{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T04:02:43Z","timestamp":1792900963753,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.fct.2023.113795","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T15:56:24Z","timestamp":1682524584000},"page":"113795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["GSPE attenuates CSE-induced lung inflammation and emphysema by regulating autophagy via the reactive oxygen species\/TFEB signaling pathway"],"prefix":"10.1016","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8517-0898","authenticated-orcid":false,"given":"Ok Joo","family":"Sul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0992-5398","authenticated-orcid":false,"given":"Hye Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimi","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2458-8414","authenticated-orcid":false,"given":"Seung Won","family":"Ra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2023.113795_bib1","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1248\/bpb.23.1370","article-title":"Antiallergic effect of apple polyphenols on the allergic model mouse","volume":"23","author":"Akiyama","year":"2000","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.fct.2023.113795_bib2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.5603\/FM.a2017.0120","article-title":"Vascular endothelial growth factor receptor inhibition enhances chronic obstructive pulmonary disease picture in mice exposed to waterpipe smoke","volume":"77","author":"Alzoubi","year":"2018","journal-title":"Folia Morphol."},{"key":"10.1016\/j.fct.2023.113795_bib3","first-page":"179","article-title":"Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro","volume":"95","author":"Bagchi","year":"1997","journal-title":"Res. Commun. Mol. Pathol. Pharmacol."},{"key":"10.1016\/j.fct.2023.113795_bib4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1165\/rcmb.2016-0270OC","article-title":"Nicotine impairs macrophage control of mycobacterium tuberculosis","volume":"57","author":"Bai","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.fct.2023.113795_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1081\/COPD-120028701","article-title":"Alveolar macrophages as orchestrators of COPD","volume":"1","author":"Barnes","year":"2004","journal-title":"COPD"},{"key":"10.1016\/j.fct.2023.113795_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/313142","article-title":"Grape seed procyanidins in pre- and mild hypertension: a registry study","author":"Belcaro","year":"2013","journal-title":"Evid. Based Compl. Alternat. Med."},{"key":"10.1016\/j.fct.2023.113795_bib7","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1182\/blood-2009-09-244129","article-title":"Bortezomib modulates surface CD20 in B-cell malignancies and affects rituximab-mediated complement-dependent cytotoxicity","volume":"115","author":"Bil","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.fct.2023.113795_bib8","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.bbrc.2008.12.178","article-title":"Autophagy is upregulated in rats with status epilepticus and partly inhibited by Vitamin E","volume":"379","author":"Cao","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2023.113795_bib9","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/10245332.2016.1165446","article-title":"ROS functions as an upstream trigger for autophagy to drive hematopoietic stem cell differentiation","volume":"21","author":"Cao","year":"2016","journal-title":"Hematology"},{"key":"10.1016\/j.fct.2023.113795_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.prostaglandins.2018.08.001","article-title":"The anti-inflammatory effect of BML-111 on COPD may be mediated by regulating NLRP3 inflammasome activation and ROS production","volume":"138","author":"Cao","year":"2018","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.fct.2023.113795_bib11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4161\/auto.26927","article-title":"Autophagy-mediated regulation of macrophages and its applications for cancer","volume":"10","author":"Chen","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.fct.2023.113795_bib12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/sj.cdd.4402233","article-title":"Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells","volume":"15","author":"Chen","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fct.2023.113795_bib13","doi-asserted-by":"crossref","first-page":"L648","DOI":"10.1152\/ajplung.90270.2008","article-title":"Protective effect of beraprost sodium, a stable prostacyclin analog, in the development of cigarette smoke extract-induced emphysema","volume":"296","author":"Chen","year":"2009","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.fct.2023.113795_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003316","article-title":"Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease","volume":"3","author":"Chen","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2023.113795_bib15","doi-asserted-by":"crossref","first-page":"18880","DOI":"10.1073\/pnas.1005574107","article-title":"Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl. 2","key":"10.1016\/j.fct.2023.113795_bib16","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/sj.cdd.4401751","article-title":"Autophagy and signaling: their role in cell survival and cell death","volume":"12","author":"Codogno","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fct.2023.113795_bib17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/01902148.2020.1800139","article-title":"Cigarette smoke extract triggers neoplastic change in lungs and impairs locomotor activity through wnt3a-\u03b2-catenin signaling in aged COPD rodent model","volume":"46","author":"Devi","year":"2020","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.fct.2023.113795_bib18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fcell.2019.00114","article-title":"Transcriptional regulation of autophagy: mechanisms and diseases","volume":"7","author":"Di Malta","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.fct.2023.113795_bib19","first-page":"90","article-title":"Risk from tobacco and potentials for health gain","volume":"3","author":"Doll","year":"1999","journal-title":"Int. J. Tubercul. Lung Dis."