{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:51:18Z","timestamp":1787698278501,"version":"build-2784847793"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872530"],"award-info":[{"award-number":["31872530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.fct.2023.113741","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T18:07:53Z","timestamp":1679422073000},"page":"113741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Role of ROS\/JAK2\/STAT3 signaling pathway in di-n-butyl phthalate-induced testosterone synthesis inhibition and antagonism of lycopene"],"prefix":"10.1016","volume":"175","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2023.113741_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cbi.2016.12.011","article-title":"Lycopene inhibits reactive oxygen species production in SK-Hep-1 cells and attenuates acetaminophen-induced liver injury in C57BL\/6 mice","volume":"263","author":"Bandeira","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2023.113741_bib2","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1210\/jcem.86.11.7983","article-title":"Clinical review 138: anabolic-androgenic steroid therapy in the treatment of chronic diseases","volume":"86","author":"Basaria","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.fct.2023.113741_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112737","article-title":"Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway","volume":"225","author":"Cao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2023.113741_bib4","doi-asserted-by":"crossref","first-page":"5731","DOI":"10.1038\/s41467-020-19547-6","article-title":"Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model","volume":"11","author":"Cen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fct.2023.113741_bib5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.etap.2013.04.013","article-title":"Effects of di(n-butyl) and monobutyl phthalate on steroidogenesis pathways in the murine Leydig tumor cell line MLTC-1","volume":"36","author":"Chen","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2023.113741_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1139\/Y10-010","article-title":"Methods for detecting autophagy and determining autophagy-induced cell death","volume":"88","author":"Chen","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.fct.2023.113741_bib7","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.foodchem.2017.11.055","article-title":"Can lycopene be considered an effective protection against cardiovascular disease?","volume":"245","author":"Costa-Rodrigues","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2023.113741_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138500","article-title":"Effects of fast food packaging plasticizers and their metabolites on steroid hormone synthesis in H295R cells","volume":"726","author":"Duan","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.113741_bib9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4103\/1008-682X.126384","article-title":"Lycopene and male infertility","volume":"16","author":"Durairajanayagam","year":"2014","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.fct.2023.113741_bib10","first-page":"13","article-title":"Clinico-hormonal correlation of oligospermic patients in the below sea level environment (Jordan Valley)","volume":"26","author":"Elmigdadi","year":"2005","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.fct.2023.113741_bib11","article-title":"Complete biodegradation of di-n-butyl phthalate (DBP) by a novel Pseudomonas sp","volume":"761","author":"Feng","year":"2021","journal-title":"YJB6. Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.113741_bib12","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.scitotenv.2015.09.148","article-title":"Phthalate esters in the environment: a critical review of their occurrence, biodegradation, and removal during wastewater treatment processes","volume":"541","author":"Gao","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.113741_bib13","doi-asserted-by":"crossref","first-page":"9804","DOI":"10.1021\/es5024898","article-title":"Urinary concentrations of phthalates in couples planning pregnancy and its association with 8-hydroxy-2'-deoxyguanosine, a biomarker of oxidative stress: longitudinal investigation of fertility and the environment study","volume":"48","author":"Guo","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2023.113741_bib14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.toxlet.2018.03.016","article-title":"ROS generation and MAPKs activation contribute to the Ni-induced testosterone synthesis disturbance in rat Leydig cells","volume":"290","author":"Han","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2023.113741_bib15","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/01.ede.0000235996.89953.d7","article-title":"Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites","volume":"17","author":"Hauser","year":"2006","journal-title":"Epidemiology"},{"key":"10.1016\/j.fct.2023.113741_bib16","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3892\/ijmm.2013.1295","article-title":"Hepatitis B virus X protein modulates apoptosis in human renal proximal tubular epithelial cells by activating the JAK2\/STAT3 signaling pathway","volume":"31","author":"He","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.fct.2023.113741_bib17","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1093\/humrep\/dem205","article-title":"Associations between urinary phthalate monoesters and thyroid hormones in pregnant women","volume":"22","author":"Huang","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.fct.2023.113741_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jchemneu.2013.02.005","article-title":"JAK2 inhibition is neuroprotective and reduces astrogliosis after quinolinic acid striatal lesion in adult mice","volume":"48\u201349","author":"Ignarro","year":"2013","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.fct.2023.113741_bib19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/toxsci\/kfr020","article-title":"Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways","volume":"120","author":"Johnson","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2023.113741_bib20","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.3390\/ijms23158718","article-title":"Adult exposure to