{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:44:15Z","timestamp":1788871455105,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.fct.2023.113810","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T18:09:46Z","timestamp":1683137386000},"page":"113810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Comprehensive analysis and identification of the circ_0084615\/miR-451a\/MEF2D axis in benzo(a)pyrene exposed tumor cells in hepato-carcinogenesis"],"prefix":"10.1016","volume":"176","author":[{"given":"Wei","family":"Mu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2023.113810_bib1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1289\/ehp.1408524","article-title":"Effects of benzo[a]pyrene exposure on human hepatocellular carcinoma cell angiogenesis, metastasis, and NF-\u03baB signaling","volume":"123","author":"Ba","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2023.113810_bib2","first-page":"556","article-title":"Benzo[a]pyrene stimulates miR-650 expression to promote the pathogenesis of fatty liver disease and hepatocellular carcinoma via SOCS3\/JAK\/STAT3 cascades","volume":"13","author":"Ge","year":"2021","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.fct.2023.113810_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.envpol.2016.04.081","article-title":"Benzo(a)pyrene in Europe: ambient air concentrations, population exposure and health effects","volume":"214","author":"Guerreiro","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.113810_bib4","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.3390\/cancers13112772","article-title":"Clinicopathological-associated regulatory network of deregulated circRNAs in hepatocellular carcinoma","volume":"13","author":"Han","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.fct.2023.113810_bib5","article-title":"Epigenome-wide DNA methylation signature of benzo[a]pyrene exposure and their mediation roles in benzo[a]pyrene-associated lung cancer development","volume":"416","author":"Hua","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.113810_bib6","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1007\/s13577-021-00607-y","article-title":"Construction of a ceRNA network and a genomic-clinicopathologic nomogram to predict survival for HBV-related HCC","volume":"34","author":"Huang","year":"2021","journal-title":"Hum. Cell"},{"key":"10.1016\/j.fct.2023.113810_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111372","article-title":"Insight about methods used for polycyclic aromatic hydrocarbons reduction in smoked or grilled fishery and meat products for future re-engineering: a systematic review","volume":"141","author":"Iko Af\u00e9","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2023.113810_bib8","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.jhep.2021.08.012","article-title":"Epidemiology and risk-stratification of NAFLD-associated HCC","volume":"75","author":"Ioannou","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.fct.2023.113810_bib9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.fct.2023.113810_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2021.02.004","article-title":"CircRNA in cancer: fundamental mechanism and clinical potential","volume":"505","author":"Liang","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2023.113810_bib11","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1158\/0008-5472.CAN-13-2171","article-title":"Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes","volume":"74","author":"Ma","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2023.113810_bib12","article-title":"The emerging roles and potential applications of circular RNAs in ovarian cancer: a comprehensive review","author":"Najafi","year":"2022","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.fct.2023.113810_bib13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.ijbiomac.2022.03.103","article-title":"Circular RNAs as emerging players in cervical cancer tumorigenesis; A review to roles and biomarker potentials","volume":"206","author":"Najafi","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fct.2023.113810_bib14","first-page":"5554","article-title":"MiR-451a suppressed cell migration and invasion in non-small cell lung cancer through targeting ATF2","volume":"22","author":"Shen","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.fct.2023.113810_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.556","article-title":"Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma","volume":"8","author":"Shi","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2023.113810_bib16","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00204-015-1572-z","article-title":"New insights into B[a]P-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis","volume":"90","author":"Souz","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2023.113810_bib17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.annepidem.2013.10.019","article-title":"Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China","volume":"24","author":"Su","year":"2014","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.fct.2023.113810_bib18","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3390\/ijerph17030970","article-title":"Long-Term exposure to Benzo[a]Pyrene affects sexual differentiation and embryos toxicity in three generations of Marine Medaka (Oryzias Melastigma)","volume":"17","author":"Sun","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.fct.2023.113810_bib19","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.1158\/0008-5472.CAN-16-0246","article-title":"MEF2D transduces microenvironment stimuli to ZEB1 to promote epithelial-mesenchymal transition and metastasis in colorectal cancer","volume":"76","author":"Su","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2023.113810_bib20","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.scitotenv.2015.10.003","article-title":"Association of environmental benzo[a]pyrene exposure and DNA methylation alterations in hepatocellular carcinoma: a Chinese case-control study","volume":"541","author":"Tian","year":"2015","journal-title":"Sci. Total Environ."},{"issue":"12","key":"10.1016\/j.fct.2023.113810_bib21","first-page":"150","article-title":"Disruption of SIRT7 increases the efficacy of checkpoint inhibitor via MEF2D regulation of PD-L1 in hepatocellular carcinoma cells","volume":"158","author":"Xiang","year":"2019","journal-title":"Gastroenterology"},{"issue":"26","key":"10.1016\/j.fct.2023.113810_bib22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41392-020-00375-5","article-title":"CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1","volume":"5","author":"Xu","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.fct.2023.113810_bib23","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","article-title":"A global view of hepatocellular carcinoma: trends, risk, prevention and management","volume":"16","author":"Yang","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.fct.2023.113810_bib24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1476-4598-12-150","article-title":"Loss of MEF2D expression inhibits differentiation and contributes to oncogenesis in rhabdomyosarcoma cells","volume":"12","author":"Zhang","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.fct.2023.113810_bib25","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12943-020-01222-5","article-title":"Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.fct.2023.113810_bib26","article-title":"Comprehensive profile of circRNAs in formaldehyde induced heart development","volume":"26","author":"Zhang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2023.113810_bib27","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12943-021-01343-5","article-title":"Epigenetic silencing of miR-144\/451a cluster contributes to HCC progression via paracrine HGF\/MIF-mediated TAM remodeling","volume":"20","author":"Zhao","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.fct.2023.113810_bib28","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1002\/hep.32046","article-title":"Dietary N-nitroso compounds and risk of hepatocellular carcinoma: a USA-based study","volume":"74","author":"Zheng","year":"2021","journal-title":"Hepatology"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691523002120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691523002120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T14:10:10Z","timestamp":1736345410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691523002120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":28,"alternative-id":["S0278691523002120"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2023.113810","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive analysis and identification of the circ_0084615\/miR-451a\/MEF2D axis in benzo(a)pyrene exposed tumor cells in hepato-carcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2023.113810","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113810"}}