulation","volume":"99","author":"Zirkin","year":"2018","journal-title":"Biol. Reprod."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691522007748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691522007748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:21:31Z","timestamp":1759530091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691522007748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":49,"alternative-id":["S0278691522007748"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2022.113576","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to acrylamide inhibits testosterone production in mice testes and Leydig cells by activating ERK1\/2 phosphorylation","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2022.113576","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113576"}}