di-N-Butyl Phthalate (DBP) induces persistent effects on testicular cell markers and testosterone biosynthesis in mice","volume":"23","author":"K\u00e4llsten","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2023.113741_bib21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.envint.2016.09.013","article-title":"A global assessment of phthalates burden and related links to health effects","volume":"97","author":"Katsikantami","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2023.113741_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413390","article-title":"JAK inhibition prevents DNA damage and apoptosis in testicular ischemia-reperfusion injury via modulation of the ATM\/ATR\/Chk pathway","volume":"22","author":"Khashab","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2023.113741_bib23","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1095\/biolreprod.111.092379","article-title":"Mediators of the Jak\/STAT signaling pathway in human spermatozoa","volume":"85","author":"Lachance","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.fct.2023.113741_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1213\/ANE.0b013e31821a9fbe","article-title":"Reactive oxygen species scavenger inhibits STAT3 activation after transient focal cerebral ischemia-reperfusion injury in rats","volume":"113","author":"Lei","year":"2011","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.fct.2023.113741_bib25","first-page":"2013","article-title":"Effect of JAK2\/STAT3 signaling pathway on liver injury associated with severe acute pancreatitis in rats","volume":"16","author":"Li","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.fct.2023.113741_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cbi.2016.11.021","article-title":"Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways","volume":"261","author":"Li","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2023.113741_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/01.shk.0000233197.40989.31","article-title":"Role of Janus kinase\/signal transducer and activator of transcription pathway in regulation of expression and inflammation-promoting activity of high mobility group box protein 1 in rat peritoneal macrophages","volume":"27","author":"Liu","year":"2007","journal-title":"Shock"},{"key":"10.1016\/j.fct.2023.113741_bib28","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.tiv.2012.04.026","article-title":"Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells","volume":"26","author":"Liu","year":"2012","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2023.113741_bib29","doi-asserted-by":"crossref","first-page":"R217","DOI":"10.1530\/REP-13-0111","article-title":"Oxidative stress and ageing of the post-ovulatory oocyte","volume":"146","author":"Lord","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.fct.2023.113741_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120314","article-title":"Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig cells","volume":"314","author":"Lu","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.113741_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152860","article-title":"Environmentally relevant perinatal exposure to DBP disturbs testicular development and puberty onset in male mice","volume":"459","author":"Ma","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2023.113741_bib32","doi-asserted-by":"crossref","first-page":"440","DOI":"10.21037\/atm.2019.08.101","article-title":"PQQ ameliorates skeletal muscle atrophy, mitophagy and fiber type transition induced by denervation via inhibition of the inflammatory signaling pathways","volume":"7","author":"Ma","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.fct.2023.113741_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1191\/0960327102ht213oa","article-title":"Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity","volume":"21","author":"Martin","year":"2002","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.fct.2023.113741_bib34","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1007\/s12011-021-02881-1","article-title":"Lycopene alleviates titanium dioxide nanoparticle-induced testicular toxicity by inhibiting oxidative stress and apoptosis in mice","volume":"200","author":"Meng","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fct.2023.113741_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mce.2008.07.016","article-title":"Leydig cell aging and the mechanisms of reduced testosterone synthesis","volume":"299","author":"Midzak","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.fct.2023.113741_bib36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40360-020-00469-4","article-title":"N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test","volume":"22","author":"Nakhaee","year":"2021","journal-title":"BMC Pharmacol Toxicol"},{"key":"10.1016\/j.fct.2023.113741_bib37","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s11906-014-0452-x","article-title":"Oxidative stress and organ damages","volume":"16","author":"Ogura","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.fct.2023.113741_bib38","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1289\/ehp.9016","article-title":"Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China","volume":"114","author":"Pan","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2023.113741_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3218605","article-title":"Lycopene deficiency in ageing and cardiovascular disease","author":"Petyaev","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.fct.2023.113741_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.07.014","article-title":"Modulation of cardiac AKT and STAT3 signalling in preclinical cancer models and their impact on the heart","volume":"1867","author":"Pietzsch","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.fct.2023.113741_bib41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.theriogenology.2017.01.022","article-title":"Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro","volume":"93","author":"Shi","year":"2017","journal-title":"Theriogenology"},{"key":"10.1016\/j.fct.2023.113741_bib42","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.biocel.2007.10.011","article-title":"Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells","volume":"40","author":"Shimizu","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.fct.2023.113741_bib43","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1248\/bpb.b18-00205","article-title":"Mechanisms