},{"key":"10.1016\/j.fct.2023.113795_bib20","doi-asserted-by":"crossref","first-page":"737","DOI":"10.7314\/APJCP.2014.15.2.737","article-title":"Effect of grape procyanidins on tumor angiogenesis in liver cancer xenograft models","volume":"15","author":"Feng","year":"2014","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.fct.2023.113795_bib21","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3390\/antiox11030464","article-title":"The emerging role of macrophages in chronic obstructive pulmonary disease: the potential impact of oxidative stress and extracellular vesicle on macrophage polarization and function","volume":"11","author":"Finicelli","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2023.113795_bib22","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.4049\/jimmunol.157.7.3097","article-title":"Characterization of murine lung interstitial macrophages in comparison with alveolar macrophages in vitro","volume":"157","author":"Franke-Ullmann","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.fct.2023.113795_bib23","doi-asserted-by":"crossref","first-page":"630","DOI":"10.4161\/onci.20297","article-title":"Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease","volume":"1","author":"Fujii","year":"2012","journal-title":"OncoImmunology"},{"key":"10.1016\/j.fct.2023.113795_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12971-017-0130-2","article-title":"Experimental animal models for COPD: a methodological review","volume":"15","author":"Ghorani","year":"2017","journal-title":"Tob. Induc. Dis."},{"key":"10.1016\/j.fct.2023.113795_bib25","doi-asserted-by":"crossref","first-page":"9629","DOI":"10.1002\/jcp.26868","article-title":"Oxidative stress regulates autophagy in cultured muscle cells of patients with chronic obstructive pulmonary disease","volume":"233","author":"Gouzi","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.fct.2023.113795_bib26","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.4049\/jimmunol.1102975","article-title":"CaMKI\u03b1 regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation","volume":"190","author":"Guo","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.fct.2023.113795_bib27","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.2147\/COPD.S147144","article-title":"Characteristics and potential role of M2 macrophages in COPD","volume":"12","author":"He","year":"2017","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.fct.2023.113795_bib29","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1165\/rcmb.2009-0459OC","article-title":"Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine","volume":"44","author":"Hodge","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.fct.2023.113795_bib30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.pathol.4.110807.092145","article-title":"The pathology of chronic obstructive pulmonary disease","volume":"4","author":"Hogg","year":"2009","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.fct.2023.113795_bib31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.abb.2010.05.013","article-title":"Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD","volume":"500","author":"Hwang","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.fct.2023.113795_bib32","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1152\/japplphysiol.01246.2003","article-title":"Tissue heterogeneity in the mouse lung: effects of elastase treatment","volume":"97","author":"Ito","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.fct.2023.113795_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109652","article-title":"Unique synergistic antiviral effects of Shufeng Jiedu Capsule and oseltamivir in influenza A viral-induced acute exacerbation of chronic obstructive pulmonary disease","volume":"121","author":"Ji","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2023.113795_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2349045","article-title":"Dysregulated functions of lung macrophage populations in COPD","author":"Kapellos","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.fct.2023.113795_bib35","doi-asserted-by":"crossref","first-page":"887","DOI":"10.4161\/auto.6767","article-title":"Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1","volume":"4","author":"Kim","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.fct.2023.113795_bib36","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1038\/s41418-021-00770-7","article-title":"PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with \u03b2-catenin-TCF\/LEF1","volume":"28","author":"Kim","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fct.2023.113795_bib37","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.antiviral.2011.02.011","article-title":"Oligomeric procyanidins stimulate innate antiviral immunity in dengue virus infected human PBMCs","volume":"90","author":"Kimmel","year":"2011","journal-title":"Antivir. Res."