of Yangjing Capsule in Leydig cell apoptosis and testosterone synthesis via promoting StAR expression","volume":"41","author":"Sun","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.fct.2023.113741_bib44","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.envpol.2018.08.089","article-title":"Role of autophagy in di-2-ethylhexyl phthalate (DEHP)-induced apoptosis in mouse Leydig cells","volume":"243","author":"Sun","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.113741_bib45","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1289\/ehp.8100","article-title":"Decrease in anogenital distance among male infants with prenatal phthalate exposure","volume":"113","author":"Swan","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2023.113741_bib46","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1210\/en.2003-1475","article-title":"Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism","volume":"145","author":"Thompson","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.fct.2023.113741_bib47","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000176049","article-title":"Testosterone, bone and osteoporosis","volume":"37","author":"Tuck","year":"2009","journal-title":"Front. Horm. Res."},{"key":"10.1016\/j.fct.2023.113741_bib48","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1071\/RD09078","article-title":"Antiperoxidative and anti-apoptotic effects of lycopene and ellagic acid on cyclophosphamide-induced testicular lipid peroxidation and apoptosis","volume":"22","author":"T\u00fcrk","year":"2010","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.fct.2023.113741_bib49","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.3390\/ijms21239210","article-title":"Regulation of Beclin 1-mediated autophagy by oncogenic tyrosine kinases","volume":"21","author":"Vega-Rub\u00edn-de-Celis","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2023.113741_bib50","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3389\/fpls.2019.01240","article-title":"Fine mapping of lycopene content and flesh color related gene and development of molecular marker-assisted selection for flesh color in watermelon (citrullus lanatus)","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.fct.2023.113741_bib51","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.devcel.2020.05.014","article-title":"Endolysosomal targeting of mitochondria is integral to BAX-mediated mitochondrial permeabilization during apoptosis signaling","volume":"53","author":"Wang","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.fct.2023.113741_bib52","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1289\/ehp.97105102","article-title":"Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats","volume":"105","author":"Wine","year":"1997","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2023.113741_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154437","article-title":"Maternal DBP exposure promotes synaptic formation in offspring by activating astrocytes via the AKT\/NF-\u03baB\/IL-6\/JAK2\/STAT3 signaling pathway","volume":"829","author":"Xia","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.113741_bib54","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3892\/etm.2017.4674","article-title":"Mechanisms of autophagy and apoptosis mediated by JAK2 signaling pathway after spinal cord injury of rats","volume":"14","author":"Xia","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.fct.2023.113741_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152301","article-title":"Protective effect of lycopene on testicular toxicity induced by Benzo[a]pyrene intake in rats","volume":"427","author":"Xu","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2023.113741_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114075","article-title":"Benzo[a]pyrene inhibits testosterone biosynthesis via NDUFA10-mediated mitochondrial compromise in mouse Leydig cells: integrating experimental and in silico toxicological approaches","volume":"244","author":"Yang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2023.113741_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-44766-3","article-title":"The role and mechanism of SIRT1 in resveratrol-regulated osteoblast autophagy in osteoporosis rats","volume":"9","author":"Yang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2023.113741_bib58","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1089\/neu.2016.4814","article-title":"Testosterone plus finasteride prevents bone loss without prostate growth in a rodent spinal cord injury model","volume":"34","author":"Yarrow","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.fct.2023.113741_bib59","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1177\/1091581809342596","article-title":"Di (n-butyl) phthalate inhibits testosterone synthesis through a glucocorticoid-mediated pathway in rats","volume":"28","author":"Zhang","year":"2009","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.fct.2023.113741_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129689","article-title":"Phthalate-induced testosterone\/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene","volume":"439","author":"Zhao","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.113741_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113282","article-title":"Methyl tert-butyl ether inhibits pubertal development of Leydig cells in male rats by inducing mitophagy and apoptosis","volume":"232","author":"Zhu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691523001436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691523001436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T14:08:15Z","timestamp":1736345295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691523001436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":61,"alternative-id":["S0278691523001436"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2023.113741","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of ROS\/JAK2\/STAT3 signaling pathway in di-n-butyl phthalate-induced testosterone synthesis inhibition and antagonism of lycopene","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2023.113741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113741"}}