},{"key":"10.1016\/j.fct.2023.113795_bib38","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.resinv.2016.03.010","article-title":"Cellular senescence and autophagy in the pathogenesis of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF)","volume":"54","author":"Kuwano","year":"2016","journal-title":"Respir. Investig."},{"key":"10.1016\/j.fct.2023.113795_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/ijerph6010209","article-title":"Smoking and chronic obstructive pulmonary disease (COPD). Parallel epidemics of the 21 century","volume":"6","author":"Laniado-Labor\u00edn","year":"2009","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.fct.2023.113795_bib40","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1172\/JCI69636","article-title":"Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction","volume":"123","author":"Lam","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fct.2023.113795_bib41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1600-065X.2008.00730.x","article-title":"Inflammasomes: guardians of cytosolic sanctity","volume":"227","author":"Lamkanfi","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fct.2023.113795_bib42","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.fct.2023.113795_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18332\/tid\/143853","article-title":"Existence of multiple organ aging in animal model of emphysema induced by cigarette smoke extract","volume":"20","author":"Liang","year":"2022","journal-title":"Tob. Induc. Dis."},{"key":"10.1016\/j.fct.2023.113795_bib44","doi-asserted-by":"crossref","first-page":"9353","DOI":"10.1039\/C8RA00160J","article-title":"l-Menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammation via nuclear factor kappa B, p38 MAPK and Nrf2 signalling pathways","volume":"8","author":"Liu","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.fct.2023.113795_bib45","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/SLA.0b013e318269d0e2","article-title":"Lc3 over-expression improves survival and attenuates lung injury through increasing autophagosomal clearance in septic mice","volume":"257","author":"Lo","year":"2013","journal-title":"Ann. Surg."},{"key":"10.1016\/j.fct.2023.113795_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111588","article-title":"Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice","volume":"144","author":"Mahalanobish","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2023.113795_bib47","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1172\/JCI74985","article-title":"Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD","volume":"124","author":"Mizumura","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fct.2023.113795_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/13510002.2019.1601448","article-title":"Cigarette smoke exposure induces ROS-mediated autophagy by regulating sestrin, AMPK, and mTOR level in mice","volume":"24","author":"Morsch","year":"2019","journal-title":"Redox Rep."},{"key":"10.1016\/j.fct.2023.113795_bib49","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2183\/pjab.87.104","article-title":"Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox","volume":"87","author":"Nishizuka","year":"2011","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.fct.2023.113795_bib50","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"176","author":"Rabe","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.fct.2023.113795_bib51","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ejphar.2005.12.087","article-title":"Oxidant and antioxidant balance in the airways and airway diseases","volume":"533","author":"Rahman","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2023.113795_bib52","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0891-5849(96)00155-4","article-title":"Role of oxidants\/antioxidants in smoking-induced lung diseases","volume":"21","author":"Rahman","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fct.2023.113795_bib53","first-page":"137","article-title":"In vivo protection of DNA damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract","volume":"107","author":"Ray","year":"2000","journal-title":"Res. Commun. Mol. Pathol. Pharmacol."},{"key":"10.1016\/j.fct.2023.113795_bib54","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/apm.13089","article-title":"Pathogen-associated molecular patterns and extracellular Hsp70 interplay in NLRP3 inflammasome activation in monocytic and bronchial epithelial cellular models of COPD exacerbations","volume":"129","author":"Rumora","year":"2021","journal-title":"APMIS"},{"key":"10.1016\/j.fct.2023.113795_bib55","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/infdis\/jix528","article-title":"ELMO1 Regulates autophagy induction and bacterial clearance during enteric infection","volume":"216","author":"Sarkar","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.fct.2023.113795_bib56","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","article-title":"Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4","volume":"26","author":"Scherz-Shouval","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.fct.2023.113795_bib57","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.fct.2023.113795_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2019.108337","article-title":"Atherogenic diet-induced bone loss is primarily due to increased osteoclastogenesis in mice","volume":"79","author":"Sul","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2023.113795_bib59","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8200189","article-title":"GSPE Protects against bleomycin-induced pulmonary fibrosis in mice via ameliorating epithelial apoptosis through inhibition of oxidative stress","author":"Sul","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.fct.2023.113795_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108783","article-title":"7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts","volume":"96","author":"Sul","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2023.113795_bib61","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.2147\/COPD.S172579","article-title":"Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1-nuclear factor-\u03baB\/p65 pathway in RAW264.7 macrophages and in COPD mice","volume":"13","author":"Sun","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon."},{"key":"10.1016\/j.fct.2023.113795_bib62","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fct.2023.113795_bib63","first-page":"2689","article-title":"It takes two to tango: cigarette smoke partners with viruses to promote emphysema","volume":"118","author":"Tuder","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fct.2023.113795_bib64","doi-asserted-by":"crossref","first-page":"L109","DOI":"10.1152\/ajplung.90461.2008","article-title":"Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells","volume":"297","author":"van der Toorn","year":"2009","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.fct.2023.113795_bib65","doi-asserted-by":"crossref","first-page":"L1156","DOI":"10.1152\/ajplung.00081.2007","article-title":"Cigarette smoke irreversibly modifies glutathione in airway epithelial cells","volume":"293","author":"van der Toorn","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.fct.2023.113795_bib66","doi-asserted-by":"crossref","first-page":"C73","DOI":"10.1152\/ajpcell.00110.2016","article-title":"Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis","volume":"314","author":"Vij","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.fct.2023.113795_bib67","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.4049\/jimmunol.1701681","article-title":"MTOR suppresses cigarette smoke-induced epithelial cell death and airway inflammation in chronic obstructive pulmonary disease","volume":"200","author":"Wang","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.fct.2023.113795_bib68","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1586\/ers.10.68","article-title":"Animal models of cigarette smoke-induced chronic obstructive pulmonary disease","volume":"4","author":"Wright","year":"2010","journal-title":"Expet Rev. Respir. Med."},{"key":"10.1016\/j.fct.2023.113795_bib69","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3390\/ijms19020582","article-title":"Lung macrophage phenotypes and functional responses: role in the pathogenesis of COPD","volume":"19","author":"Yamasaki","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2023.113795_bib70","first-page":"13209","article-title":"NLRP3 inflammasome is essential for the development of chronic obstructive pulmonary disease","volume":"8","author":"Yang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.fct.2023.113795_bib71","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2023.113795_bib72","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3109\/01902148.2012.745910","article-title":"Intraperitoneal injection of cigarette smoke extract induced emphysema, and injury of cardiac and skeletal muscles in BALB\/C mice","volume":"39","author":"Zhang","year":"2013","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.fct.2023.113795_bib73","doi-asserted-by":"crossref","first-page":"L173","DOI":"10.1152\/ajplung.00083.2014","article-title":"Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation","volume":"307","author":"Zhang","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.fct.2023.113795_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.733650","article-title":"Cigarette smoke promotes interleukin-8 production in alveolar macrophages through the reactive oxygen species\/stromal interaction molecule 1\/Ca2+ axis","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.fct.2023.113795_bib28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12971-015-0033-z","article-title":"Comparison between cigarette smoke-induced emphysema and cigarette smoke extract-induced emphysema","volume":"13","author":"He","year":"2015","journal-title":"Tob. Induc. Dis."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691523001977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691523001977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T14:09:57Z","timestamp":1736345397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691523001977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":74,"alternative-id":["S0278691523001977"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2023.113795","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GSPE attenuates CSE-induced lung inflammation and emphysema by regulating autophagy via the reactive oxygen species\/TFEB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2023.113795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"113795"}}